Glutaminolysis and autophagy in cancer

Hallmarks of Cancer: The Next Generation

Hanahan, D., & Weinberg, R. A. (2011) · Cell · doi:10.1016/j.cell.2011.02.013 · Cited by 66,590 · see citing works

Repertoires of Autophagy in the Pathogenesis of Ocular Diseases

Li, Y., Jiang, Q. L., Cao, G.-F., Yao, J., & Yan, B. (2015) · Cellular Physiology and Biochemistry · doi:10.1159/000373980 · Cited by 16,351 · see citing works

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

Vander Heiden, M. G., Cantley, L. C., & Thompson, C. B. (2009) · Science · doi:10.1126/science.1160809 · Cited by 16,197 · see citing works

mTOR Signaling in Growth Control and Disease

Laplante, M., & Sabatini, D. M. (2012) · Cell · doi:10.1016/j.cell.2012.03.017 · Cited by 8,509 · see citing works

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

Kim, J., Kundu, M., Viollet, B., & Guan, K.-L. (2011) · Nature Cell Biology · doi:10.1038/ncb2152 · Cited by 7,227 · see citing works

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

Sarbassov, D. D., Guertin, D. A., Ali, S. M., & Sabatini, D. M. (2005) · Science · doi:10.1126/science.1106148 · Cited by 6,216 · see citing works

Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?

Trachootham, D., Alexandre, J., & Huang, P. (2009) · Nature Reviews Drug Discovery · doi:10.1038/nrd2803 · Cited by 5,452 · see citing works

TSC2 Mediates Cellular Energy Response to Control Cell Growth and Survival

Inoki, K., Zhu, T., & Guan, K.-L. (2003) · Cell · doi:10.1016/s0092-8674(03)00929-2 · Cited by 3,914 · see citing works

Autophagy and the Integrated Stress Response

Kroemer, G., Mariño, G., & Levine, B. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.09.023 · Cited by 3,506 · see citing works

The Role of Atg Proteins in Autophagosome Formation

Mizushima, N., Yoshimori, T., & Ohsumi, Y. (2011) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-092910-154005 · Cited by 2,978 · see citing works

Defining the role of mTOR in cancer

Guertin, D. A., & Sabatini, D. M. (2007) · Cancer Cell · doi:10.1016/j.ccr.2007.05.008 · Cited by 2,833 · see citing works

The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1

Sancak, Y., Peterson, T. R., Shaul, Y. D., Lindquist, R. A., Thoreen, C. C., Bar-Peled, L., & Sabatini, D. M. (2008) · Science · doi:10.1126/science.1157535 · Cited by 2,773 · see citing works

Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis

DeBerardinis, R. J., Mancuso, A., Daikhin, E., Nissim, I., Yudkoff, M., Wehrli, S., & Thompson, C. B. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0709747104 · Cited by 2,622 · see citing works

Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene

Qu, X., Yu, J., Bhagat, G., Furuya, N., Hibshoosh, H., Troxel, A., Rosen, J., Eskelinen, E.-L., Mizushima, N., Ohsumi, Y., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci20039 · Cited by 2,311 · see citing works

Self-consumption: the interplay of autophagy and apoptosis

Mariño, G., Niso-Santano, M., Baehrecke, E. H., & Kroemer, G. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3735 · Cited by 2,172 · see citing works

Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor

Yue, Z., Jin, S., Yang, C., Levine, A. J., & Heintz, N. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2436255100 · Cited by 2,116 · see citing works

Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4

Scherz‐Shouval, R., Shvets, E., Fass, E., Shorer, H., Gil, L., & Elazar, Z. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601623 · Cited by 2,101 · see citing works

Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction

Wise, D. R., DeBerardinis, R. J., Mancuso, A., Sayed, N., Zhang, X.-Y., Pfeiffer, H. K., Nissim, I., Daikhin, E., Yudkoff, M., McMahon, S. B., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0810199105 · Cited by 2,001 · see citing works

Autophagy and Metabolism

Rabinowitz, J. D., & White, E. (2010) · Science · doi:10.1126/science.1193497 · Cited by 1,982 · see citing works

Mammalian autophagy: core molecular machinery and signaling regulation

Yang, Z., & Klionsky, D. J. (2010) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2009.11.014 · Cited by 1,956 · see citing works

Bidirectional Transport of Amino Acids Regulates mTOR and Autophagy

Nicklin, P., Bergman, P., Zhang, B., Triantafellow, E., Wang, H., Nyfeler, B., Yang, H., Hild, M., Kung, C., Wilson, C., et al. (2009) · Cell · doi:10.1016/j.cell.2008.11.044 · Cited by 1,798 · see citing works

Glutamine addiction: a new therapeutic target in cancer

Wise, D. R., & Thompson, C. B. (2010) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2010.05.003 · Cited by 1,770 · see citing works

Deconvoluting the context-dependent role for autophagy in cancer

White, E. (2012) · Nature reviews. Cancer · doi:10.1038/nrc3262 · Cited by 1,698 · see citing works

Termination of autophagy and reformation of lysosomes regulated by mTOR

Yu, L., McPhee, C. K., Zheng, L., Mardones, G. A., Rong, Y., Peng, J., Mi, N., Zhao, Y., Liu, Z., Wan, F., et al. (2010) · Nature · doi:10.1038/nature09076 · Cited by 1,544 · see citing works

Hypoxia-Induced Autophagy Is Mediated through Hypoxia-Inducible Factor Induction of BNIP3 and BNIP3L via Their BH3 Domains

Bellot, G., Garcia-Medina, R., Gounon, P., Chiche, J., Roux, D., Pouysségur, J., & Mazure, N. M. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.00166-09 · Cited by 1,501 · see citing works

Role of AMPK-mTOR-Ulk1/2 in the regulation of autophagy: cross talk, shortcuts, and feedbacks

Alers, S., Löffler, A. S., Wesselborg, S., & Stork, B. (2012) · Molecular and Cellular Biology · doi:10.1128/mcb.06159-11 · Cited by 1,483 · see citing works

Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer

Carracedo, A., Ma, L., Teruya-Feldstein, J., Rojo, F., Salmena, L., Alimonti, A., Egia, A., Sasaki, A. T., Thomas, G., Kozma, S. C., et al. (2008) · Journal of Clinical Investigation · doi:10.1172/jci34739 · Cited by 1,381 · see citing works

Q's next: the diverse functions of glutamine in metabolism, cell biology and cancer

DeBerardinis, R. J., & Cheng, T. (2010) · Oncogene · doi:10.1038/onc.2009.358 · Cited by 1,365 · see citing works

MTORC1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of TFEB

Martina, J. A., Chen, Y., Guček, M., & Puertollano, R. (2012) · Autophagy · doi:10.4161/auto.19653 · Cited by 1,360 · see citing works

HIF prolyl‐hydroxylase 2 is the key oxygen sensor setting low steady‐state levels of HIF‐1α in normoxia

Berra, E., Benizri, E., Ginouvès, A., Volmat, V., Roux, D., & Pouysségur, J. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg392 · Cited by 1,348 · see citing works

Autophagy-deficient mice develop multiple liver tumors

Takamura, A., Komatsu, M., Hara, T., Sakamoto, A., Kishi, C., Waguri, S., Eishi, Y., Hino, O., Tanaka, K., & Mizushima, N. (2011) · Genes & Development · doi:10.1101/gad.2016211 · Cited by 1,342 · see citing works

Emerging regulation and functions of autophagy

Boya, P., Reggiori, F., & Codogno, P. (2013) · Nature Cell Biology · doi:10.1038/ncb2788 · Cited by 1,216 · see citing works

Autophagy and chemotherapy resistance: a promising therapeutic target for cancer treatment

Sui, X., Chen, R. B., Wang, Z., Huang, Z., Kong, N., Zhang, M., Han, W., Lou, F., Yang, J., Zhang, Q., et al. (2013) · Cell Death and Disease · doi:10.1038/cddis.2013.350 · Cited by 1,209 · see citing works

Functional and physical interaction between Bcl‐XL and a BH3‐like domain in Beclin‐1

Maiuri, M. C., Toumelin-Braizat, G. L., Criollo, A., Rain, J., Gautier, F., Juin, P. P., Tasdemir, E., Pierron, G., Troulinaki, K., Tavernarakis, N., et al. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601689 · Cited by 1,107 · see citing works

Antitumor activity of the glutaminase inhibitor CB-839 in triple-negative breast cancer

Gross, M. I., Demo, S. D., Dennison, J. B., Chen, L., Chernov-Rogan, T., Goyal, B., Janes, J. R., Laidig, G. J., Lewis, E. R., Li, J., et al. (2014) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-13-0870 · Cited by 1,068 · see citing works

Making new contacts: the mTOR network in metabolism and signalling crosstalk

Shimobayashi, M., & Hall, M. N. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3757 · Cited by 1,053 · see citing works

