Zizimin1, a novel Cdc42 activator, reveals a new GEF domain for Rho proteins

Meller, Nahum, Irani-Tehrani, Mohammad, Kiosses, William B., Del Pozo, Miguel A., Schwartz, Martin A.·2002·Nature Cell Biology

Cited by (171)

Items 101–171 of 171

  1. Rac1 Is Essential for Basement Membrane-Dependent Epiblast Survival
    Xiaowen He, Jie Liu, Yanmei Qi, Cord Brakebusch, Anna Chrostek‐Grashoff, David Edgar, Peter D. Yurchenco, Siobhan Corbett, Stephen F. Lowry, Alan M. Graham et al. · 2010 · Molecular and Cellular Biology
  2. RHO protein regulation of contraction in the human uterus
    Jon Lartey, A. López Bernal · 2009 · Reproduction
  3. Proteomic Analysis of α-Amino-3-hydroxy-5-methyl-4-isoxazole Propionate Receptor Complexes
    Kang, Myoung-Goo, Nuriya, Mutsuo, Guo, Yurong, Martindale, Kevin D., Lee, Daniel Z., Huganir, Richard L. · 2012 · Journal of Biological Chemistry
  4. Evolutionarily conserved modules in actin nucleation: lessons from Dictyostelium discoideum and plants
    Fatima Cvrčková, Fernando Rivero, B. Bavlnka · 2004 · PROTOPLASMA
  5. Age-related guanine nucleotide exchange factor, mouse Zizimin2, induces filopodia in bone marrow-derived dendritic cells
    Sakabe, Isamu, Asai, Azusa, Iijima, Junko, Maruyama, Mitsuo · 2012 · Immunity & Ageing
  6. The regulation of DOCK family proteins on T and B cells
    Yuanyuan Chen, Yan Chen, Wei Yin, Hong Ryul Han, Heather E. Miller, Jianrong Li, Andrés A. Herrada, Masato Kubo, Zhiwei Sui, Quan Gong et al. · 2020 · Journal of Leukocyte Biology
  7. Function of the N-terminus of zizimin1: autoinhibition and membrane targeting
    Nahum Meller, M. Jody Westbrook, John D. Shannon, Chittibabu Guda, Martin Alexander Schwartz · 2007 · Biochemical Journal
  8. A fluorescence resonance energy transfer activation sensor for Arf6
    Brian Hall, Mark A. McLean, Kathryn Davis, James E. Casanova, Steven G. Sligar, Martin Alexander Schwartz · 2007 · Analytical Biochemistry
  9. MicroRNA Regulation of the Small Rho GTPase Regulators—Complexities and Opportunities in Targeting Cancer Metastasis
    Brock A. Humphries, Zhishan Wang, Chengfeng Yang · 2020 · Cancers
  10. Methyltransferase Nsd2 Ensures Germinal Center Selection by Promoting Adhesive Interactions between B Cells and Follicular Dendritic Cells
    Jingjing Chen, Ni Li, Yuye Yin, Nan Zheng, Min Min, Bichun Lin, Le Zhang, Xuehui Long, Yang Zhang, Zhenming Cai et al. · 2018 · Cell Reports
  11. ZizB, a novel RacGEF regulates development, cell motility and cytokinesis in Dictyostelium.
    Nicholl K. Pakes, Douwe M. Veltman, Francisco Rivero, Jamal Nasir, Robert H. Insall, Robin S. B. Williams · 2012 · Journal of Cell Science
  12. Human and mouse DOCK10 splicing isoforms with alternative first coding exon usage are differentially expressed in T and B lymphocytes
    María José Alcaraz García, Natalia Ruiz-Lafuente, Silvia Sebastián-Ruiz, María Juliana Majado, Consuelo González‐García, María Victoria Bernardo, María Rocío López-Álvarez, Antonio Parrado · 2011 · Human Immunology
  13. Zizimin and Dock guanine nucleotide exchange factors in cell function and disease
    Pakes, Nicholl K., Veltman, Douwe M., Williams, Robin S.B. · 2013 · Small GTPases
  14. Rac3-induced Neuritogenesis Requires Binding to Neurabin I
    Donata Orioli, Ivan Nicola Colaluca, Miria Stefanini, Silvano Riva, Carlos G. Dotti, Fiorenzo Antonio Peverali · 2006 · Molecular Biology of the Cell
