Fusion-independent satellite cell communication to muscle fibers during load-induced hypertrophy
Open accessAbstract
Abstract The “canonical” function of Pax7+ muscle stem cells (satellite cells) during hypertrophic growth of adult muscle fibers is myonuclear donation via fusion to support increased transcriptional output. In recent years, however, emerging evidence suggests that satellite cells play an important secretory role in promoting load-mediated growth. Utilizing genetically modified mouse models of delayed satellite cell fusion and in vivo extracellular vesicle (EV) tracking, we provide evidence for satellite cell communication to muscle fibers during hypertrophy. Myogenic progenitor cell-EV-mediated communication to myotubes in vitro influences extracellular matrix (ECM)-related gene expression, which is congruent with in vivo overload experiments involving satellite cell depletion, as well as in silico analyses. Satellite cell-derived EVs can transfer a Cre-induced, cytoplasmic-localized fluorescent reporter to muscle cells as well as microRNAs that regulate ECM genes such as matrix metalloproteinase 9 (Mmp9), which may facilitate growth. Delayed satellite cell fusion did not limit long-term load-induced muscle hypertrophy indicating that early fusion-independent communication from satellite cells to muscle fibers is an underappreciated aspect of satellite cell biology. We cannot exclude the possibility that satellite cell-mediated myonuclear accretion is necessary to maintain prolonged growth, specifically in the later phases of adaptation, but these data collectively highlight how EV delivery from satellite cells can directly contribute to mechanical load-induced muscle fiber hypertrophy, independent of cell fusion to the fiber.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
This facilitates an explosive re-accumulation of translational capacity, a process further optimized by early, fusion-independent communication from resident satellite cells that creates a highly permissive environment for long-term growth.
“This facilitates an explosive re-accumulation of translational capacity, a process further optimized by early, fusion-independent communication from resident satellite cells that creates a highly permissive environment for long-term growth [122,123,124].”
From Ribosome Biogenesis as a Putative Bottleneck to Skeletal Muscle Hypertrophy: Mechanisms, Human Evidence, and Practical Modulators (2026) · cites this paper as [123]
The Results section (‘Delayed Satellite Cell Fusion Does Not Inhibit Long-Term Muscle Hypertrophy’; page unavailable) says that satellite-cell secretory products delivered early during loading may promote prolonged growth without early fusion. The paper does not establish explosive re-accumulation of translational capacity or show that this communication optimizes that process; it discusses extracellular-matrix-related signaling instead. (LLM, conf=0.86)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
2 retracted
Zhang, S., Zhang, C., Liu, W., et al. (2015) · International Journal of Oncology · doi:10.3892/ijo.2015.3117 · Cited by 36 · see citing works
RetractedHu, H., Xu, H., Lu, F., Zhang, J., Xu, L. L., Xu, S., Jiang, H., Zeng, Q., Chen, E., & He, Z. (2020) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2020.00259 · Cited by 30 · see citing works
RetractedValadi, H., Ekström, K., Bossios, A., Sjöstrand, M., Lee, J. J., & Lötvall, J. O. (2007) · Nature Cell Biology · doi:10.1038/ncb1596 · Cited by 12,834 · see citing works
A robust and high-throughput Cre reporting and characterization system for the whole mouse brain
Madisen, L., Zwingman, T. A., Sunkin, S. M., Oh, S. W., Zariwala, H. A., Gu, H., Ng, L. L., Palmiter, R. D., Hawrylycz, M. J., Jones, A. R., et al. (2010) · Nature Neuroscience · doi:10.1038/nn.2467 · Cited by 6,907 · see citing works
Amplification efficiency: linking baseline and bias in the analysis of quantitative PCR data
Ruijter, J. M., Ramakers, C., Hoogaars, W. M. H., Karlen, Y., Bakker, O., van den Hoff, M. J. B., & Moorman, A. F. M. (2009) · Nucleic Acids Research · doi:10.1093/nar/gkp045 · Cited by 3,043 · see citing works
Pax7 Is Required for the Specification of Myogenic Satellite Cells
Seale, P., Sabourin, L. A., Girgis-Gabardo, A., Mansouri, A., Gruß, P., & Rudnicki, M. A. (2000) · Cell · doi:10.1016/s0092-8674(00)00066-0 · Cited by 2,345 · see citing works
Mesopelagic fish biomass and trophic efficiency of the open ocean
Irigoien, X., Klevjer, J., Røstad, A., Martínez, U., Boyra, G., Acuña, J. L., Bode, A., Echevarrı́a, F., González-Gordillo, J. L., Hernández‐León, S., et al. (2014) · DIGITAL.CSIC (Spanish National Research Council (CSIC)) · Cited by 1,813 · see citing works
miRWalk: An online resource for prediction of microRNA binding sites
Sticht, C., Torre, C. D. L., Parveen, A., & Gretz, N. (2018) · PLoS ONE · doi:10.1371/journal.pone.0206239 · Cited by 1,807 · see citing works
DIANA-miRPath v3.0: deciphering microRNA function with experimental support