Targeting cellular metabolism to improve cancer therapeutics

Zhao, Y., Butler, E. B., & Tan, M. (2013) · Cell Death and Disease · doi:10.1038/cddis.2013.60 · Cited by 994 · see citing works

Autophagy—a key player in cellular and body metabolism

Kim, K. H., & Lee, M. (2014) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2014.35 · Cited by 962 · see citing works

Principles and Current Strategies for Targeting Autophagy for Cancer Treatment

Amaravadi, R. K., Lippincott‐Schwartz, J., Yin, X., Weiss, W. A., Takebe, N., Timmer, W. C., DiPaola, R. S., Lotze, M. T., & White, E. (2011) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-10-2634 · Cited by 899 · see citing works

Amino acid signalling upstream of mTOR

Jewell, J. L., Russell, R. C., & Guan, K.-L. (2013) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3522 · Cited by 894 · see citing works

Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function

Hu, W., Zhang, C., Wu, R., Sun, Y., Levine, A., & Feng, Z. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1001006107 · Cited by 862 · see citing works

AMP-activated Protein Kinase Suppresses Protein Synthesis in Rat Skeletal Muscle through Down-regulated Mammalian Target of Rapamycin (mTOR) Signaling

Bolster, D. R., Crozier, S. J., Kimball, S. R., & Jefferson, L. S. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.c200171200 · Cited by 851 · see citing works

Autophagy as a target for anticancer therapy

Jankú, F., McConkey, D. J., Hong, D. S., & Kurzrock, R. (2011) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2011.71 · Cited by 803 · see citing works

Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor

Hirsilä, M., Koivunen, P., Günzler, V., Kivirikko, K. I., & Myllyharju, J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m304982200 · Cited by 794 · see citing works

Regulation of mTORC1 by amino acids

Bar-Peled, L., & Sabatini, D. M. (2014) · Trends in Cell Biology · doi:10.1016/j.tcb.2014.03.003 · Cited by 773 · see citing works

The mitochondrial transporter family (SLC25): physiological and pathological implications

Palmieri, F. (2004) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-003-1099-7 · Cited by 757 · see citing works

Glutaminolysis Activates Rag-mTORC1 Signaling

Durán, R. V., Oppliger, W., Robitaille, A. M., Heiserich, L., Skendaj, R., Gottlieb, E., & Hall, M. N. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.05.043 · Cited by 723 · see citing works

ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS

Alexander, A., Cai, S.-L., Kim, J., Nanez, A., Sahin, M., MacLean, K. H., Inoki, K., Guan, K.-L., Shen, J., Person, M. D., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0913860107 · Cited by 717 · see citing works

Autophagy regulation by nutrient signaling

Russell, R. C., Yuan, H., & Guan, K. (2013) · Cell Research · doi:10.1038/cr.2013.166 · Cited by 713 · see citing works

Phosphate-activated glutaminase (GLS2), a p53-inducible regulator of glutamine metabolism and reactive oxygen species

Suzuki, S., Tanaka, T., Poyurovsky, M. V., Nagano, H., Mayama, T., Ohkubo, S., Lokshin, M., Hosokawa, H., Nakayama, T., Suzuki, Y., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1002459107 · Cited by 705 · see citing works

Phosphorylation of ribosomal protein S6 is inhibitory for autophagy in isolated rat hepatocytes

Blommaart, E. F. C., Luiken, J. J. F. P., Blommaart, P. J. E., van Woerkom, G. M., & Meijer, A. J. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.5.2320 · Cited by 686 · see citing works

Regulation of Glutaminase Activity and Glutamine Metabolism

Curthoys, N. P., & Watford, M. (1995) · Annual Review of Nutrition · doi:10.1146/annurev.nu.15.070195.001025 · Cited by 643 · see citing works

The mTORC1 Pathway Stimulates Glutamine Metabolism and Cell Proliferation by Repressing SIRT4

Csibi, A., Fendt, S.-M., Li, C., Poulogiannis, G., Choo, A. Y., Chapski, D. J., Jeong, S. M., Dempsey, J. M., Parkhitko, A., Morrison, T., et al. (2013) · Cell · doi:10.1016/j.cell.2013.04.023 · Cited by 586 · see citing works

AMPK—Sensing Energy while Talking to Other Signaling Pathways

Hardie, D. G. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.09.013 · Cited by 581 · see citing works

Metabolism of amino-acids

Krebs, H. A. (1935) · Biochemical Journal · doi:10.1042/bj0291951 · Cited by 571 · see citing works

The metabolite alpha-ketoglutarate extends lifespan by inhibiting the ATP synthase and TOR

Chin, R., Fu, X., Pai, M. Y., Vergnes, L., Hwang, H., Deng, G., Diep, S., Lomenick, B., Meli, V., Monsalve, G. C., et al. (2014) · Nature · doi:10.1038/nature13264 · Cited by 570 · see citing works

p62 Is a Key Regulator of Nutrient Sensing in the mTORC1 Pathway

Durán, Á., Amanchy, R., Linares, J. F., Joshi, J. P., Abu‐Baker, S., Porollo, A., Hansen, M., Moscat, J., & Díaz-Meco, M. T. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.06.038 · Cited by 502 · see citing works

Regulation of autophagy by cytosolic acetyl-coenzyme A

Mariño, G., Pietrocola, F., Eisenberg, T., Kong, Y., Malik, S. A., Andryushkova, A., Schroeder, S., Pendl, T., Harger, A., Niso-Santano, M., et al. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.01.016 · Cited by 500 · see citing works

Autophagy-Mediated Tumor Promotion

Guo, J. Y., Xia, B., & White, E. (2013) · Cell · doi:10.1016/j.cell.2013.11.019 · Cited by 499 · see citing works

Balancing Akt with S6K

Manning, B. D. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200408161 · Cited by 474 · see citing works

AMP-activated Protein Kinase and the Regulation of Autophagic Proteolysis

Meley, D., Bauvy, C., Houben-Weerts, J. H. P. M., Dubbelhuis, P. F., Helmond, M. T. J., Codogno, P., & Meijer, A. J. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m605488200 · Cited by 461 · see citing works

Autophagy Sustains Mitochondrial Glutamine Metabolism and Growth of <i>Braf</i> V600E–Driven Lung Tumors

Strohecker, A. M., Guo, J. Y., Karsli-Uzunbas, G., Price, S. M., Chen, G. J., Mathew, R., McMahon, M., & White, E. (2013) · Cancer Discovery · doi:10.1158/2159-8290.cd-13-0397 · Cited by 435 · see citing works

Inhibition of the lysosomal pathway of protein degradation in isolated rat hepatocytes by ammonia, methylamine, chloroquine and leupeptin.

Seglen, P., Grinde, B., & Solheim, A. E. (1979) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1979.tb12956.x · Cited by 430 · see citing works

mTOR and autophagy: a dynamic relationship governed by nutrients and energy.

Dunlop, E., & Tee, A. (2014) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2014.08.006 · Cited by 428 · see citing works

Glioblastoma Cells Require Glutamate Dehydrogenase to Survive Impairments of Glucose Metabolism or Akt Signaling

Yang, C., Sudderth, J., Dang, T. T., Bachoo, R. G., McDonald, J. G., & DeBerardinis, R. J. (2009) · Cancer Research · doi:10.1158/0008-5472.can-09-2266 · Cited by 425 · see citing works

Elucidating TOR Signaling and Rapamycin Action: Lessons from Saccharomyces cerevisiae

Crespo, J., & Hall, M. (2002) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.66.4.579-591.2002 · Cited by 389 · see citing works

The role of high rates of glycolysis and glutamine utilization in rapidly dividing cells

Newsholme, E. A., Crabtree, B., & Ardawi, M. S. (1985) · Bioscience Reports · doi:10.1007/bf01116556 · Cited by 364 · see citing works

Prdx1 inhibits tumorigenesis via regulating PTEN/AKT activity

Cao, J., Schulte, J., Knight, A., Leslie, N. R., Zagożdżon, A., Bronson, R. T., Manevich, Y., Beeson, C. C., & Neumann, C. A. (2009) · The EMBO Journal · doi:10.1038/emboj.2009.101 · Cited by 344 · see citing works

Glutamine and its relationship with intracellular redox status, oxidative stress and cell proliferation/death

Matés, J. M., Pérez‐Gómez, C., de Castro, I. N., Asenjo, M., & Márquez, J. (2002) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/s1357-2725(01)00143-1 · Cited by 340 · see citing works

Hypoxia signals autophagy in tumor cells via AMPK activity, independent of HIF-1, BNIP3, and BNIP3L

Papandreou, I., Lim, A. L., Laderoute, K., & Denko, N. C. (2008) · Cell Death &amp; Differentiation · doi:10.1038/cdd.2008.84 · Cited by 334 · see citing works

Ammonia Derived from Glutaminolysis Is a Diffusible Regulator of Autophagy

Eng, C. H., Yu, K., Lucas, J., White, E., & Abraham, R. T. (2010) · Science Signaling · doi:10.1126/scisignal.2000911 · Cited by 334 · see citing works

