Exosome engineering for efficient intracellular delivery of soluble proteins using optically reversible protein-protein interaction module

Yim, Nambin, Ryu, Seung-Wook, Choi, Kyungsun, Lee, Kwang Ryeol, Lee, Seunghee, Choi, Hojun, Kim, Jeongjin, Shaker, Mohammed R., Sun, Woong, Park, Ji-Ho, Kim, Daesoo, Heo, Won Do, Choi, Chulhee·2016·Nature Communications

DOI 10.1038/ncomms12277

Cited by (584)

Items 101–200 of 584

Engineering of extracellular vesicles for efficient intracellular delivery of multimodal therapeutics including genome editors
Xiuming Liang, Dhanu Gupta, Junhua Xie, Elien Van Wonterghem, Lien Van Hoecke, Justin Hean, Zheyu Niu, Marziyeh Ghaeidamini, Oscar P. B. Wiklander, Wenyi Zheng et al. · 2025 · Nature Communications
The Potential Use of Mesenchymal Stem Cells and Their Derived Exosomes for Orthopedic Diseases Treatment
Kosar Malekpour, Ali Hazrati, Marziah Zahar, Alexander Anatolyevich Markov, Angelina Olegovna Zekiy, Jamshid Gholizadeh Navashenaq, Leila Roshangar, Majid Ahmadi · 2021 · Stem Cell Reviews and Reports
Role of Extracellular Vesicle Surface Proteins in the Pharmacokinetics of Extracellular Vesicles
Chonlada Charoenviriyakul, Yuki Takahashi, Masaki Morishita, Makiya Nishikawa, Yoshinobu Takakura · 2018 · Molecular Pharmaceutics
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Xabier Osteikoetxea, Andreia Machado da Silva, Elisa Lázaro‐Ibáñez, Nikki Salmond, Olga Shatnyeva, Josia Stein, Jan Schick, Stephen A. C. Wren, Julia Lindgren, Mike A. Firth et al. · 2022 · Journal of Extracellular Vesicles
Clinical relevance of extracellular vesicles in cancer — therapeutic and diagnostic potential
David W. Greening, Rong Xu, Alin Rai, Wittaya Suwakulsiri, Maoshan Chen, Richard J. Simpson · 2025 · Nature Reviews Clinical Oncology
Exosomes as Drug Delivery Systems: Endogenous Nanovehicles for Treatment of Systemic Lupus Erythematosus
Ana Ortega, Olga Martínez-Arroyo, María José Forner, Raquel Cortés · 2020 · Pharmaceutics
The Therapeutic Potential and Clinical Significance of Exosomes as Carriers of Drug Delivery System
Li, Tianwei, Li, Xiaoqing, Han, Guiping, Liang, Ming, Yang, Zongrui, Zhang, Congyi, Huang, Shizhuan, Tai, Sheng, Yu, Shan · 2022 · Pharmaceutics
Effective and Selective Anti‐Cancer Protein Delivery via All‐Functions‐in‐One Nanocarriers Coupled with Visible Light‐Responsive, Reversible Protein Engineering
Hua He, Yongbing Chen, Yongjuan Li, Ziyuan Song, Yinan Zhong, Rongying Zhu, Jianjun Cheng, Lichen Yin · 2018 · Advanced Functional Materials
Cyclic-recombinase-reporter mouse model to determine exosome communication and function during pregnancy
Samantha Sheller‐Miller, Kyungsun Choi, Chulhee Choi, Ramkumar Menon · 2019 · American Journal of Obstetrics and Gynecology
Exosomal miRNA‐1231 derived from bone marrow mesenchymal stem cells inhibits the activity of pancreatic cancer
Song Shang, Jinfeng Wang, Shilin Chen, Renyun Tian, Hui Zeng, Liang Wang, Man Xia, Haizhen Zhu, Chaohui Zuo · 2019 · Cancer Medicine
Engineering stem cells to produce exosomes with enhanced bone regeneration effects: an alternative strategy for gene therapy
Feiyang Li, Jun Wu, Daiye Li, Liuzhi Hao, Yanqun Li, Dan Yi, Kwk Yeung, Di Chen, William W. Lu, Haobo Pan et al. · 2022 · Journal of Nanobiotechnology
Targeted delivery of extracellular vesicles in heart injury
Peier Chen, Ling Wang, Xianglin Fan, Xiaodong Ning, Bin Yu, Caiwen Ou, Minsheng Chen · 2020 · Theranostics
On the Choice of the Extracellular Vesicles for Therapeutic Purposes
