Adipose tissue browning and metabolic health

Brown Adipose Tissue: Function and Physiological Significance

CANNON, B., & NEDERGAARD, J. (2004) · Physiological Reviews · doi:10.1152/physrev.00015.2003 · Cited by 6,433 · see citing works

A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis

Boström, P., Wu, J., Jedrychowski, M. P., Korde, A., Ye, L., Lo, J. C., Rasbach, K. A., Boström, E. A., Choi, J. H., Long, J. Z., et al. (2012) · Nature · doi:10.1038/nature10777 · Cited by 4,810 · see citing works

Obesity induces a phenotypic switch in adipose tissue macrophage polarization

Lumeng, C. N., Bodzin, J. L., & Saltiel, A. R. (2007) · Journal of Clinical Investigation · doi:10.1172/jci29881 · Cited by 4,664 · see citing works

Identification and Importance of Brown Adipose Tissue in Adult Humans

Cypess, A. M., Lehman, S., Williams, G., Tal, I., Rodman, D., Goldfine, A. B., Kuo, F. C., Palmer, E. L., Tseng, Y.-H., Doria, A., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0810780 · Cited by 4,399 · see citing works

Resveratrol Improves Mitochondrial Function and Protects against Metabolic Disease by Activating SIRT1 and PGC-1α

Lagouge, M., Argmann, C., Gerhart-Hines, Z., Meziane, H., Lerin, C., Daussin, F., Messadeq, N., Milne, J., Lambert, P., Elliott, P., et al. (2006) · Cell · doi:10.1016/j.cell.2006.11.013 · Cited by 4,057 · see citing works

Autophagy regulates lipid metabolism

Singh, R., Kaushik, S., Wang, Y., Xiang, Y., Novak, I., Komatsu, M., Tanaka, K., Cuervo, A. M., & Czaja, M. J. (2009) · Nature · doi:10.1038/nature07976 · Cited by 3,975 · see citing works

A Cold-Inducible Coactivator of Nuclear Receptors Linked to Adaptive Thermogenesis

Puigserver, P., Wu, Z., Park, C. W., Graves, R., Wright, M., & Spiegelman, B. M. (1998) · Cell · doi:10.1016/s0092-8674(00)81410-5 · Cited by 3,864 · see citing works

Cold-Activated Brown Adipose Tissue in Healthy Men

van Marken Lichtenbelt, W. D., Vanhommerig, J. W., Smulders, N. M., Drossaerts, J. M. A. F. L., Kemerink, G. J., Bouvy, N. D., Schrauwen, P., & Teule, G. J. J. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0808718 · Cited by 3,452 · see citing works

AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity

Cantó, C., Gerhart-Hines, Z., Feige, J. N., Lagouge, M., Noriega, L., Milne, J. C., Elliott, P. J., Puigserver, P., & Auwerx, J. (2009) · Nature · doi:10.1038/nature07813 · Cited by 3,300 · see citing works

Beige Adipocytes Are a Distinct Type of Thermogenic Fat Cell in Mouse and Human

Wu, J., Boström, P., Sparks, L. M., Li, Y., Choi, J. H., Giang, A.-H., Khandekar, M. J., Virtanen, K. A., Nuutila, P., Schaart, G., et al. (2012) · Cell · doi:10.1016/j.cell.2012.05.016 · Cited by 3,299 · see citing works

Nutrient control of glucose homeostasis through a complex of PGC-1α and SIRT1

Rodgers, J. T., Lerin, C., Haas, W., Gygi, S. P., Spiegelman, B. M., & Puigserver, P. (2005) · Nature · doi:10.1038/nature03354 · Cited by 3,160 · see citing works

Functional Brown Adipose Tissue in Healthy Adults

Virtanen, K. A., Lidell, M. E., Orava, J., Heglind, M., Westergren, R., Niemi, T., Taittonen, M., Laine, J., Savisto, N.-J., Enerbäck, S., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0808949 · Cited by 3,058 · see citing works

Muscles, exercise and obesity: skeletal muscle as a secretory organ

Pedersen, B. K., & Febbraio, M. A. (2012) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2012.49 · Cited by 2,909 · see citing works

Mechanisms linking obesity with cardiovascular disease

Van Gaal, L. F., Mertens, I. L., & De Block, C. E. (2006) · Nature · doi:10.1038/nature05487 · Cited by 2,814 · see citing works

Endoplasmic reticulum stress and the inflammatory basis of metabolic disease

Hotamisligil, G. S. (2010) · Cell · doi:10.1016/j.cell.2010.02.034 · Cited by 2,802 · see citing works

Adipocyte differentiation from the inside out

Rosen, E. D., & MacDougald, O. A. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2066 · Cited by 2,607 · see citing works

AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1α

Jäger, S., Handschin, C., St.-Pierre, J., & Spiegelman, B. M. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0705070104 · Cited by 2,491 · see citing works

PRDM16 controls a brown fat/skeletal muscle switch

Seale, P., Bjork, B., Yang, W., Kajimura, S., Chin, S., Kuang, S., Scimè, A., Devarakonda, S., Conroe, H. M., Erdjument-Bromage, H., et al. (2008) · Nature · doi:10.1038/nature07182 · Cited by 2,347 · see citing works

Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes.

Guilherme, A., Virbasius, J. V., Puri, V., & Czech, M. P. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2391 · Cited by 2,292 · see citing works

High Incidence of Metabolically Active Brown Adipose Tissue in Healthy Adult Humans

Saito, M., Okamatsu-Ogura, Y., Matsushita, M., Watanabe, K., Yoneshiro, T., Nio-Kobayashi, J., Iwanaga, T., Miyagawa, M., Kameya, T., Nakada, K., et al. (2009) · Diabetes · doi:10.2337/db09-0530 · Cited by 1,848 · see citing works

Transcriptional control of adipocyte formation

Farmer, S. R. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.07.001 · Cited by 1,836 · see citing works

Unexpected evidence for active brown adipose tissue in adult humans

Nedergaard, J., Bengtsson, T., & Cannon, B. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00691.2006 · Cited by 1,824 · see citing works

Brown adipose tissue activity controls triglyceride clearance

Bartelt, A., Bruns, O. T., Reimer, R., Hohenberg, H., Ittrich, H., Peldschus, K., Kaul, M. G., Tromsdorf, U. I., Weller, H., Waurisch, C., et al. (2011) · Nature Medicine · doi:10.1038/nm.2297 · Cited by 1,608 · see citing works

Developmental Origin of Fat: Tracking Obesity to Its Source

Gesta, S., Tseng, Y.-H., & Kahn, C. R. (2007) · Cell · doi:10.1016/j.cell.2007.10.004 · Cited by 1,508 · see citing works

FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesis

Fisher, F. M., Kleiner, S., Douris, N., Fox, E. C., Mepani, R. J., Verdeguer, F., Wu, J., Kharitonenkov, A., Flier, J. S., Maratos-Flier, E., et al. (2012) · Genes & Development · doi:10.1101/gad.177857.111 · Cited by 1,478 · see citing works

Mice lacking mitochondrial uncoupling protein are cold-sensitive but not obese

Enerbäck, S., Jacobsson, A., Simpson, E. M., Guerra, C., Yamashita, H., Harper, M.-E., & Kozak, L. P. (1997) · Nature · doi:10.1038/387090a0 · Cited by 1,379 · see citing works

Defective lipolysis and altered energy metabolism in mice lacking adipose triglyceride lipase

Haemmerle, G., Lass, A., Zimmermann, R., Gorkiewicz, G., Meyer, C., Rozman, J., Heldmaier, G., Maier, R., Theussl, C., Eder, S., et al. (2006) · Science · doi:10.1126/science.1123965 · Cited by 1,375 · see citing works

Resveratrol Ameliorates Aging-Related Metabolic Phenotypes by Inhibiting cAMP Phosphodiesterases

Park, S. J., Ahmad, F., Philp, A., Baar, K., Williams, T., Luo, H., Ke, H., Rehmann, H., Taussig, R., Brown, A. L., et al. (2012) · Cell · doi:10.1016/j.cell.2012.01.017 · Cited by 1,352 · see citing works

UCP1 Ablation Induces Obesity and Abolishes Diet-Induced Thermogenesis in Mice Exempt from Thermal Stress by Living at Thermoneutrality

Feldmann, H. M., Golozoubova, V., Cannon, B., & Nedergaard, J. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2008.12.014 · Cited by 1,318 · see citing works

Peroxisome-Proliferator-Activated Receptor δ Activates Fat Metabolism to Prevent Obesity

Wang, Y.-X., Lee, C.-H., Tiep, S., Yu, R. T., Ham, J., Kang, H., & Evans, R. M. (2003) · Cell · doi:10.1016/s0092-8674(03)00269-1 · Cited by 1,296 · see citing works

Chronic Peroxisome Proliferator-activated Receptor γ (PPARγ) Activation of Epididymally Derived White Adipocyte Cultures Reveals a Population of Thermogenically Competent, UCP1-containing Adipocytes Molecularly Distinct from Classic Brown Adipocytes

Petrovic, N., Walden, T. B., Shabalina, I. G., Timmons, J. A., Cannon, B., & Nedergaard, J. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.053942 · Cited by 1,263 · see citing works

Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice

Seale, P., Conroe, H. M., Estall, J. L., Kajimura, S., Frontini, A., Ishibashi, J., Cohen, P., Cinti, S., & Spiegelman, B. M. (2010) · Journal of Clinical Investigation · doi:10.1172/jci44271 · Cited by 1,241 · see citing works

Brown adipose tissue regulates glucose homeostasis and insulin sensitivity

Stanford, K. I., Middelbeek, R. J. W., Townsend, K. L., An, D., Nygaard, E. B., Hitchcox, K. M., Markan, K. R., Nakano, K., Hirshman, M. F., Tseng, Y.-H., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci62308 · Cited by 1,180 · see citing works

Transcriptional Control of Brown Fat Determination by PRDM16

Seale, P., Kajimura, S., Yang, W., Chin, S., Rohas, L. M., Uldry, M., Tavernier, G., Langin, D., & Spiegelman, B. M. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.06.001 · Cited by 1,174 · see citing works

FAT SIGNALS - Lipases and Lipolysis in Lipid Metabolism and Signaling

Zechner, R., Zimmermann, R., Eichmann, T. O., Kohlwein, S., Haemmerle, G., Lass, A., & Madeo, F. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2011.12.018 · Cited by 1,105 · see citing works