Common corruption of the mTOR signaling network in human tumors

Menon, S., & Manning, B. D. (2008) · Oncogene · doi:10.1038/onc.2009.352 · Cited by 328 · see citing works

Induction of autophagy by amino-acid deprivation in perfused rat liver

Mortimore, G., & Schworer, C. (1977) · Nature · doi:10.1038/270174a0 · Cited by 326 · see citing works

Therapeutic targets in cancer cell metabolism and autophagy

Cheong, H., Lü, C., Lindsten, T., & Thompson, C. B. (2012) · Nature Biotechnology · doi:10.1038/nbt.2285 · Cited by 316 · see citing works

Cell death by autophagy: emerging molecular mechanisms and implications for cancer therapy

Fulda, S., & Kögel, D. (2015) · Oncogene · doi:10.1038/onc.2014.458 · Cited by 307 · see citing works

Punctate LC3B Expression Is a Common Feature of Solid Tumors and Associated with Proliferation, Metastasis, and Poor Outcome

Lazova, R., Camp, R. L., Klump, V., Siddiqui, S. F., Amaravadi, R. K., & Pawelek, J. M. (2012) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-11-1282 · Cited by 305 · see citing works

Glutamine and Cancer

Souba, W. W. (1993) · Annals of Surgery · doi:10.1097/00000658-199312000-00004 · Cited by 294 · see citing works

Starvation-induced autophagy is regulated by mitochondrial reactive oxygen species leading to AMPK activation

Li, L., Chen, Y., & Gibson, S. B. (2012) · Cellular Signalling · doi:10.1016/j.cellsig.2012.09.020 · Cited by 292 · see citing works

Warburg Meets Autophagy: Cancer-Associated Fibroblasts Accelerate Tumor Growth and Metastasis via Oxidative Stress, Mitophagy, and Aerobic Glycolysis

Pavlides, S., Vera, I., Gândara, R., Sneddon, S., Pestell, R. G., Mercier, I., Martinez‐Outschoorn, U., Whitaker‐Menezes, D., Howell, A., Sotgia, F., et al. (2011) · Antioxidants and Redox Signaling · doi:10.1089/ars.2011.4243 · Cited by 289 · see citing works

Metformin inhibits growth and enhances radiation response of non-small cell lung cancer (NSCLC) through ATM and AMPK

Storozhuk, Y., Hopmans, S., Sanli, T., Barron, C. C., Tsiani, E., Cutz, J.-C., Pond, G. R., Wright, J. R., Singh, G., & Tsakiridis, T. K. (2013) · British Journal of Cancer · doi:10.1038/bjc.2013.187 · Cited by 272 · see citing works

Autophagy: shaping the tumor microenvironment and therapeutic response

Maes, H., Rubio, N., Garg, A. D., & Agostinis, P. (2013) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2013.04.005 · Cited by 266 · see citing works

Simultaneous Induction of Non-Canonical Autophagy and Apoptosis in Cancer Cells by ROS-Dependent ERK and JNK Activation

Wong, C. H., Iskandar, K. B., Yadav, S. K., Hirpara, J. L., Loh, T. K. S., & Pervaiz, S. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009996 · Cited by 263 · see citing works

Glucose Addiction of TSC Null Cells Is Caused by Failed mTORC1-Dependent Balancing of Metabolic Demand with Supply

Choo, A. Y., Kim, S. G., Heiden, M. G. V., Mahoney, S. J., Vu, H., Yoon, S.-O., Cantley, L. C., & Blenis, J. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.05.007 · Cited by 248 · see citing works

Autophagy regulation and its role in cancer

Lorin, S., Hamaï, A., Mehrpour, M., & Codogno, P. (2013) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2013.06.007 · Cited by 247 · see citing works

Modulation of glutamine metabolism by the PI(3)K–PKB–FOXO network regulates autophagy

van der Vos, K. E., Eliasson, P., Proikas‐Cezanne, T., Vervoort, S. J., van Boxtel, R., Putker, M., van Zutphen, I. J., Mauthe, M., Zellmer, S., Pals, C. E. G. M., et al. (2012) · Nature Cell Biology · doi:10.1038/ncb2536 · Cited by 246 · see citing works

Measurements of Tumor Cell Autophagy Predict Invasiveness, Resistance to Chemotherapy, and Survival in Melanoma

Ma, X.-H., Piao, S., Wang, D., Mcafee, Q. W., Nathanson, K. L., Lum, J. J., Li, L. Z., & Amaravadi, R. K. (2011) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-10-2372 · Cited by 234 · see citing works

The role of glutamine in the oxidative metabolism of malignant cells.

Kovacević, Z., & Morris, H. P. (1972) · PubMed · Cited by 225 · see citing works

The metabolic significance of anion transport in mitochondria

Meijer, A. J., & DAM, K. V. (1974) · Biochimica et Biophysica Acta (BBA) - Reviews on Bioenergetics · doi:10.1016/0304-4173(74)90001-9 · Cited by 223 · see citing works

AMP-activated protein kinase (AMPK) beyond metabolism: A novel genomic stress sensor participating in the DNA damage response pathway

Sanli, T., Steinberg, G. R., Singh, G., & Tsakiridis, T. (2014) · Cancer Biology &amp; Therapy · doi:10.4161/cbt.26726 · Cited by 220 · see citing works

Metabolic Stress Controls mTORC1 Lysosomal Localization and Dimerization by Regulating the TTT-RUVBL1/2 Complex

Kim, S. G., Hoffman, G. R., Poulogiannis, G., Buel, G. R., Jang, Y. J., Lee, K. W., Kim, B.-Y., Erikson, R. L., Cantley, L. C., Choo, A. Y., et al. (2013) · Molecular Cell · doi:10.1016/j.molcel.2012.10.003 · Cited by 215 · see citing works

Autophagy in cellular metabolism and cancer

Jiang, X., Overholtzer, M., & Thompson, C. B. (2015) · Journal of Clinical Investigation · doi:10.1172/jci73942 · Cited by 198 · see citing works

Nitrogen Source Activates TOR (Target of Rapamycin) Complex 1 via Glutamine and Independently of Gtr/Rag Proteins

Stracka, D., Jozefczuk, S., Rudroff, F., Sauer, U., & Hall, M. N. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.574335 · Cited by 189 · see citing works

Autophagy Is a Protective Mechanism for Human Melanoma Cells under Acidic Stress

Marino, M. L., Pellegrini, P., Di Lernia, G., Djavaheri-Mergny, M., Brnjic, S., Zhang, X., Hägg, M., Linder, S., Fais, S., Codogno, P., et al. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.339127 · Cited by 184 · see citing works

The interplay between autophagy and ROS in tumorigenesis

Kongara, S., & Karantza, V. (2012) · Frontiers in Oncology · doi:10.3389/fonc.2012.00171 · Cited by 182 · see citing works

Amino acid inhibition of the autophagic/lysosomal pathway of protein degradation in isolated rat hepatocytes

Seglen, P. O., Gordon, P. B., & Poli, A. (1980) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/0304-4165(80)90141-5 · Cited by 179 · see citing works

A growing role for mTOR in promoting anabolic metabolism

Howell, J. J., Ricoult, S. J. H., Ben‐Sahra, I., & Manning, B. D. (2013) · Biochemical Society Transactions · doi:10.1042/bst20130041 · Cited by 176 · see citing works

Regulation of autophagy by amino acids and MTOR-dependent signal transduction

Meijer, A., Lorin, S., Blommaart, E., & Codogno, P. (2014) · Amino Acids · doi:10.1007/s00726-014-1765-4 · Cited by 175 · see citing works

Understanding the central role of citrate in the metabolism of cancer cells

Icard, P., Poulain, L., & Lincet, H. (2011) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2011.10.007 · Cited by 162 · see citing works

Pyruvate and related α-ketoacids protect mammalian cells in culture against hydrogen peroxide-induced cytotoxicity

Andrae, U., Singh, J., & Ziegler-Skylakakis, K. (1985) · Toxicology Letters · doi:10.1016/0378-4274(85)90015-3 · Cited by 161 · see citing works

Transcriptional Control of Cellular Metabolism by mTOR Signaling

Yecies, J. L., & Manning, B. D. (2011) · Cancer Research · doi:10.1158/0008-5472.can-10-4158 · Cited by 160 · see citing works

Association and dissociation of autophagy, apoptosis and necrosis by systematic chemical study

Shen, S., Kepp, O., Michaud, M., Martins, I., Minoux, H., Métivier, D., Maiuri, M. C., Kroemer, R. T., & Kroemer, G. (2011) · Oncogene · doi:10.1038/onc.2011.168 · Cited by 159 · see citing works

Glutamine homeostasis and mitochondrial dynamics

Matés, J. M., Segura, J. A., Campos-Sandoval, J. A., Lobo, C., Alonso, L., Alonso, F. J., & Márquez, J. (2009) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2009.03.003 · Cited by 157 · see citing works

