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Exosome engineering for efficient intracellular delivery of soluble proteins using optically reversible protein-protein interaction module
Open accessAbstract
Nanoparticle-mediated delivery of functional macromolecules is a promising method for treating a variety of human diseases. Among nanoparticles, cell-derived exosomes have recently been highlighted as a new therapeutic strategy for the in vivo delivery of nucleotides and chemical drugs. Here we describe a new tool for intracellular delivery of target proteins, named 'exosomes for protein loading via optically reversible protein-protein interactions' (EXPLORs). By integrating a reversible protein-protein interaction module controlled by blue light with the endogenous process of exosome biogenesis, we are able to successfully load cargo proteins into newly generated exosomes. Treatment with protein-loaded EXPLORs is shown to significantly increase intracellular levels of cargo proteins and their function in recipient cells in vitro and in vivo. These results clearly indicate the potential of EXPLORs as a mechanism for the efficient intracellular transfer of protein-based therapeutics into recipient cells and tissues.
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“Exosomes may provide a more rational way for therapeutic protein delivery to exert antitumor effects as we highlighted above [42].”
From The Therapeutic Potential and Clinical Significance of Exosomes as Carriers of Drug Delivery System (2022) · cites this paper as [42]
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Metadata
- Authors
- Yim, N., Ryu, S.-W., Choi, K., Lee, K. R., Lee, S., Choi, H., Kim, J., Shaker, M. R., Sun, W., Park, J.-H., Kim, D., Heo, W. D., & Choi, C.
- Affiliations
- Korea Advanced Institute of Science and Technology (KR)
- Korea University (KR)
- Corresponding author
- Choi, Kyungsun
- Choi, Chulhee
- ORCID
- Venue
- Nature Communications
- Published
- 2016-07-22
- Volume
- 7
- Issue
- 1
- Pages
- 12277-12277
- ISSN
- 2041-1723 (ISSN-L)
- PMC
- PMC4961865
- OpenAlex
- W2477351770
- Cited by
- 578
- References
- 34
- Citations by year
- 2026: 37 · 2025: 62 · 2024: 68 · 2023: 65 · 2022: 88 · 2021: 80 · 2020: 63 · 2019: 50 · 2018: 34 · 2017: 29 · 2016: 2
- FWCI
- 19.93
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Nature Communications (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Research Foundation
- Korea Health Industry Development Institute (HI14C0042)
- Korea Basic Science Institute
- National Research Foundation of Korea (HI14C0042)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
- Keywords
- exosomes, exosome engineering, intracellular protein delivery, blue light, cargo loading, exosome biogenesis, therapeutic proteins
- MeSH terms
- Animals, Genetic Engineering, HeLa Cells, Humans, Mice, Transgenic, Recombinant Proteins, Drug Delivery Systems, Arabidopsis Proteins, Basic Helix-Loop-Helix Transcription Factors, Basic Helix-Loop-Helix Proteins, Exosomes, Cryptochromes, HEK293 Cells, Optical Imaging
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