New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure

Tseng, Y.-H., Kokkotou, E., Schulz, T. J., Huang, T. L., Winnay, J. N., Taniguchi, C. M., Tran, T. T., Suzuki, R., Espinoza, D. O., Yamamoto, Y., et al. (2008) · Nature · doi:10.1038/nature07221 · Cited by 1,099 · see citing works

The role of exercise and PGC1α in inflammation and chronic disease

Handschin, C., & Spiegelman, B. M. (2008) · Nature · doi:10.1038/nature07206 · Cited by 1,083 · see citing works

Development of obesity in transgenic mice after genetic ablation of brown adipose tissue

Lowell, B. B., S-Susulic, V., Hamann, A., Lawitts, J. A., Himms-Hagen, J., Boyer, B. B., Kozak, L. P., & Flier, J. S. (1993) · Nature · doi:10.1038/366740a0 · Cited by 1,075 · see citing works

FNDC5 and Irisin in Humans: I. Predictors of Circulating Concentrations in Serum and Plasma and II. mRNA Expression and Circulating Concentrations in Response to Weight Loss and Exercise

Huh, J. Y., Panagiotou, G., Mougios, V., Brinkoetter, M., Vamvini, M. T., Schneider, B. E., & Mantzoros, C. S. (2012) · Metabolism · doi:10.1016/j.metabol.2012.09.002 · Cited by 1,040 · see citing works

Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis

Nguyen, K. D., Qiu, Y., Cui, X., Goh, Y. P. S., Mwangi, J., David, T., Mukundan, L., Brombacher, F., Locksley, R. M., & Chawla, A. (2011) · Nature · doi:10.1038/nature10653 · Cited by 1,038 · see citing works

TFEB controls cellular lipid metabolism through a starvation-induced autoregulatory loop

Settembre, C., De Cegli, R., Mansueto, G., Saha, P. K., Vetrini, F., Visvikis, O., Huynh, T., Carissimo, A., Palmer, D., Jürgen Klisch, T., et al. (2013) · Nature Cell Biology · doi:10.1038/ncb2718 · Cited by 1,022 · see citing works

Brown adipose tissue oxidative metabolism contributes to energy expenditure during acute cold exposure in humans

Ouellet, V., Labbé, S. M., Blondin, D. P., Phoenix, S., Guérin, B., Haman, F., Turcotte, É. E., Richard, D., & Carpentier, A. C. (2012) · Journal of Clinical Investigation · doi:10.1172/jci60433 · Cited by 985 · see citing works

Recruited brown adipose tissue as an antiobesity agent in humans

Yoneshiro, T., Aita, S., Matsushita, M., Kayahara, T., Kameya, T., Kawai, Y., Iwanaga, T., & Saito, M. (2013) · Journal of Clinical Investigation · doi:10.1172/jci67803 · Cited by 957 · see citing works

Cardiac natriuretic peptides act via p38 MAPK to induce the brown fat thermogenic program in mouse and human adipocytes

Bordicchia, M., Liu, D., Amri, E.-Z., Ailhaud, G., Dessì-Fulgheri, P., Zhang, C., Takahashi, N., Sarzani, R., & Collins, S. (2012) · Journal of Clinical Investigation · doi:10.1172/jci59701 · Cited by 872 · see citing works

Cold acclimation recruits human brown fat and increases nonshivering thermogenesis

van der Lans, A. A. J. J., Joris Hoeks, J., Brans, B. T., Vijgen, G. H. E. J., Visser, M. G. W., Vosselman, M. J., Hansen, J., Jörgensen, J. A., Wu, J., Mottaghy, F. M., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci68993 · Cited by 841 · see citing works

Brown Remodeling of White Adipose Tissue by SirT1-Dependent Deacetylation of Pparγ

Qiang, L., Wang, L., Kon, N., Zhao, W., Lee, S., Zhang, Y., ROSENBAUM, M. S., Zhao, Y., Gu, W. J., Farmer, S. R., et al. (2012) · Cell · doi:10.1016/j.cell.2012.06.027 · Cited by 802 · see citing works

Bi-directional interconversion of brite and white adipocytes

Rosenwald, M., Perdikari, A., Rülicke, T., & Wolfrum, C. (2013) · Nature Cell Biology · doi:10.1038/ncb2740 · Cited by 792 · see citing works

Irisin is expressed and produced by human muscle and adipose tissue in association with obesity and insulin resistance

Moreno-Navarrete, J. M., Ortega, F., Serrano, M., Guerra, E., Pardo, G., Tinahones, F., Ricart, W., & Fernández-Real, J. M. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-2749 · Cited by 788 · see citing works

Autophagy deficiency leads to protection from obesity and insulin resistance by inducing Fgf21 as a mitokine

Kim, K. H., Jeong, Y. T., Oh, H., Kim, S. H., Cho, J. M., Kim, Y.-N., Kim, S. S., Kim, D. H., Hur, K. Y., Kim, H. K., et al. (2013) · Nature Medicine · doi:10.1038/nm.3014 · Cited by 774 · see citing works

Use of Cells Expressing γ Subunit Variants to Identify Diverse Mechanisms of AMPK Activation

Hawley, S. A., Ross, F. A., Chevtzoff, C., Green, K. A., Evans, A., Fogarty, S., Towler, M. C., Brown, L. J., Ogunbayo, O. A., Evans, A. M., et al. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.04.001 · Cited by 773 · see citing works

ATGL-mediated fat catabolism regulates cardiac mitochondrial function via PPAR-α and PGC-1

Haemmerle, G., Moustafa, T., Wölkart, G., Büttner, S., Schmidt, A. G., van de Weijer, T., Hesselink, M. K. C., Jaeger, D., Kienesberger, P. C., Zierler, K. A., et al. (2011) · Nature Medicine · doi:10.1038/nm.2439 · Cited by 767 · see citing works

The emergence of cold-induced brown adipocytes in mouse white fat depots is determined predominantly by white to brown adipocyte transdifferentiation

Barbatelli, G., Murano, I., Madsen, L., Hao, Q., Jimenez, M., Kristiansen, K., Giacobino, J., Matteis, R. D., & Cinti, S. (2010) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00600.2009 · Cited by 751 · see citing works

PPARγ agonists Induce a White-to-Brown Fat Conversion through Stabilization of PRDM16 Protein

Ohno, H., Shinoda, K., Spiegelman, B. M., & Kajimura, S. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.01.019 · Cited by 749 · see citing works

Autophagy regulates adipose mass and differentiation in mice

Singh, R., Xiang, Y., Wang, Y., Baikati, K., Cuervo, A. M., Luu, Y. K., Tang, Y., Pessin, J. E., Schwartz, G. J., & Czaja, M. J. (2009) · Journal of Clinical Investigation · doi:10.1172/jci39228 · Cited by 748 · see citing works

Endocannabinoid control of food intake and energy balance

Marzo, V. D., & Matias, I. (2005) · Nature Neuroscience · doi:10.1038/nn1457 · Cited by 746 · see citing works

The Ancient Drug Salicylate Directly Activates AMP-Activated Protein Kinase

Hawley, S. A., Fullerton, M. D., Ross, F. A., Schertzer, J. D., Chevtzoff, C., Walker, K. J., Peggie, M. W., Zibrova, D., Green, K. A., Mustard, K. J., et al. (2012) · Science · doi:10.1126/science.1215327 · Cited by 745 · see citing works

Myogenic gene expression signature establishes that brown and white adipocytes originate from distinct cell lineages

Timmons, J. A., Wennmalm, K., Larsson, O., Walden, T. B., Lassmann, T., Petrovic, N., Hamilton, D. L., Gimeno, R. E., Wahlestedt, C., Baar, K., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0610615104 · Cited by 732 · see citing works

Different Metabolic Responses of Human Brown Adipose Tissue to Activation by Cold and Insulin

Orava, J., Nuutila, P., Lidell, M. E., Oikonen, V., Noponen, T., Viljanen, T., Scheinin, M., Taittonen, M. T., Niemi, T. S., Enerbäck, S., et al. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.06.012 · Cited by 729 · see citing works

The presence of UCP1 demonstrates that metabolically active adipose tissue in the neck of adult humans truly represents brown adipose tissue

Zingaretti, M. C., Crosta, F., Vitali, A., Guerrieri, M., Frontini, A., Cannon, B., Nedergaard, J., & Cinti, S. (2009) · The FASEB Journal · doi:10.1096/fj.09-133546 · Cited by 725 · see citing works

Beneficial Effects of Subcutaneous Fat Transplantation on Metabolism

Tran, T. T., Yamamoto, Y., Gesta, S., & Kahn, C. R. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.04.004 · Cited by 705 · see citing works

A PGC-1α isoform induced by resistance training regulates skeletal muscle hypertrophy

Ruas, J. L., White, J. P., Rao, R. R., Kleiner, S., Brannan, K. T., Harrison, B. C., Greene, N. P., Wu, J., Estall, J. L., Irving, B. A., et al. (2012) · Cell · doi:10.1016/j.cell.2012.10.050 · Cited by 677 · see citing works

In Vivo Identification of Bipotential Adipocyte Progenitors Recruited by β3-Adrenoceptor Activation and High-Fat Feeding

Lee, Y., Petkova, A. P., Mottillo, E. P., & Granneman, J. G. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.03.009 · Cited by 676 · see citing works

Anatomical localization, gene expression profiling and functional characterization of adult human neck brown fat

Cypess, A. M., White, A. P., Vernochet, C., Schulz, T. J., Xue, R., Sass, C. A., Huang, T. L., Roberts‐Toler, C., Weiner, L. S., Sze, C., et al. (2013) · Nature Medicine · doi:10.1038/nm.3112 · Cited by 667 · see citing works

Evidence for two types of brown adipose tissue in humans

Lidell, M. E., Betz, M. J., Leinhard, O. D., Heglind, M., Elander, L., Slawik, M., Mussack, T., Nilsson, D., Romu, T., Nuutila, P., et al. (2013) · Nature Medicine · doi:10.1038/nm.3017 · Cited by 658 · see citing works

Emergence of brown adipocytes in white fat in mice is under genetic control. Effects on body weight and adiposity.