Vlachos, I. S., Zagganas, K., Paraskevopoulou, M. D., Georgakilas, G. K., Karagkouni, D., Vergoulis, T., Dalamagas, T., & Hatzigeorgiou, A. G. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv403 · Cited by 1,682 · see citing works
Dillies, M., Rau, A., Aubert, J., Hennequet‐Antier, C., Jeanmougin, M., Servant, N., Keime, C., Marot, G., Castel, D., Estellé, J., et al. (2012) · Briefings in Bioinformatics · doi:10.1093/bib/bbs046 · Cited by 1,281 · see citing works
Murphy, M. M., Lawson, J. A., Mathew, S. J., Hutcheson, D. A., & Kardon, G. (2011) · Development · doi:10.1242/dev.064162 · Cited by 1,249 · see citing works
The ConsensusPathDB interaction database: 2013 update
Kamburov, A., Stelzl, U., Lehrach, H. R., & Herwig, R. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks1055 · Cited by 808 · see citing works
Effective fiber hypertrophy in satellite cell-depleted skeletal muscle
McCarthy, J. J., Mula, J., Miyazaki, M., Erfani, R., Garrison, K., Farooqui, A. B., Srikuea, R., Lawson, B. A., Grimes, B., Keller, C., et al. (2011) · Development · doi:10.1242/dev.068858 · Cited by 616 · see citing works
Self-citationSicco, C. L., Reverberi, D., Balbi, C., Ulivi, V., Principi, E., Pascucci, L., Becherini, P., Bosco, M. C., Varesio, L., Franzin, C., et al. (2017) · Stem Cells Translational Medicine · doi:10.1002/sctm.16-0363 · Cited by 560 · see citing works
DIANA miRPath v.2.0: investigating the combinatorial effect of microRNAs in pathways
Vlachos, I. S., Kostoulas, N., Vergoulis, T., Georgakilas, G. K., Reczko, M., Maragkakis, M., Paraskevopoulou, M. D., Prionidis, K., Dalamagas, T., & Hatzigeorgiou, A. G. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks494 · Cited by 523 · see citing works
Dynamics of muscle fibre growth during postnatal mouse development
White, R. B., Biérinx, A.-S., Gnocchi, V. F., & Zammit, P. S. (2010) · BMC Developmental Biology · doi:10.1186/1471-213x-10-21 · Cited by 512 · see citing works
Mesenchymal‐stem‐cell‐derived exosomes accelerate skeletal muscle regeneration
Nakamura, Y., Miyaki, S., Ishitobi, H., Matsuyama, S., Nakasa, T., Kamei, N., Akimoto, T., Higashi, Y., & Ochi, M. (2015) · FEBS Letters · doi:10.1016/j.febslet.2015.03.031 · Cited by 511 · see citing works
MG53 nucleates assembly of cell membrane repair machinery
Cai, C., Masumiya, H., Weisleder, N. L., Matsuda, N., Nishi, M., Hwang, M., Ko, J., Lin, P., Thornton, A., Zhao, X., et al. (2008) · Nature Cell Biology · doi:10.1038/ncb1812 · Cited by 472 · see citing works
Differential fates of biomolecules delivered to target cells via extracellular vesicles
Kanada, M., Bachmann, M. H., Hardy, J. W., Frimannson, D. O., Bronsart, L. L., Wang, A., Sylvester, M. D., Schmidt, T. L., Kaspar, R. L., Butte, M. J., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1418401112 · Cited by 467 · see citing works
Transcriptomic profiling of skeletal muscle adaptations to exercise and inactivity
Pillon, N. J., Gabriel, B. M., Dollet, L., Smith, J. A. B., Sardón Puig, L., Botella, J., Bishop, D. J., Krook, A., & Zierath, J. R. (2020) · Nature Communications · doi:10.1038/s41467-019-13869-w · Cited by 457 · see citing works
Petrella, J. K., Kim, J.-S., Mayhew, D. L., Cross, J. M., & Bamman, M. M. (2008) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01215.2007 · Cited by 435 · cited 1× · see citing works
“a certain threshold of growth to control the “myonuclear domain” (22, 95, 96), which is the maximal area that each myonucleus can transcriptionally govern, although this limit is equivocal and may be muscle and/or fiber type-specific (22, 42, 61, 82, 83).”
BackgroundFry, C. S., Lee, J. D., Mula, J., Kirby, T. J., Jackson, J. R., Liu, F., Yang, L., Mendias, C. L., Dupont-Versteegden, E. E., McCarthy, J. J., et al. (2015) · Nature Medicine · doi:10.1038/nm.3710 · Cited by 432 · see citing works
Analyzing and interpreting genome data at the network level with ConsensusPathDB
Herwig, R., Hardt, C., Lienhard, M., & Kamburov, A. (2016) · Nature Protocols · doi:10.1038/nprot.2016.117 · Cited by 404 · see citing works
Isolation of skeletal muscle stem cells by fluorescence-activated cell sorting
Liu, L. A., Cheung, T. H., Charville, G. W., & Rando, T. A. (2015) · Nature Protocols · doi:10.1038/nprot.2015.110 · Cited by 396 · see citing works
A lipase-independent pathway of lipid release and immune modulation by adipocytes
Flaherty, S. E., Grijalva, A., Xu, X., Ables, E. V., Nomani, A., & Ferrante, A. W. (2019) · Science · doi:10.1126/science.aaw2586 · Cited by 378 · see citing works
Fry, C. S., Kirby, T. J., Kosmac, K., McCarthy, J. J., & Peterson, C. A. (2017) · Cell stem cell · doi:10.1016/j.stem.2016.09.010 · Cited by 372 · see citing works
Self-citationMechanism of Ca2+-triggered ESCRT assembly and regulation of cell membrane repair
Scheffer, L., Sreetama, S. C., Sharma, N., Medikayala, S., Brown, K. J., Defour, A., & Jaiswal, J. K. (2014) · Nature Communications · doi:10.1038/ncomms6646 · Cited by 358 · see citing works
Petrella, J. K., Kim, J.-S., Cross, J. M., Kosek, D. J., & Bamman, M. M. (2006) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00190.2006 · Cited by 356 · see citing works
A Muscle Stem Cell Support Group: Coordinated Cellular Responses in Muscle Regeneration