Reactive oxygen species regulation of autophagy in cancer: Implications for cancer treatment

Li, L., Ishdorj, G., & Gibson, S. B. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.07.011 · Cited by 153 · see citing works

mTOR kinase inhibitors as potential cancer therapeutic drugs

Sun, S. (2013) · Cancer Letters · doi:10.1016/j.canlet.2013.06.017 · Cited by 147 · see citing works

HIF-independent role of prolyl hydroxylases in the cellular response to amino acids

Durán, R. V., MacKenzie, E. D., Boulahbel, H., Frezza, C., Heiserich, L., Tardito, S., Bussolati, O., Rocha, S., Hall, M. N., & Gottlieb, E. (2013) · Oncogene · doi:10.1038/onc.2012.465 · Cited by 139 · see citing works

Glutaminase regulation in cancer cells: a druggable chain of events

Katt, W. P., & Cerione, R. A. (2013) · Drug Discovery Today · doi:10.1016/j.drudis.2013.10.008 · Cited by 130 · see citing works

The structure and allosteric regulation of mammalian glutamate dehydrogenase

Li, M., Li, C., Allen, A., Stanley, C. A., & Smith, T. J. (2011) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2011.10.015 · Cited by 124 · see citing works

Autophagy in tumour cell death

Macintosh, R. L., & Ryan, K. M. (2013) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2013.05.006 · Cited by 122 · see citing works

AN EFFECT OF L-LEUCINE AND OTHER ESSENTIAL AMINO ACIDS ON THE STRUCTURE AND ACTIVITY OF GLUTAMIC DEHYDROGENASE

Yielding, K. L., & Tomkins, G. M. (1961) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.47.7.983 · Cited by 120 · see citing works

Regulation of Tumor Cell Dormancy by Tissue Microenvironments and Autophagy

Sosa, M. S., Bragado, P., Debnath, J., & Aguirre‐Ghiso, J. A. (2012) · Advances in experimental medicine and biology · doi:10.1007/978-1-4614-1445-2_5 · Cited by 109 · see citing works

Knock-down of glutaminase 2 expression decreases glutathione, NADH, and sensitizes cervical cancer to ionizing radiation

Xiang, L., Xie, G., Liu, C., Zhou, J., Chen, J., Yu, S., Li, J., Pang, X., Shi, H., & Liang, H. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2013.08.003 · Cited by 105 · see citing works

mTOR regulates DNA damage response through NF-κB-mediated FANCD2 pathway in hematopoietic cells

Guo, F., Li, J., Du, W., Zhang, S., O’Connor, M. P., Thomas, G., Kozma, S. C., Zingarelli, B., Pang, Q., & Zheng, Y. (2013) · Leukemia · doi:10.1038/leu.2013.93 · Cited by 93 · see citing works

Regulation of FANCD2 by the mTOR Pathway Contributes to the Resistance of Cancer Cells to DNA Double-Strand Breaks

Shen, C., Oswald, D. J., Phelps, D. A., Çam, H., Pelloski, C. E., Pang, Q., & Houghton, P. J. (2013) · Cancer Research · doi:10.1158/0008-5472.can-12-4282 · Cited by 92 · see citing works

Outcome of early clinical trials of the combination of hydroxychloroquine with chemotherapy in cancer

Poklepovic, A. S., & Gewirtz, D. A. (2014) · Autophagy · doi:10.4161/auto.29428 · Cited by 91 · see citing works

THE UTILIZATION OF GLUTAMINE, GLUTAMIC ACID, AND AMMONIA FOR THE BIOSYNTHESIS OF NUCLEIC ACID BASES IN MAMMALIAN CELL CULTURES

Salzman, N. P., Eagle, H., & Sebring, E. D. (1958) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)70522-x · Cited by 89 · see citing works

Molecular damage in cancer: an argument for mTOR-driven aging

Blagosklonny, M. V. (2011) · Aging · doi:10.18632/aging.100422 · Cited by 87 · see citing works

HIF prolyl hydroxylase-3 mediates alpha-ketoglutarate-induced apoptosis and tumor suppression

Tennant, D. A., & Gottlieb, E. (2010) · Journal of Molecular Medicine · doi:10.1007/s00109-010-0627-0 · Cited by 83 · see citing works

Prolyl hydroxylases as regulators of cell metabolism

Boulahbel, H., Durán, R. V., & Gottlieb, E. (2009) · Biochemical Society Transactions · doi:10.1042/bst0370291 · Cited by 82 · see citing works

The autophagy conundrum in cancer: influence of tumorigenic metabolic reprogramming

Eng, C. H., & Abraham, R. T. (2011) · Oncogene · doi:10.1038/onc.2011.220 · Cited by 81 · see citing works

Glutaminolysis feeds mTORC1

Durán, R. V., & Hall, M. N. (2012) · Cell Cycle · doi:10.4161/cc.22632 · Cited by 77 · see citing works

Glutamine in neoplastic cells: Focus on the expression and roles of glutaminases

Szeliga, M., & Obara-Michlewska, M. (2009) · Neurochemistry International · doi:10.1016/j.neuint.2009.01.008 · Cited by 76 · see citing works

Glutamate dehydrogenase contributes to leucine sensing in the regulation of autophagy

Lorin, S., Tol, M. J. P. M., Bauvy, C., Strijland, A., Poüs, C., Verhoeven, A. J., Codogno, P., & Meijer, A. J. (2013) · Autophagy · doi:10.4161/auto.24083 · Cited by 73 · see citing works

Detachment-induced autophagy during<i>anoikis</i>and lumen formation in epithelial acini

Debnath, J. (2008) · Autophagy · doi:10.4161/auto.5523 · Cited by 70 · see citing works

Counteracting Autophagy Overcomes Resistance to Everolimus in Mantle Cell Lymphoma

Rosich, L., Xargay‐Torrent, S., López‐Guerra, M., Campo, E., Colomer, D., & Roué, G. (2012) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-12-0351 · Cited by 70 · see citing works

Combined inhibition of PI3K-related DNA damage response kinases and mTORC1 induces apoptosis in MYC-driven B-cell lymphomas

Shortt, J., Martin, B. P., Newbold, A., Hannan, K. M., Devlin, J. R., Baker, A. J., Ralli, R., Cullinane, C. M., Schmitt, C. A., Reimann, M., et al. (2013) · Blood · doi:10.1182/blood-2012-08-446096 · Cited by 68 · see citing works

Glutamate Dehydrogenase: Structure, Allosteric Regulation, and Role in Insulin Homeostasis

Li, M., Li, C., Allen, A., Stanley, C. A., & Smith, T. J. (2013) · Neurochemical Research · doi:10.1007/s11064-013-1173-2 · Cited by 65 · see citing works

Control of Rat‐Liver Glutaminase by Ammonia and pH

Verhoeven, A. J., van Iwaarden, J. F., Joseph, S. K., & Meijer, A. J. (1983) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1983.tb07454.x · Cited by 65 · see citing works

Glutaminolysis and glycolysis interactions in proliferant cells

Medina, M. Á., Ignacio, N., & Castro, D. (1990) · International Journal of Biochemistry · doi:10.1016/0020-711x(90)90001-j · Cited by 64 · see citing works

Azaserine, DON, and azotomycin: three diazo analogs of L-glutamine with clinical antitumor activity.

Catane, R., Hoff, D. D. V., Glaubiger, D. L., & Muggia, F. M. (1979) · PubMed · Cited by 63 · see citing works

Glutamine metabolism links growth factor signaling to the regulation of autophagy

van der Vos, K. E., & Coffer, P. J. (2012) · Autophagy · doi:10.4161/auto.22152 · Cited by 58 · see citing works

The mTOR pathway negatively controls ATM by up-regulating miRNAs

Shen, C., & Houghton, P. J. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1220898110 · Cited by 50 · see citing works

The roles of BECN1 and autophagy in cancer are context dependent

Gong, C., Song, E., Codogno, P., & Mehrpour, M. (2012) · Autophagy · doi:10.4161/auto.21996 · Cited by 49 · see citing works

Autophagy in stress and disease

Maiuri, M. C., & Kroemer, G. (2015) · Cell Death and Differentiation · doi:10.1038/cdd.2014.236 · Cited by 44 · see citing works

Stress eating and tuning out: Cancer cells re-wire metabolism to counter stress

Stine, Z. E., & Dang, C. V. (2013) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.3109/10409238.2013.844093 · Cited by 43 · see citing works

Characteristics of the activation of glutaminase by ammonia in sonicated rat liver mitochondria

McGivan, J. D., & Bradford, N. M. (1983) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/0304-4165(83)90327-6 · Cited by 39 · see citing works

Autophagy and ammonia

Cheong, H., Lindsten, T., & Thompson, C. B. (2012) · Autophagy · doi:10.4161/auto.8.1.18078 · Cited by 37 · see citing works

Therapeutic Targeting of Cellular Metabolism in Cells with Hyperactive mTORC1: A Paradigm Shift