Guerra, C., Koza, R. A., Yamashita, H., Walsh, K., & Kozak, L. P. (1998) · Journal of Clinical Investigation · doi:10.1172/jci3155 · Cited by 635 · see citing works

Human BAT Possesses Molecular Signatures That Resemble Beige/Brite Cells

Sharp, L. Z., Shinoda, K., Ohno, H., Scheel, D. W., Tomoda, E., Ruiz, L., Hu, H., Wang, L. L., Pavlova, Z., Gilsanz, V., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0049452 · Cited by 635 · see citing works

Evidence for a role of developmental genes in the origin of obesity and body fat distribution

Gesta, S., Blüher, M., Yamamoto, Y., Norris, A. W., Berndt, J., Kralisch, S., Boucher, J., Lewis, C. R., & Kahn, C. R. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0601752103 · Cited by 617 · see citing works

Mitochondrial remodeling in adipose tissue associated with obesity and treatment with rosiglitazone.

Wilson-Fritch, L., Nicoloro, S., Chouinard, M., Lazar, M. A., Chui, P. C., Leszyk, J., Straubhaar, J., Czech, M. P., & Corvera, S. (2004) · Journal of Clinical Investigation · doi:10.1172/jci21752 · Cited by 616 · see citing works

p38 Mitogen-Activated Protein Kinase Is the Central Regulator of Cyclic AMP-Dependent Transcription of the Brown Fat Uncoupling Protein 1 Gene

Cao, W., Daniel, K. W., Robidoux, J., Puigserver, P., Medvedev, A. V., Bai, X., Floering, L. M., Spiegelman, B. M., & Collins, S. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.7.3057-3067.2004 · Cited by 605 · see citing works

Multilocular fat cells in WAT of CL-316243-treated rats derive directly from white adipocytes

Himms-Hagen, J., Melnyk, A., Zingaretti, M. C., Ceresi, E., Barbatelli, G., & Cinti, S. (2000) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.2000.279.3.c670 · Cited by 593 · see citing works

BMP8B Increases Brown Adipose Tissue Thermogenesis through Both Central and Peripheral Actions

Whittle, A. J., Carobbio, S., Martins, L., Slawik, M., Hondares, E., Vázquez, M. J., Morgan, D., Csikasz, R. I., Gallego, R., Rodriguez-Cuenca, S., et al. (2012) · Cell · doi:10.1016/j.cell.2012.02.066 · Cited by 573 · see citing works

Recruited vs. nonrecruited molecular signatures of brown, “brite,” and white adipose tissues

Waldén, T. B., Hansen, I. R., Timmons, J. A., Cannon, B., & Nedergaard, J. (2011) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00249.2011 · Cited by 565 · see citing works

Outdoor Temperature, Age, Sex, Body Mass Index, and Diabetic Status Determine the Prevalence, Mass, and Glucose-Uptake Activity of 18F-FDG-Detected BAT in Humans

Ouellet, V., Routhier-Labadie, A., Bellemare, W., Lakhal‐Chaieb, L., Turcotte, É. E., Carpentier, A. C., & Richard, D. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-0989 · Cited by 564 · see citing works

FOXC2 Is a Winged Helix Gene that Counteracts Obesity, Hypertriglyceridemia, and Diet-Induced Insulin Resistance

Cederberg, A., Grønning, L. M., Åhrén, B., Taskén, K., Carlsson, P., & Enerbäck, S. (2001) · Cell · doi:10.1016/s0092-8674(01)00474-3 · Cited by 555 · see citing works

Expression of the mitochondrial uncoupling protein gene from the aP2 gene promoter prevents genetic obesity.

Kopecky, J., Clarke, G., Enerbäck, S., Spiegelman, B., & Kozak, L. P. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118363 · Cited by 553 · see citing works

Sarcolipin is a newly identified regulator of muscle-based thermogenesis in mammals

Bal, N. C., Maurya, S. K., Sopariwala, D. H., Sahoo, S. K., Gupta, S. C., Shaikh, S. A., Pant, M., Rowland, L. A., Bombardier, É., Goonasekera, S. A., et al. (2012) · Nature Medicine · doi:10.1038/nm.2897 · Cited by 553 · see citing works

A Classical Brown Adipose Tissue mRNA Signature Partly Overlaps with Brite in the Supraclavicular Region of Adult Humans

Jespersen, N. Z., Larsen, T. J., Peijs, L., Daugaard, S., Homøe, P., Loft, A., de Jong, J. M. A., Mathur, N., Cannon, B., Nedergaard, J., et al. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.04.011 · Cited by 539 · see citing works

Fibroblast Growth Factor-21 Regulates PPARγ Activity and the Antidiabetic Actions of Thiazolidinediones

Dutchak, P. A., Katafuchi, T., Bookout, A. L., Choi, J. H., Yu, R. T., Mangelsdorf, D. J., & Kliewer, S. A. (2012) · Cell · doi:10.1016/j.cell.2011.11.062 · Cited by 537 · see citing works

Desnutrin/ATGL Is Regulated by AMPK and Is Required for a Brown Adipose Phenotype

Ahmadian, M., Abbott, M. J., Tang, T., Hudak, C. S. S., Kim, Y., Bruss, M. D., Hellerstein, M. K., Lee, H., Samuel, V. T., Shulman, G. I., et al. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.05.002 · Cited by 526 · see citing works

Cyclooxygenase-2 Controls Energy Homeostasis in Mice by de Novo Recruitment of Brown Adipocytes

Vegiopoulos, A., Müller‐Decker, K., Strzoda, D., Schmitt, I. M., Chichelnitskiy, E., Ostertag, A., Díaz, M. B., Rozman, J., de Angelis, M. H., Nüsing, R. M., et al. (2010) · Science · doi:10.1126/science.1186034 · Cited by 459 · see citing works

Identification of inducible brown adipocyte progenitors residing in skeletal muscle and white fat

Schulz, T. J., Huang, T. L., Tran, T. T., Zhang, H., Townsend, K. L., Shadrach, J. L., Cerletti, M., McDougall, L. E., Giorgadze, N., Tchkonia, T., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1010929108 · Cited by 459 · see citing works

SRC-1 and TIF2 Control Energy Balance between White and Brown Adipose Tissues

Picard, F., Géhin, M., Annicotte, J., Rocchi, S., Champy, M., O’Malley, B. W., Chambon, P., & Auwerx, J. H. (2002) · Cell · doi:10.1016/s0092-8674(02)01169-8 · Cited by 444 · see citing works

Zfp423 Expression Identifies Committed Preadipocytes and Localizes to Adipose Endothelial and Perivascular Cells

Gupta, R. K., Mepani, R. J., Kleiner, S., Lo, J. C., Khandekar, M. J., Cohen, P., Frontini, A., Bhowmick, D. C., Ye, L., Cinti, S., et al. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.01.010 · Cited by 426 · see citing works

Brown Adipose Tissue, Whole‐Body Energy Expenditure, and Thermogenesis in Healthy Adult Men

Yoneshiro, T., Aita, S., Matsushita, M., Kameya, T., Nakada, K., Kawai, Y., & Saito, M. (2010) · Obesity · doi:10.1038/oby.2010.105 · Cited by 421 · see citing works

Impact of Age on the Relationships of Brown Adipose Tissue With Sex and Adiposity in Humans

Pfannenberg, C., Werner, M. K., Ripkens, S., Stef, I., Deckert, A., Schmadl, M., Reimold, M., Häring, H., Claussen, C. D., & Stefan, N. (2010) · Diabetes · doi:10.2337/db10-0004 · Cited by 420 · see citing works

Transcriptional Control of Brown Fat Development

Kajimura, S., Seale, P., & Spiegelman, B. M. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.03.005 · Cited by 417 · see citing works

Commitment of C3H10T1/2 pluripotent stem cells to the adipocyte lineage

Tang, Q.-Q., Otto, T. C., & Lane, M. D. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0403100101 · Cited by 415 · see citing works

Adipose tissue reduction in mice lacking the translational inhibitor 4E-BP1

Tsukiyama–Kohara, K., Poulin, F., Kohara, M., DeMaria, C. T., Cheng, A., Wu, Z., Gingras, A., Katsume, A., Elchebly, M., Spiegelman, B. M., et al. (2001) · Nature Medicine · doi:10.1038/nm1001-1128 · Cited by 392 · see citing works

FSP27 contributes to efficient energy storage in murine white adipocytes by promoting the formation of unilocular lipid droplets

Nishino, N., Tamori, Y., Tateya, S., Kawaguchi, T., Shibakusa, T., Mizunoya, W., Inoue, K., Kitazawa, R., Kitazawa, S., Matsuki, Y., et al. (2008) · Journal of Clinical Investigation · doi:10.1172/jci34090 · Cited by 388 · see citing works

The Vascular Endothelium of the Adipose Tissue Gives Rise to Both White and Brown Fat Cells

Tran, K., Gealekman, O., Frontini, A., Zingaretti, M. C., Morroni, M., Giordano, A., Smorlesi, A., Perugini, J., Matteis, R. D., Sbarbati, A., et al. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.01.008 · Cited by 381 · see citing works

White to Brown Fat Phenotypic Switch Induced by Genetic and Environmental Activation of a Hypothalamic-Adipocyte Axis

Cao, L., Choi, E., Liu, X., Martin, A. S., Wang, C., Xu, X., & During, M. J. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.06.020 · Cited by 380 · see citing works

Brown-fat paucity due to impaired BMP signalling induces compensatory browning of white fat

Schulz, T. J., Huang, P. C., Huang, T. L., Xue, R., McDougall, L. E., Townsend, K. L., Cypess, A. M., Mishina, Y. M., Gussoni, E., & Tseng, Y. (2013) · Nature · doi:10.1038/nature11943 · Cited by 378 · see citing works

Hepatic FGF21 Expression Is Induced at Birth via PPARα in Response to Milk Intake and Contributes to Thermogenic Activation of Neonatal Brown Fat

Hondares, E., Rosell, M., Gonzalez, F. J., Giralt, M., Iglesias, R., & Villarroya, F. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.02.001 · Cited by 377 · see citing works

Nuclear receptor corepressor RIP140 regulates fat accumulation

Leonardsson, G., Steel, J. H., Christian, M., Pocock, V., Milligan, S., Bell, J., So, P.-W., Medina-Gomez, G., Vidal-Puig, A., White, R., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0401013101 · Cited by 366 · see citing works

Differential roles of NHERF1, NHERF2, and PDZK1 in regulating CFTR-mediated intestinal anion secretion in mice

Singh, A. K., Riederer, B., Krabbenhöft, A., Rausch, B., Bonhagen, J., Lehmann, U., de Jonge, H. R., Donowitz, M., Yun, C. C., Weinman, E. J., et al. (2009) · Journal of Clinical Investigation · doi:10.1172/jci35541 · Cited by 364 · see citing works