Wosczyna, M. N., & Rando, T. A. (2018) · Developmental Cell · doi:10.1016/j.devcel.2018.06.018 · Cited by 353 · see citing works
Verma, M., Asakura, Y., Murakonda, B. S. R., Pengo, T., Latroche, C., Chazaud, B., McLoon, L. K., & Asakura, A. (2018) · Cell stem cell · doi:10.1016/j.stem.2018.09.007 · Cited by 349 · see citing works
Orphan nuclear receptor NR4A1 regulates transforming growth factor-β signaling and fibrosis
Palumbo‐Zerr, K., Zerr, P., Distler, A., Fliehr, J., Mancuso, R., Huang, J., Mielenz, D., Tomčík, M., Fürnrohr, B. G., Scholtysek, C., et al. (2015) · Nature Medicine · doi:10.1038/nm.3777 · Cited by 344 · see citing works
Human skeletal muscle possesses an epigenetic memory of hypertrophy
Seaborne, R. A., Strauss, J., Cocks, M., Shepherd, S., O’Brien, T. D., van Someren, K. A., Bell, P. G., Murgatroyd, C., Morton, J. P., Stewart, C. E., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-20287-3 · Cited by 334 · see citing works
Myonuclei acquired by overload exercise precede hypertrophy and are not lost on detraining
Bruusgaard, J. C., Johansen, I. B., Egner, I. M., Rana, Z. A., & Gundersen, K. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0913935107 · Cited by 327 · see citing works
Pearson, R. A., Gonzalez-Cordero, A., West, E. L., Ribeiro, J., Aghaizu, N. D., Goh, D., Sampson, R. D., Georgiadis, A., Waldron, P. V., Durán, Y., et al. (2016) · Nature Communications · doi:10.1038/ncomms13029 · Cited by 311 · see citing works
Brack, A. S., Bildsoe, H., & Hughes, S. M. (2005) · Journal of Cell Science · doi:10.1242/jcs.02602 · Cited by 308 · see citing works
Muscle stem cells contribute to myofibres in sedentary adult mice
Keefe, A. C., Lawson, J. A., Flygare, S. D., Fox, Z. D., Colasanto, M. P., Mathew, S. J., Yandell, M., & Kardon, G. (2015) · Nature Communications · doi:10.1038/ncomms8087 · Cited by 279 · cited 4× · see citing works
“caution for accurately determining the contribution of satellite cell fusion to muscle fibers (21, 59, 73, 93, 114).”
BackgroundMethodInfluentialRetinal transplantation of photoreceptors results in donor–host cytoplasmic exchange
Santos‐Ferreira, T., Llonch, S., Borsch, O., Postel, K., Haas, J., & Ader, M. (2016) · Nature Communications · doi:10.1038/ncomms13028 · Cited by 277 · see citing works
Dysferlin and muscle membrane repair
Han, R., & Campbell, K. P. (2007) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2007.07.001 · Cited by 275 · see citing works
Regulation of the muscle fiber micro environment by activated satellite cells during hypertrophy
Fry, C. S., Lee, J. D., Jackson, J. R., Kirby, T. J., Stasko, S. A., Liu, H., Dupont‐Versteegden, E. E., McCarthy, J. J., & Peterson, C. A. (2014) · The FASEB Journal · doi:10.1096/fj.13-239426 · Cited by 273 · see citing works
Self-citationReprogramming of the tumour microenvironment by stromal PTEN-regulated miR-320
Bronisz, A., Godlewski, J. A., Wallace, J. A., Merchant, A. S., Nowicki, M. O., Mathsyaraja, H., Srinivasan, R., Trimboli, A. J., Martin, C. K., Li, F., et al. (2011) · Nature Cell Biology · doi:10.1038/ncb2396 · Cited by 270 · see citing works
Lommel, S., Benesch, S., Rottner, K., Franz, T., Wehland, J., & Kühn, R. (2001) · EMBO Reports · doi:10.1093/embo-reports/kve197 · Cited by 259 · see citing works
MyoVision: software for automated high-content analysis of skeletal muscle immunohistochemistry
Wen, Y., Murach, K. A., Vechetti, I. J., Fry, C. S., Vickery, C., Peterson, C. A., McCarthy, J. J., & Campbell, K. S. (2017) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00762.2017 · Cited by 251 · see citing works
Self-citationBlaauw, B., Canato, M., Agatea, L., Toniolo, L., Mammucari, C., Masiero, E., Abraham, R., Sandri, M., Schiaffino, S., & Reggiani, C. (2009) · The FASEB Journal · doi:10.1096/fj.09-131870 · Cited by 244 · see citing works
Deryugina, E. I., & Quigley, J. P. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2009.09.017 · Cited by 234 · see citing works
Kadi, F., & Thornell, L. (2000) · Histochemistry and Cell Biology · doi:10.1007/s004180050012 · Cited by 232 · see citing works
Matrix metalloproteinases and skeletal muscle: A brief review
Carmeli, E., Moas, M., Reznick, A. Z., & Coleman, R. (2004) · Muscle & Nerve · doi:10.1002/mus.10529 · Cited by 219 · see citing works
Wu, S., Wu, Y.-Y., & Capecchi, M. (2006) · Development · doi:10.1242/dev.02236 · Cited by 206 · see citing works
Satellite cell depletion prevents fiber hypertrophy in skeletal muscle
Egner, I. M., Bruusgaard, J. C., & Gundersen, K. (2016) · Development · doi:10.1242/dev.134411 · Cited by 203 · see citing works
Choi, J. S., Yoon, H. I., Lee, K. S., Choi, Y. C., Yang, S. H., Kim, I.-S., & Cho, Y. W. (2015) · Journal of Controlled Release · doi:10.1016/j.jconrel.2015.12.018 · Cited by 197 · see citing works
Muscle hypertrophy driven by myostatin blockade does not require stem/precursor-cell activity
Amthor, H., Otto, A., Vulin, A., Rochat, A., Dumonceaux, J., Garcı́a, L., Mouisel, É., Hourdé, C., Macharia, R., Friedrichs, M., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0811129106 · Cited by 195 · see citing works