Medvetz, D. A., Priolo, C., & Henske, E. P. (2014) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-14-0343 · Cited by 37 · see citing works

The Synergistic Effect of Everolimus and Chloroquine on Endothelial Cell Number Reduction Is Paralleled by Increased Apoptosis and Reduced Autophagy Occurrence

Grimaldi, A., Balestrieri, M. L., D’Onofrio, N., Domenico, G. D., Nocera, C., Lamberti, M., Tonini, G., Zoccoli, A., Santini, D., Caraglia, M., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0079658 · Cited by 28 · see citing works

p62/SQSTM1 regulates cellular oxygen sensing by attenuating PHD3 activity through aggregate sequestration and enhanced degradation

Rantanen, K., Pursiheimo, J., Högel, H., Miikkulainen, P., Sundström, J. T. T., & Jaakkola, P. (2013) · Journal of Cell Science · doi:10.1242/jcs.115667 · Cited by 26 · see citing works

Nutrient sensing: TOR's Ragtime

Meijer, A. J., & Codogno, P. (2008) · Nature Cell Biology · doi:10.1038/ncb0808-881 · Cited by 23 · see citing works

mTOR kinase inhibitor sensitizes T-cell lymphoblastic leukemia for chemotherapy-induced DNA damage via suppressing FANCD2 expression

Guo, F., Li, J., Zhang, S., Du, W., Amarachintha, S. P., Sipple, J., Phelan, J. D., Grimes, H. L., Zheng, Y., & Pang, Q. (2013) · Leukemia · doi:10.1038/leu.2013.215 · Cited by 18 · see citing works

Giving Anemia a Boost with Inhibitors of Prolyl Hydroxylase

Denny, W. A. (2012) · Journal of Medicinal Chemistry · doi:10.1021/jm300314a · Cited by 12 · see citing works

Correction for Alexander et al., ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS

(2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1206201109 · Cited by 5 · see citing works

Glutamine reliance in cell metabolism

Yoo, H. C., Yu, Y. C., Sung, Y., & Han, J. M. (2020) · Experimental &amp; Molecular Medicine · doi:10.1038/s12276-020-00504-8 · Cited by 1,021 · see citing works

Molecular mechanisms of ferroptosis and its role in cancer therapy

Xu, T., Ding, W., Ji, X., Ao, X., Liu, Y., Yu, W., & Wang, J. (2019) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.14511 · Cited by 639 · see citing works

Autophagy in health and disease: A comprehensive review

Saha, S., Panigrahi, D. P., Patil, S., & Bhutia, S. K. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.05.007 · Cited by 514 · see citing works

Cancer-associated adipocytes: key players in breast cancer progression

Wu, Q., Li, B., Li, Z., Li, J., Sun, S., & Sun, S. (2019) · Journal of Hematology &amp; Oncology · doi:10.1186/s13045-019-0778-6 · Cited by 462 · see citing works

The Interplay of Reactive Oxygen Species, Hypoxia, Inflammation, and Sirtuins in Cancer Initiation and Progression

Tafani, M., Sansone, L., Limana, F., Arcangeli, T., Santis, E. D., Polese, M., Fini, M., & Russo, M. A. (2015) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/3907147 · Cited by 371 · see citing works

Metabolic reprogramming in cancer: Mechanisms and therapeutics

Nong, S., Han, X., Yu, X., Qian, Y., Wei, Y., Zhang, T., Tian, K., Shen, K., Yang, J., & Ma, X. (2023) · MedComm · doi:10.1002/mco2.218 · Cited by 292 · see citing works

Phosphorylation of PDHA by AMPK Drives TCA Cycle to Promote Cancer Metastasis

Cai, Z., Li, C., Han, F., Liu, C., Zhang, A., Hsu, C.-C., Peng, D., Zhang, X., Jin, G., Rezaeian, A.-H., et al. (2020) · Molecular Cell · doi:10.1016/j.molcel.2020.09.018 · Cited by 231 · see citing works

mTORC1 as a Regulator of Mitochondrial Functions and a Therapeutic Target in Cancer

de la Cruz-López, K. G., Toledo-Guzmán, M. E., Sánchez, E. O., & Carrancá, A. G. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.01373 · Cited by 215 · see citing works

Cytotoxic T-cells mediate exercise-induced reductions in tumor growth

Rundqvist, H., Veliça, P., Barbieri, L., Gameiro, P. A., Bargiela, D., Gojkovic, M., Mijwel, S., Reitzner, S. M., Wulliman, D., Ahlstedt, E., et al. (2020) · eLife · doi:10.7554/elife.59996 · Cited by 216 · see citing works

Glutamine metabolism regulates autophagy-dependent mTORC1 reactivation during amino acid starvation

Tan, H. W. S., Sim, A. Y. L., & Long, Y. C. (2017) · Nature Communications · doi:10.1038/s41467-017-00369-y · Cited by 193 · see citing works

S‐adenosylmethionine: A metabolite critical to the regulation of autophagy

Ouyang, Y., Wu, Q., Li, J., Sun, S., & Sun, S. (2020) · Cell Proliferation · doi:10.1111/cpr.12891 · Cited by 176 · see citing works

IL‐1β‐Induced Elevation of Solute Carrier Family 7 Member 11 Promotes Hepatocellular Carcinoma Metastasis Through Up‐regulating Programmed Death Ligand 1 and Colony‐Stimulating Factor 1

He, Q., Liu, M., Huang, W., Chen, X., Zhang, B., Zhang, T., Wang, Y., Liu, D., Xie, M., Ji, X., et al. (2021) · Hepatology · doi:10.1002/hep.32062 · Cited by 178 · see citing works

ASCT2 (SLC1A5)-dependent glutamine uptake is involved in the progression of head and neck squamous cell carcinoma

Zhang, Z., Liu, R., Shuai, Y., Huang, Y., Jin, R., Wang, X., & Luo, J. (2019) · British Journal of Cancer · doi:10.1038/s41416-019-0637-9 · Cited by 125 · see citing works

Baicalin combats glutamate excitotoxicity via protecting glutamine synthetase from ROS-induced 20S proteasomal degradation

Song, X., Gong, Z., Liu, K., Kou, J., Liu, B., & Liu, K. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101559 · Cited by 114 · see citing works

Metabolic reprogramming in the pathogenesis of chronic lung diseases, including BPD, COPD, and pulmonary fibrosis

Zhao, H., Dennery, P. A., & Yao, H. (2018) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00521.2017 · Cited by 113 · see citing works

Non-apoptotic cell death in malignant tumor cells and natural compounds

Ye, J., Zhang, R., Wu, F., Zhai, L., Wang, K., Xiao, M., Xie, T., & Sui, X. (2018) · Cancer Letters · doi:10.1016/j.canlet.2018.01.061 · Cited by 102 · see citing works

The Mechanism of Ferroptosis and Applications in Tumor Treatment

Lin, X., Ping, J., Wen, Y., & Wu, Y. R. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.01061 · Cited by 104 · see citing works

Therapeutic implications of tumor interstitial acidification

Kolosenko, I., Avnet, S., Baldini, N., Viklund, J., & Milito, A. D. (2017) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2017.01.008 · Cited by 100 · see citing works

Targeting ATF4-dependent pro-survival autophagy to synergize glutaminolysis inhibition

Han, S., Zhu, L., Zhu, Y., Meng, Y. G., Li, J., Song, P., Yousafzai, N. A., Feng, L., Chen, M., Wang, Y., et al. (2021) · Theranostics · doi:10.7150/thno.60028 · Cited by 95 · see citing works

Polyphenols as Promising Drugs against Main Breast Cancer Signatures

Losada-Echeberría, M., Herranz‐López, M., Micol, V., & Barrajón‐Catalán, E. (2017) · Antioxidants · doi:10.3390/antiox6040088 · Cited by 94 · see citing works

mTORC1 inhibition in cancer cells protects from glutaminolysis-mediated apoptosis during nutrient limitation

Villar, V. H., Nguyen, T.-L., Delcroix, V., Terés, S., Bouchecareilh, M., Salin, B., Bodineau, C., Vacher, P., Priault, M., Soubeyran, P., et al. (2017) · Nature Communications · doi:10.1038/ncomms14124 · Cited by 90 · see citing works

Two parallel pathways connect glutamine metabolism and mTORC1 activity to regulate glutamoptosis

Bodineau, C., Tomé, M., Courtois, S., Costa, A. S. H., Sciacovelli, M., Rousseau, B., Richard, É., Vacher, P., Parejo-Pérez, C., Bessède, E., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-25079-4 · Cited by 84 · see citing works

Identification of a novel glycolysis-related gene signature that can predict the survival of patients with lung adenocarcinoma

Liu, C., Li, Y., Wei, M., Zhao, L., Yu, Y., & Li, G. (2019) · Cell Cycle · doi:10.1080/15384101.2019.1578146 · Cited by 82 · see citing works

