The Hippo pathway in organ size control, tissue regeneration and stem cell self-renewal

Zhao, Bin, Tumaneng, Karen, Guan, Kun-Liang·2011·Nature Cell Biology

DOI 10.1038/ncb2303

Cited by (1,000)

Items 201–300 of 1,000

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Funiu Qin, Jing Tian, Dawang Zhou, Lanfen Chen · 2013 · Cell & Bioscience
YAP Suppresses Lung Squamous Cell Carcinoma Progression via Deregulation of the DNp63–GPX2 Axis and ROS Accumulation
Hsin‐Yi Huang, Wenjing Zhang, Yafang Pan, Yijun Gao, Lei Deng, Fuming Li, Fei Li, Xueyan Ma, Shenda Hou, Jing Xu et al. · 2017 · Cancer Research
Dynamic Fluctuations in Subcellular Localization of the Hippo Pathway Effector Yorkie In Vivo
Samuel A. Manning, Lucas Dent, Shu Kondo, Ziqing Zhao, Nicolas Plachta, Kieran F. Harvey · 2018 · Current Biology
WWP1 E3 Ligase Targets LATS1 for Ubiquitin-Mediated Degradation in Breast Cancer Cells
Benjamin Yeung, King Ching Ho, Xiaolong Yang · 2013 · PLoS ONE
The Hippo Signaling Pathway in Drug Resistance in Cancer
Zeng, Renya, Dong, Jixin · 2021 · Cancers
An Integrative Analysis of the Tumorigenic Role of TAZ in Human Non–Small Cell Lung Cancer
Satoshi F. Noguchi, Akira Saito, Masafumi Horie, Yu Mikami, Hiroshi I. Suzuki, Yasuyuki Morishita, Mitsuhiro Ohshima, Yoshimitsu Abiko, Johanna Sofia Margareta Mattsson, Helena König et al. · 2014 · Clinical Cancer Research
Substrate stiffness- and topography-dependent differentiation of annulus fibrosus-derived stem cells is regulated by Yes-associated protein
Genglei Chu, Zhangqin Yuan, Caihong Zhu, Pinghui Zhou, Huan Wang, Weidong Zhang, Yan Cai, Xuesong Zhu, Huilin Yang, Bin Li · 2019 · Acta Biomaterialia
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Lingbin Liu, Qihai Xiao, Elizabeth Ruth Gilbert, Zhifu Cui, Xiaoling Zhao, Yan Wang, Huadong Yin, Diyan Li, Haihan Zhang, Qing Chun Zhu · 2018 · Scientific Reports
Cell tension and mechanical regulation of cell volume
Nicolas Perez Gonzalez, Jiaxiang Tao, Nash D. Rochman, Dhruv Vig, Evelyn Chiu, Denis Wirtz, Sean X. Sun · 2018 · Molecular Biology of the Cell
The roles and mechanisms of YTH domain-containing proteins in cancer development and progression.
