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The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.

Dicer1–miR-328–Bace1 signalling controls brown adipose tissue differentiation and function

Oliverio, Matteo, Schmidt, Elena, Mauer, Jan, Baitzel, Catherina, Hansmeier, Nils, Khani, Sajjad, Konieczka, Sandra, Pradas-Juni, Marta, Brodesser, Susanne, Van, Trieu-My, Bartsch, Deniz, Brönneke, Hella S., Heine, Markus, Hilpert, Hans, Tarcitano, Emilio, Garinis, George A., Frommolt, Peter, Heeren, Joerg, Mori, Marcelo A., Brüning, Jens C., Kornfeld, Jan-Wilhelm·2016·Nature Cell Biology
DOI 10.1038/ncb3316
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Abstract

Activation of brown adipose tissue (BAT) controls energy homeostasis in rodents and humans and has emerged as an innovative strategy for the treatment of obesity and type 2 diabetes mellitus. Here we show that ageing- and obesity-associated dysfunction of brown fat coincides with global microRNA downregulation due to reduced expression of the microRNA-processing node Dicer1. Consequently, heterozygosity of Dicer1 in BAT aggravated diet-induced-obesity (DIO)-evoked deterioration of glucose metabolism. Analyses of differential microRNA expression during preadipocyte commitment and mouse models of progeria, longevity and DIO identified miR-328 as a regulator of BAT differentiation. Reducing miR-328 blocked preadipocyte commitment, whereas miR-328 overexpression instigated BAT differentiation and impaired muscle progenitor commitment-partly through silencing of the β-secretase Bace1. Loss of Bace1 enhanced brown preadipocyte specification in vitro and was overexpressed in BAT of obese and progeroid mice. In vivo Bace1 inhibition delayed DIO-induced weight gain and improved glucose tolerance and insulin sensitivity. These experiments reveal Dicer1-miR-328-Bace1 signalling as a determinant of BAT function, and highlight the potential of Bace1 inhibition as a therapeutic approach to improve not only neurodegenerative diseases but also ageing- and obesity-associated impairments of BAT function.

Overview

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Crossref · 10.1038/ncb3316

Cites

6 of 6 references verified0 citation errors · 0 not checkable

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  • Reduction in miR-328 was accompanied by a decrease in genes associated with BAT function, including UCP1.

    “This reduction is miR‐328 was accompanied by a decrease in genes associated with BAT function, including UCP1.”

    From BACE1: More than just a β‐secretase (2022) · cites this paper as [124]

  • In DIO models, Dicer1 downregulation resulted in decreased expression of miR-328.

    “In DIO models, Dicer1 downregulation resulted in decreased expression of miR‐328.”

    From BACE1: More than just a β‐secretase (2022) · cites this paper as [124]

  • BACE1 has been implicated in body weight regulation via thermogenesis and its role in BAT differentiation.

    “In addition to β‐oxidation via leptin signaling, BACE1 has also been implicated in body weight regulation via thermogenesis and its role in BAT differentiation.”

    From BACE1: More than just a β‐secretase (2022) · cites this paper as [124]

Citations

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Research works printed but not linked: 32

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Metadata

Authors
Oliverio, M., Schmidt, E., Mauer, J., Baitzel, C., Hansmeier, N., Khani, S., Konieczka, S., Pradas-Juni, M., Brodesser, S., Van, T.-M., Bartsch, D., Brönneke, H. S., Heine, M., Hilpert, H., Tarcitano, E., Garinis, G. A., Frommolt, P., Heeren, J., Mori, M. A., Brüning, J. C., & Kornfeld, J.-W.
ORCID
Venue
Nature Cell Biology
Publisher
Springer Science and Business Media LLC
Published
2016-02-22
Volume
18
Issue
3
Pages
328-336
ISSN
  • 1465-7392
  • 1476-4679
DOI
10.1038/ncb3316
Cited by
94
References
6
Language
en
Licence
www.springer.com/tdm (tdm)

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