Low-Concentration PTX And RSL3 Inhibits Tumor Cell Growth Synergistically By Inducing Ferroptosis In Mutant p53 Hypopharyngeal Squamous Carcinoma

Ye, J., Jiang, X., Dong, Z., Hu, S., & Xiao, M. (2019) · Cancer Management and Research · doi:10.2147/cmar.s217944 · Cited by 77 · see citing works

Tumor Metabolic Reprogramming by Adipokines as a Critical Driver of Obesity-Associated Cancer Progression

Pham, D., & Park, P. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22031444 · Cited by 71 · see citing works

Energy Metabolism Rewiring Precedes UVB-Induced Primary Skin Tumor Formation

Hosseini, M., Dousset, L., Mahfouf, W., Serrano-Sanchez, M., Redonnet‐Vernhet, I., Mesli, S., Kasraian, Z., Obre, É., Bonneu, M., Claverol, S., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.05.060 · Cited by 70 · see citing works

The ‘Achilles Heel’ of Metabolism in Renal Cell Carcinoma: Glutaminase Inhibition as a Rational Treatment Strategy

Hoerner, C. R., Chen, V. J., & Fan, A. C. (2019) · Kidney Cancer · doi:10.3233/kca-180043 · Cited by 68 · see citing works

Glutamine Metabolism Drives Growth in Advanced Hormone Receptor Positive Breast Cancer

Demas, D. M., Demo, S. D., Fallah, Y., Clarke, R. C., Nephew, K. P., Althouse, S. K., Sandusky, G. E., He, W., & Shajahan‐Haq, A. N. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.00686 · Cited by 66 · see citing works

Regulation of mTORC1 by amino acids in mammalian cells: A general picture of recent advances

Zhang, S.-Z., Lin, X.-Y., Hou, Q.-L., Hu, Z.-Y., Wang, Y., & Wang, Z.-H. (2021) · Animal Nutrition · doi:10.1016/j.aninu.2021.05.003 · Cited by 56 · see citing works

The metabolic waste ammonium regulates mTORC2 and mTORC1 signaling

Merhi, A., Delrée, P., & Marini, A. M. (2017) · Scientific Reports · doi:10.1038/srep44602 · Cited by 51 · see citing works

The Epithelial to Mesenchymal Transition Related Gene Calumenin Is an Adverse Prognostic Factor of Bladder Cancer Correlated With Tumor Microenvironment Remodeling, Gene Mutation, and Ferroptosis

Du, Y., Miao, W., Jiang, X. W., Cao, J., Wang, B., Wang, Y., Yu, J., Wang, X., & Liu, H. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.683951 · Cited by 49 · see citing works

Glutamine metabolism: from proliferating cells to cardiomyocytes

Shen, Y., Zhang, Y., Li, W., Chen, K., Xiang, M., & Ma, H. (2021) · Metabolism · doi:10.1016/j.metabol.2021.154778 · Cited by 44 · see citing works

Glutamine Metabolism: Molecular Regulation, Biological Functions, and Diseases

Kumar, M. A., Baba, S. K., Khan, I. R., Khan, M. S., Husain, F. M., Ahmad, S., Haris, M., Singh, M., Akil, A. A., Macha, M. A., et al. (2025) · MedComm · doi:10.1002/mco2.70120 · Cited by 49 · see citing works

Ammonia and autophagy: An emerging relationship with implications for disorders with hyperammonemia

Soria, L. R., & Brunetti‐Pierri, N. (2019) · Journal of Inherited Metabolic Disease · doi:10.1002/jimd.12061 · Cited by 43 · see citing works

Triclocarban-induced responses of endogenous and xenobiotic metabolism in human hepatic cells: Toxicity assessment based on nontargeted metabolomics approach

Zhang, H., Lu, Y. P., Liang, Y., Jiang, L.-L., & Cai, Z. (2020) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2020.122475 · Cited by 43 · see citing works

The role of PKM2 in cancer progression and its structural and biological basis

Wu, B., Liang, Z., Lan, H., Teng, X., & Wang, C. (2024) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-024-01007-0 · Cited by 42 · see citing works

The role of the glutamine transporter ASCT2 in antineoplastic therapy

Teixeira, E., Silva, C., & Martel, F. (2021) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-020-04218-6 · Cited by 42 · see citing works

Downregulation of Glutamine Synthetase, not glutaminolysis, is responsible for glutamine addiction in Notch1‐driven acute lymphoblastic leukemia

Nguyen, T.-L., Nokin, M., Terés, S., Tomé, M., Bodineau, C., Galmar, O., Pasquet, J., Rousseau, B., van Liempd, S., Falcón‐Pérez, J. M., et al. (2020) · Molecular Oncology · doi:10.1002/1878-0261.12877 · Cited by 41 · see citing works

Grainyhead-like 2 Reverses the Metabolic Changes Induced by the Oncogenic Epithelial–Mesenchymal Transition: Effects on Anoikis

Farris, J. C., Pifer, P. M., Zheng, L., Gottlieb, E., Denvir, J., & Frisch, S. M. (2016) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-16-0050 · Cited by 41 · see citing works

Tumor-associated macrophages/C-X-C motif chemokine ligand 1 promotes breast cancer autophagy-mediated chemoresistance via IGF1R/STAT3/HMGB1 signaling

Yang, B., Li, G., Wang, S., Zheng, Y., Zhang, J., Pan, B., Wang, N., & Wang, Z. (2024) · Cell Death and Disease · doi:10.1038/s41419-024-07123-5 · Cited by 40 · see citing works

Tumor-produced ammonia is metabolized by regulatory T cells to further impede anti-tumor immunity

Gu, J., Yu, L., Chen, Q., Song, Z., Qian, Q., Liang, Y., Huang, T., Qiao, L., Li, X., Yu, M., et al. (2025) · Cell · doi:10.1016/j.cell.2025.11.034 · Cited by 40 · see citing works

Activation of p53 by costunolide blocks glutaminolysis and inhibits proliferation in human colorectal cancer cells

Hu, M., Liu, L., & Yao, W. (2018) · Gene · doi:10.1016/j.gene.2018.08.048 · Cited by 39 · see citing works

Mitochondrial General Control of Amino Acid Synthesis 5 Like 1 Regulates Glutaminolysis, Mammalian Target of Rapamycin Complex 1 Activity, and Murine Liver Regeneration

Wang, L., Zhu, L., Wu, K., Chen, Y., Lee, D., Guček, M., & Sack, M. N. (2019) · Hepatology · doi:10.1002/hep.30876 · Cited by 38 · see citing works

Violacein induces death of RAS-mutated metastatic melanoma by impairing autophagy process

Gonçalves, P. R., Pelizzaro‐Rocha, K. J., Fernandes, M. R. N., Abrantes, J. L. F., Durán, N., & Ferreira‐Halder, C. V. (2016) · Tumor Biology · doi:10.1007/s13277-016-5265-x · Cited by 38 · see citing works

Targeting glutaminase-mediated glutamine dependence in papillary thyroid cancer

Yu, Y. W., Yu, X., Fan, C., Wang, H., Wang, R., Feng, C., & Guan, H. (2018) · Journal of Molecular Medicine · doi:10.1007/s00109-018-1659-0 · Cited by 38 · see citing works

Prolyl hydroxylase domain enzymes and their role in cell signaling and cancer metabolism

Nguyen, T.-L., & Durán, R. V. (2016) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2016.09.026 · Cited by 37 · see citing works

NAD(P)H-triggered probe for dual-modal imaging during energy metabolism and novel strategy of enhanced photothermal therapy in tumor

Tian, Y., Jiang, W., Wang, W., Mao, G., Li, Y., & Li, C. (2021) · Biomaterials · doi:10.1016/j.biomaterials.2021.120736 · Cited by 36 · see citing works

The Arabidopsis Target of Rapamycin kinase regulates ammonium assimilation and glutamine metabolism

Ingargiola, C., Jéhanno, I., Forzani, C., Marmagne, A., Broutin, J., Clément, G., Leprince, A., & Meyer, C. (2023) · PLANT PHYSIOLOGY · doi:10.1093/plphys/kiad216 · Cited by 36 · see citing works

Extracellular Vesicle-Mediated Mitochondrial Reprogramming in Cancer

Carles-Fontana, R., Heaton, N. D., Palma, E., & Khorsandi, S. E. (2022) · Cancers · doi:10.3390/cancers14081865 · Cited by 34 · see citing works

Metabolic therapy and bioenergetic analysis: The missing piece of the puzzle

Duraj, T., Carrión-Navarro, J., Seyfried, T. N., Garcia‐Romero, N., & Ayuso‐Sacido, Á. (2021) · Molecular Metabolism · doi:10.1016/j.molmet.2021.101389 · Cited by 34 · see citing works

Restricting Glutamine Uptake Enhances NSCLC Sensitivity to Third-Generation EGFR-TKI Almonertinib

