Cited by 1,205Hippo pathway signaling and YAP/TAZMicrotubule and mitosis dynamicsDevelopmental Biology and Gene Regulation

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The Hippo pathway in organ size control, tissue regeneration and stem cell self-renewal

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Zhao, Bin, Tumaneng, Karen, Guan, Kun-Liang·2011·Nature Cell Biology

DOI 10.1038/ncb2303PMC PMC3987945

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Abstract

Precise control of organ size is crucial during animal development and regeneration. In Drosophila and mammals, studies over the past decade have uncovered a critical role for the Hippo tumour-suppressor pathway in the regulation of organ size. Dysregulation of this pathway leads to massive overgrowth of tissue. The Hippo signalling pathway is highly conserved and limits organ size by phosphorylating and inhibiting the transcription co-activators YAP and TAZ in mammals and Yki in Drosophila, key regulators of proliferation and apoptosis. The Hippo pathway also has a critical role in the self-renewal and expansion of stem cells and tissue-specific progenitor cells, and has important functions in tissue regeneration. Emerging evidence shows that the Hippo pathway is regulated by cell polarity, cell adhesion and cell junction proteins. In this review we summarize current understanding of the composition and regulation of the Hippo pathway, and discuss how cell polarity and cell adhesion proteins inform the role of this pathway in organ size control and regeneration.

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Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control
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Self-citation
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Self-citation
Elucidation of a universal size-control mechanism in Drosophila and mammals
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Self-citation
YAP1 increases organ size and expands undifferentiated progenitor cells
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hippo Encodes a Ste-20 Family Protein Kinase that Restricts Cell Proliferation and Promotes Apoptosis in Conjunction with salvador and warts
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Authors: Zhao, B., Tumaneng, K., & Guan, K.-L.
Affiliations: Zhejiang University (CN)
University of California San Diego (US)
Corresponding author: Guan, Kun-Liang
ORCID: Zhao, Bin
Guan, Kun-Liang
Venue: Nature Cell Biology
Publisher: Springer Science and Business Media LLC
Published: 2011-08
Volume: 13
Issue: 8
Pages: 877-883
ISSN: 1465-7392 (ISSN-L)
1476-4679
DOI: 10.1038/ncb2303
PMC: PMC3987945
OpenAlex: W2033360354
Cited by: 1,205
References: 130
Citations by year: 2026: 29 · 2025: 53 · 2024: 69 · 2023: 66 · 2022: 110 · 2021: 105 · 2020: 90 · 2019: 97 · 2018: 102 · 2017: 70 · 2016: 80 · 2015: 94 · 2014: 88 · 2013: 88 · 2012: 61
FWCI: 6.52
Type: journal article
Language: en
Open access: green
europepmc.org
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature Cell Biology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
National Cancer Institute (R01CA132809)
National Institute of General Medical Sciences (R01GM051586, T32GM007752)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Hippo pathway signaling and YAP/TAZ
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Keywords: Hippo signaling pathway, organ size control, tissue regeneration, stem cell self-renewal, YAP, TAZ, Yki, cell polarity, cell adhesion, cell junction proteins, tumor suppression, tissue overgrowth, Drosophila, mammals
MeSH terms: Hippo Kinases, Animals, Cell Adhesion, Drosophila, Humans, Intercellular Junctions, Models, Biological, Organ Size, Regeneration, Stem Cells, Signal Transduction, Cell Polarity, Protein Serine-Threonine Kinases, Drosophila Proteins, Intracellular Signaling Peptides and Proteins, Mice

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The Hippo pathway in organ size control, tissue regeneration and stem cell self-renewal

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