The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Infrared light excites cells by changing their electrical capacitance
Open accessAbstract
Optical stimulation has enabled important advances in the study of brain function and other biological processes, and holds promise for medical applications ranging from hearing restoration to cardiac pace making. In particular, pulsed laser stimulation using infrared wavelengths >1.5 μm has therapeutic potential based on its ability to directly stimulate nerves and muscles without any genetic or chemical pre-treatment. However, the mechanism of infrared stimulation has been a mystery, hindering its path to the clinic. Here we show that infrared light excites cells through a novel, highly general electrostatic mechanism. Infrared pulses are absorbed by water, producing a rapid local increase in temperature. This heating reversibly alters the electrical capacitance of the plasma membrane, depolarizing the target cell. This mechanism is fully reversible and requires only the most basic properties of cell membranes. Our findings underscore the generality of pulsed infrared stimulation and its medical potential. Pulsed infrared laser light can directly stimulate nerves and muscles, but the underlying biophysical mechanism has remained enigmatic. This study reveals that infrared pulses depolarize target cells by reversibly altering the electrical capacitance of the plasma membrane.
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Cites
The development and application of optogenetics
Fenno, L., Yizhar, O., & Deisseroth, K. (2011) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-061010-113817 · Cited by 1,822
Combined optical and electrical stimulation of neural tissue in vivo
Duke, A. R., Cayce, J. M., Malphrus, J. D., Konrad, P., Mahadevan-Jansen, A., & Jansen, E. D. (2009) · Journal of Biomedical Optics · doi:10.1117/1.3257230 · Cited by 76
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Functional and Biomimetic Materials for Engineering of the Three-Dimensional Cell Microenvironment
Huang, G., Li, F., Zhao, X., Ma, Y., Li, Y., Lin, M., Jin, G., Lu, T. J., Genin, G. M., & Xu, F. (2017) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00094 · Cited by 825
A Materials Roadmap to Functional Neural Interface Design
Wellman, S. M., Eles, J. R., Ludwig, K. A., Seymour, J. P., Michelson, N. J., McFadden, W. E., Vazquez, A. L., & Kozai, T. D. Y. (2018) · Advanced Functional Materials · doi:10.1002/adfm.201701269 · Cited by 389
The cochlear implant: historical aspects and future prospects
Eshraghi, A. A., Nazarian, R., Telischi, F. F., Rajguru, S. M., Truy, E., & Gupta, C. (2012) · The Anatomical Record · doi:10.1002/ar.22580 · Cited by 285
Wu, X., Jiang, Y., Rommelfanger, N. J., Yang, F., Zhou, Q., Yin, R., Liu, J., Cai, S., Ren, W., Shin, A., et al. (2022) · Nature Biomedical Engineering · doi:10.1038/s41551-022-00862-w · Cited by 222
Optical Stimulation of Neurons
C. Thompson, A., R. Stoddart, P., & Jansen, E. D. (2015) · Current Molecular Imaging · doi:10.2174/2211555203666141117220611 · Cited by 105
“As INS depends on a thermal gradient in time [54, 56], understanding the heat distribution in tissue may help to optimise the process and assist in emitter design.”
BackgroundMethodInfluential
Metadata
- Authors
- Shapiro, M. G., Homma, K., Villarreal, S., Richter, C.-P., & Bezanilla, F.
- Venue
- Nature Communications
- Published
- 2012-03-13
- Volume
- 3
- Issue
- 1
- Pages
- 736-736
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W1983140929
- Cited by
- 611
- References
- 2
- FWCI
- 26.92
- Type
- journal article
- Language
- en
- Open access
- hybrid
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