  15. Expression profiling reveals functionally important genes and coordinately regulated signaling pathway genes during in vitro angiogenesis
    Christopher Norman Hahn, Zishan Su, Chris Drogemuller, Anna Tsykin, Scott R. Waterman, Peter J Brautigan, Shanhe Yu, Gabriel Kremmidiotis, A. Gardner, P. J. Solomon et al. · 2005 · Physiological Genomics
  16. Genomic Implications of H2O2 for Cell Proliferation and Growth of Caco-2 Cells
    Theresa Herring, Susan L. Cuppett, Janos Zempleni · 2007 · Digestive Diseases and Sciences
  17. Mechanisms involved in AMPK-mediated deposition of tight junction components to the plasma membrane
    Jingshing Wu, Pascal Rowart, François Jouret, Brandon M. Gassaway, Vanathy Rajendran, Jesse Rinehart, Michael J. Caplan · 2020 · American Journal of Physiology-Cell Physiology
  18. LKB1‐MARK2 signalling mediates lipopolysaccharide‐induced production of cytokines in mouse macrophages
    Jie Deng, Chunmei Wen, Xiangyu Ding, Xi Zhang, Guoqing Hou, Andong Liu, Hui Xu, Xuan Cao, Yongheng Bai · 2020 · Journal of Cellular and Molecular Medicine
  19. Ras Superfamily and Interacting Proteins Database
    André Bernards · 2006 · Methods in enzymology on CD-ROM/Methods in enzymology
  20. Identification of DOCK4 and its splicing variant as PIP<sub>3</sub> binding proteins
    Kanai, Akinori, Ihara, Sayoko, Ohdaira, Tsutomu, Shinohara‐Kanda, Azusa, Iwamatsu, Akihiro, Fukui, Yasuhisa · 2008 · IUBMB Life
  21. Lipid nanoparticle-encapsulated DOCK11-siRNA efficiently reduces hepatitis B virus cccDNA level in infected mice
    Hikari Okada, Takeharu Sakamoto, Kouki Nio, Ying-Yi Li, Kazuyuki Kuroki, Saiho Sugimoto, Tetsuro Shimakami, Nobuhide Doi, Masao Honda, Motoharu Seiki et al. · 2024 · Molecular Therapy — Methods & Clinical Development
  22. Pediatric keratoconus
    Yogita Gupta, Chandradevi Shanmugam, Kuralarasi Priyadarshini, Sohini Mandal, Radhika Tandon, Namrata Sharma · 2024 · Survey of Ophthalmology
  23. Proteomic profiling of the molecular targets of interactions of the mastoparan peptide Protopolybia MP‐III at the level of endosomal membranes from rat mast cells
    Lucilene Delazari dos Santos, José Roberto Aparecido dos Santos Pinto, Anally Ribeiro da Silva Menegasso, Daniel Menezes Saidemberg, Ana Maria Garcia, Mário Sérgio Palma · 2012 · PROTEOMICS
  24. DOCK9 induces membrane ruffles and Rac1 activity in cancer HeLa epithelial cells
    Ruiz-Lafuente, Natalia, Minguela, Alfredo, Parrado, Antonio · 2018 · Biochemistry and Biophysics Reports
  25. DOCK4 Regulation of Rho GTPases Mediates Pulmonary Vascular Barrier Function
    Pascal Yazbeck, Xavier Culleré, Paul Bennett, Vijay Yajnik, Huan Wang, Kenji Kawada, Vanessa M. Davis, Asit Parikh, Andrew Kuo, Vijayashree Mysore et al. · 2022 · Arteriosclerosis Thrombosis and Vascular Biology
  26. Two protein-coding genes act as a novel clinical signature to predict prognosis in patients with ovarian serous cystadenocarcinoma
    Jue Zhang, Meng Xu, Han Jie Gao, Jin‐Chen Guo, Yulin Guo, Miao Zou, Xufeng Wu · 2018 · Oncology Letters
  27. Identification of Key Genes and Molecular Pathways in Keratoconus: Integrating Text Mining and Bioinformatics Analysis
    Di Hu, Zenan Lin, Junhong Jiang, Pan Li, Zhehuan Zhang, Chenhao Yang · 2022 · BioMed Research International