Liu, Y., Ge, X., Pang, J., Zhang, Y., Zhang, H., Wu, H., Fan, F., & Liu, H. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.671328 · Cited by 31 · see citing works

Unfolding the role of autophagy in the cancer metabolism

Pandey, A., Yadav, P., & Shukla, S. (2021) · Biochemistry and Biophysics Reports · doi:10.1016/j.bbrep.2021.101158 · Cited by 29 · see citing works

Knockdown of KPNA2 inhibits autophagy in oral squamous cell carcinoma cell lines by blocking p53 nuclear translocation

Lin, F., Gao, L., Su, Z., Cao, X., Zhan, Y., Li, Y., & Zhang, B. (2018) · Oncology Reports · doi:10.3892/or.2018.6451 · Cited by 28 · see citing works

Loss of SDHB Induces a Metabolic Switch in the hPheo1 Cell Line toward Enhanced OXPHOS

Tabebi, M., Dutta, R. K., Skoglund, C., Söderkvist, P., & Gimm, O. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23010560 · Cited by 27 · see citing works

Rapamycin (mTORC1 inhibitor) reduces the production of lactate and 2-hydroxyglutarate oncometabolites in IDH1 mutant fibrosarcoma cells

Hujber, Z., Petővári, G., Szoboszlai, N., Dankó, T., Nagy, N., Kriston, C., Krencz, I., Paku, S., Ozohanics, O., Drahos, L., et al. (2017) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-017-0544-y · Cited by 25 · see citing works

Resveratrol relieves particulate matter (mean diameter < 2.5 μm)‐induced oxidative injury of lung cells through attenuation of autophagy deregulation

Li, Y., Qian, W., Wang, D., Meng, Y., Wang, X., Chen, Y., Li, X., Xie, C., Zhong, C., & Fu, S. (2018) · Journal of Applied Toxicology · doi:10.1002/jat.3636 · Cited by 24 · see citing works

Lopinavir enhances anoikis by remodeling autophagy in a circRNA-dependent manner

Wu, Y., Chen, Y., Yan, X., Dai, X., Liao, Y., Yuan, J., Wang, L., Liu, D., Niu, D., Sun, L., et al. (2024) · Autophagy · doi:10.1080/15548627.2024.2325304 · Cited by 23 · see citing works

Pharmacologic approaches to amino acid depletion for cancer therapy

Wilder, C. S., Chen, Z., & DiGiovanni, J. (2021) · Molecular Carcinogenesis · doi:10.1002/mc.23349 · Cited by 23 · see citing works

Mechanism, Clinical Significance, and Treatment Strategy of Warburg Effect in Hepatocellular Carcinoma

Chen, H., Wu, Q., Peng, L., Cao, T., Deng, M.-L., Liu, Y.-W., Huang, J., Hu, Y., Fu, N., Zhou, K.-B., et al. (2021) · Journal of Nanomaterials · doi:10.1155/2021/5164100 · Cited by 22 · see citing works

Glutamine is essential for overcoming the immunosuppressive microenvironment in malignant salivary gland tumors

Cao, S., Hung, Y., Wang, Y.-C., Chung, Y., Qi, Y., Ouyang, C., Zhong, X., Hu, W., Coblentz, A., Maghami, E. G., et al. (2022) · Theranostics · doi:10.7150/thno.73896 · Cited by 22 · see citing works

One-Carbon and Polyamine Metabolism as Cancer Therapy Targets

Islam, A., Shaukat, Z., Hussain, R., & Gregory, S. L. (2022) · Biomolecules · doi:10.3390/biom12121902 · Cited by 22 · see citing works

Metabolic reprogramming of glutamine involved in tumorigenesis, multidrug resistance and tumor immunity

Wang, X., Xiao-xia, Y., Peng-Fei, S., Zong-Xue, Z., & Xiu-li, G. (2022) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2022.175323 · Cited by 23 · see citing works

Amino acid metabolic reprogramming in the tumor microenvironment and its implication for cancer therapy

Zhang, J., Chen, M., Yang, Y., Liu, Z., Guo, W., Xiang, P., Zeng, Z., Wang, D., & Xiong, W. (2024) · Journal of Cellular Physiology · doi:10.1002/jcp.31349 · Cited by 23 · see citing works

mTOR Inhibition via Displacement of Phosphatidic Acid Induces Enhanced Cytotoxicity Specifically in Cancer Cells

Nguyen, T.-L., Nokin, M., Egorov, M., Tomé, M., Bodineau, C., Primo, C. D., Minder, L., Wdzieczak‐Bakala, J., Garcia-Alvarez, M. C., Bignon, J. S., et al. (2018) · Cancer Research · doi:10.1158/0008-5472.can-18-0232 · Cited by 22 · see citing works

Metabolic reprogramming and its clinical application in thyroid cancer (Review)

Wen, S., Zhang, T., Xue, D.-X., Wu, W.-L., Wang, Y., Wang, Y., Ji, Q., Zhu, Y., Qu, N., & Shi, R. (2019) · Oncology Letters · doi:10.3892/ol.2019.10485 · Cited by 21 · see citing works

Ubiquitylation of the ER-Shaping Protein Lunapark via the CRL3KLHL12 Ubiquitin Ligase Complex

Yuniati, L., Lauriola, A., Gerritsen, M., Abreu, S., Ni, E., Tesoriero, C., Onireti, J., Low, T. Y., Heck, A. J. R., Vettori, A., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.107664 · Cited by 21 · see citing works

Interactions between the metabolic reprogramming of liver cancer and tumor microenvironment

Yang, H., Li, J., Niu, Y., Zhou, T., Zhang, P., Liu, Y., & Li, Y. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1494788 · Cited by 21 · see citing works

Mitochondria as Regulators of Nonapoptotic Cell Death in Cancer

Malla, S., Neupane, R., Sood, S., Hussein, N. A., Abou-Dahech, M. S., Terrero, D., Ashby, C. R., Babu, R. J., & Tiwari, A. K. (2025) · MedComm · doi:10.1002/mco2.70244 · Cited by 19 · see citing works

Identification of Novel Glycolysis-Related Gene Signatures Associated With Prognosis of Patients With Clear Cell Renal Cell Carcinoma Based on TCGA

Wu, C., Cai, X., Yan, J., Deng, A., Cao, Y., & Zhu, X. (2020) · Frontiers in Genetics · doi:10.3389/fgene.2020.589663 · Cited by 18 · see citing works

Ferroptosis, Acyl Starvation, and Breast Cancer

Bobiński, R., Dutka, M., Pizon, M., Waksmańska, W., & Pielesz, A. (2022) · Molecular Pharmacology · doi:10.1124/molpharm.122.000607 · Cited by 19 · see citing works

Metabolism and signaling crosstalk in glioblastoma progression and therapy resistance

Zarzuela, L., Durán, R. V., & Tomé, M. (2023) · Molecular Oncology · doi:10.1002/1878-0261.13571 · Cited by 19 · see citing works

Recent advancements in nanomaterial-mediated ferroptosis-induced cancer therapy: Importance of molecular dynamics and novel strategies

Dhas, N. L., Kudarha, R. R., Tıwarı, R., Tiwari, G., Garg, N., Kumar, P., Kulkarni, S., Kulkarni, J., Soman, S., Hegde, A. R., et al. (2024) · Life Sciences · doi:10.1016/j.lfs.2024.122629 · Cited by 19 · see citing works

Exploring the relationship between anastasis and mitochondrial ROS-mediated ferroptosis in metastatic chemoresistant cancers: a call for investigation

Cao, Y., Lu, C., Beeraka, N. M., Efetov, S. K., Enikeev, M. E., Fu, Y., Yang, X., Basappa, B., He, M., & Li, Z. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1428920 · Cited by 19 · see citing works

Deferoxamine Counteracts Cisplatin Resistance in A549 Lung Adenocarcinoma Cells by Increasing Vulnerability to Glutamine Deprivation-Induced Cell Death

Liu, W., Pan, P.-Y., Sun, Y., Wang, J., Zhou, H., Xie, X., Duan, Z., Dong, H.-Y., Chen, W., Zhang, L.-D., et al. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2021.794735 · Cited by 19 · see citing works

Amino acids metabolism: a potential target for cancer treatment

Ren, S., Zhou, X., Wang, Z., & Yuan, K. (2025) · Molecular Cancer · doi:10.1186/s12943-025-02523-3 · Cited by 18 · see citing works

Downregulation of STK25 promotes autophagy via the Janus kinase 2/signal transducer and activator of transcription 3 pathway in colorectal cancer

Chen, J., Gao, P., Peng, L., Liu, T., Wu, F., Xu, K., Chen, L., Tan, F., Xing, P., Wang, Z., et al. (2022) · Molecular Carcinogenesis · doi:10.1002/mc.23403 · Cited by 16 · see citing works

Alpha ketoglutarate levels, regulated by p53 and OGDH, determine autophagy and cell fate/apoptosis in response to Nutlin-3a