Shuiping Liu, Guohua Li, Qiujie Li, Qin Zhang, Lvjia Zhuo, Xiaying Chen, Bingtao Zhai, Xinbing Sui, Ke Chen, Tian Xie · 2020 · PubMed Central
The H ippo pathway in chemotherapeutic drug resistance
Yulei Zhao, Xiaolong Yang · 2014 · International Journal of Cancer
Role of Osteocyte-derived Insulin-Like Growth Factor I in Developmental Growth, Modeling, Remodeling, and Regeneration of the Bone
Matilda H.‐C. Sheng, K.‐H. William Lau, David J. Baylink · 2014 · Journal of Bone Metabolism
Emerging role of Hippo pathway in gastric and other gastrointestinal cancers
Wei Kang · 2016 · World Journal of Gastroenterology
Morin attenuates diethylnitrosamine-induced rat liver fibrosis and hepatic stellate cell activation by co-ordinated regulation of Hippo/Yap and TGF-β1/Smad signaling
Naveenkumar Perumal, Madan Kumar Perumal, Halagowder Devaraj, Sivasithamparam NiranjaliDevaraj · 2017 · Biochimie
Hippo pathway inhibition by blocking the YAP/TAZ–TEAD interface: a patent review
James J. Crawford, Sarah M. Bronner, Jason R. Zbieg · 2018 · Expert Opinion on Therapeutic Patents
Geranylgeranylation signals to the Hippo pathway for breast cancer cell proliferation and migration
Wenyi Mi, Qiong Lin, Chandra Childress, Marius Sudol, Janet D. Robishaw, Catherine H. Berlot, Mohsen M. Shabahang, Wannian Yang · 2014 · Oncogene
Nuclear TAZ expression associates with the triple-negative phenotype in breast cancer
Juan Díaz‐Martín, María Ángeles López‐García, Laura Romero‐Pérez, María Reina Atienza-Amores, María Luisa Pecero, María Ángeles Castilla, Michele Biscuola, Almudena Santón, José Palacios · 2015 · Endocrine Related Cancer
Angiomotin decreases lung cancer progression by sequestering oncogenic YAP/TAZ and decreasing Cyr61 expression
Y-L Hsu, J-Y. Hung, S. H. Chou, M.-Y. Huang, M-J Tsai, Y S Lin, S-Y Chiang, Y-W Ho, C-Y Wu, P-L Kuo · 2014 · Oncogene
A reciprocal regulatory loop between TAZ/YAP and G-protein Gαs regulates Schwann cell proliferation and myelination
Yaqi Deng, Lai Man Natalie Wu, Shujun Bai, Chuntao Zhao, Haibo Wang, Jincheng Wang, Lingli Xu, Masahide Sakabe, Wenhao Zhou, Mei Xin et al. · 2017 · Nature Communications
Role of extracellular matrix and YAP/TAZ in cell fate determination
Jin Hao, Yueling Zhang, Yating Wang, Rui Ye, Jingyi Qiu, Zhihe Zhao, Juan Li · 2013 · Cellular Signalling
The alteration of Hippo/YAP signaling in the development of hypertrophic cardiomyopathy
Wang, Pei, Mao, Beibei, Luo, Wen, Wei, Bin, Jiang, Wenjian, Liu, Dong, Song, Lei, Ji, Guangju, Yang, Zhongzhou, Lai, Yong-Qiang et al. · 2014 · Basic Research in Cardiology
The Hippo Signaling Pathway in Cardiac Development and Diseases
Masum M. Mia, Manvendra Kumar Singh · 2019 · Frontiers in Cell and Developmental Biology
New insights into the ambivalent role of YAP/TAZ in human cancers
Juan Luo, Liang Deng, Hailin Zou, Yibo Guo, Tongyu Tong, Mingli Huang, Gengqiang Ling, Peng Li · 2023 · Journal of Experimental & Clinical Cancer Research
Stress and stem cells
John Tower · 2012 · Wiley Interdisciplinary Reviews Developmental Biology
Hippo signalling in the G2/M cell cycle phase: Lessons learned from the yeast MEN and SIN pathways
Alexander Hergovich, Brian A. Hemmings · 2012 · Seminars in Cell and Developmental Biology
Promotion Effects of miR-375 on the Osteogenic Differentiation of Human Adipose-Derived Mesenchymal Stem Cells
Si Chen, Yunfei Zheng, Shan Zhang, Lingfei Jia, Yongsheng Zhou · 2017 · Stem Cell Reports
Non-coding RNAs: emerging players in cardiomyocyte proliferation and cardiac regeneration
