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Cell polarity in development and cancer

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Wodarz, Andreas, Näthke, Inke·2007·Nature Cell Biology

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Abstract

The development of cancer is a multistep process in which the DNA of a single cell accumulates mutations in genes that control essential cellular processes. Loss of cell–cell adhesion and cell polarity is commonly observed in advanced tumours and correlates well with their invasion into adjacent tissues and the formation of metastases. Growing evidence indicates that loss of cell–cell adhesion and cell polarity may also be important in early stages of cancer. The strongest hints in this direction come from studies on tumour suppressor genes in the fruitfly Drosophila melanogaster, which have revealed their importance in the control of apical–basal cell polarity.

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See all 395

Authors: Wodarz, A., & Näthke, I.
Venue: Nature Cell Biology
Publisher: Springer Science and Business Media LLC
Published: 2007-09
Volume: 9
Issue: 9
Pages: 1016-1024
ISSN: 1465-7392 (ISSN-L)
1476-4679
DOI: 10.1038/ncb433
OpenAlex: W2008939826
Cited by: 395
References: 108
FWCI: 10.06
Type: journal article
Language: en
Open access: green

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Cell polarity in development and cancer

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