Mitchell, R., Mellows, B., Sheard, J., Antonioli, M., Kretz, O., Chambers, D., Zeuner, M.-T., Tomkins, J. E., Denecke, B., Musante, L., et al. (2019) · Stem cell research & therapeutics · doi:10.1186/s13287-019-1213-1 · Cited by 186 · see citing works
Alexakis, C., Partridge, T. A., & Bou–Gharios, G. (2007) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00061.2007 · Cited by 182 · see citing works
Pervasive satellite cell contribution to uninjured adult muscle fibers
Pawlikowski, B. T., Pulliam, C., Betta, N. D., Kardon, G., & Olwin, B. B. (2015) · Skeletal Muscle · doi:10.1186/s13395-015-0067-1 · Cited by 182 · see citing works
An actin-dependent annexin complex mediates plasma membrane repair in muscle
Demonbreun, A. R., Quattrocelli, M., Barefield, D. Y., Allen, M. V., Swanson, K. E., & McNally, E. M. (2016) · The Journal of Cell Biology · doi:10.1083/jcb.201512022 · Cited by 180 · see citing works
Li, H., Mittal, A., Makonchuk, D. Y., Bhatnagar, S., & Kumar, A. (2009) · Human Molecular Genetics · doi:10.1093/hmg/ddp191 · Cited by 179 · see citing works
Estrogen Regulates the Satellite Cell Compartment in Females
Collins, B. C., Arpke, R. W., Larson, A. A., Baumann, C. W., Xie, N., Cabelka, C. A., Nash, N. L., Juppi, H., Laakkonen, E. K., Sipilä, S., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.06.025 · Cited by 177 · see citing works
Forterre, A. V., Jalabert, A., Berger, E., Baudet, M., Chikh, K., Errazuriz-Cerda, E., Larichaudy, J. D., Chanon, S., Weiss‐Gayet, M., Hesse, A.-M., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0084153 · Cited by 176 · see citing works
Nur77 Coordinately Regulates Expression of Genes Linked to Glucose Metabolism in Skeletal Muscle
Chao, L. C., Zhang, Z., Pei, L., Saito, T., Tontonoz, P., & Pilch, P. F. (2007) · Molecular Endocrinology · doi:10.1210/me.2007-0169 · Cited by 173 · see citing works
Lee, S., Huynh, T. V., Lee, Y., Sebald, S. M., Wilcox‐Adelman, S. A., Iwamori, N., Lepper, C., Matzuk, M. M., & Fan, C. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1206410109 · Cited by 167 · see citing works
In Vivo Migration of Transplanted Myoblasts Requires Matrix Metalloproteinase Activity
Fahime, E. E., Torrente, Y., Caron, N. J., Bresolin, M. D., & Tremblay, J. P. (2000) · Experimental Cell Research · doi:10.1006/excr.2000.4962 · Cited by 160 · see citing works
Nur77 Regulates Lipolysis in Skeletal Muscle Cells
Maxwell, M., Cleasby, M. E., Harding, A. S., Stark, A., Cooney, G. J., & Muscat, G. E. O. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m409580200 · Cited by 158 · see citing works
Requirement of myomaker-mediated stem cell fusion for skeletal muscle hypertrophy
Goh, Q., & Millay, D. P. (2017) · eLife · doi:10.7554/elife.20007 · Cited by 157 · see citing works
Farup, J., Madaro, L., Puri, P., & Mikkelsen, U. R. (2015) · Cell Death and Disease · doi:10.1038/cddis.2015.198 · Cited by 156 · see citing works
JunB transcription factor maintains skeletal muscle mass and promotes hypertrophy
Raffaello, A., Milan, G., Masiero, E., Carnio, S., Lee, D., Lanfranchi, G., Goldberg, A. L., & Sandri, M. (2010) · Journal of Cell Biology · doi:10.1083/jcb.201001136 · Cited by 156 · see citing works
Murach, K. A., White, S. H., Wen, Y., Ho, A., Dupont-Versteegden, E. E., McCarthy, J. J., & Peterson, C. A. (2017) · Skeletal Muscle · doi:10.1186/s13395-017-0132-z · Cited by 156 · see citing works
Le Bihan, M.-C., Bigot, A., Jensen, S. S., Dennis, J. L., Rogowska-Wrzesinska, A., Lainé, J., Gache, V., Furling, D., Jensen, O. N., Voit, T., et al. (2012) · Journal of Proteomics · doi:10.1016/j.jprot.2012.09.008 · Cited by 153 · see citing works
Cossetti, C., Lugini, L., Astrologo, L., Saggio, I., Fais, S., & Spadafora, C. (2014) · PLoS ONE · doi:10.1371/journal.pone.0101629 · Cited by 151 · see citing works
The Acute Satellite Cell Response and Skeletal Muscle Hypertrophy following Resistance Training
Bellamy, L. M., Joanisse, S., Grubb, A., Mitchell, C. J., McKay, B. R., Phillips, S. M., Baker, S., & Parise, G. (2014) · PLoS ONE · doi:10.1371/journal.pone.0109739 · Cited by 149 · see citing works
The role of extracellular vesicles in skeletal muscle and systematic adaptation to exercise
Vechetti, I. J., Valentino, T., Mobley, C. B., & McCarthy, J. J. (2021) · The Journal of Physiology · doi:10.1113/jp278929 · Cited by 141 · see citing works
Self-citationStarring or supporting role? Satellite cells and skeletal muscle fiber size regulation
Murach, K. A., Fry, C. S., Kirby, T. J., Jackson, J. R., Lee, J. D., White, S. H., Dupont-Versteegden, E. E., McCarthy, J. J., & Peterson, C. A. (2018) · Physiology · doi:10.1152/physiol.00019.2017 · Cited by 137 · see citing works
Self-citationA Reinterpretation of Cell Transplantation: GFP Transfer From Donor to Host Photoreceptors
Ortín-Martínez, A., Tsai, E. L. S., Nickerson, P. E. B., Bergeret, M., Lu, Y., Smiley, S., Comanita, L., & Wallace, V. A. (2016) · Stem Cells · doi:10.1002/stem.2552 · Cited by 136 · see citing works
Guérin, C., & Holland, P. C. (1995) · Developmental Dynamics · doi:10.1002/aja.1002020109 · Cited by 134 · see citing works