Naisam Abbas, Filippo Perbellini, Thomas Thum · 2020 · Basic Research in Cardiology
Adaptations in Hippo-Yap signaling and myofibroblast fate underlie scar-free ear appendage wound healing in spiny mice
Chris M. Brewer, Branden R. Nelson, Paul Wakenight, Sarah Collins, Daryl M. Okamura, Xiu Rong Dong, William M. Mahoney, Aaron McKenna, Jay Shendure, Andrew E. Timms et al. · 2021 · Developmental Cell
Reconsidering regeneration in metazoans: an evo-devo approach
Stefano Tiozzo, Richard R. Copley · 2015 · Frontiers in Ecology and Evolution
The Hippo pathway in colorectal cancer
Piotr Wierzbicki, Agnieszka Rybarczyk · 2015 · Folia Histochemica et Cytobiologica
A framework for how environment contributes to cancer risk
Michael Hochberg, Robert Noble · 2017 · Ecology Letters
Acoustic tweezing cytometry enhances osteogenesis of human mesenchymal stem cells through cytoskeletal contractility and YAP activation
Xufeng Xue, Xiaowei Hong, Zida Li, Cheri Xiaoyu Deng, Jianping Fu · 2017 · Biomaterials
Targeting tumor lineage plasticity in hepatocellular carcinoma using an anti-CLDN6 antibody-drug conjugate
Fan-En Kong, Guangmeng Li, Yun-Qiang Tang, Shaoyan Xi, Jane Ho Chun Loong, Meimei Li, Haolong Li, Wei Cheng, Wenjie Zhu, Jia-Qiang Mo et al. · 2021 · Science Translational Medicine
Hippo Signaling in Cancer: Lessons From Drosophila Models
Kirti Snigdha, Karishma Gangwani, Gauri V. Lapalikar, Amit Singh, Madhuri Kango‐Singh · 2019 · Frontiers in Cell and Developmental Biology
A novel genome-wide in vivo screen for metastatic suppressors in human colon cancer identifies the positive WNT-TCF pathway modulators TMED3 and SOX12
Arnaud Duquet, A. Melotti, Sonakshi Mishra, M. Malerba, Chandan Seth, Arwen Conod, A. R. I. Altaba · 2014 · EMBO Molecular Medicine
Stem cell regulation by the Hippo pathway
Samantha E. Hiemer, Xaralabos Varelas · 2012 · Biochimica et Biophysica Acta (BBA) - General Subjects
Cartilage regeneration for treatment of osteoarthritis: a paradigm for nonsurgical intervention
MOTI L. TIKU, Hatem E. Sabaawy · 2015 · Therapeutic Advances in Musculoskeletal Disease
Integration of morphogen signalling within the growth regulatory network
Luis Alberto Baena-López, Hisashi Nojima, Jean‐Paul Vincent · 2012 · Current Opinion in Cell Biology
YAP overexpression promotes the epithelial-mesenchymal transition and chemoresistance in pancreatic cancer cells
Yanli Yuan, Deyu Li, Haibo Li, Liancai Wang, GUANGJIN TIAN, YADONG DONG · 2015 · Molecular Medicine Reports
Involvement of the Hippo pathway in regeneration and fibrogenesis after ischaemic acute kidney injury: YAP is the key effector
Jing Xu, Pei-Xue Li, Jun Wu, Yijun Gao, Meng-Xin Yin, Ye Lin, Ming Yang, Dongping Chen, Haipeng Sun, Zeng-Bo Liu et al. · 2015 · Clinical Science
The Nedd4-like ubiquitin E3 ligases target angiomotin/p130 to ubiquitin-dependent degradation
Chenji Wang, Jian An, Pingzhao Zhang, Chen Xu, Kun Gao, Di Wu, Dejie Wang, Hongxiu Yu, Jun O. Liu, Long Yu · 2012 · Biochemical Journal
The actin-binding protein EPS8 binds VE-cadherin and modulates YAP localization and signaling
Costanza Giampietro, Andrea Disanza, Luca Bravi, Miriam Barrios‐Rodiles, Monica Corada, Emanuela Frittoli, Cecilia Savorani, Maria Grazia Lampugnani, Barbara Boggetti, Carien M. Niessen et al. · 2015 · The Journal of Cell Biology
Tumor suppressor genes and their underlying interactions in paclitaxel resistance in cancer therapy
Jiahui Xu, Shilian Hu, Guodong Shen, Gan Shen · 2016 · Cancer Cell International
