Cited by 2,079DNA Repair MechanismsTelomeres, Telomerase, and SenescenceBacterial Genetics and Biotechnology

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Causes and consequences of replication stress

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Zeman, Michelle K., Cimprich, Karlene A.·2014·Nature Cell Biology

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Abstract

Replication stress is a complex phenomenon that has serious implications for genome stability, cell survival and human disease. Generation of aberrant replication fork structures containing single-stranded DNA activates the replication stress response, primarily mediated by the kinase ATR (ATM- and Rad3-related). Along with its downstream effectors, ATR stabilizes and helps to restart stalled replication forks, avoiding the generation of DNA damage and genome instability. Understanding this response may be key to diagnosing and treating human diseases caused by defective responses to replication stress.

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Authors: Zeman, M. K., & Cimprich, K. A.
Affiliations: Stanford Medicine (US)
Corresponding author: Cimprich, Karlene A.
ORCID: Cimprich, Karlene A.
Venue: Nature Cell Biology
Publisher: Springer Science and Business Media LLC
Published: 2013-12-24
Volume: 16
Issue: 1
Pages: 2-9
ISSN: 1465-7392 (ISSN-L)
1476-4679
DOI: 10.1038/ncb2897
PMC: PMC4354890
OpenAlex: W2040860750
Cited by: 2,079
References: 142
Citations by year: 2026: 158 · 2025: 182 · 2024: 173 · 2023: 197 · 2022: 190 · 2021: 233 · 2020: 209 · 2019: 162 · 2018: 147 · 2017: 150 · 2016: 137 · 2015: 103 · 2014: 37
FWCI: 8.50
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Nature Cell Biology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of General Medical Sciences (R01GM100489)
National Institute of Environmental Health Sciences (R01ES016486)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
Keywords: replication stress, genomic instability, ATR kinase, replication stress response, replication fork restart, single-stranded DNA, DNA damage response, cell survival, DNA replication defects, human disease
MeSH terms: Disease, DNA Replication, Eukaryotic Cells, Humans, Models, Biological, Stress, Physiological

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