Bachman, J. F., Klose, A. M., Liu, W., Paris, N. D., Blanc, R. S., Schmalz, M., Knapp, E. K., & Chakkalakal, J. V. (2018) · Development · doi:10.1242/dev.167197 · Cited by 133 · see citing works
Fibre type‐specific satellite cell response to aerobic training in sedentary adults
Fry, C. S., Noehren, B. W., Mula, J., Ubele, M. F., Westgate, P. M., Kern, P. A., & Peterson, C. A. (2014) · The Journal of Physiology · doi:10.1113/jphysiol.2014.271288 · Cited by 132 · see citing works
Self-citationLek, A., Evesson, F. J., Lemckert, F. A., Redpath, G., Piper, A., Turnbull, L., Whitchurch, C. B., North, K. N., & Cooper, S. T. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.3560-12.2013 · Cited by 132 · see citing works
Biomarker system for studying muscle, stem cells, and cancer in vivo
Nishijo, K., Hosoyama, T., Bjornson, C. R. R., Schaffer, B. S., Prajapati, S. I., Bahadur, A. N., Hansen, M. S. T., Blandford, M. C., McCleish, A. T., Rubin, B. P., et al. (2009) · The FASEB Journal · doi:10.1096/fj.08-128116 · Cited by 132 · see citing works
Prediction of microRNAs affecting mRNA expression during retinal development
Arora, A., Guduric‐Fuchs, J., Harwood, L., Dellett, M., Cogliati, T., & Simpson, D. A. C. (2010) · BMC Developmental Biology · doi:10.1186/1471-213x-10-1 · Cited by 127 · see citing works
Myostatin inhibition induces muscle fibre hypertrophy prior to satellite cell activation
Wang, Q., & McPherron, A. C. (2012) · The Journal of Physiology · doi:10.1113/jphysiol.2011.226001 · Cited by 122 · see citing works
Muscle growth after postdevelopmental myostatin gene knockout
Welle, S. L., Bhatt, K. S., Pinkert, C. A., Tawil, R., & Thornton, C. A. (2006) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00531.2006 · Cited by 113 · see citing works
Li, H., Mittal, A., Paul, P. K., Kumar, M., Srivastava, D. S., Tyagi, S. C., & Kumar, A. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m805546200 · Cited by 112 · see citing works
Myonuclear accretion is a determinant of exercise-induced remodeling in skeletal muscle
Goh, Q., Song, T., Petrany, M. J., Cramer, A., Sun, C., Sadayappan, S., Lee, S., & Millay, D. P. (2019) · eLife · doi:10.7554/elife.44876 · Cited by 110 · see citing works
The actin regulator N-WASp is required for muscle-cell fusion in mice
Gruenbaum‐Cohen, Y., Harel, I., Umansky, K. B., Tzahor, E., Snapper, S. B., Shilo, B., & Schejter, E. D. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1116065109 · Cited by 106 · see citing works
Álvarez-Aznar, A., Martínez‐Corral, I., Daubel, N., Betsholtz, C., Mäkinen, T., & Gaengel, K. (2019) · Transgenic Research · doi:10.1007/s11248-019-00177-8 · Cited by 106 · see citing works
Tierney, M. T., Gromova, A., Sesillo, F. B., Sala, D., Spenlé, C., Orend, G., & Sacco, A. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.01.072 · Cited by 104 · see citing works
Jimenez, L., Yu, H., McKenzie, A. J., Franklin, J. L., Patton, J. G., Liu, Q., & Weaver, A. M. (2019) · Journal of Proteome Research · doi:10.1021/acs.jproteome.8b00647 · Cited by 101 · see citing works
Time course of gene expression during mouse skeletal muscle hypertrophy
Chaillou, T., Lee, J. D., England, J. H., Esser, K. A., & McCarthy, J. J. (2013) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00611.2013 · Cited by 97 · see citing works
Self-citationMurach, K. A., Englund, D. A., Dupont‐Versteegden, E. E., McCarthy, J. J., & Peterson, C. A. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00635 · Cited by 96 · see citing works
Self-citationProdrug suicide gene therapy for cancer targeted intracellular by mesenchymal stem cell exosomes
Altanerova, U., Jakubechova, J., Benejova, K., Priščáková, P., Pešta, M., Pitule, P., Topolčan, O., Kausitz, J., Zdurienčíková, M., Repiská, V., et al. (2018) · International Journal of Cancer · doi:10.1002/ijc.31792 · Cited by 94 · see citing works
Zimowska, M., Brzóska, E., Swierczynska, M. M., Stremińska, W., & Moraczewski, J. (2008) · The International Journal of Developmental Biology · doi:10.1387/ijdb.072331mz · Cited by 92 · see citing works
Kawamura, K., Takano, K., Suetsugu, S., Kurisu, S., Yamazaki, D., Miki, H., Takenawa, T., & Endo, T. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m408057200 · Cited by 91 · see citing works
Englund, D. A., Murach, K. A., Dungan, C. M., Figueiredo, V. C., Vechetti, I. J., Dupont‐Versteegden, E. E., McCarthy, J. J., & Peterson, C. A. (2020) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00090.2020 · Cited by 90 · see citing works
Self-citationXu, K., Liu, X., Mao, X., et al. (2015) · Cellular Physiology and Biochemistry · doi:10.1159/000369715 · Cited by 89 · see citing works
Kirby, T. J., Patel, R. M., McClintock, T. S., Dupont‐Versteegden, E. E., Peterson, C. A., & McCarthy, J. J. (2016) · Molecular Biology of the Cell · doi:10.1091/mbc.e15-08-0585 · Cited by 86 · see citing works
Self-citationIntracellular sodium elevation reprograms cardiac metabolism
Aksentijević, D., Karlstaedt, A., Basalay, M. V., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-18160-x · Cited by 85 · see citing works
