Bioengineering strategies for restoring vision

Cehajic-Kapetanovic, Jasmina; Singh, Mandeep S.; Zrenner, Eberhart; MacLaren, Robert E.

doi:10.1038/s41551-021-00836-4

Cited by 79Retinal Development and DisordersRetinal Diseases and TreatmentsNeuroscience and Neural Engineering

Bioengineering strategies for restoring vision

Cehajic-Kapetanovic, Jasmina, Singh, Mandeep S., Zrenner, Eberhart, MacLaren, Robert E.·2022·Nature Biomedical Engineering

DOI 10.1038/s41551-021-00836-4

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Abstract

Late-stage retinal degenerative disease involving photoreceptor loss can be treated by optogenetic therapy, cell transplantation and retinal prostheses. These approaches aim to restore light sensitivity to the retina as well as visual perception by integrating neuronal responses for transmission to the cortex. In age-related macular degeneration, some cell-based therapies also aim to restore photoreceptor-supporting tissue to prevent complete photoreceptor loss. In the earlier stages of degeneration, gene-replacement therapy could attenuate retinal-disease progression and reverse loss of function. And gene-editing strategies aim to correct the underlying genetic defects. In this Review, we highlight the most promising gene therapies, cell therapies and retinal prostheses for the treatment of retinal disease, discuss the benefits and drawbacks of each treatment strategy and the factors influencing whether functional tissue is reconstructed and repaired or replaced with an electronic device, and summarize upcoming technologies for enhancing the restoration of vision.

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Prospective approaches such as gene and cell therapies or optogenetics only focus on the retina and are ineffective when pathologies irremediably damage the retina or the optic nerve.
“Prospective approaches, like gene and cell therapies or optogenetics, only focus on the retina [5,6], and they are ineffective when pathologies irremediably damage the retina or the optic nerve [7,8].”
From Advances in visual prostheses: engineering and biological challenges (2022) · cites this paper as [8]

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Advances in visual prostheses: engineering and biological challenges
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cGMP‐dependent cone photoreceptor degeneration in the cpfl1 mouse retina
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Rhodopsin Mutations as the Cause of Retinal Degeneration
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Authors: Cehajic-Kapetanovic, J., Singh, M. S., Zrenner, E., & MacLaren, R. E.
Affiliations: Johns Hopkins University (US)
University of Tübingen (DE)
University of Oxford (GB)
ORCID: Cehajic-Kapetanovic, Jasmina
Singh, Mandeep S.
Zrenner, Eberhart
MacLaren, Robert E.
Venue: Nature Biomedical Engineering
Publisher: Springer Science and Business Media LLC
Published: 2022-01-31
Volume: 7
Issue: 4
Pages: 387-404
ISSN: 2157-846X (ISSN-L)
DOI: 10.1038/s41551-021-00836-4
OpenAlex: W4210615010
Cited by: 79
References: 207
Citations by year: 2026: 8 · 2025: 24 · 2024: 19 · 2023: 19 · 2022: 9
FWCI: 1.85
Type: journal article
Language: en
Open access: closed
Licence: www.springernature.com/gp/researchers/text-and-data-mining (tdm)
www.springernature.com/gp/researchers/text-and-data-mining (vor)
Locations: Nature Biomedical Engineering (publishedVersion)
PubMed (publishedVersion)
Funders: Oxford Biomedical Research Centre.
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinal Development and Disorders
Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
Keywords: vision restoration, retinal degeneration, photoreceptor loss, optogenetic therapy, cell transplantation, retinal prosthesis, age-related macular degeneration, gene therapy, genome editing, visual perception
MeSH terms: Humans, Retina, Retinal Degeneration, Vision, Ocular, Cell Transplantation, Bioengineering

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