  28. GEF without a Dbl domain?
    Vania M. M. Braga · 2002 · Nature Cell Biology
  29. Rac and cell migration: CDM proteins integrate signals
    Henry R. Bourne · 2005 · Nature Cell Biology
  30. Phosphatidic acid binds to and regulates guanine nucleotide exchange factor 8 (GEF8) activity in Arabidopsis
    Chunyan Cao, Peipei Wang, Hongdi Song, Wen Jing, Like Shen, Qun Zhang, Wenhua Zhang · 2017 · Functional Plant Biology
  31. 2.1 – Myogenesis and Muscle Development
    S. M. Abmayr, L. Balagopalan, B. Galletta, S. Hong · 2005 · Elsevier eBooks
  32. Modulation of the Pol II CTD Phosphorylation Code by Rac1 and Cdc42 Small GTPases in Cultured Human Cancer Cells and Its Implication for Developing a Synthetic-Lethal Cancer Therapy
    Bo Zhang, Xuelin Zhong, Moira Sauane, Yihong Zhao, Zhi‐Liang Zheng · 2020 · Cells
  33. Expression of DOCK9 and DOCK11 Analyzed with Commercial Antibodies: Focus on Regulation of Mutually Exclusive First Exon Isoforms
    Parrado, Antonio · 2020 · Antibodies
  34. Snapshots Form a Big Picture of Guanine Nucleotide Exchange
    Katrin Rittinger · 2009 · Science Signaling
  35. ROP GTPases and the Cytoskeleton
    Ying Fu · 2009 · Signaling and communication in plants
  36. Two Lipids That Give Direction
    Jean‐François Côté, Kristiina Vuori · 2009 · Science
  37. DOCK8-related Immunodeficiency Syndrome (DIDS): Report of Novel Mutations in Iranian Patients
    Sahar Yousefnezhad, Jalal Gharesouran, Soudeh Ghafouri‐Fard, Hassan Hosseinzadeh, Javad Ahmadian Heris, Amir Hossein Jafari-Rouhi, Mohammad Naser Taheri, Maryam Rezazadeh · 2021 · Journal of Molecular Neuroscience
  38. A narrative review: the role of DOCK2 in immune-related diseases, hematopoietic or vascular diseases and solid tumor
    Yuanyuan Chen, Muping Di, Yan Tang, Jian‐Chuan Xia · 2021 · Annals of Blood
  39. Roles Played by DOCK11, a Guanine Nucleotide Exchange Factor, in HBV Entry and Persistence in Hepatocytes
    Ying-Yi Li, Kazuhisa Murai, Junyan Lyu, Masao Honda · 2024 · Viruses
  40. Solution structure of the SH3 domain of DOCK180
    Xiangrong Liu, Fengjuan Li, Zhu Pan, Wenning Wang, Wenyu Wen · 2013 · Proteins Structure Function and Bioinformatics
  41. Variable Distribution of DOCK-D Proteins between Cytosol and Nucleoplasm in Cell Lines, Effect of Interleukin-4 on DOCK10 in B-Cell Lymphoid Neoplasms, and Validation of a New DOCK10 Antiserum for Immunofluorescence Studies
    Natalia Ruiz-Lafuente, Alfredo Minguela, Jose Maria Moraleda, Manuel Muro, Antonio Parrado · 2021 · Antibodies
  42. Rat Monoclonal Antibodies Against New Guanine Nucleotide Exchange Factor, Mouse Zizimin2
    Yanjun Jia, Azusa Asai, Isamu Sakabe, Mitsuo Maruyama · 2010 · Hybridoma
  43. Interactions between genetic variants and environmental risk factors are associated with the severity of pelvic organ prolapse
    Lei Li, Guangyi Zhao, Jie Wu, Haiyu Pang, Tianli Zhang, Juan Chen, Kunlin Zhang, Lan Zhu · 2023 · Menopause The Journal of The North American Menopause Society
  44. Overview of Rho GTPase History
    Ellen V. Stevens, Channing J. Der · 2009 · Springer eBooks
  45. Rho GTPases and Their Activators, Guanine Nucleotide Exchange Factors (GEFs): Their Roles in Glioma Cell Invasion
    Bo Hu, Marc H. Symons, Bodour Salhia, Shannon P. Fortin Ensign, Nhan L. Tran, James T. Rutka, Shi‐Yuan Cheng · 2011 · Springer eBooks
  46. Cytoskeletal Requirements duringArabidopsisTrichome Development
    Mark A. Beilstein, Dan Szymanski · 2017 · Wiley eBooks
  47. Structural basis for CDC42 and RAC activation by the dual specificity GEF DOCK10
    Danni Fan, Jing Yang, Nora Cronin, David Barford · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
