Cimprich, Karlene A.

Causes and consequences of replication stress

Zeman, M. K., & Cimprich, K. A. (2014) · Nature Cell Biology

DNA Repair MechanismsTelomeres, Telomerase, and Senescence

Cited by 2,079

Activation of the ATM Kinase by Ionizing Radiation and Phosphorylation of p53

Canman, C. E., Lim, D.-S., Cimprich, K. A., Taya, Y., Tamai, K., Sakaguchi, K., Appella, E., Kastan, M. B., & Siliciano, J. D. (1998) · Science

DNA Repair MechanismsCancer-related Molecular Pathways

Cited by 2,042

ATR: an essential regulator of genome integrity

Cimprich, K. A., & Cortez, D. (2008) · Nature Reviews Molecular Cell Biology

DNA Repair MechanismsCancer-related Molecular Pathways

Cited by 1,798

Functional uncoupling of MCM helicase and DNA polymerase activities activates the ATR-dependent checkpoint

Byun, T. S., Pacek, M., Yee, M.-C., Walter, J. C., & Cimprich, K. A. (2005) · Genes & Development

DNA Repair MechanismsGenomics and Chromatin Dynamics

Cited by 767

cDNA cloning and gene mapping of a candidate human cell cycle checkpoint protein.

Cimprich, K. A., Shin, T. B., Keith, C. T., & Schreiber, S. L. (1996) · Proceedings of the National Academy of Sciences

DNA Repair MechanismsPI3K/AKT/mTOR signaling in cancer

Cited by 273

The structural determinants of checkpoint activation

MacDougall, C. A., Byun, T. S., Van, C., Yee, M.-C., & Cimprich, K. A. (2007) · Genes & Development

DNA Repair MechanismsCancer-related Molecular Pathways

Cited by 240

A Role for the MRN Complex in ATR Activation via TOPBP1 Recruitment

Duursma, A. M., Driscoll, R., Elias, J. E., & Cimprich, K. A. (2013) · Molecular Cell

DNA Repair MechanismsEffects of Radiation Exposure

Cited by 153

Monoubiquitination of proliferating cell nuclear antigen induced by stalled replication requires uncoupling of DNA polymerase and mini-chromosome maintenance helicase activities

Chang, D. J., Lupardus, P. J., & Cimprich, K. A. (2006) · Journal of Biological Chemistry

DNA Repair MechanismsUbiquitin and proteasome pathways

Cited by 101

Opposing effects of the UV lesion repair protein XPA and UV bypass polymerase η on ATR checkpoint signaling

Bomgarden, R. D., Lupardus, P. J., Soni, D. V., Yee, M., Ford, J. M., & Cimprich, K. A. (2006) · The EMBO Journal

DNA Repair MechanismsNuclear Structure and Function

Cited by 87

AAV-mediated genome editing is influenced by the formation of R-loops

Puzzo, F., Crossley, M. P., Goswami, A., Zhang, F., Pekrun, K., Garzon, J. L., Cimprich, K. A., & Kay, M. A. (2024) · Molecular Therapy

Virus-based gene therapy researchCRISPR and Genetic Engineering

Cited by 4

AAV-mediated genome editing is influenced by the formation of R-loops

Puzzo, F., Crossley, M. P., Goswami, A., Zhang, F., Pekrun, K., Garzon, J. L., Cimprich, K. A., & Kay, M. A. (2024) · Molecular Therapy

Virus-based gene therapy researchCRISPR and Genetic Engineering

Cited by 4