Advanced Role of Hippo Signaling in Endometrial Fibrosis
Hai-Yan Zhu, Tianxiang Ge, Yibin Pan, Songying Zhang · 2017 · Chinese Medical Journal
The role of the Hippo pathway in the pathogenesis of inflammatory bowel disease
Zhuo Xie, Ying Wang, Guang Yang, Jing Han, Liguo Zhu, Li Li, Shenghong Zhang · 2021 · Cell Death and Disease
Transglutaminase Interaction with α6/β4-Integrin Stimulates YAP1-Dependent ΔNp63α Stabilization and Leads to Enhanced Cancer Stem Cell Survival and Tumor Formation
Matthew L. Fisher, Candace L. Kerr, Gautam Adhikary, Daniel Grun, Wen Xu, Jeffrey W. Keillor, Richard L. Eckert · 2016 · Cancer Research
Dishevelled has a YAP nuclear export function in a tumor suppressor context-dependent manner
Yoonmi Lee, Nam Hee Kim, Eunae Sandra Cho, Ji Hye Yang, Yong Hoon Cha, Hee Eun Kang, Jun Seop Yun, Sue Bean Cho, Seon-Hyeong Lee, Petra Paclíková et al. · 2018 · Nature Communications
Elevated YAP and Its Downstream Targets CCN1 and CCN2 in Basal Cell Carcinoma
Taihao Quan, Yiru Xu, Zhaoping Qin, Patrick Robichaud, Stephanie Betcher, Ken Calderone, Tianyuan He, Timothy M. Johnson, John J. Voorhees, Gary J. Fisher · 2014 · American Journal Of Pathology
Changes in miRNA levels of sperm and small extracellular vesicles of seminal plasma are associated with transient scrotal heat stress in bulls
Maíra Bianchi Rodrigues Alves, Rubens Paes de Arruda, Leonardo Batissaco, Laura Nataly Garcia‐Oliveros, Vitor Hugo Guilger Gonzaga, Vinícius José Moreira Nogueira, Flávia dos Santos Almeida, Sâmara Cristine Costa Pinto, Gabriella Mamede Andrade, Felipe Perecin et al. · 2020 · Theriogenology
mTOR: A Potential New Target in Nonalcoholic Fatty Liver Disease
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A Challenge of Numbers and Diversity: Neurogenesis in the Drosophila Optic Lobe
Holger Apitz, Iris Salecker · 2014 · Journal of Neurogenetics
The TEAD4–YAP/TAZ Protein–Protein Interaction: Expected Similarities and Unexpected Differences
Jean Christophe Hau, Dirk Erdmann, Yannick Mesrouze, Pascal Furet, Patrizia Fontana, Catherine Zimmermann, Tobias Schmelzle, Francesco Hofmann, Patrick Chêne · 2013 · ChemBioChem
The Hippo-Salvador signaling pathway regulates renal tubulointerstitial fibrosis
Eunjeong Seo, Wan‐Young Kim, Jeongmi Hur, Hanbyul Kim, Sun Ah Nam, Arum Choi, Yumi Kim, Sang Hee Park, Chaeuk Chung, Jin Kim et al. · 2016 · Scientific Reports
Evidence, Mechanism, and Clinical Relevance of the Transdifferentiation from Lung Adenocarcinoma to Squamous Cell Carcinoma
Shenda Hou, Shiyu Zhou, Zhen Qin, Yang Liu, Xiangkun Han, Shun Yao, Hongbin Ji · 2017 · American Journal Of Pathology
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Jae‐Won Shin, Joe Swift, Irena Lambrova Ivanovska, Kyle R. Spinler, Amnon Buxboim, Dennis E. Discher · 2013 · Differentiation
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Lucie P. Pellissier, C. Henrique Alves, Peter M. J. Quinn, Rogier M. Vos, Naoyuki Tanimoto, Ditte M. S. Lundvig, Jacobus J. Dudok, Berend Hooibrink, Fabrice Richard, Susanne C Beck et al. · 2013 · PLoS Genetics
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Naihua Liu, Liu Mei, Xueying Fan, Chao Tang, Xing Ji, Xinhua Hu, Wei Shi, Yu Qian, Musaddique Hussain, Junsong Wu et al. · 2016 · Cancer Letters
Mycobacterium tuberculosis-triggered Hippo pathway orchestrates CXCL1/2 expression to modulate host immune responses
Monoranjan Boro, Vikas Singh, Kithiganahalli Narayanaswamy Balaji · 2016 · Scientific Reports
Angiomotin Family Members: Oncogenes or Tumor Suppressors?