Claudia Campanella, Celeste Caruso Bavisotto, Mariantonia Logozzi, Antonella Marino, Davide Mizzoni, Francesco Cappello, Stefano Fais · 2019 · International Journal of Molecular Sciences
Engineered Extracellular Vesicles: Tailored-Made Nanomaterials for Medical Applications
Kenny Man, Mathieu Y. Brunet, Marie‐Christine Jones, Sophie Constance Cox · 2020 · Nanomaterials
Exosomes in diagnosis and therapy of prostate cancer
Jun Pan, Meng Ding, Kai Xu, Chunhua Yang, Lijun Mao · 2017 · Oncotarget
Serum Deprivation of Mesenchymal Stem Cells Improves Exosome Activity and Alters Lipid and Protein Composition
Réka Ágnes Haraszti, Rachael Miller, Michelle L. Dubuke, Hannah E. Rockwell, Andrew H. Coles, Ellen Sapp, Marie-Cécile Didiot, Dimas Echeverria, Matteo Stoppato, Yves Y. Sere et al. · 2019 · iScience
Delivery strategies for macromolecular drugs in cancer therapy
Qin Guo, Chen Jiang · 2020 · Acta Pharmaceutica Sinica B
Exosome-Mediated Impact on Systemic Metabolism
Karina Cunha e Rocha, Wei Ying, Jerrold M. Olefsky · 2024 · Annual Review of Physiology
Extracellular vesicles versus lipid nanoparticles for the delivery of nucleic acids
Johannes Bader, Finn Brigger, Jean‐Christophe Leroux · 2024 · Advanced Drug Delivery Reviews
Roles and Regulation of Extracellular Vesicles in Cardiovascular Mineral Metabolism
Mark C. Blaser, Elena Aïkawa · 2018 · Frontiers in Cardiovascular Medicine
Exosome-based delivery of super-repressor IκBα ameliorates kidney ischemia-reperfusion injury
Kim, Seonghun, Lee, Sul A, Yoon, Heakyung, Kim, Myung Yoon, Yoo, Jae-Kwang, Ahn, So-Hee, Park, Cheol Hyoung, Park, Jimin, Nam, Bo Young, Park, Jung Tak et al. · 2021 · Kidney International
Engineered Extracellular Vesicles as a Reliable Tool in Cancer Nanomedicine
Francesca Susa, Tania Limongi, Bianca Dumontel, Veronica Vighetto, Valentina Cauda · 2019 · Cancers
Exosome loaded genipin crosslinked hydrogel facilitates full thickness cutaneous wound healing in rat animal model
Qijun Li, Shiqiang Gong, Weifan Yao, Ziting Yang, Renjun Wang, Zhaojin Yu, Minjie Wei · 2021 · Drug Delivery
High affinity single-chain variable fragments are specific and versatile targeting motifs for extracellular vesicles
Andrea Longatti, Christina Schindler, Andie Collinson, Lesley Jenkinson, Carl Matthews, Laura FitzPatrick, Margaret Blundy, Ralph Minter, Tristan J. Vaughan, Michael Shaw et al. · 2018 · Nanoscale
Nanoengineering facilitating the target mission: targeted extracellular vesicles delivery systems design
Haoyue Song, Xiaohang Chen, Yujia Hao, Jia Wang, Qingpeng Xie, Xing Wang · 2022 · Journal of Nanobiotechnology
Biology and therapeutic potential of extracellular vesicle targeting and uptake
Léa Ripoll, Antje Maria Zickler, Pieter Vader, Samir EL Andaloussi, Frederik J. Verweij, Guillaume van Niel · 2026 · Nature Reviews Molecular Cell Biology
Role of Exosomes for Delivery of Chemotherapeutic Drugs
Aragaw Gebeyehu, Nagavendra Kommineni, David G. Meckes, Mandip Singh Sachdeva · 2021 · Critical Reviews in Therapeutic Drug Carrier Systems
Extracellular vesicles-mediated noncoding RNAs transfer in cancer
Pei Ma, Yutian Pan, Wei Li, Chongqi Sun, Jie Liu, Tongpeng Xu, Yongqian Shu · 2017 · Journal of Hematology & Oncology
Genetically encoding multiple functionalities into extracellular vesicles for the targeted delivery of biologics to T cells
Devin M. Stranford, Lacy M. Simons, Katherine E. Berman, Luyi Cheng, Beth N. DiBiase, Michelle E. Hung, Julius B. Lucks, Judd F. Hultquist, Joshua N. Leonard · 2023 · Nature Biomedical Engineering
Systematic review of extracellular vesicle‐based treatments for lung injury: are EVs a potential therapy for COVID‐19?