The adipose organ at a glance

Cinti, S. (2012) · Disease Models & Mechanisms · doi:10.1242/dmm.009662 · Cited by 350 · see citing works

C/EBPα is required for differentiation of white, but not brown, adipose tissue

Linhart, H., Ishimura‐Oka, K., DeMayo, F. J., Kibe, T., Repka, D., Poindexter, B. J., Bick, R. J., & Darlington, G. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.211416898 · Cited by 333 · see citing works

Evidence against a Beneficial Effect of Irisin in Humans

Raschke, S., Elsen, M., Gassenhuber, J., Sommerfeld, M. R., Schwahn, U., Brockmann, B., Jung, R., Wisløff, U., Tjønna, A. E., Raastad, T., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0073680 · Cited by 322 · see citing works

Rb regulates fate choice and lineage commitment in vivo

Calo, E., Quintero-Estades, J. A., Danielian, P. S., Nedelcu, S., Berman, S. D., & Lees, J. A. (2010) · Nature · doi:10.1038/nature09264 · Cited by 313 · see citing works

BMP4-mediated brown fat-like changes in white adipose tissue alter glucose and energy homeostasis

Qian, S., Tang, Y., Li, X., Liu, Y., Zhang, Y.-Y., Huang, H.-Y., Xue, R.-D., Yu, H.-Y., Guo, L., Gao, H.-D., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1215236110 · Cited by 311 · see citing works

Mir193b–365 is essential for brown fat differentiation

Sun, L., Xie, H., Mori, M. A., Alexander, R., Yuan, B., Hattangadi, S. M., Liu, Q., Kahn, C. R., & Lodish, H. F. (2011) · Nature Cell Biology · doi:10.1038/ncb2286 · Cited by 310 · see citing works

Myostatin Knockout Drives Browning of White Adipose Tissue through Activating the AMPK-PGC1α-Fndc5 Pathway in Muscle

Shan, T., Liang, X., Bi, P., & Kuang, S. (2013) · The FASEB Journal · doi:10.1096/fj.12-225755 · Cited by 301 · see citing works

Peroxisome Proliferator-activated Receptor α (PPARα) Induces PPARγ Coactivator 1α (PGC-1α) Gene Expression and Contributes to Thermogenic Activation of Brown Fat

Hondares, E., Rosell, M., Díaz-Delfín, J., Olmos, Y., Monsalve, M., Iglesias, R., Villarroya, F., & Giralt, M. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.252775 · Cited by 295 · see citing works

Retinoblastoma protein functions as a molecular switch determining white versus brown adipocyte differentiation

Hansen, J. B., Jørgensen, C., Petersen, R. K., Hallenborg, P., De Matteis, R., Bøye, H. A., Petrovic, N., Enerbäck, S., Nedergaard, J., Cinti, S., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0301964101 · Cited by 287 · see citing works

miR-155 regulates differentiation of brown and beige adipocytes via a bistable circuit

Chen, Y., Siegel, F., Kipschull, S., Haas, B., Fröhlich, H., Meister, G., & Pfeifer, A. (2013) · Nature Communications · doi:10.1038/ncomms2742 · Cited by 285 · see citing works

Pharmacological and nutritional agents promoting browning of white adipose tissue

Bonet, M. L., Oliver, P., & Palou, A. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2012.12.002 · Cited by 276 · see citing works

Up-regulation of mitochondrial activity and acquirement of brown adipose tissue-like property in the white adipose tissue of fsp27 deficient mice

Toh, S. Y., Gong, J., Du, G., Li, J. Z., Yang, S., Ye, J., Yao, H., Zhang, Y., Xue, B., Li, Q., et al. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002890 · Cited by 267 · see citing works

UCP1 mRNA does not produce heat

Nedergaard, J., & Cannon, B. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2013.01.009 · Cited by 264 · see citing works

MyomiR-133 regulates brown fat differentiation through Prdm16

Trajkovski, M., Ahmed, K., Esau, C., & Stoffel, M. (2012) · Nature Cell Biology · doi:10.1038/ncb2612 · Cited by 263 · see citing works

Blunted metabolic responses to cold and insulin stimulation in brown adipose tissue of obese humans

Orava, J., Nuutila, P., Noponen, T., Parkkola, R. K., Viljanen, T., Enerbäck, S., Rissanen, A., Pietiläinen, K. H., & Virtanen, K. A. (2013) · Obesity · doi:10.1002/oby.20456 · Cited by 258 · see citing works

Fat cells directly sense temperature to activate thermogenesis

Li, Y., Wu, J., Cohen, P., Kazak, L., Khandekar, M. J., Jedrychowski, M. P., Zeng, X., Gygi, S. P., & Spiegelman, B. M. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1310261110 · Cited by 245 · see citing works

Inhibiting Adipose Tissue Lipogenesis Reprograms Thermogenesis and PPARγ Activation to Decrease Diet-Induced Obesity

Lodhi, I. J., Yin, L., Jensen-Urstad, A. P. L., Funai, K., Coleman, T., Baird, J. H., Ramahi, M. K. E., Razani, B., Song, H., Hsu, F., et al. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.06.013 · Cited by 245 · see citing works

Remodeling of White Adipose Tissue after Retinoic Acid Administration in Mice

Mercader, J., Ribot, J., Murano, I., Felipe, F., Cinti, S., Bonet, M. L., & Palou, A. (2006) · Endocrinology · doi:10.1210/en.2006-0760 · Cited by 244 · see citing works

Essential Role for miR-196a in Brown Adipogenesis of White Fat Progenitor Cells

Mori, M., Nakagami, H., Rodriguez-Araujo, G., Nimura, K., & Kaneda, Y. (2012) · PLoS Biology · doi:10.1371/journal.pbio.1001314 · Cited by 243 · see citing works

Brown adipose tissue transplantation improves whole-body energy metabolism

Liu, X., Zheng, Z., Zhu, X., Meng, M., Li, L., Shen, Y., Chi, Q., Wang, D., Zhang, Z., Li, C., et al. (2013) · Cell Research · doi:10.1038/cr.2013.64 · Cited by 238 · see citing works

Inhibition of Class I Histone Deacetylases Unveils a Mitochondrial Signature and Enhances Oxidative Metabolism in Skeletal Muscle and Adipose Tissue

Galmozzi, A., Mitro, N., Ferrari, A., Gers, E., Gilardi, F., Godio, C., Cermenati, G., Gualerzi, A., Donetti, E., Rotili, D., et al. (2012) · Diabetes · doi:10.2337/db12-0548 · Cited by 236 · see citing works

Chapter 21 Interleukin‐6 and Insulin Resistance

Kim, J., Bachmann, R. A., & Chen, J. (2009) · Vitamins & Hormones · doi:10.1016/s0083-6729(08)00621-3 · Cited by 224 · see citing works

Twist-1 Is a PPARδ-Inducible, Negative-Feedback Regulator of PGC-1α in Brown Fat Metabolism

Pan, D., Fujimoto, M., Lopes, A., & Wang, Y. (2009) · Cell · doi:10.1016/j.cell.2009.01.051 · Cited by 218 · see citing works

Retinaldehyde dehydrogenase 1 regulates a thermogenic program in white adipose tissue

Kiefer, F. W., Vernochet, C., O’Brien, P., Spoerl, S., Brown, J. D., Nallamshetty, S., Zeyda, M., Stulnig, T. M., Cohen, D. E., Kahn, C. R., et al. (2012) · Nature Medicine · doi:10.1038/nm.2757 · Cited by 210 · see citing works

Lipolytic Products Activate Peroxisome Proliferator-activated Receptor (PPAR) α and δ in Brown Adipocytes to Match Fatty Acid Oxidation with Supply

Mottillo, E. P., Bloch, A. E., Leff, T., & Granneman, J. G. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.374041 · Cited by 200 · see citing works

Exercise ameliorates high-fat diet-induced metabolic and vascular dysfunction, and increases adipocyte progenitor cell population in brown adipose tissue

Xu, X., Ying, Z., Cai, M., Xu, Z., Li, Y., Jiang, S. Y., Tzan, K., Wang, A., Parthasarathy, S., He, G., et al. (2011) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00806.2010 · Cited by 200 · see citing works

Rb and p107 regulate preadipocyte differentiation into white versus brown fat through repression of PGC-1α

Scimè, A., Grenier, G., Huh, M. S., Gillespie, M. A., Bevilacqua, L., Harper, M.-E., & Rudnicki, M. A. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.10.002 · Cited by 199 · see citing works

Expression of the Irisin Precursor FNDC5 in Skeletal Muscle Correlates With Aerobic Exercise Performance in Patients With Heart Failure

Lecker, S. H., Zavin, A., Cao, P., Arena, R. A., Allsup, K., Daniels, K. M., Joseph, J., Schulze, P. C., & Forman, D. E. (2012) · Circulation Heart Failure · doi:10.1161/circheartfailure.112.969543 · Cited by 197 · see citing works

UCP1 Induction during Recruitment of Brown Adipocytes in White Adipose Tissue Is Dependent on Cyclooxygenase Activity

Madsen, L., Pedersen, L. M., Lillefosse, H. H., Fjære, E., Brønstad, I., Hao, Q., Petersen, R. K., Hallenborg, P., Ma, T., Matteis, R. D., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011391 · Cited by 195 · see citing works

A Novel Regulatory Pathway of Brown Fat Thermogenesis

Alvarez, R., de Andrés, J., Yubero, P., Viñas, O., Mampel, T., Iglesias, R., Giralt, M., & Villarroya, F. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.10.5666 · Cited by 194 · see citing works

Inhibition of myostatin protects against diet-induced obesity by enhancing fatty acid oxidation and promoting a brown adipose phenotype in mice

Zhang, C., McFarlane, C., Lokireddy, S., Masuda, S., Ge, X., Gluckman, P. D., Sharma, M., & Kambadur, R. (2012) · Diabetologia · doi:10.1007/s00125-011-2304-4 · Cited by 192 · see citing works

Central Control of Brown Adipose Tissue Thermogenesis

Morrison, S. F., Madden, C. J., & Tupone, D. (2012) · Frontiers in Endocrinology · doi:10.3389/fendo.2012.00005 · Cited by 189 · see citing works

Thiazolidinediones and Rexinoids Induce Peroxisome Proliferator-Activated Receptor-Coactivator (PGC)-1α Gene Transcription: An Autoregulatory Loop Controls PGC-1α Expression in Adipocytes via Peroxisome Proliferator-Activated Receptor-γ Coactivation