Dahiya, S., Bhatnagar, S., Hindi, S. M., Jiang, C., Paul, P. K., Kuang, S., & Kumar, A. (2011) · Human Molecular Genetics · doi:10.1093/hmg/ddr362 · Cited by 77 · see citing works
Fukuda, S., Kaneshige, A., Kaji, T., Noguchi, Y.-T., Takemoto, Y., Zhang, L., Tsujikawa, K., Kokubo, H., Uezumi, A., Maehara, K., et al. (2019) · eLife · doi:10.7554/elife.48284 · Cited by 75 · see citing works
Srf controls satellite cell fusion through the maintenance of actin architecture
Randrianarison-Huetz, V., Papaefthymiou, A., Herledan, G., Noviello, C., Faradova, U., Collard, L., Pincini, A., Schol, E., Decaux, J., Maire, P., et al. (2017) · The Journal of Cell Biology · doi:10.1083/jcb.201705130 · Cited by 72 · see citing works
Comparative analysis of CreER transgenic mice for the study of brain macrophages: A case study
Chappell‐Maor, L., Kolesnikov, M., Kim, J., Shemer, A., Haimon, Z., Grozovski, J., Boura‐Halfon, S., Masuda, T., Prinz, M., & Jung, S. (2020) · European Journal of Immunology · doi:10.1002/eji.201948342 · Cited by 70 · see citing works
Deshmukh, A. S., Cox, J., Jensen, L. J., Meissner, F., & Mann, M. (2015) · Journal of Proteome Research · doi:10.1021/acs.jproteome.5b00720 · Cited by 67 · see citing works
Xu, Y., Zhang, Z., Zheng, Y.-F., et al. (2015) · Spine · doi:10.1097/brs.0000000000001375 · Cited by 64 · see citing works
MyD88 promotes myoblast fusion in a cell-autonomous manner
Hindi, S. M., Shin, J. S., Gallot, Y. S., Straughn, A. R., Simionescu-Bankston, A., Hindi, L., Xiong, G., Friedland, R. P., & Kumar, A. (2017) · Nature Communications · doi:10.1038/s41467-017-01866-w · Cited by 61 · see citing works
Chenette, D. M., Cadwallader, A. B., Antwine, T. L., Larkin, L. C., Wang, J., Olwin, B. B., & Schneider, R. J. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.06.095 · Cited by 60 · see citing works
Muscle Fiber Hypertrophy and Myonuclei Addition: A Systematic Review and Meta-analysis
Conceição, M. S., VECHIN, F. C., Lixandrão, M. E., Damas, F., Libardi, C. A., Tricoli, V., Roschel, H., CAMERA, D. M., & Ugrinowitsch, C. (2018) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000001593 · Cited by 60 · see citing works
Omairi, S., Matsakas, A., Degens, H., Kretz, O., Hansson, K., Solbrå, A. V., Bruusgaard, J. C., Joch, B., Sartori, R., Giallourou, N., et al. (2016) · eLife · doi:10.7554/elife.16940 · Cited by 57 · see citing works
M2 Macrophages Promote HCC Cells Invasion and Migration via miR-149-5p/MMP9 Signaling
Liu, G., Yin, L., Ouyang, X., et al. (2019) · Journal of Cancer · doi:10.7150/jca.35444 · Cited by 57 · see citing works
A novel method for the quantification of fatty infiltration in skeletal muscle
Biltz, N. K., & Meyer, G. A. (2017) · Skeletal Muscle · doi:10.1186/s13395-016-0118-2 · Cited by 53 · see citing works
The myonuclear DNA methylome in response to an acute hypertrophic stimulus
von Walden, F., Rea, M., Mobley, C. B., Fondufe‐Mittendorf, Y. N., McCarthy, J. J., Peterson, C. A., & Murach, K. A. (2020) · Epigenetics · doi:10.1080/15592294.2020.1755581 · Cited by 53 · see citing works
Self-citationVan Hove, H., Antunes, A. R. P., De Vlaminck, K., Scheyltjens, I., Van Ginderachter, J. A., & Movahedi, K. (2020) · European Journal of Immunology · doi:10.1002/eji.201948162 · Cited by 52 · see citing works
Patsalos, A., Pap, A., Varga, T., Trencsényi, G., Contreras, G. A., Garai, I., Papp, Z. L., Dezsö, B., Pintye, É., & Nagy, L. (2017) · The Journal of Physiology · doi:10.1113/jp274361 · Cited by 51 · see citing works
Accornero, F., Kanisicak, O., Tjondrokoesoemo, A., et al. (2014) · Human Molecular Genetics · doi:10.1093/hmg/ddu413 · Cited by 50 · see citing works
The Orphan Nuclear Receptor Nur77 Is a Determinant of Myofiber Size and Muscle Mass in Mice
Tontonoz, P., Cortez-Toledo, O., Wroblewski, K., Hong, C., Lim, L., Carranza, R., Conneely, O. M., METZGER, D., & Chao, L. C. (2015) · Molecular and Cellular Biology · doi:10.1128/mcb.00715-14 · Cited by 49 · see citing works
McCarthy, J. J., Dupont‐Versteegden, E. E., Fry, C. S., Murach, K. A., & Peterson, C. A. (2017) · Development · doi:10.1242/dev.145797 · Cited by 49 · see citing works
Self-citationSTOP floxing around: Specificity and leakiness of inducible Cre/loxP systems
Stifter, S. A., & Greter, M. (2020) · European Journal of Immunology · doi:10.1002/eji.202048546 · Cited by 48 · see citing works
Osteogenic potential of alpha smooth muscle actin expressing muscle resident progenitor cells
Matthews, B. G., Torreggiani, E., Roeder, E., Matić, I., Grčević, D., & Kalajzić, I. (2015) · Bone · doi:10.1016/j.bone.2015.12.010 · Cited by 45 · see citing works
Petrosino, J. M., Leask, A., & Accornero, F. (2018) · The FASEB Journal · doi:10.1096/fj.201800622rr · Cited by 45 · see citing works
Wyss, R., Grasso, L., Wolf, C., Grosse, W., Demurtas, D., & Vogel, H. (2014) · Analytical Chemistry · doi:10.1021/ac501801m · Cited by 44 · see citing works
Decrease of MMP-9 Activity Improves Soleus Muscle Regeneration
Zimowska, M., Olszynski, K. H., Swierczynska, M. M., et al. (2012) · Tissue Engineering Part A · doi:10.1089/ten.tea.2011.0459 · Cited by 43 · see citing works