Kasra Khalaj, Rebeca Lopes Figueira, Lina Antounians, Giuseppe Lauriti, Augusto Zani · 2020 · Journal of Extracellular Vesicles
Intracellular Protein Delivery: Approaches, Challenges, and Clinical Applications
Alexander Chan, Andrew Tsourkas · 2023 · BME Frontiers
Blood TfR+ exosomes separated by a pH-responsive method deliver chemotherapeutics for tumor therapy
Lijun Yang, Donglin Han, Qi Zhan, Xueping Li, Peipei Shan, Yunjie Hu, Han Ding, Yu Wang, Lei Zhang, Yuan Zhang et al. · 2019 · Theranostics
Enhancing extracellular vesicle cargo loading and functional delivery by engineering protein-lipid interactions
Justin A. Peruzzi, Taylor F. Gunnels, Hailey I. Edelstein, Peilong Lu, David A. Baker, Joshua N. Leonard, Neha P. Kamat · 2024 · Nature Communications
Optogenetic engineered umbilical cord MSC-derived exosomes for remodeling of the immune microenvironment in diabetic wounds and the promotion of tissue repair
Xin Zhao, Luo‐Qin Fu, Hai Zou, Yichen He, Yi Pan, Luyi Ye, Yilin Huang, Weijiao Fan, Jungang Zhang, Ying‐Yu Ma et al. · 2023 · Journal of Nanobiotechnology
Exosomal delivery of NF-κB inhibitor delays LPS-induced preterm birth and modulates fetal immune cell profile in mouse models
Samantha Sheller‐Miller, Enkhtuya Radnaa, Jae‐Kwang Yoo, Kyungsun Choi, Youngeun Kim, Yu Na Kim, Eunsoo Kim, Lauren Richardson, Chulhee Choi, Ramkumar Menon · 2021 · Science Advances
Exosome-based drug delivery systems and their therapeutic applications
Jae‐Wook Lee, Ji-Heon Lee, Kushal Chakraborty, Joon Hwang, Yong-Kyu Lee · 2022 · RSC Advances
Macrophage-inherited exosome excise tumor immunosuppression to expedite immune-activated ferroptosis
Duo Wang, Guanhua Qiu, Xiaoqi Zhu, Qin Wang, Chunyan Zhu, Chao Fang, Junjie Liu, Kun Zhang, Yan Liu · 2023 · Journal for ImmunoTherapy of Cancer
Identification of scaffold proteins for improved endogenous engineering of extracellular vesicles
Wenyi Zheng, Julia Rädler, Helena Sork, Zheyu Niu, Samantha Roudi, Jeremy Bost, André Görgens, Ying Heng Zhao, Doste Rashid Mamand, Xiuming Liang et al. · 2023 · Nature Communications
Engineered exosomes with a photoinducible protein delivery system enable CRISPR-Cas–based epigenome editing in Alzheimer’s disease
Jihoon Han, Jae Hoon Sul, Jeongmi Lee, Eunae Kim, Hark Kyun Kim, Minshik Chae, Jeein Lim, Jongho Kim, C.H. Kim, J.S. Kim et al. · 2024 · Science Translational Medicine
The emerging role of exosomes as novel therapeutics: Biology, technologies, clinical applications, and the next
Yonghee Song, Youngeun Kim, Sun‐Hyung Ha, Samantha Sheller‐Miller, Jae‐Kwang Yoo, Chulhee Choi, Cheol Hyoung Park · 2020 · American Journal of Reproductive Immunology
Current knowledge of hybrid nanoplatforms composed of exosomes and organic/inorganic nanoparticles for disease treatment and cell/tissue imaging
Fatemeh Soltanmohammadi, Adel Mahmoudi Gharehbaba, Ali Rajabi Zangi, Khosro Adibkia, Yousef Javadzadeh · 2024 · Biomedicine & Pharmacotherapy
Macrophage-Derived Extracellular Vesicle Promotes Hair Growth
