The DOI matches its Crossref record; 57 of the 57 references it cites were found in a registry or an index.
The role of differential VE-cadherin dynamics in cell rearrangement during angiogenesis
Open accessAbstract
Endothelial cells show surprising cell rearrangement behaviour during angiogenic sprouting; however, the underlying mechanisms and functional importance remain unclear. By combining computational modelling with experimentation, we identify that Notch/VEGFR-regulated differential dynamics of VE-cadherin junctions drive functional endothelial cell rearrangements during sprouting. We propose that continual flux in Notch signalling levels in individual cells results in differential VE-cadherin turnover and junctional-cortex protrusions, which powers differential cell movement. In cultured endothelial cells, Notch signalling quantitatively reduced junctional VE-cadherin mobility. In simulations, only differential adhesion dynamics generated long-range position changes, required for tip cell competition and stalk cell intercalation. Simulation and quantitative image analysis on VE-cadherin junctional patterning in vivo identified that differential VE-cadherin mobility is lost under pathological high VEGF conditions, in retinopathy and tumour vessels. Our results provide a mechanistic concept for how cells rearrange during normal sprouting and how rearrangement switches to generate abnormal vessels in pathologies.
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Cites
A global double-fluorescent Cre reporter mouse
Muzumdar, M. D., Tasic, B., Miyamichi, K., Li, L., & Luo, L. (2007) · genesis · doi:10.1002/dvg.20335 · Cited by 3,491
VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia
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Self-citationBasic and Therapeutic Aspects of Angiogenesis
Potente, M., Gerhardt, H., & Carmeliet, P. (2011) · Cell · doi:10.1016/j.cell.2011.08.039 · Cited by 2,771
Self-citationDll4 signalling through Notch1 regulates formation of tip cells during angiogenesis
Hellström, M., Phng, L.-K., Hofmann, J. J., Wallgard, E., Coultas, L., Lindblom, P., Alva, J., Nilsson, A.-K., Karlsson, L., Gaiano, N., et al. (2007) · Nature · doi:10.1038/nature05571 · Cited by 1,775
Self-citationOxygen-induced retinopathy in the mouse.
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Simulation of biological cell sorting using a two-dimensional extended Potts model
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Long-term, high-resolution imaging in the mouse neocortex through a chronic cranial window
Holtmaat, A., Bonhoeffer, T., Chow, D. K., Chuckowree, J., De Paola, V., Hofer, S. B., Hübener, M., Keck, T., Knott, G., Lee, W.-C. A., et al. (2009) · Nature Protocols · doi:10.1038/nprot.2009.89 · Cited by 1,023
Myosin-dependent junction remodelling controls planar cell intercalation and axis elongation
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Endothelial cells dynamically compete for the tip cell position during angiogenic sprouting
Jakobsson, L., Franco, C. A., Bentley, K., Collins, R. T., Ponsioen, B., Aspalter, I. M., Rosewell, I., Busse, M., Thurston, G., Medvinsky, A., et al. (2010) · Nature Cell Biology · doi:10.1038/ncb2103 · Cited by 971
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Nanocomposite scaffolds for accelerating chronic wound healing by enhancing angiogenesis
Nosrati, H., Aramideh Khouy, R., Nosrati, A., Khodaei, M., Banitalebi-Dehkordi, M., Ashrafi-Dehkordi, K., Sanami, S., & Alizadeh, Z. (2021) · Journal of Nanobiotechnology · doi:10.1186/s12951-020-00755-7 · Cited by 720
Macrophage Metabolism Controls Tumor Blood Vessel Morphogenesis and Metastasis
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Dynamic Endothelial Cell Rearrangements Drive Developmental Vessel Regression
Franco, C. A., Jones, M. L., Bernabeu, M. O., Geudens, I., Mathivet, T., Rosa, A., Lopes, F. M., Lima, A. P., Ragab, A., Collins, R. T., et al. (2015) · PLOS Biology · doi:10.1371/journal.pbio.1002125 · Cited by 295
Self-citationTargeting vascular and leukocyte communication in angiogenesis, inflammation and fibrosis
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VEGFR2 pY949 signalling regulates adherens junction integrity and metastatic spread
Li, X., Padhan, N., Sjöström, E. O., Roche, F. P., Testini, C., Honkura, N., Sáinz-Jaspeado, M., Gordon, E., Bentley, K., Philippides, A., et al. (2016) · Nature Communications · doi:10.1038/ncomms11017 · Cited by 149
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Metadata
- Authors
- Bentley, K., Franco, C. A., Philippides, A., Blanco, R., Dierkes, M., Gebala, V., Stanchi, F., Jones, M., Aspalter, I. M., Cagna, G., Weström, S., Claesson-Welsh, L., Vestweber, D., & Gerhardt, H.
- Venue
- Nature Cell Biology
- Published
- 2014-03-23
- Volume
- 16
- Issue
- 4
- Pages
- 309-321
- ISSN
- 1465-7392 (ISSN-L)
- 1476-4679
- OpenAlex
- W1991797784
- Cited by
- 364
- References
- 57
- FWCI
- 15.33
- Type
- journal article
- Language
- en
- Open access
- green
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- Bentley, K., Franco, C. A., Philippides, A., Blanco, R., Dierkes, M., Gebala, V., Stanchi, F., Jones, M., Aspalter, I. M., Cagna, G., Weström, S., Claesson-Welsh, L., Vestweber, D., & Gerhardt, H. (2014). The role of differential VE-cadherin dynamics in cell rearrangement during angiogenesis. Nature Cell Biology. https://doi.org/10.1038/ncb2926
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