Kanzleiter, T., Preston, E., Wilks, D. L., Ho, B., Benrick, A., Reznick, J., Heilbronn, L. K., Turner, N. A., & Cooney, G. J. (2010) · Diabetologia · doi:10.1007/s00125-010-1703-2 · Cited by 42 · see citing works
Palmieri, D., Capponi, S., Geroldi, A., et al. (2013) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2013.11.092 · Cited by 41 · see citing works
Acute mechanical overload increases IGF-I and MMP-9 mRNA in 3D tissue-engineered skeletal muscle
Player, D. J., Martin, N. R. W., Passey, S. L., Sharples, A. P., Mudera, V., & Lewis, M. P. (2014) · Biotechnology Letters · doi:10.1007/s10529-014-1464-y · Cited by 41 · see citing works
miR-486-5p regulates the migration and invasion of colorectal cancer cells through targeting PIK3R1
Zhang, Y., Fu, J. F., Zhang, Z., et al. (2018) · Oncology Letters · doi:10.3892/ol.2018.8233 · Cited by 41 · see citing works
Yeghiazaryan, M., Żybura-Broda, K., Cabaj, A. M., Włodarczyk, J., Sławińska, U., Rylski, M., & Wilczynski, G. M. (2012) · Histochemistry and Cell Biology · doi:10.1007/s00418-012-0940-5 · Cited by 38 · see citing works
Ventayol, M., Viñas, J. L., Solà, A., et al. (2014) · Cell Death and Disease · doi:10.1038/cddis.2014.2 · Cited by 37 · see citing works
Synergist Ablation as a Rodent Model to Study Satellite Cell Dynamics in Adult Skeletal Muscle
Kirby, T. J., McCarthy, J. J., Peterson, C. A., & Fry, C. S. (2016) · Methods in molecular biology · doi:10.1007/978-1-4939-3810-0_4 · Cited by 37 · see citing works
Self-citationAkt1 deficiency diminishes skeletal muscle hypertrophy by reducing satellite cell proliferation
Moriya, N., & Miyazaki, M. (2018) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00336.2017 · Cited by 37 · see citing works
Satellite cells express distinct patterns of myogenic proteins in immature skeletal muscle
Schultz, E., Chamberlain, C. S., McCormick, K. M., & Mozdziak, P. E. (2006) · Developmental Dynamics · doi:10.1002/dvdy.20976 · Cited by 36 · see citing works
Resident muscle stem cells are not required for testosterone-induced skeletal muscle hypertrophy
Englund, D. A., Peck, B. D., Murach, K. A., Neal, A. C., Caldwell, H. A., McCarthy, J. J., Peterson, C. A., & Dupont‐Versteegden, E. E. (2019) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00260.2019 · Cited by 35 · see citing works
Self-citationZhen, Y., Liu, J., Huang, Y., et al. (2017) · Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics · doi:10.3727/096504016x14800889609439 · Cited by 34 · see citing works
MicroRNA-24 attenuates vascular remodeling in diabetic rats through PI3K/Akt signaling pathway
Cai, W., Zhang, J., Yang, J., Fan, Z., Liu, X., Gao, W.-Q., Zeng, P., Xiong, M., Ma, C., & Yang, J. (2019) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2019.03.002 · Cited by 34 · see citing works
Myogenic skeletal muscle satellite cells communicate by tunnelling nanotubes
Tavi, P., Korhonen, T., Hänninen, S. L., Bruton, J. D., Lööf, S., Simon, A., & Westerblad, H. (2010) · Journal of Cellular Physiology · doi:10.1002/jcp.22044 · Cited by 33 · see citing works
Cell‐Derived Vesicles for Single‐Molecule Imaging of Membrane Proteins
Moonschi, F. H., Effinger, A. K., Zhang, X., Martin, W. E., Fox-Loe, A. M., Heidary, D. K., DeRouchey, J. E., & Richards, C. I. (2014) · Angewandte Chemie International Edition · doi:10.1002/anie.201408707 · Cited by 32 · see citing works
Self-citationNur77 deletion impairs muscle growth during developmental myogenesis and muscle regeneration in mice
Cortez-Toledo, O., Schnair, C., Sangngern, P., METZGER, D., & Chao, L. C. (2017) · PLoS ONE · doi:10.1371/journal.pone.0171268 · Cited by 32 · see citing works
Shiba, N., Miyazaki, D., Yoshizawa, T., Fukushima, K., Shiba, Y., Inaba, Y., Imamura, M., Takeda, S., Koike, K., & Nakamura, A. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2015.07.008 · Cited by 30 · see citing works
MicroRNA-149* suppresses hepatic inflammatory response through antagonizing STAT3 signaling pathway
Zhang, Q.-Q., Su, J., Wang, Z., Qi, H., Ge, Z., Li, Z., Chen, W.-D., & Wang, Y.-D. (2017) · OncoTarget · doi:10.18632/oncotarget.18541 · Cited by 28 · see citing works
Pleiotropic Effects of Myocardial MMP-9 Inhibition to Prevent Ventricular Arrhythmia
Weng, C.-H., Chung, F., Chen, Y., et al. (2016) · Scientific Reports · doi:10.1038/srep38894 · Cited by 26 · see citing works
Egner, I. M., Bruusgaard, J. C., & Gundersen, K. (2017) · Development · doi:10.1242/dev.148163 · Cited by 26 · see citing works
Mehan, R. S., Greybeck, B. J., Emmons, K., et al. (2011) · Cells Tissues Organs · doi:10.1159/000323654 · Cited by 25 · see citing works
Murach, K. A., Confides, A. L., Ho, A., Jackson, J. R., Ghazala, L. S., Peterson, C. A., & Dupont‐Versteegden, E. E. (2017) · The Journal of Physiology · doi:10.1113/jp274611 · Cited by 25 · see citing works
Self-citationmiR-24 represses metastasis of human osteosarcoma cells by targeting Ack1 via AKT/MMPs pathway
Liu, Z., Liu, Z., Zhang, Y., et al. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.02.045 · Cited by 24 · see citing works
miRNA-149* suppresses liver cancer progression by down-regulating TRADD protein expression.