Ramya Lakshmi Rajendran, Prakash Gangadaran, Chang Hoon Seo, Mi Hee Kwack, Ji Min Oh, Ho‐Won Lee, Arunnehru Gopal, Young Kwan Sung, Shin Young Jeong, Sang‐Woo Lee et al. · 2020 · Cells
Exosome Traceability and Cell Source Dependence on Composition and Cell-Cell Cross Talk
Rabab N. Hamzah, Karrer M. Alghazali, Alexandru Sorin Biris, Robert J. Griffin · 2021 · International Journal of Molecular Sciences
Biodistribution of therapeutic extracellular vesicles
Dhanu Gupta, Oscar P. B. Wiklander, Matthew J. A. Wood, Samir EL Andaloussi · 2023 · Extracellular Vesicles and Circulating Nucleic Acids
Exosomes in cancer nanomedicine: biotechnological advancements and innovations
Jacky J. J. Liu, Duanrui Liu, Sally K. Y. To, Alice S.T. Wong · 2025 · Molecular Cancer
Plasma- and Saliva Exosome Profile Reveals a Distinct MicroRNA Signature in Chronic Periodontitis
Nik Nur Syazana Bt Nik Mohamed Kamal, Raja Azman Awang, Suharni Mohamad, Wan Nazatul Shima Shahidan · 2020 · Frontiers in Physiology
Advances in extracellular vesicle functionalization strategies for tissue regeneration
Dandan Zheng, Huitong Ruan, Wei Chen, Yuhui Zhang, Wenguo Cui, Hao Chen, Hongxing Shen · 2022 · Bioactive Materials
A Novel Strategy to Increase the Yield of Exosomes (Extracellular Vesicles) for an Expansion of Basic Research
Sherif E. Emam, Hidenori Ando, Amr Selim Abu Lila, Taro Shimizu, Masami Ukawa, Keiichiro Okuhira, Yu Ishima, Mahmoud A. Mahdy, Fakhr-eldin S. Ghazy, Tatsuhiro Ishida · 2018 · Biological and Pharmaceutical Bulletin
Functional Extracellular Vesicles for Regenerative Medicine
Han Young Kim, Seunglee Kwon, Wooram Um, Sol Shin, Chan Ho Kim, Jae Hyung Park, Byung‐Soo Kim · 2022 · Small
Endosomal Escape Enhancing Compounds Facilitate Functional Delivery of Extracellular Vesicle Cargo
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Engineering approaches for effective therapeutic applications based on extracellular vesicles
Seunglee Kwon, Sol Shin, Minjae Do, Byeong Hoon Oh, Yeari Song, Van Dat Bui, Eun Sook Lee, Dong‐Gyu Jo, Yong Woo Cho, Deok‐Ho Kim et al. · 2020 · Journal of Controlled Release
Native and Bioengineered Exosomes for Ischemic Stroke Therapy
Haroon Latif Khan, Jiaji Pan, Yong-Fang Li, Zhijun Zhang, Guo‐Yuan Yang · 2021 · Frontiers in Cell and Developmental Biology
Delivery of an Artificial Transcription Regulator dCas9-VPR by Extracellular Vesicles for Therapeutic Gene Activation
Duško Lainšček, Lucija Kadunc, Mateja Manček Keber, Iva Hafner‐Bratkovič, Rok Romih, Roman Jerala · 2018 · ACS Synthetic Biology
Multiplexed strategies toward clinical translation of extracellular vesicles
Junying Song, Baoqiang Song, Lijun Yuan, Guodong Yang · 2022 · Theranostics
Self-powered triboelectric-responsive microneedles with controllable release of optogenetically engineered extracellular vesicles for intervertebral disc degeneration repair
Weifeng Zhang, Xuan Qin, Gaocai Li, Xingyu Zhou, Hongyang Li, Di Wu, Yu Song, Kangcheng Zhao, Kun Wang, Xiaobo Feng et al. · 2024 · Nature Communications
Molecular engineering of extracellular vesicles for drug delivery: Strategies, challenges, and perspectives