Hondares, E., Mora, O., Yubero, P., de la Concepción, M. L. R., Iglesias, R., Giralt, M., & Villarroya, F. (2006) · Endocrinology · doi:10.1210/en.2006-0070 · Cited by 183 · see citing works

Real-time magnetic resonance imaging and quantification of lipoprotein metabolism in vivo using nanocrystals

Bruns†, O. T., Ittrich, H., Peldschus, K., Kaul, M. G., Tromsdorf, U. I., Lauterwasser, J., Nikolić, M. S., Mollwitz†, B., Merkel, M., Bigall, N. C., et al. (2009) · Nature Nanotechnology · doi:10.1038/nnano.2008.405 · Cited by 165 · see citing works

Cardiovascular responses to cold exposure

Sun, Z. (2010) · Frontiers in Bioscience-Elite · doi:10.2741/e108 · Cited by 161 · see citing works

A Role for Bone Morphogenetic Protein-4 in Adipocyte Development

Bowers, R. R., & Lane, M. D. (2007) · Cell Cycle · doi:10.4161/cc.6.4.3804 · Cited by 153 · see citing works

Synaptic plasticity in neuronal circuits regulating energy balance

Zeltser, L. M., Seeley, R. J., & Tschöp, M. H. (2012) · Nature Neuroscience · doi:10.1038/nn.3219 · Cited by 147 · see citing works

Adipose Subtype-Selective Recruitment of TLE3 or Prdm16 by PPARγ Specifies Lipid Storage versus Thermogenic Gene Programs

Villanueva, C. J., Vergnes, L., Wang, J., Drew, B. G., Hong, C., Tu, Y., Hu, Y., Xu, P., Xu, F., Sáez, E., et al. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.01.016 · Cited by 147 · see citing works

miR-133a Regulates Adipocyte Browning In Vivo

Liu, W., Bi, P., Shan, T., Yang, X., Yin, H., Wang, Y.-X., Liu, N., Rudnicki, M. A., & Kuang, S. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003626 · Cited by 144 · see citing works

Increased cGMP promotes healthy expansion and browning of white adipose tissue

Mitschke, M. M., Hoffmann, L. S., Gnad, T., Scholz, D., Katja, K., Mayer, P., Haas, B., Sassmann, A., Pfeifer, A., & Kilić, A. (2013) · The FASEB Journal · doi:10.1096/fj.12-221580 · Cited by 142 · see citing works

Identification of brown adipose tissue in mice with fat–water IDEAL‐MRI

Hu, P., Smith, D. L., Nayak, K. S., Goran, M. I., & Nagy, T. R. (2010) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.22162 · Cited by 141 · see citing works

Tumor necrosis factor α mediates apoptosis of brown adipocytes and defective brown adipocyte function in obesity

Nisoli, E., Briscini, L., Giordano, A., Tonello, C., Wiesbrock, S. M., Uysal, K. T., Cinti, S., Carruba, M. O., & Hotamışlıgil, G. S. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.14.8033 · Cited by 136 · see citing works

p62 Links β-adrenergic input to mitochondrial function and thermogenesis

Müller, T. D., Lee, S. J., Jastroch, M., Kabra, D. G., Stemmer, K., Aichler, M., Abplanalp, B., Ananthakrishnan, G., Bhardwaj, N. J., Collins, S., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci64209 · Cited by 122 · see citing works

Nutrient preference and diet-induced adiposity in C57BL/6ByJ and 129P3/J mice

Bachmanov, A. A., Reed, D. R., Tordoff, M. G., Price, R. A., & Beauchamp, G. K. (2001) · Physiology & Behavior · doi:10.1016/s0031-9384(01)00412-7 · Cited by 107 · see citing works

Adenosine 5′-Monophosphate-Activated Protein Kinase-Mammalian Target of Rapamycin Cross Talk Regulates Brown Adipocyte Differentiation

Vila‐Bedmar, R., Lorenzo, M., & Fernández‐Veledo, S. (2010) · Endocrinology · doi:10.1210/en.2009-0810 · Cited by 107 · see citing works

Common Genetic Variation in the Human FNDC5 Locus, Encoding the Novel Muscle-Derived ‘Browning’ Factor Irisin, Determines Insulin Sensitivity

Staiger, H., Böhm, A., Scheler, M., Berti, L., Machann, J., Schick, F., Machicao, F. E., Fritsche, A., Stefan, N., Weigert, C., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0061903 · Cited by 105 · see citing works

Dual-Energy CT of the Heart

Vliegenthart, R., Pelgrim, G. J., Ebersberger, U., Rowe, G. W., Oudkerk, M., & Schoepf, U. J. (2012) · American Journal of Roentgenology · doi:10.2214/ajr.12.9208 · Cited by 104 · see citing works

Vascular endothelial growth factor is important for brown adipose tissue development and maintenance

Bagchi, M., Kim, L. A., Boucher, J., Walshe, T. E., Kahn, C. R., & D'Amore, P. A. (2013) · The FASEB Journal · doi:10.1096/fj.12-221812 · Cited by 101 · see citing works

Measurement of Human Brown Adipose Tissue Volume and Activity Using Anatomic MR Imaging and Functional MR Imaging

Chen, Y. I., Cypess, A. M., Chen, Y. I., Palmer, M. R., Kolodny, G. M., Kahn, C. R., & Kwong, K. K. (2013) · Journal of Nuclear Medicine · doi:10.2967/jnumed.112.117275 · Cited by 100 · see citing works

Brain–gut–adipose-tissue communication pathways at a glance

Yi, C., & Tschöp, M. H. (2012) · Disease Models & Mechanisms · doi:10.1242/dmm.009902 · Cited by 92 · see citing works

Perilipin Overexpression in White Adipose Tissue Induces a Brown Fat-Like Phenotype

Sawada, T., Miyoshi, H., Shimada, K., Suzuki, A. K., Okamatsu‐Ogura, Y., Perfield, J. W., Kondo, T., Nagai, S., Shimizu, C., Yoshioka, N., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0014006 · Cited by 88 · see citing works

Anatomical and Functional Assessment of Brown Adipose Tissue by Magnetic Resonance Imaging

Chen, Y. I., Cypess, A. M., Sass, C. A., Brownell, A., Jokivarsi, K. T., Kahn, C. R., & Kwong, K. K. (2012) · Obesity · doi:10.1038/oby.2012.22 · Cited by 86 · see citing works

Brown fat like gene expression in the epicardial fat depot correlates with circulating HDL-cholesterol and triglycerides in patients with coronary artery disease

Chechi, K., Blanchard, P.-G., Mathieu, P., Deshaies, Y., & Richard, D. (2012) · International Journal of Cardiology · doi:10.1016/j.ijcard.2012.06.008 · Cited by 76 · see citing works

Functional assessment of white and brown adipocyte development and energy metabolism in cell culture Dissociation of terminal differentiation and thermogenesis in brown adipocytes

Klaus, S., Ely, M., Encke, D., & Heldmaier, G. (1995) · Journal of Cell Science · doi:10.1242/jcs.108.10.3171 · Cited by 74 · see citing works

The holy grail of metabolic disease

Bartelt, A., & Heeren, J. (2012) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e328352dcef · Cited by 70 · see citing works

Chronic AMP-kinase activation with AICAR reduces adiposity by remodeling adipocyte metabolism and increasing leptin sensitivity

Gaidhu, M. P., Frontini, A., Hung, S., Pistor, K., Cinti, S., & Ceddia, R. B. (2011) · Journal of Lipid Research · doi:10.1194/jlr.m015354 · Cited by 69 · see citing works

How brown is brown fat? It depends where you look

Nedergaard, J., & Cannon, B. (2013) · Nature Medicine · doi:10.1038/nm.3187 · Cited by 68 · see citing works

Effects of adipocyte lipoprotein lipase on de novo lipogenesis and white adipose tissue browning

Bartelt, A., Weigelt, C., Cherradi, M. L., Niemeier, A., Tödter, K., Heeren, J., & Scheja, L. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2012.11.011 · Cited by 59 · see citing works

Shox2 is a molecular determinant of depot-specific adipocyte function

Lee, K. Y., Yamamoto, Y., Boucher, J., Winnay, J. N., Gesta, S., Cobb, J. A., Blüher, M., & Kahn, C. R. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1310331110 · Cited by 44 · see citing works

Novel Aspects of Brown Adipose Tissue Biology

Heeren, J., & Münzberg, H. (2012) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2012.11.004 · Cited by 42 · see citing works

A new, powerful player in lipoprotein metabolism: brown adipose tissue

Bartelt, A., Merkel, M., & Heeren, J. (2012) · Journal of Molecular Medicine · doi:10.1007/s00109-012-0858-3 · Cited by 41 · see citing works

Beneficial effects of PTP1B deficiency on brown adipocyte differentiation and protection against apoptosis induced by pro- and anti-inflammatory stimuli

Miranda, S., González‐Rodríguez, Á., Revuelta‐Cervantes, J., Rondinone, C. M., & Valverde, Á. M. (2009) · Cellular Signalling · doi:10.1016/j.cellsig.2009.11.019 · Cited by 40 · see citing works

Insulin increases the adrenergic stimulation of 5′ deiodinase activity and mRNA expression in rat brown adipocytes; role of MAPK and PI3K

de Mena, R. M., & Obregón, M.-J. (2005) · Journal of Molecular Endocrinology · doi:10.1677/jme.1.01568 · Cited by 38 · see citing works

Brown Fat Develops a Brite Future

Klingenspor, M., Herzig, S., & Pfeifer, A. (2012) · Obesity Facts · doi:10.1159/000346337 · Cited by 24 · see citing works

Brown adipocyte progenitor population is modified in obese and diabetic skeletal muscle

Russell, A. P., Crisan, M., Léger, B., Corselli, M., McAinch, A. J., O’Brien, P. E., Cameron‐Smith, D., Péault, B., Casteilla, L., & Giacobino, J.-P. (2011) · International Journal of Obesity · doi:10.1038/ijo.2011.85 · Cited by 18 · see citing works

Nanocrystals, a New Tool to Study Lipoprotein Metabolism and Atherosclerosis

Heeren, J., & Bruns†, O. T. (2012) · Current Pharmaceutical Biotechnology · doi:10.2174/138920112799095293 · Cited by 10 · see citing works

Aggregation-Induced Emission: Together We Shine, United We Soar!