Meng Lv, Yanwei Shen, Jiao Yang, Shuting Li, Biyuan Wang, Zheling Chen, Peijun Liu, Peijun Liu, Jin Yang · 2017 · International Journal of Biological Sciences
Yap/Taz mediates mTORC2-stimulated fibroblast activation and kidney fibrosis
Yuan Gui, Jianzhong Li, Qingmiao Lu, Feng Ye, Mingjie Wang, Weichun He, Junwei Yang, Chunsun Dai · 2018 · Journal of Biological Chemistry
OTUB1 suppresses Hippo signaling via modulating YAP protein in gastric cancer
Cheng Yan, Huijie Yang, Peng Su, Xin Li, Zhongbo Li, Dehai Wang, Yifeng Zang, Tianshi Wang, Ziping Liu, Zhuo-Cong Bao et al. · 2022 · Oncogene
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Weiyi Qian, Lanqi Gong, Xin Cui, Zijing Zhang, Apratim Bajpai, Chao Liu, Alesha B. Castillo, Jeremy C. M. Teo, Weiqiang Chen · 2017 · ACS Applied Materials & Interfaces
Lats2 Modulates Adipocyte Proliferation and Differentiation via Hippo Signaling
An, Yang, Kang, Qianqian, Zhao, Yaofeng, Hu, Xiaoxiang, Li, Ning · 2013 · PLoS ONE
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Juliet Rashidian, Erwan Le Scolan, Xiao‐Dan Ji, Qingwei Zhu, Melinda M. Mulvihill, Daniel K. Nomura, Kunxin Luo · 2015 · Science Signaling
The kinases NDR1/2 act downstream of the Hippo homolog MST1 to mediate both egress of thymocytes from the thymus and lymphocyte motility
Fengyuan Tang, Jason W. Gill, Xenia Ficht, Thomas Barthlott, Hauke Cornils, Debora Schmitz-Rohmer, Debby Hynx, Dawang Zhou, Lei Zhang, Gongda Xue et al. · 2015 · Science Signaling
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Qi Feng, Huichang Gao, Hongji Wen, Hanhao Huang, Qingtao Li, Minhua Liang, Yang Liu, Hua Dong, Xiaodong Cao · 2020 · Acta Biomaterialia
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Simon de Beco, Marcello Ziosi, Laura A. Johnston · 2012 · Developmental Dynamics
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Robert N. Judson, Stuart Robert Gray, Claire A. Walker, Andrew M. Carroll, Cécile Itzstein, Arimantas Lionikas, Peter S. Zammit, Cosimo De Bari, Henning Wackerhage · 2013 · PLoS ONE
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Proliferation of hepatic stellate cells, mediated by YAP and TAZ, contributes to liver repair and regeneration after liver ischemia-reperfusion injury
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S1P Stimulates Proliferation by Upregulating CTGF Expression through S1PR2-Mediated YAP Activation
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Homeodomain-Interacting Protein Kinase Regulates Hippo Pathway-Dependent Tissue Growth
Carole L.C. Poon, Xiaomeng Zhang, Jane I. Lin, Samuel A. Manning, Kieran F. Harvey · 2012 · Current Biology
Tumor suppressors: enhancers or suppressors of regeneration?
