Cited by 160Angiogenesis and VEGF in CancerCell Adhesion Molecules ResearchBarrier Structure and Function Studies

Targeting vascular and leukocyte communication in angiogenesis, inflammation and fibrosis

Kreuger, Johan, Phillipson, Mia·2016·Nature Reviews Drug Discovery

Abstract

Regulation of vascular permeability, recruitment of leukocytes from blood to tissue and angiogenesis are all processes that occur at the level of the microvasculature during both physiological and pathological conditions. The interplay between microvascular cells and leukocytes during inflammation, together with the emerging roles of leukocytes in the modulation of the angiogenic process, make leukocyte-vascular interactions prime targets for therapeutics to potentially treat a wide range of diseases, including pathological and dysfunctional vessel growth, chronic inflammation and fibrosis. In this Review, we discuss how the different cell types that are present in and around microvessels interact, cooperate and instruct each other, and in this context we highlight drug targets as well as emerging druggable processes that can be exploited to restore tissue homeostasis.

Integrity signals

Registry

Crossref · 10.1038/nrd.2015.2

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251 of 251 references verified0 citation errors · 0 not checkable

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Authors
Kreuger, J., & Phillipson, M.
Affiliations
Uppsala University (SE)
Corresponding author
Phillipson, Mia
Venue
Nature Reviews Drug Discovery
Published
2015-11-27
Volume
15
Issue
2
Pages
125-142
ISSN
  • 1474-1776 (ISSN-L)
  • 1474-1784
OpenAlex
W2174540735
Cited by
160
References
252
Citations by year
2026: 11 · 2025: 15 · 2024: 13 · 2023: 20 · 2022: 13 · 2021: 16 · 2020: 9 · 2019: 16 · 2018: 13 · 2017: 23 · 2016: 11
FWCI
1.52
Type
journal article
Language
en
Open access
closed
Locations
  • Nature Reviews Drug Discovery (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Royal Swedish Academy of Sciences
  • Stiftelsen för Strategisk Forskning
  • Knut och Alice Wallenbergs Stiftelse
  • Vetenskapsrådet
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
  • Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
  • Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
Keywords
angiogenesis, inflammation, fibrosis, microcirculation, leukocyte recruitment, vascular permeability, intracellular communication, therapeutic target, drug delivery systems, tissue homeostasis
MeSH terms
Animals, Capillary Permeability, Cell Communication, Endothelium, Vascular, Fibrosis, Growth Inhibitors, Humans, Inflammation, Leukocytes, Neovascularization, Pathologic

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