  48. Activation of GTPases by Dock180 Family of Proteins
    Mingjian Lu, Kodi S. Ravichandran · 2005 · Springer eBooks
  49. Ras Family Proteins
    Jean de Gunzburg · 2006 · Springer eBooks
  50. Restricted expression of new guanine nucleotide exchange factor Zizimin2 in aged acquired immune system.
    Yanjun Jia, Isamu Sakabe, Takenori Matsuda, Tomoko Hayakawa, Mitsuo Maruyama · 2012 · Europe PMC (PubMed Central)
  51. DOCK8 in immune cells: roles and mechanisms
    Zixuan Liao, Sicheng Luo, Weijie Shen, Huiru Lv, Zekai Xu, LW Xu · 2026 · Frontiers in Immunology
  52. The roles of Cdc42 and Rac1 in the formation of plasma membrane protrusions in cancer epithelial HeLa cells
    Natalia Ruiz-Lafuente, Alfredo Minguela, Manuel Muro, Antonio Parrado · 2021 · Molecular Biology Reports
  53. Rôle des GTPases de la famille Rho et de leurs régulateurs dans les propriétés transformantes des lymphomes anaplasiques NPM-ALK positifs
    Audrey Colomba · 2007 · OpenGrey (Institut de l'Information Scientifique et Technique)
  54. Atypical Guanine Nucleotide Exchange Factors for Rho Family GTPases: DOCK9 Activation of Cdc42 and SmgGDS activation of RhoA
    Brant Hamel · 2019 · Carolina Digital Repository (University of North Carolina at Chapel Hill)
  55. Utilising omics approaches to understand Kaposi's sarcoma-associated herpesvirus
    Christopher B. Owen · 2015 · White Rose eTheses Online (University of Leeds, The University of Sheffield, University of York)
  56. The Dock Family of Atypical Guanine Nucleotide Exchange Factors: Regulation by ELMO1 and RhoG
    Cynthia P. Holley · 2019 · Carolina Digital Repository (University of North Carolina at Chapel Hill)
  57. RhoGTPase signaling in cell polarity and gene regulation.
    Ann‐Sofi Johansson · 2006 · Uppsala University Publications (Uppsala University)
  58. Rho GTPases and their regulators in cell polarity of the filamentous ascomycete Neurospora crassa
    Corinna Richthammer · 2011
  59. Drosophila DOCK Family Protein Zizimin Involves in Pigment Cell Differentiation in Pupal Retinae
    Fumito Ozasa, Kazushige Morishita, Ngoc Anh Suong Dang, Seiji Miyata, Hideki Yoshida, Masamitsu Yamaguchi · 2017 · Cell Structure and Function
  60. Small Rho GTPase Family Member Cdc42 and Its Role in Neuronal Survival and Apoptosis
    Noelle Punessen · 2017 · Digital Commons - DU (University of Denver)
  61. Mechanisms of Cell Polarity Establishment and Polar Auxin Transport
    Arthur J. Molendijk, Olaf Tietz, Benedetto Ruperti, Ivan A. Paponov, Klaus J. Palme · 2017 · Wiley eBooks
  62. Focal Adhesion Kinase Signaling Spatially Regulates Adhesion Dynamics in Fibroblasts
    Marcin Iwanicki · 2008
  63. Faculty Opinions recommendation of A novel and evolutionarily conserved PtdIns(3,4,5)P3-binding domain is necessary for DOCK180 signalling.
    Christopher E. Turner · 2005 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
  64. Rho GTPases
    Michael J. Lukey, Richard A. Cerione · 2015 · Elsevier eBooks
  65. Rho GTPases
    Michael J. Lukey, Yijian Qiu, Wen‐Hsuan Yang, Richard A. Cerione · 2022 · Elsevier eBooks
  66. Flamingo/Starry Night in embryonic abdominal sensory axon development of Drosophila
    Martin Claus Steinel · 2008 · Minerva Access (University of Melbourne)
  67. A prevalent disease-associated SNP in the human ID3 gene regulates E-protein activity and cellular proliferation
    Christopher A. Henderson, Brett P. Ransegnola, James C. Garmey, Ali Khan, Rédouane Aherrahrou, Michael D. Purdy, Shijie Wu, Andrea Zhou, Jennifer L. Kirby, Michael Joseph Lipinski et al. · 2026 · NAR Molecular Medicine
  68. Multi-omics analysis reveals NSUN2-mediated m5C methylation of DOCK9 regulating vascular stability in brain arteriovenous malformations
    Ganglei Li, Hongfei Zhang, Biyun Wang, Junrui Chen, Jiahui Yang, Guo Yu, Kai Quan, Sichen Li, Yingjun Liu, Yuan Shi et al. · 2026 · Cell Reports
  69. A hypothesis and evidence map for neuroimmune regulation of DOCK-family cytoskeletal programs in solid tumors
    Lei Zhou, Yuning Ren, Lina Han, Xiaodan Wang, Xiaoling Zhang · 2026 · Frontiers in Immunology
  70. The evolution of small GTP binding proteins in cellular organisms. Studies of RAS GTPases in arabidopsis thaliana and the Ral GTPase from Drosophila melanogaster
    Per Winge · 2002 · BIBSYS Brage (BIBSYS (Norway))
  71. Analysing dopamine receptor interacting proteins using the biomedical model Dictyostelium discoideum
    Nicholl K. Pakes · 2012 · Royal Holloway Digital Repository (Royal Holloway University of London)