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Ryan J. Atkins, Wayne Ng, Stanley S. Stylli, Christopher M. Hovens, Andrew H. Kaye · 2014 · Journal of Clinical Neuroscience
Hippo pathway in mammary gland development and breast cancer
Peiguo Shi, Jing Chun Feng, Ceshi Chen · 2014 · Acta Biochimica et Biophysica Sinica
Evolutionary and Molecular Facts Link the WWC Protein Family to Hippo Signaling
Dirk Oliver Wennmann, Jürgen Schmitz, Michael C. Wehr, Michael P. Krahn, Nora Koschmal, Sascha Gromnitza, Ulf Schulze, Thomas Weide, Anil Chekuri, Boris V. Skryabin et al. · 2014 · Molecular Biology and Evolution
DNA-binding mechanism of the Hippo pathway transcription factor TEAD4
Zhubing Shi, F He, Mei Chen, Lei Hua, Wenshuai Wang, Shi Jiao, Zhaocai Zhou · 2017 · Oncogene
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Yu Na Kim, So Ra Choe, Kyung Hwa Cho, Do Yeun Cho, Jaeku Kang, Chang Gyo Park, Hoi Young Lee · 2017 · Experimental & Molecular Medicine
Downregulation of MiR-31 stimulates expression of LATS2 via the hippo pathway and promotes epithelial-mesenchymal transition in esophageal squamous cell carcinoma
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Discovery of tertiary amide derivatives incorporating benzothiazole moiety as anti-gastric cancer agents in vitro via inhibiting tubulin polymerization and activating the Hippo signaling pathway
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Coupling of Hedgehog and Hippo pathways promotes stem cell maintenance by stimulating proliferation
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Valeri I. Vasioukhin · 2012 · Sub-cellular biochemistry/Subcellular biochemistry
The PDZ-binding motif of Yes-associated protein is required for its co-activation of TEAD-mediated CTGF transcription and oncogenic cell transforming activity
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Jing Wang, Yifan Zhang, Ning Zhang, Chuandong Wang, Tanja Herrler, Qingfeng Li · 2015 · Cellular and Molecular Life Sciences
Par-1 Regulates Tissue Growth by Influencing Hippo Phosphorylation Status and Hippo-Salvador Association
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Wnt/β-catenin signaling via Axin2 is required for myogenesis and, together with YAP/Taz and Tead1, active in IIa/IIx muscle fibers
Danyil Huraskin, Nane Eiber, Martin Reichel, Laura M Zidek, Bojana Kravić, Dominic B. Bernkopf, Julia von Maltzahn, Jürgen Behrens, Said Hashemolhosseini · 2016 · Development
VGLL4 is a transcriptional cofactor acting as a novel tumor suppressor via interacting with TEADs.
Xiaochong Deng, Lin Fang · 2018 · Europe PMC (PubMed Central)
YAP is overexpressed in clear cell renal cell carcinoma and its knockdown reduces cell proliferation and induces cell cycle arrest and apoptosis
JIAN-JIA CAO, Xiumin Zhao, Delin Wang, Ke-Hong Chen, XIA SHENG, Wenbin Li, Meicai Li, Wujiang Liu, JIANG HE · 2014 · Oncology Reports
Statin suppresses Hippo pathway-inactivated malignant mesothelioma cells and blocks the YAP/CD44 growth stimulatory axis
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Kindlin-2 Inhibits the Hippo Signaling Pathway by Promoting Degradation of MOB1
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Salvianolic acid B ameliorates atherosclerosis via inhibiting YAP/TAZ/JNK signaling pathway in endothelial cells and pericytes
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Lu Zhou, Clemens Oliver Hanemann · 2012 · FEBS Letters
Matrix Rigidity Controls Endothelial Differentiation and Morphogenesis of Cardiac Precursors
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Alterations in the NF2/LATS1/LATS2/YAP Pathway in Schwannomas
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Single-cell sequencing reveals Hippo signaling as a driver of fibrosis in hidradenitis suppurativa
Kelsey R. van Straalen, Feiyang Ma, Pei‐Suen Tsou, Olesya Plazyo, Mehrnaz Gharaee‐Kermani, Marta Calbet, Xianying Xing, Mrinal K. Sarkar, Ranjitha Uppala, Paul W. Harms et al. · 2023 · Journal of Clinical Investigation
Signalling through mechanical inputs – a coordinated process
Huimin Zhang, Michel Labouesse · 2012 · Journal of Cell Science