Feng, Q., Zhang, H.-L., Nie, X.-B., Li, Y., Chen, W.-D., & Wang, Y.-D. (2019) · American Journal of Pathology · doi:10.1016/j.ajpath.2019.10.010 · Cited by 22 · see citing works
Early accentuated muscle hypertrophy is strongly associated with myonuclear accretion
Lundberg, T. R., Martínez-Aranda, L. M., Sanz, G., Hansson, B., von Walden, F., Tesch, P. A., & Fernandez‐Gonzalo, R. (2020) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00061.2020 · Cited by 19 · see citing works
Hentati-Kallel, M., Jan, S. L., Bernard, P., Antonicelli, F. D., & Trussardi‐Régnier, A. (2016) · International Journal of Oncology · doi:10.3892/ijo.2016.3830 · Cited by 15 · see citing works
Modeling Intercellular Transfer of Biomolecules Through Tunneling Nanotubes
Suhail, Y., Kshitiz, Lee, J. C., Walker, M., Kim, D.-H., Brennan, M. D., Bader, J., & Levchenko, A. (2013) · Bulletin of Mathematical Biology · doi:10.1007/s11538-013-9819-4 · Cited by 12 · see citing works
Reibe, S., Hjorth, M., Febbraio, M., & Whitham, M. (2018) · Physiological Genomics · doi:10.1152/physiolgenomics.00127.2017 · Cited by 11 · see citing works
Intercellular Protein Transfer from Thymocytes to Thymic Epithelial Cells
Wang, H., Qiu, Y., & Zhong, X. (2016) · PLoS ONE · doi:10.1371/journal.pone.0152641 · Cited by 7 · see citing works
Blaauw, B. (2017) · FEBS Letters · doi:10.1002/1873-3468.12602 · Cited by 4 · see citing works
Limitations of the Pax7-creER T2 transgene for driving deletion of Nf1 in adult mouse muscle
Summers, M. A., Mikulec, K., Peacock, L., Little, D. G., & Schindeler, A. (2017) · The International Journal of Developmental Biology · doi:10.1387/ijdb.170182as · Cited by 2 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Exercise Metabolism and Adaptation in Skeletal Muscle
Smith, J. A. B., Murach, K. A., Dyar, K. A., & Zierath, J. R. (2023) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-023-00606-x · Cited by 342 · see citing works
Self-citationRoberts, M. D., McCarthy, J. J., Hornberger, T. A., Phillips, S. M., Mackey, A. L., Nader, G. A., Boppart, M. D., Kavazis, A. N., Reidy, P. T., Ogasawara, R., et al. (2023) · Physiological Reviews · doi:10.1152/physrev.00039.2022 · Cited by 214 · see citing works
Self-citationFusion and beyond: Satellite cell contributions to loading-induced skeletal muscle adaptation
Murach, K. A., Fry, C. S., Dupont‐Versteegden, E. E., McCarthy, J. J., & Peterson, C. A. (2021) · The FASEB Journal · doi:10.1096/fj.202101096r · Cited by 120 · see citing works
Self-citationEarly satellite cell communication creates a permissive environment for long-term muscle growth
Murach, K. A., Peck, B. D., Policastro, R. A., Vechetti, I. J., Van Pelt, D. W., Dungan, C. M., Denes, L. T., Fu, X., Brightwell, C. R., Zentner, G. E., et al. (2021) · iScience · doi:10.1016/j.isci.2021.102372 · Cited by 75 · see citing works
Self-citationMuñoz López, M., López-Gil, J. F., Ramírez de la piscina Viúdez, X., Baz-Valle, E., & Tornero Aguilera, J. F. (2026) · Cells · doi:10.3390/cells15111041 · Cited by 1 · see citing works
- Authors
- Murach, K. A., Vechetti, I. J., Van Pelt, D. W., Crow, S. E., Dungan, C. M., Figueiredo, V. C., Kosmac, K., Fu, X., Richards, C. I., Fry, C. S., McCarthy, J. J., & Peterson, C. A.
- Affiliations
- University of Kentucky (US)
- The Center for Muscle Biology, University of Kentucky, Lexington, KY 40536, USA
- Corresponding author
- Peterson, Charlotte A
- ORCID
- Venue
- Function
- Publisher
- American Physiological Society
- Published
- 2020-01-01
- Volume
- 1
- Issue
- 1
- Pages
- zqaa009-zqaa009
- ISSN
- 2633-8823 (ISSN-L)
- PMC
- PMC7448100
- OpenAlex
- W3038607983
- Cited by
- 94
- References
- 147
- Citations by year
- 2026: 10 · 2025: 16 · 2024: 14 · 2023: 15 · 2022: 11 · 2021: 21 · 2020: 7
- FWCI
- 4.38
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Function (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- NIH
- National Institute on Aging (AG049086)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK119619)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
- Keywords
- satellite cells, muscle hypertrophy, extracellular vesicles, Pax7, extracellular matrix, microRNA, MMP-9, mechanical loading, myogenic progenitor cells, myonuclear accretion
- MeSH terms
- Animals, Cell Communication, Disease Models, Animal, Extracellular Matrix, Hypertrophy, Muscle Fibers, Skeletal, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
