The DOI matches its Crossref record; 50 of the 50 references it cites were found in a registry or an index.
A molecular network for de novo generation of the apical surface and lumen
Open accessAbstract
To form epithelial organs cells must polarize and generate de novo an apical domain and lumen. Epithelial polarization is regulated by polarity complexes that are hypothesized to direct downstream events, such as polarized membrane traffic, although this interconnection is not well understood. We have found that Rab11a regulates apical traffic and lumen formation through the Rab guanine nucleotide exchange factor (GEF), Rabin8, and its target, Rab8a. Rab8a and Rab11a function through the exocyst to target Par3 to the apical surface, and control apical Cdc42 activation through the Cdc42 GEF, Tuba. These components assemble at a transient apical membrane initiation site to form the lumen. This Rab11a-directed network directs Cdc42-dependent apical exocytosis during lumen formation, revealing an interaction between the machineries of vesicular transport and polarization.
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Coordination of Rab8 and Rab11 in primary ciliogenesis
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Metadata
- Authors
- Bryant, D. M., Datta, A., Rodríguez-Fraticelli, A. E., Peränen, J., Martín-Belmonte, F., & Mostov, K. E.
- Venue
- Nature Cell Biology
- Published
- 2010-10-03
- Volume
- 12
- Issue
- 11
- Pages
- 1035-1045
- ISSN
- 1465-7392 (ISSN-L)
- 1476-4679
- OpenAlex
- W2069354876
- Cited by
- 585
- References
- 50
- FWCI
- 16.08
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
