The DOI matches its Crossref record; 141 of the 142 references it cites were found in a registry or an index.
Causes and consequences of replication stress
Open accessAbstract
Replication stress is a complex phenomenon that has serious implications for genome stability, cell survival and human disease. Generation of aberrant replication fork structures containing single-stranded DNA activates the replication stress response, primarily mediated by the kinase ATR (ATM- and Rad3-related). Along with its downstream effectors, ATR stabilizes and helps to restart stalled replication forks, avoiding the generation of DNA damage and genome instability. Understanding this response may be key to diagnosing and treating human diseases caused by defective responses to replication stress.
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“The resulting replicative and transcriptional stresses stall DNA polymerization during replication and pol II progression in RNA synthesis11, 12, respectively, leading to an accumulation of stretches of single-strand DNA (ssDNA), which become coated with the ssDNA-binding replication protein A (RPA) 26.”
From Xeroderma Pigmentosa Group A (XPA), Nucleotide Excision Repair and Regulation by ATR in Response to Ultraviolet Irradiation (2017) · cites this paper as [26]
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Cites
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Cited by
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ROS and the DNA damage response in cancer
Srinivas, U. S., Tan, B. W. Q., Vellayappan, B. A., & Jeyasekharan, A. D. (2019) · Redox Biology · doi:10.1016/j.redox.2018.101084 · Cited by 2,144
“physical obstacles to the replication fork [29].”
BackgroundTargeting the DNA Damage Response in Cancer
O’Connor, M. J. (2015) · Molecular Cell · doi:10.1016/j.molcel.2015.10.040 · Cited by 1,602
Matthews, H. K., Bertoli, C., & de Bruin, R. A. M. (2022) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-021-00404-3 · Cited by 1,506
DNA double-strand break repair-pathway choice in somatic mammalian cells
Scully, R., Panday, A., Elango, R., & Willis, N. A. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-019-0152-0 · Cited by 1,542
DNA damage and the balance between survival and death in cancer biology
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Metadata
- Authors
- Zeman, M. K., & Cimprich, K. A.
- Affiliations
- Stanford Medicine (US)
- Corresponding author
- Cimprich, Karlene A.
- ORCID
- Cimprich, Karlene A.
- Venue
- Nature Cell Biology
- Published
- 2013-12-24
- Volume
- 16
- Issue
- 1
- Pages
- 2-9
- ISSN
- 1465-7392 (ISSN-L)
- 1476-4679
- PMC
- PMC4354890
- OpenAlex
- W2040860750
- Cited by
- 2,079
- References
- 142
- Citations by year
- 2026: 158 · 2025: 182 · 2024: 173 · 2023: 197 · 2022: 190 · 2021: 233 · 2020: 209 · 2019: 162 · 2018: 147 · 2017: 150 · 2016: 137 · 2015: 103 · 2014: 37
- FWCI
- 8.50
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of General Medical Sciences (R01GM100489)
- National Institute of Environmental Health Sciences (R01ES016486)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Keywords
- replication stress, genomic instability, ATR kinase, replication stress response, replication fork restart, single-stranded DNA, DNA damage response, cell survival, DNA replication defects, human disease
- MeSH terms
- Disease, DNA Replication, Eukaryotic Cells, Humans, Models, Biological, Stress, Physiological
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