The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
A human microprotein that interacts with the mRNA decapping complex
Open accessAbstract
Proteomic detection of non-annotated microproteins indicates the translation of hundreds of small open reading frames in human cells, but whether these microproteins are functional is unknown. Here, we report the discovery and characterization of a 7-kilodalton human microprotein we named non-annotated P-body dissociating polypeptide (NoBody). NoBody interacts with mRNA decapping proteins, which remove the 5’ cap from mRNAs to promote 5’-3’ decay. Decapping proteins participate in mRNA turnover and nonsense mediated decay (NMD). NoBody localizes to mRNA decay-associated RNA-protein granules called P-bodies. Modulation of NoBody levels reveals that its abundance is anti-correlated with cellular P-body numbers and alters the steady-state levels of a cellular NMD substrate. These results implicate NoBody as a novel component of the mRNA decapping complex and demonstrate potential functionality of a newly discovered microprotein.
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Structured elements drive extensive circular RNA translation
Chen, C.-K., Cheng, R., Demeter, J., Chen, J., Weingarten-Gabbay, S., Jiang, L., Snyder, M. P., Weissman, J. S., Segal, E., Jackson, P. K., et al. (2021) · Molecular Cell · doi:10.1016/j.molcel.2021.07.042 · Cited by 316
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Ribosome Profiling: Global Views of Translation
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The translation of non-canonical open reading frames controls mucosal immunity
Jackson, R., Kroehling, L., Khitun, A., Bailis, W., Jarret, A., York, A. G., Khan, O. M., Brewer, J. R., Skadow, M. H., Duizer, C., et al. (2018) · Nature · doi:10.1038/s41586-018-0794-7 · Cited by 242
Self-citation
Metadata
- Authors
- D'Lima, N. G., Ma, J., Winkler, L., Chu, Q., Loh, K. H., Corpuz, E. O., Budnik, B. A., Lykke-Andersen, J., Saghatelian, A., & Slavoff, S. A.
- Venue
- Nature Chemical Biology
- Published
- 2016-12-05
- Volume
- 13
- Issue
- 2
- Pages
- 174-180
- ISSN
- 1552-4450 (ISSN-L)
- 1552-4469
- OpenAlex
- W2559953833
- Cited by
- 304
- References
- 44
- FWCI
- 9.18
- Type
- journal article
- Language
- en
- Open access
- green
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- D'Lima, N. G., Ma, J., Winkler, L., Chu, Q., Loh, K. H., Corpuz, E. O., Budnik, B. A., Lykke-Andersen, J., Saghatelian, A., & Slavoff, S. A. (2017). A human microprotein that interacts with the mRNA decapping complex. Nature Chemical Biology. https://doi.org/10.1038/nchembio.2249
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