Kandarp M. Dave, Paromita Paul Pinky, Devika Soundara Manickam · 2025 · Journal of Controlled Release
Targetting Exosomes as a New Biomarker and Therapeutic Approach for Alzheimer’s Disease
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Recent Advances of Membrane-Cloaked Nanoplatforms for Biomedical Applications
Xiangzhao Ai, Ming Hu, Zhimin Wang, Wenmin Zhang, Juan Li, Huanghao Yang, Jun Lin, Bengang Xing · 2018 · Bioconjugate Chemistry
Recent advances on extracellular vesicles in therapeutic delivery: Challenges, solutions, and opportunities
Mei Lu, Haonan Xing, Zhen Lu Yang, Yanping Sun, Tianzhi Yang, Xiaoyun Zhao, Cuifang Cai, Dongkai Wang, Pingtian Ding · 2017 · European Journal of Pharmaceutics and Biopharmaceutics
Extracellular vesicle mediated feto-maternal HMGB1 signaling induces preterm birth
Enkhtuya Radnaa, Lauren Richardson, Samantha Sheller‐Miller, Tuvshintugs Baljinnyam, Mariana de Castro Silva, Ananth Kumar Kammala, Rheanna Urrabaz‐Garza, Talar B. Kechichian, Sungjin Kim, Arum Han et al. · 2021 · Lab on a Chip
RETRACTED: Hypoxia-induced lncHILAR promotes renal cancer metastasis via ceRNA for the miR-613/206/ 1-1-3p/Jagged-1/Notch/CXCR4 signaling pathway
Guanghui Hu, Junjie Ma, Jin Zhang, Yonghui Chen, Huan Liu, Yong Huang, Junhua Zheng, Yunfei Xu, Wei Xue, Wei Zhai · 2021 · Molecular Therapy · Retracted
Identifying extracellular vesicle populations from single cells
Jonas M. Nikoloff, Mario Alberto Saucedo‐Espinosa, André Kling, Petra Stephanie Dittrich · 2021 · Proceedings of the National Academy of Sciences
Extracellular Vesicles – Advanced Nanocarriers in Cancer Therapy: Progress and Achievements
Ting Huyan, Hongduo Li, Hourong Peng, Jinzhao Chen, Ruixin Yang, Wei Zhang, Qi Li · 2020 · International Journal of Nanomedicine
Polymeric coating on β-TCP scaffolds provides immobilization of small extracellular vesicles with surface-functionalization and ZEB1-Loading for bone defect repair in diabetes mellitus
Shi‐Cong Tao, Xuran Li, Wen-Jia Wei, Zhanying Wei, Chang‐Ru Zhang, Fei Wang, Helen Dawes, Shang Guo · 2022 · Biomaterials
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Dmitry S. Kostyushev, Anastasiya Kostyusheva, Sergey Brezgin, Smirnov Vv, Elena V. Volchkova, Alexander N. Lukashev, Vladimir Chulanov · 2020 · International Journal of Molecular Sciences
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Extracellular Vesicles: Opportunities and Challenges for the Treatment of Renal Diseases
Tao‐Tao Tang, Lin‐Li Lv, Hui-Yao Lan, Bi‐Cheng Liu · 2019 · Frontiers in Physiology
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Soheila Mohammadi, Fatemeh Yousefi, Zahra Shabaninejad, Ahmad Movahedpour, Maryam Mahjoubin‐Tehran, Alimohammad Shafiee, Sanaz Moradizarmehri, Sarah Hajighadimi, Amir Savardashtaki, Hamed Mirzaei · 2019 · IUBMB Life
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The Art of Intercellular Wireless Communications: Exosomes in Heart Disease and Therapy
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Exosomes in Head and Neck Squamous Cell Carcinoma
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