Mei, J., Leung, N. L. C., Kwok, R. T. K., Lam, J. W. Y., & Tang, B. Z. (2015) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00263 · Cited by 8,270 · see citing works

Adipose tissue dysfunction as determinant of obesity-associated metabolic complications

Longo, M., Zatterale, F., Naderi, J., Parrillo, L., Formisano, P., Raciti, G. A., Beguinot, F., & Miele, C. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20092358 · Cited by 1,575 · see citing works

Adipose Tissue Remodeling: Its Role in Energy Metabolism and Metabolic Disorders

Choe, S. S., Huh, J. Y., Hwang, I. J., Kim, J. I., & Kim, J. B. (2016) · Frontiers in Endocrinology · doi:10.3389/fendo.2016.00030 · Cited by 1,206 · see citing works

Gut microbiota–bile acid–interleukin-22 axis orchestrates polycystic ovary syndrome

Qi, X., Yun, C., Sun, L., Xia, J., Wu, Q., Wang, Y., Wang, L., Zhang, Y., Liang, X., Wang, L., et al. (2019) · Nature Medicine · doi:10.1038/s41591-019-0509-0 · Cited by 860 · see citing works

Brown adipose tissue as a secretory organ

Villarroya, F., Cereijo, R., Villarroya, J., & Giralt, M. (2016) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2016.136 · Cited by 677 · see citing works

Regulation of metabolism by the innate immune system

Lackey, D. E., & Olefsky, J. M. (2016) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2015.189 · Cited by 667 · see citing works

The endocrine function of adipose tissues in health and cardiometabolic disease

Scheja, L., & Heeren, J. (2019) · Nature Reviews Endocrinology · doi:10.1038/s41574-019-0230-6 · Cited by 663 · see citing works

Interleukin-33 in tissue homeostasis, injury, and inflammation

Molofsky, A. B., Savage, A. K., & Locksley, R. M. (2015) · Immunity · doi:10.1016/j.immuni.2015.06.006 · Cited by 638 · see citing works

Mapping of human brown adipose tissue in lean and obese young men

Leitner, B. P., Huang, S., Brychta, R. J., Duckworth, C. J., Baskin, A. S., McGehee, S., Tal, I., Dieckmann, W., Gupta, G., Kolodny, G. M., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1705287114 · Cited by 530 · see citing works

Immune Regulation of Metabolic Homeostasis in Health and Disease

Brestoff, J. R., & Artis, D. (2015) · Cell · doi:10.1016/j.cell.2015.02.022 · Cited by 498 · see citing works

EGR1 Transcription Factor is a Multifaceted Regulator of Matrix Production in Tendons and Other Connective Tissues

Havis, E., & Duprez, D. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21051664 · Cited by 498 · see citing works

Metabolically healthy versus metabolically unhealthy obesity

Iacobini, C., Pugliese, G., Blasetti Fantauzzi, C., Federici, M., & Menini, S. (2019) · Metabolism · doi:10.1016/j.metabol.2018.11.009 · Cited by 453 · see citing works

The gut microbiota in human energy homeostasis and obesity

Rosenbaum, M., Knight, R., & Leibel, R. L. (2015) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2015.07.002 · Cited by 450 · see citing works

Brown fat activation reduces hypercholesterolaemia and protects from atherosclerosis development

Berbée, J. F. P., Boon, M. R., Khedoe, P. P. S. J., Bartelt, A., Schlein, C., Worthmann, A., Kooijman, S., Hoeke, G., Mol, I. M., John, C., et al. (2015) · Nature Communications · doi:10.1038/ncomms7356 · Cited by 428 · see citing works

Leptin and Insulin Act on POMC Neurons to Promote the Browning of White Fat

Dodd, G. T., Decherf, S., Loh, K., Simonds, S. E., Wiede, F., Balland, E., Merry, T. L., Münzberg, H., Zhang, Z.-Y., Kahn, B. B., et al. (2015) · Cell · doi:10.1016/j.cell.2014.12.022 · Cited by 398 · see citing works

Adenosine activates brown adipose tissue and recruits beige adipocytes via A2A receptors

Gnad, T., Scheibler, S., von Kügelgen, I., Scheele, C. C., Kilić, A., Glöde, A., Hoffmann, L. S., Reverte-Salisa, L., Horn, P., Mutlu, S., et al. (2014) · Nature · doi:10.1038/nature13816 · Cited by 394 · see citing works

Dietary Polyphenol, Gut Microbiota, and Health Benefits

Wang, X., Qi, Y., & Zheng, H. (2022) · Antioxidants · doi:10.3390/antiox11061212 · Cited by 412 · see citing works

Exercise-induced irisin secretion is independent of age or fitness level and increased irisin may directly modulate muscle metabolism through AMPK activation

Huh, J. Y., Mougios, V., Kabasakalis, A., Fatouros, I., Siopi, A., Douroudos, I. I., Filippaios, A., Panagiotou, G., Park, K. H., & Mantzoros, C. S. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2014-1437 · Cited by 363 · see citing works

Calcium Homeostasis and Organelle Function in the Pathogenesis of Obesity and Diabetes

Arruda, A. P., & Hotamışlıgil, G. S. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.06.010 · Cited by 338 · see citing works

Capsaicin induces browning of white adipose tissue and counters obesity by activating TRPV1 channel‐dependent mechanisms

Baskaran, P., Krishnan, V., Ren, J. T., & Thyagarajan, B. (2016) · British Journal of Pharmacology · doi:10.1111/bph.13514 · Cited by 325 · see citing works

Cold-induced conversion of cholesterol to bile acids in mice shapes the gut microbiome and promotes adaptive thermogenesis

Worthmann, A., John, C., Rühlemann, M. C., Baguhl, M., Heinsen, F.-A., Schaltenberg, N., Heine, M., Schlein, C., Evangelakos, I., Mineo, C., et al. (2017) · Nature Medicine · doi:10.1038/nm.4357 · Cited by 318 · see citing works

Identification of entacapone as a chemical inhibitor of FTO mediating metabolic regulation through FOXO1

Peng, S., Xiao, W., Ju, D., Sun, B., Hou, N., Liu, Q., Wang, Y., Zhao, H., Gao, C., Zhang, S., et al. (2019) · Science Translational Medicine · doi:10.1126/scitranslmed.aau7116 · Cited by 317 · see citing works

Regulation of glucose and lipid metabolism in health and disease

Chen, L., Chen, X., Huang, X., Song, B., Wang, Y., & Wang, Y. (2019) · Science China Life Sciences · doi:10.1007/s11427-019-1563-3 · Cited by 309 · see citing works

Brown adipose tissue whitening leads to brown adipocyte death and adipose tissue inflammation

Kotzbeck, P., Giordano, A., Mondini, E., Murano, I., Severi, I., Venema, W., Cecchini, M. P., Kershaw, E. E., Barbatelli, G., Haemmerle, G., et al. (2018) · Journal of Lipid Research · doi:10.1194/jlr.m079665 · Cited by 294 · see citing works

The TMAO-Producing Enzyme Flavin-Containing Monooxygenase 3 Regulates Obesity and the Beiging of White Adipose Tissue

Schugar, R. C., Shih, D. M., Warrier, M., Helsley, R. N., Burrows, A., Ferguson, D., Brown, A. L., Gromovsky, A. D., Heine, M., Chatterjee, A., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.05.077 · Cited by 291 · see citing works

Current body composition measurement techniques

Lemos, T., & Gallagher, D. (2017) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0000000000000360 · Cited by 281 · see citing works

Resveratrol induces brown-like adipocyte formation in white fat through activation of AMP-activated protein kinase (AMPK) α1

Wang, S., Liang, X., Yang, Q., Fu, X., Rogers, C. J., Zhu, M. J., Rodgers, B. D., Jiang, Q., Dodson, M. V., & Du, ‬. (2015) · International Journal of Obesity · doi:10.1038/ijo.2015.23 · Cited by 280 · see citing works

The Ever-Expanding Myokinome: Discovery Challenges and Therapeutic Implications

Whitham, M., & Febbraio, M. A. (2016) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2016.153 · Cited by 279 · see citing works

The Role of Exercise in the Interplay between Myokines, Hepatokines, Osteokines, Adipokines, and Modulation of Inflammation for Energy Substrate Redistribution and Fat Mass Loss: A Review

Gonzalez-Gil, A. M., & Elizondo-Montemayor, L. (2020) · Nutrients · doi:10.3390/nu12061899 · Cited by 278 · see citing works

The Role of Adipose Tissue Mitochondria: Regulation of Mitochondrial Function for the Treatment of Metabolic Diseases

Lee, J. H., Park, A., Oh, K., Lee, S. C., Kim, W. K., & Bae, K. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20194924 · Cited by 270 · see citing works

O-GlcNAc Transferase Enables AgRP Neurons to Suppress Browning of White Fat

Ruan, H.-B., Dietrich, M. O., Liu, Z.-W., Zimmer, M. R., Li, M.-D., Singh, J. P., Zhang, K., Yin, R., Wu, J., Horvath, T. L., et al. (2014) · Cell · doi:10.1016/j.cell.2014.09.010 · Cited by 281 · see citing works

Impact of Retinoic Acid on Immune Cells and Inflammatory Diseases

Oliveira, L. D. M., Teixeira, F. M. E., & Sato, M. N. (2018) · Mediators of Inflammation · doi:10.1155/2018/3067126 · Cited by 267 · see citing works

Browning of White Adipose Cells by Intermediate Metabolites: An Adaptive Mechanism to Alleviate Redox Pressure

Carrière, A., Jeanson, Y., Berger-Müller, S., André, M., Chenouard, V., Arnaud, E., Barreau, C., Walther, R., Galinier, A., Wdziekonski, B., et al. (2014) · Diabetes · doi:10.2337/db13-1885 · Cited by 267 · see citing works

AMP-Activated Protein Kinase (AMPK) Regulates Energy Metabolism through Modulating Thermogenesis in Adipose Tissue

Wu, L., Zhang, L., Li, B., Jiang, H., Duan, Y., Xie, Z., Shuai, L., Li, J., & Li, J. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00122 · Cited by 255 · see citing works

White adipose tissue mitochondrial metabolism in health and in obesity

Heinonen, S., Jokinen, R., Rissanen, A., & Pietiläinen, K. H. (2019) · Obesity Reviews · doi:10.1111/obr.12958 · Cited by 243 · see citing works

AIEgens for biological process monitoring and disease theranostics

Gu, X., Kwok, R. T. K., Lam, J. W. Y., & Tang, B. Z. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2017.09.004 · Cited by 240 · see citing works

