The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
A tripartite transcription factor network regulates primordial germ cell specification in mice
Open accessAbstract
Transitions in cell states are controlled by combinatorial actions of transcription factors. BLIMP1, the key regulator of primordial germ cell (PGC) specification, apparently acts together with PRDM14 and AP2γ. To investigate their individual and combinatorial functions, we first sought an in vitro system for transcriptional readouts and chromatin immunoprecipitation sequencing analysis. We then integrated this data with information from single-cell transcriptome analysis of normal and mutant PGCs. Here we show that BLIMP1 binds directly to repress somatic and cell proliferation genes. It also directly induces AP2γ, which together with PRDM14 initiates the PGC-specific fate. We determined the occupancy of critical genes by AP2γ—which, when computed altogether with those of BLIMP1 and PRDM14 (both individually and cooperatively), reveals a tripartite mutually interdependent transcriptional network for PGCs. We also demonstrate that, in principle, BLIMP1, AP2γ and PRDM14 are sufficient for PGC specification, and the unprecedented resetting of the epigenome towards a basal state.
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NANOG alone induces germ cells in primed epiblast in vitro by activation of enhancers
Murakami, K., Günesdogan, U., Zylicz, J. J., Tang, W. W. C., Sengupta, R., Kobayashi, T., Kim, S., Butler, R., Dietmann, S., & Azim Surani, M. (2016) · Nature · doi:10.1038/nature16480 · Cited by 180
Self-citationA TFEB nuclear export signal integrates amino acid supply and glucose availability
Li, L., Friedrichsen, H. J., Andrews, S., Picaud, S., Volpon, L., Ngeow, K., Berridge, G., Fischer, R., Borden, K. L. B., Filippakopoulos, P., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-04849-7 · Cited by 114
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Metadata
- Authors
- Magnúsdóttir, E., Dietmann, S., Murakami, K., Günesdogan, U., Tang, F., Bao, S., Diamanti, E., Lao, K., Gottgens, B., & Azim Surani, M.
- Venue
- Nature Cell Biology
- Published
- 2013-07-14
- Volume
- 15
- Issue
- 8
- Pages
- 905-915
- ISSN
- 1465-7392 (ISSN-L)
- 1476-4679
- OpenAlex
- W1967341601
- Cited by
- 266
- References
- 4
- FWCI
- 10.22
- Type
- journal article
- Language
- en
- Open access
- green
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- Magnúsdóttir, E., Dietmann, S., Murakami, K., Günesdogan, U., Tang, F., Bao, S., Diamanti, E., Lao, K., Gottgens, B., & Azim Surani, M. (2013). A tripartite transcription factor network regulates primordial germ cell specification in mice. Nature Cell Biology. https://doi.org/10.1038/ncb2798
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