Targeting vascular and leukocyte communication in angiogenesis, inflammation and fibrosis
Abstract
Regulation of vascular permeability, recruitment of leukocytes from blood to tissue and angiogenesis are all processes that occur at the level of the microvasculature during both physiological and pathological conditions. The interplay between microvascular cells and leukocytes during inflammation, together with the emerging roles of leukocytes in the modulation of the angiogenic process, make leukocyte-vascular interactions prime targets for therapeutics to potentially treat a wide range of diseases, including pathological and dysfunctional vessel growth, chronic inflammation and fibrosis. In this Review, we discuss how the different cell types that are present in and around microvessels interact, cooperate and instruct each other, and in this context we highlight drug targets as well as emerging druggable processes that can be exploited to restore tissue homeostasis.
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Mechanical forces during rapid tumor growth induce intussusceptive/splitting angiogenesis.
“Mechanical forces that exist during the rapid growth of a tumor induce this kind of angiogenesis (86).”
From The ominous triad of adipose tissue dysfunction: inflammation, fibrosis, and impaired angiogenesis. (2017) · cites this paper as [86]
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- Authors
- Kreuger, J., & Phillipson, M.
- Affiliations
- Uppsala University (SE)
- Corresponding author
- Phillipson, Mia
- Venue
- Nature Reviews Drug Discovery
- Published
- 2015-11-27
- Volume
- 15
- Issue
- 2
- Pages
- 125-142
- ISSN
- 1474-1776 (ISSN-L)
- 1474-1784
- OpenAlex
- W2174540735
- Cited by
- 160
- References
- 252
- Citations by year
- 2026: 11 · 2025: 15 · 2024: 13 · 2023: 20 · 2022: 13 · 2021: 16 · 2020: 9 · 2019: 16 · 2018: 13 · 2017: 23 · 2016: 11
- FWCI
- 1.52
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nature Reviews Drug Discovery (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Royal Swedish Academy of Sciences
- Stiftelsen för Strategisk Forskning
- Knut och Alice Wallenbergs Stiftelse
- Vetenskapsrådet
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Keywords
- angiogenesis, inflammation, fibrosis, microcirculation, leukocyte recruitment, vascular permeability, intracellular communication, therapeutic target, drug delivery systems, tissue homeostasis
- MeSH terms
- Animals, Capillary Permeability, Cell Communication, Endothelium, Vascular, Fibrosis, Growth Inhibitors, Humans, Inflammation, Leukocytes, Neovascularization, Pathologic
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