Mitochondria in White, Brown, and Beige Adipocytes

Čedíková, M., Kripnerová, M., Dvořáková, J., Pitule, P., Grundmanova, M., Babuška, V., Müllerová, D., & Kuncová, J. (2016) · Stem Cells International · doi:10.1155/2016/6067349 · Cited by 237 · see citing works

Brown Fat and Browning for the Treatment of Obesity and Related Metabolic Disorders

Kim, S. H., & Plutzky, J. (2016) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2016.40.1.12 · Cited by 232 · see citing works

VEGFB/VEGFR1-Induced Expansion of Adipose Vasculature Counteracts Obesity and Related Metabolic Complications

Robciuc, M. R., Kivelä, R., Williams, I. M., de Boer, J. F., van Dijk, T. H., Elamaa, H. P., Tigistu‐Sahle, F., Molotkov, D. A., Leppänen, V., Käkelä, R., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.03.004 · Cited by 234 · see citing works

Brown Adipose Tissue: an Update on Recent Findings

Marlatt, K. L., & Ravussin, É. (2017) · Current Obesity Reports · doi:10.1007/s13679-017-0283-6 · Cited by 230 · see citing works

Perivascular adipose tissue (PVAT) in atherosclerosis: a double-edged sword

Qi, X.-Y., Qu, S.-L., Xiong, W., Rom, O., Chang, L., & Jiang, Z. (2018) · Cardiovascular Diabetology · doi:10.1186/s12933-018-0777-x · Cited by 230 · see citing works

Locally Induced Adipose Tissue Browning by Microneedle Patch for Obesity Treatment

Zhang, Y., Liu, Q., Yu, J., Yu, S., Wang, J., Qiang, L., & Gu, Z. (2017) · ACS Nano · doi:10.1021/acsnano.7b04348 · Cited by 226 · see citing works

Brown adipose tissue thermogenic adaptation requires Nrf1-mediated proteasomal activity

Bartelt, A., Widenmaier, S. B., Schlein, C., Johann, K., Gonçalves, R. L. S., Eguchi, K., Fischer, A. W., Parlakgül, G., Snyder, N., Nguyen, T. B., et al. (2018) · Nature Medicine · doi:10.1038/nm.4481 · Cited by 208 · see citing works

The brown fat secretome: metabolic functions beyond thermogenesis

Wang, G.-X., Zhao, X.-Y., & Lin, J. D. (2015) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2015.03.002 · Cited by 206 · see citing works

Adipose tissue at single-cell resolution

Maniyadath, B., Zhang, Q., Gupta, R. K., & Mandrup, S. (2023) · Cell Metabolism · doi:10.1016/j.cmet.2023.02.002 · Cited by 207 · see citing works

High-Resolution PET Imaging with Therapeutic Antibody-based PD-1/PD-L1 Checkpoint Tracers

Hettich, M., Braun, F., Bartholomä, M. D., Schirmbeck, R., & Niedermann, G. (2016) · Theranostics · doi:10.7150/thno.15253 · Cited by 194 · see citing works

Metrnl: A secreted protein with new emerging functions

Zheng, S.-L., Li, Z.-Y., Song, J., Liu, J.-M., & Miao, C.-Y. (2016) · Acta Pharmacologica Sinica · doi:10.1038/aps.2016.9 · Cited by 190 · see citing works

Crosstalk between adipokines and myokines in fat browning

Rodrı́guez, A., Becerril, S., Ezquerro, S., Méndez-Giménez, L., & Frühbeck, G. (2016) · Acta Physiologica · doi:10.1111/apha.12686 · Cited by 192 · see citing works

IL-27 signalling promotes adipocyte thermogenesis and energy expenditure

Wang, Q., Li, D., Cao, G., Shi, Q., Zhu, J., Zhang, M., Cheng, H., Wen, Q., Xu, H. Y., Zhu, L., et al. (2021) · Nature · doi:10.1038/s41586-021-04127-5 · Cited by 187 · see citing works

Mouse strains to study cold-inducible beige progenitors and beige adipocyte formation and function

Berry, D. C., Jiang, Y., & Graff, J. M. (2016) · Nature Communications · doi:10.1038/ncomms10184 · Cited by 185 · see citing works

A self-sustained loop of inflammation-driven inhibition of beige adipogenesis in obesity

Chung, K.-J., Chatzigeorgiou, A., Economopoulou, M., Garcia-Martin, R., Alexaki, V. I., Mitroulis, I., Nati, M., Gebler, J., Ziemssen, T., Goelz, S. E., et al. (2017) · Nature Immunology · doi:10.1038/ni.3728 · Cited by 175 · see citing works

The Importance of Breast Adipose Tissue in Breast Cancer

Kothari, C., Diorio, C., & Durocher, F. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21165760 · Cited by 171 · see citing works

Metabolic interplay between white, beige, brown adipocytes and the liver

Scheja, L., & Heeren, J. (2016) · Journal of Hepatology · doi:10.1016/j.jhep.2016.01.025 · Cited by 171 · see citing works

Resveratrol increases brown adipose tissue thermogenesis markers by increasing SIRT1 and energy expenditure and decreasing fat accumulation in adipose tissue of mice fed a standard diet

Andrade, J. M. O., Frade, A. C. M., Guimarães, J. B., Freitas, K. M., Lopes, M. T. P., Guimarães, A. L. S., de Paula, A. M. B., Coimbra, C. C., & Santos, S. H. S. (2014) · European Journal of Nutrition · doi:10.1007/s00394-014-0655-6 · Cited by 168 · see citing works

Adipose Organ Development and Remodeling

Cinti, S. (2018) · Comprehensive physiology · doi:10.1002/cphy.c170042 · Cited by 187 · see citing works

Obesity causes mitochondrial fragmentation and dysfunction in white adipocytes due to RalA activation

Xia, W., Veeragandham, P., Cao, Y., Xu, Y., Rhyne, T. E., Qian, J., Hung, C.-W., Zhao, P., Jones, Y., Gao, H., et al. (2024) · Nature Metabolism · doi:10.1038/s42255-024-00978-0 · Cited by 176 · see citing works

Irisin, an exercise‐induced myokine as a metabolic regulator: an updated narrative review

Chen, N., Li, Q., Liu, J., & Jia, S. (2015) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.2660 · Cited by 164 · see citing works

Brown, Beige, and White: The New Color Code of Fat and Its Pharmacological Implications

Pfeifer, A., & Hoffmann, L. S. (2014) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010814-124346 · Cited by 163 · see citing works

Free radicals and male reproduction.

Agarwal, A. K., & Allamaneni, S. S. R. (2011) · PubMed · Cited by 154 · see citing works

Taking control over intracellular fatty acid levels is essential for the analysis of thermogenic function in cultured primary brown and brite/beige adipocytes

Li, Y., Fromme, T., Schweizer, S., Schöttl, T., & Klingenspor, M. (2014) · EMBO Reports · doi:10.15252/embr.201438775 · Cited by 159 · see citing works

GLP-1 receptor agonist promotes brown remodelling in mouse white adipose tissue through SIRT1

Xu, F., Lin, B., Zheng, X., Chen, Z., Cao, H., Xu, H., Liang, H., & Weng, J. (2016) · Diabetologia · doi:10.1007/s00125-016-3896-5 · Cited by 157 · see citing works

Photoacoustic molecular imaging-escorted adipose photodynamic–browning synergy for fighting obesity with virus-like complexes

Chen, R., Huang, S., Lin, T., Ma, H., Shan, W., Duan, F., Lv, J., Zhang, J., Ren, L., & Nie, L. (2021) · Nature Nanotechnology · doi:10.1038/s41565-020-00844-6 · Cited by 152 · see citing works

Curcumin promotes browning of white adipose tissue in a norepinephrine-dependent way

Wang, S., Wang, X., Ye, Z., Xu, C., Zhang, M., Ruan, B., Wei, M., Jiang, Y., Zhang, Y., Wang, L., et al. (2015) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2015.09.018 · Cited by 148 · see citing works

Interaction between adipocytes and high-density lipoprotein:new insights into the mechanism of obesity-induced dyslipidemia and atherosclerosis

Zhang, T., Chen, J., Tang, X., Luo, Q., Xu, D., & Yu, B. (2019) · Lipids in Health and Disease · doi:10.1186/s12944-019-1170-9 · Cited by 149 · see citing works

‘Browning’ the cardiac and peri-vascular adipose tissues to modulate cardiovascular risk

Aldiss, P., Davies, G., Woods, R., Budge, H., Sacks, H. S., & Symonds, M. E. (2017) · International Journal of Cardiology · doi:10.1016/j.ijcard.2016.11.074 · Cited by 148 · see citing works

FGF21 as a Stress Hormone: The Roles of FGF21 in Stress Adaptation and the Treatment of Metabolic Diseases

Kim, K. H., & Lee, M.-S. (2014) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2014.38.4.245 · Cited by 146 · see citing works

Thermogenic adipocytes promote HDL turnover and reverse cholesterol transport

Bartelt, A., John, C., Schaltenberg, N., Berbée, J. F. P., Worthmann, A., Cherradi, M. L., Schlein, C., Piepenburg, J., Boon, M. R., Rinninger, F., et al. (2017) · Nature Communications · doi:10.1038/ncomms15010 · Cited by 138 · see citing works

PPARs-Orchestrated Metabolic Homeostasis in the Adipose Tissue

Sun, C., Mao, S., Chen, S., Zhang, W., & Liu, C. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22168974 · Cited by 140 · see citing works

An Update on the Secretory Functions of Brown, White, and Beige Adipose Tissue: Towards Therapeutic Applications

Ghesmati, Z., Rashid, M., Fayezi, S., Gieseler, F., Alizadeh, E., & Darabi, M. (2024) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-023-09850-0 · Cited by 139 · see citing works

Diet‐induced obesity causes insulin resistance in mouse brown adipose tissue

Roberts‐Toler, C., O'Neill, B. T., & Cypess, A. M. (2015) · Obesity · doi:10.1002/oby.21134 · Cited by 138 · see citing works

Fibroblast growth factor 21 in non-alcoholic fatty liver disease

Tucker, B., Li, H., Long, X., Rye, K., & Ong, K. L. (2019) · Metabolism · doi:10.1016/j.metabol.2019.153994 · Cited by 132 · see citing works

Human Bone Marrow Is Comprised of Adipocytes with Specific Lipid Metabolism

Attané, C., Estève, D., Chaoui, K., Iacovoni, J. S., Corre, J., Moutahir, M., Valet, P., Burlet‐Schiltz, O., Reina, N., & Muller, C. (2020) · Cell Reports · doi:10.1016/j.celrep.2019.12.089 · Cited by 137 · see citing works

