The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Islet β-cell secretion determines glucagon release from neighbouring α-cells
Open accessAbstract
Homeostasis of blood glucose is maintained by hormone secretion from the pancreatic islets of Langerhans. Glucose stimulates insulin secretion from β-cells but suppresses the release of glucagon, a hormone that raises blood glucose, from α-cells. The mechanism by which nutrients stimulate insulin secretion has been studied extensively: ATP has been identified as the main messenger and the ATP-sensitive potassium channel as an essential transducer in this process. By contrast, much less is known about the mechanisms by which nutrients modulate glucagon secretion. Here we use conventional pancreas perfusion and a transcriptional targeting strategy to analyse cell-type-specific signal transduction and the relationship between islet α- and β-cells. We find that pyruvate, a glycolytic intermediate and principal substrate of mitochondria, stimulates glucagon secretion. Our analyses indicate that, although α-cells, like β-cells, possess the inherent capacity to respond to nutrients, secretion from α-cells is normally suppressed by the simultaneous activation of β-cells. Zinc released from β-cells may be implicated in this suppression. Our results define the fundamental mechanisms of differential responses to identical stimuli between cells in a microorgan.
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SLC Transporters as Therapeutic Targets: Emerging Opportunities
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Cytosolic zinc buffering and muffling: Their role in intracellular zinc homeostasis
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Metadata
- Authors
- Ishihara, H., Maechler, P., Gjinovci, A., Herrera, P.-L., & Wollheim, C. B.
- Venue
- Nature Cell Biology
- Published
- 2003-03-17
- Volume
- 5
- Issue
- 4
- Pages
- 330-335
- ISSN
- 1465-7392 (ISSN-L)
- 1476-4679
- OpenAlex
- W1522924058
- Cited by
- 383
- References
- 27
- FWCI
- 21.62
- Type
- journal article
- Language
- en
- Open access
- green
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