Duan, L., Perez, R. E., & Maki, C. G. (2018) · Cancer Biology & Therapy · doi:10.1080/15384047.2018.1523858 · Cited by 15 · see citing works

Escaping mTOR inhibition for cancer therapy: Tumor suppressor functions of mTOR

Villar, V. H., Nguyen, T.-L., Terés, S., Bodineau, C., & Durán, R. V. (2017) · Molecular & Cellular Oncology · doi:10.1080/23723556.2017.1297284 · Cited by 14 · see citing works

Glutaminolysis is associated with mitochondrial pathway activation and can be therapeutically targeted in glioblastoma

Miki, K., Yagi, M., Hatae, R., Otsuji, R., Miyazaki, T., Katsuhiro, G. O. T. O., Setoyama, D., Fujioka, Y., Sangatsuda, Y., Kuga, D., et al. (2024) · Cancer & Metabolism · doi:10.1186/s40170-024-00364-0 · Cited by 13 · see citing works

Identification and prognostic value of a glycolysis-related gene signature in patients with bladder cancer

Wu, Z., Wen, Z., Li, Z., Yu, M., & Ye, G. (2021) · Medicine · doi:10.1097/md.0000000000023836 · Cited by 13 · see citing works

Mitochondria, Autophagy and Inflammation: Interconnected in Aging

Silva, R. C. M. C. (2024) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-024-01231-x · Cited by 12 · see citing works

Friend or Foe: Exploring the Relationship between the Gut Microbiota and the Pathogenesis and Treatment of Digestive Cancers

Profir, M., Roşu, O., Creţoiu, S. M., & Gașpar, B. S. (2024) · Microorganisms · doi:10.3390/microorganisms12050955 · Cited by 12 · see citing works

Increased Autophagy Levels Mediate Cisplatin Resistance in Cisplatin-Resistant Cells While Also Rendering Them Vulnerable to Autophagy Induction

Duan, G., Song, Z., Qi, M., Bai, X., Wang, J., Zhang, Y., Zou, X., Guo, Q., & Wan, P. (2018) · BioMed Research International · doi:10.1155/2018/1736738 · Cited by 12 · see citing works

Burgeoning Strategies for Cancer Therapy Based on Ferroptosis Induced by Nanomaterials

Gao, F., Liu, H., Liu, J., & Chen, C. (2025) · Advanced Functional Materials · doi:10.1002/adfm.202511199 · Cited by 11 · see citing works

Mechanistic Modeling of Gene Regulation and Metabolism Identifies Potential Targets for Hepatocellular Carcinoma

Sun, R., Xu, Y., Zhang, H., Yang, Q., Wang, K., Shi, Y., & Wang, Z. (2020) · Frontiers in Genetics · doi:10.3389/fgene.2020.595242 · Cited by 11 · see citing works

Hyperosmolarity Triggers the Warburg Effect in Chinese Hamster Ovary Cells and Reveals a Reduced Mitochondria Horsepower

Moreira, J. D. V., Staercke, L. D., Martínez-Basilio, P. C., Gauthier-Thibodeau, S., Montégut, L., Schwartz, L. H., & Jolicœur, M. (2021) · Metabolites · doi:10.3390/metabo11060344 · Cited by 11 · see citing works

Tumor Microenvironment Characteristics of Pancreatic Cancer to Determine Prognosis and Immune-Related Gene Signatures

Zhang, C., Ding, J., Xu, X., Liu, Y., Huang, W., Da, L., Ma, Q., & Chen, S. (2021) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2021.645024 · Cited by 11 · see citing works

T-cell Metabolism as a Target to Control Autoreactive T Cells in β-Cell Autoimmunity

Bordignon, C., Canu, A., Dyczko, A., Leone, S., & Monti, P. (2017) · Current Diabetes Reports · doi:10.1007/s11892-017-0848-5 · Cited by 10 · see citing works

Crosstalk between pancreatic cancer and adipose tissue: Molecular mechanisms and therapeutic implications

Diao, B., Fan, Z., Zhou, B., & Zhan, H. (2024) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2024.151012 · Cited by 9 · see citing works

Regulation of dendritic cell biology by amino acids and their transporters

Chen, S.-L., Li, G., Jiang, Z., Xu, Y., Aipire, A., & Li, J. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1626973 · Cited by 13 · see citing works

Untargeted Metabolomics to Go beyond the Canonical Effect of Acetylsalicylic Acid

Minno, A. D., Porro, B., Turnu, L., Manega, C. M., Eligini, S., Barbieri, S., Chiesa, M., Poggio, P., Squellerio, I., Anesi, A., et al. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm9010051 · Cited by 9 · see citing works

A synthesized olean-28,13β-lactam targets YTHDF1-GLS1 axis to induce ROS-dependent metabolic crisis and cell death in pancreatic adenocarcinoma

Wu, S., Ai, Y., Huang, H., Wu, G., Zhou, S., Hong, W., Akuetteh, P. D. P., Jin, G., Zhao, X., Zhang, Y., et al. (2022) · Cancer Cell International · doi:10.1186/s12935-022-02562-6 · Cited by 9 · see citing works

Circ_0000144 functions as a miR-623 sponge to enhance gastric cancer progression via up-regulating GPRC5A

Mi, L., Lei, L., Yin, X., Li, N., Shi, J., Han, X., Duan, X., Zhao, M., Han, G., Wang, J., et al. (2020) · Bioscience Reports · doi:10.1042/bsr20201313 · Cited by 8 · see citing works

Erratum: Urine-derived stem cells accelerate the recovery of injured mouse hepatic tissue.

Hu, C., He, Y., Fang, S., Tian, N., Gong, M., Xu, X., Zhao, L., Wang, Y., He, T., Zhang, Y., et al. (2020) · PubMed Central · Cited by 7 · see citing works

A control theoretic three timescale model for analyzing energy management in mammalian cancer cells

Dasgupta, A., Bakshi, A., Chowdhury, N., & De, R. K. (2020) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2020.12.019 · Cited by 7 · see citing works

[Changes in autophagy during maturation and differentiation of Hepa1-6 cells induced by all-trans retinoic acid].

Fang, S., Cui, J., Gong, M., He, Y., Zhang, J., & Bi, Y. (2018) · Europe PMC (PubMed Central) · doi:10.3969/j.issn.1673-4254.2018.05.04 · Cited by 5 · see citing works

Free fatty acids derived from lipophagy enhanced resistance to anoikis by activating Src in high-invasive clear cell renal cell carcinoma cells

Wu, M., Chen, G., Li, X., Ma, W., Chen, Y., Gong, Y., Zheng, H., Gu, G., Ding, Y., Dong, P., et al. (2025) · Cellular Signalling · doi:10.1016/j.cellsig.2025.111622 · Cited by 4 · see citing works

Amino Acids Supplementation in Cancer: What Do We Feed, the Patient or the Tumor?

Corsetti, G., Pasini, E., Romano, C., & Dioguardi, F. (2025) · Nutrients · doi:10.3390/nu17172813 · Cited by 4 · see citing works

Gefitinib Induces Apoptosis in NSCLC Cells by Promoting Glutaminolysis and Inhibiting the MEK/ERK Signaling Pathway

Zhang, Y., Liu, H., Liu, X., & Lang, L. (2024) · Discovery Medicine · doi:10.24976/discov.med.202436183.78 · Cited by 4 · see citing works

Accelerated lipid catabolism and autophagy are cancer survival mechanisms under inhibited glutaminolysis

Halama, A., Kuliński, M., Dib, S. S., Zaghlool, S. B., Siveen, K. S., Iskandarani, A., Zierer, J., Prabhu, K. S., Satheesh, N. J., Bhagwat, A. M., et al. (2018) · Cancer Letters · doi:10.1016/j.canlet.2018.05.017 · Cited by 74 · see citing works

Combined targeting autophagy and metabolism for cancer therapy

Tripathi, G., Mishra, S., Priyadarshan, A., Sahu, S. N., Singh, A. K., & Kumar, A. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-99879-6.00001-8

Glutaminase - A potential target for cancer treatment

Josephine, A., Varalakshmi, S., Sekar, A. K., Devarajan, N., Janakiraman, B., & Rajendran, P. (2024) · Biomedicine · doi:10.37796/2211-8039.1445 · Cited by 17 · see citing works

Targeting ATF4-dependent pro-survival autophagy to synergize glutaminolysis inhibition

Han, S., Zhu, L., Zhu, Y., Meng, Y. G., Li, J., Song, P., Yousafzai, N. A., Feng, L., Chen, M., Wang, Y., et al. (2021) · Theranostics · doi:10.7150/thno.60028 · Cited by 95 · see citing works

Role of Autophagy in Cancer Cell Metabolism

Pedroza, D. A., Chandel, V., Kumar, D., Doddapattar, P., Biradar, M. S., Lakshmanaswamy, R., Gadad, S. S., & Choudhari, R. (2020) · Springer eBooks · doi:10.1007/978-981-15-1991-8_6