Central Nervous System Regulation of Brown Adipose Tissue

Morrison, S. F., & Madden, C. J. (2014) · Comprehensive physiology · doi:10.1002/cphy.c140013 · Cited by 151 · see citing works

Natural products as novel anti-obesity agents: insights into mechanisms of action and potential for therapeutic management

Shaik Mohamed Sayed, U. F., Moshawih, S., Goh, H. P., Kifli, N., Gupta, G., Singh, S. K., Chellappan, D. K., Dua, K., Hermansyah, A., Ser, H. L., et al. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1182937 · Cited by 136 · see citing works

Cold-induced epigenetic programming of the sperm enhances brown adipose tissue activity in the offspring

Sun, W., Dong, H., Becker, A. S., Dapito, D. H., Modica, S., Grandl, G., Opitz, L., Efthymiou, V., Straub, L. G., Sarker, G., et al. (2018) · Nature Medicine · doi:10.1038/s41591-018-0102-y · Cited by 134 · see citing works

Aifm2, a NADH Oxidase, Supports Robust Glycolysis and Is Required for Cold- and Diet-Induced Thermogenesis

Nguyen, H. P., Yi, D., Lin, F., Viscarra, J. A., Nakamura-Tabuchi, C., Ngo, K., Shin, G., Lee, A. Y.-F., Wang, Y., & Sul, H. S. (2020) · Molecular Cell · doi:10.1016/j.molcel.2019.12.002 · Cited by 131 · see citing works

Leptin administration activates irisin-induced myogenesis via nitric oxide-dependent mechanisms, but reduces its effect on subcutaneous fat browning in mice

Rodrı́guez, A., Becerril, S., Méndez-Giménez, L., Ramírez, B., Sáinź, N., Catalán, V., Gómez‐Ambrosi, J., & Frühbeck, G. (2014) · International Journal of Obesity · doi:10.1038/ijo.2014.166 · Cited by 130 · see citing works

Burn-induced hypermetabolism and skeletal muscle dysfunction

Knuth, C. M., Auger, C., & Jeschke, M. G. (2021) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00106.2021 · Cited by 129 · see citing works

Transdermal Delivery of Anti‐Obesity Compounds to Subcutaneous Adipose Tissue with Polymeric Microneedle Patches

Than, A., Liang, K., Xu, S., Sun, L., Duan, H., Xi, F., Xu, C., & Chen, P. (2017) · Small Methods · doi:10.1002/smtd.201700269 · Cited by 128 · see citing works

Apelin Enhances Brown Adipogenesis and Browning of White Adipocytes

Than, A., He, H. L., Chua, S. H., Xu, D., Sun, L., Leow, M. K., & Chen, P. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.643817 · Cited by 126 · see citing works

Fatty acid metabolism and the basis of brown adipose tissue function

Calderón‐Domínguez, M., Mir, J. F., Fucho, R., Weber, M., Serra, D., & Herrero, L. (2015) · Adipocyte · doi:10.1080/21623945.2015.1122857 · Cited by 126 · see citing works

Human adipose stromal-vascular fraction self-organizes to form vascularized adipose tissue in 3D cultures

Berger-Müller, S., Ader, I., Creff, J., Leménager, H., Achard, P., Casteilla, L., Sensebé, L., Carrière, A., & Deschaseaux, F. (2019) · Scientific Reports · doi:10.1038/s41598-019-43624-6 · Cited by 124 · see citing works

Regulation of longevity by FGF21: interaction between energy metabolism and stress responses

Salminen, A., Kaarniranta, K., & Kauppinen, A. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2017.05.004 · Cited by 121 · see citing works

Angiotensin-(1-7), Adipokines and Inflammation.

Lelis, D. D. F., de Freitas, D. F., Machado, A. S., Crespo, T. S., & Santos, S. (2019) · Metabolism: Clinical and Experimental · doi:10.1016/j.metabol.2019.03.006 · Cited by 113 · see citing works

The thermogenic activity of adjacent adipocytes fuels the progression of ccRCC and compromises anti-tumor therapeutic efficacy

Wei, G., Sun, H., Dong, K., Hu, L., Wang, Q., Zhuang, Q., Zhu, Y., Zhang, X., Shao, Y., Tang, H., et al. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2021.08.012 · Cited by 119 · see citing works

White Adipose Tissue Browning: A Double-edged Sword

Abdullahi, A., & Jeschke, M. G. (2016) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2016.06.006 · Cited by 119 · see citing works

MicroRNAs and other non-coding RNAs in adipose tissue and obesity: emerging roles as biomarkers and therapeutic targets

Lorente‐Cebrián, S., González‐Muniesa, P., Milagro, F. I., & Martínez, J. A. (2019) · Clinical Science · doi:10.1042/cs20180890 · Cited by 120 · see citing works

Glucocorticoids Transcriptionally Regulate miR-27b Expression Promoting Body Fat Accumulation Via Suppressing the Browning of White Adipose Tissue

Kong, X., Yu, J., Bi, J., Qi, H., Di, W., Wu, L., Wang, L., Zha, J., Lv, S., Zhang, F., et al. (2014) · Diabetes · doi:10.2337/db14-0395 · Cited by 115 · see citing works

Comparison of diet versus exercise on metabolic function and gut microbiota in obese rats

WELLY, R. J., LIU, T.-W., ZIDON, T. M., ROWLES, J. L., PARK, Y.-M., SMITH, T. N., SWANSON, K. S., PADILLA, J., & VIEIRA-POTTER, V. J. (2016) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000000964 · Cited by 114 · see citing works

Targeting white, brown and perivascular adipose tissue in atherosclerosis development

van Dam, A. D., Boon, M. R., Berbée, J. F. P., Rensen, P. C. N., & van Harmelen, V. (2017) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2017.03.051 · Cited by 114 · see citing works

Epigenetic reprogramming in metabolic disorders: nutritional factors and beyond

Cheng, Z., Zheng, L., & Almeida, F. A. (2017) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2017.10.004 · Cited by 114 · see citing works

Carbohydrates and insulin resistance in clinical nutrition: Recommendations from the ESPEN expert group

Barazzoni, R., Deutz, N. E. P., Biolo, G., Bischoff, S., Boirie, Y., Cederholm, T., Cuerda, C., Delzenne, N., Leon Sanz, M., Ljungqvist, O., et al. (2017) · Clinical Nutrition · doi:10.1016/j.clnu.2016.09.010 · Cited by 112 · see citing works

Estrogen receptor α controls metabolism in white and brown adipocytes by regulating Polg1 and mitochondrial remodeling

Zhou, Z., Moore, T. M., Drew, B. G., Ribas, V., Wanagat, J., Civelek, M., Segawa, M., Wolf, D. M., Norheim, F., Seldin, M. M., et al. (2020) · Science Translational Medicine · doi:10.1126/scitranslmed.aax8096 · Cited by 108 · see citing works

Metabolic Impact of Flavonoids Consumption in Obesity: From Central to Peripheral

Sandoval, V., Sanz‐Lamora, H., Arias, G., Marrero, P. F., Haro, D., & Relat, J. (2020) · Nutrients · doi:10.3390/nu12082393 · Cited by 111 · see citing works

Short-term effects of glucagon-like peptide 1 (GLP-1) receptor agonists on fat distribution in patients with type 2 diabetes mellitus: An ultrasonography study

Morano, S., Romagnoli, E., Filardi, T., Nieddu, L., Mandosi, E., Fallarino, M., Turinese, I., Dagostino, M. P., Lenzi, A., & Carnevale, V. (2015) · Acta Diabetologica · doi:10.1007/s00592-014-0710-z · Cited by 110 · see citing works

From chronic overnutrition to metaflammation and insulin resistance: adipose tissue and liver contributions

Caputo, T., Gilardi, F., & Desvergne, B. (2017) · FEBS Letters · doi:10.1002/1873-3468.12742 · Cited by 111 · see citing works

Caffeine exposure induces browning features in adipose tissue in vitro and in vivo

Veličković, K., Wayne, D., Leija, H. A. L., Bloor, I. D., Morris, D. E., Law, J., Budge, H., Sacks, H. S., Symonds, M. E., & Sottile, V. (2019) · Scientific Reports · doi:10.1038/s41598-019-45540-1 · Cited by 110 · see citing works

Mechanisms controlling hormone secretion in human gut and its relevance to metabolism

Martin, A. M., Sun, E. W. L., & Keating, D. J. (2019) · Journal of Endocrinology · doi:10.1530/joe-19-0399 · Cited by 110 · see citing works

A fluorescent light-up probe with AIE characteristics for specific mitochondrial imaging to identify differentiating brown adipose cells

Gao, M., Sim, C. K., Leung, C. W. T., Hu, Q., Feng, G., Xu, F., Tang, B. Z., & Liu, B. (2014) · Chemical Communications · doi:10.1039/c4cc00452c · Cited by 107 · see citing works

Thyroid-Hormone-Induced Browning of White Adipose Tissue Does Not Contribute to Thermogenesis and Glucose Consumption

Johann, K., Cremer, A. L., Fischer, A. W., Heine, M., Pensado, E. R., Resch, J., Nock, S., Virtue, S., Harder, L., Oelkrug, R., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.05.054 · Cited by 107 · see citing works

Brown and beige adipose tissue: New therapeutic targets for metabolic disorders

Magro, B. S., & Dias, D. P. M. (2024) · Health Sciences Review · doi:10.1016/j.hsr.2024.100148 · Cited by 32 · see citing works

Physiological regulation and metabolic role of browning in white adipose tissue

Janković, A., Otašević, V., Stančić, A., Buzadžić, B., Korać, A., & Korać, B. (2017) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2017-0034 · Cited by 14 · see citing works

Metabolic regulation of brown adipose : a possible new therapeutic approach for metabolic diseases

Xiao, Z.-H. (2014) · Zhonghua neifenmi daixie zazhi · doi:10.3760/cma.j.issn.1000-6699.2014.10.001

Recent advance in brown adipose physiology and its therapeutic potential

Lee, Y., Jung, Y.-S., & Choi, D. (2014) · Experimental & Molecular Medicine · doi:10.1038/emm.2013.163 · Cited by 54 · see citing works

Brown and beige fat: Development, function and therapeutic potential

Harms, M., & Seale, P. (2013) · Nature Medicine · doi:10.1038/nm.3361 · Cited by 2,328 · see citing works