The DOI matches its Crossref record; 160 of the 161 references it cites were found in a registry or an index.
Optical Stimulation of Neurons
Open accessAbstract
Our capacity to interface with the nervous system remains overwhelmingly reliant on electrical stimulation devices, such as electrode arrays and cuff electrodes that can stimulate both central and peripheral nervous systems. However, electrical stimulation has to deal with multiple challenges, including selectivity, spatial resolution, mechanical stability, implant-induced injury and the subsequent inflammatory response. Optical stimulation techniques may avoid some of these challenges by providing more selective stimulation, higher spatial resolution and reduced invasiveness of the device, while also avoiding the electrical artefacts that complicate recordings of electrically stimulated neuronal activity. This review explores the current status of optical stimulation techniques, including optogenetic methods, photoactive molecule approaches and infrared neural stimulation, together with emerging techniques such as hybrid optical-electrical stimulation, nanoparticle enhanced stimulation and optoelectric methods. Infrared neural stimulation is particularly emphasised, due to the potential for direct activation of neural tissue by infrared light, as opposed to techniques that rely on the introduction of exogenous light responsive materials. However, infrared neural stimulation remains imperfectly understood, and techniques for accurately delivering light are still under development. While the various techniques reviewed here confirm the overall feasibility of optical stimulation, a number of challenges remain to be overcome before they can deliver their full potential.
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“ChR2 responds to blue (470 nm) lights to depolarise a neuron, and HR exhibits sensitivity toward green light (578 nm) that hyperpolarises the cell, thus inhibiting the propagation of action potentials [107].”
From Active Neural Interface Circuits and Systems for Selective Control of Peripheral Nerves: A Review (2024) · cites this paper as [107]
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Cites
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Next-generation probes, particles, and proteins for neural interfacing
Rivnay, J., Wang, H., Fenno, L., Deisseroth, K., & Malliaras, G. G. (2017) · Science Advances · doi:10.1126/sciadv.1601649 · Cited by 514
“For example, short-pulse IR light has been demonstrated for photothermal stimulation as a result of thermally sensitive ion channels or due to a change in cell capacitance (159).”
BackgroundBiological effects and medical applications of infrared radiation
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Multifunctional Optoelectronics via Harnessing Defects in Layered Black Phosphorus
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Metadata
- Authors
- C. Thompson, A., R. Stoddart, P., & Jansen, E. D.
- Venue
- Current Molecular Imaging
- Publisher
- Bentham Science Publishers Ltd.
- Published
- 2015-02-04
- Volume
- 3
- Issue
- 2
- Pages
- 162-177
- ISSN
- 2211-5544 (ISSN-L)
- 2211-5552
- PMC
- PMC4541079
- OpenAlex
- W1967609781
- Cited by
- 105
- References
- 161
- Citations by year
- 2026: 3 · 2025: 8 · 2024: 7 · 2023: 12 · 2022: 4 · 2021: 12 · 2020: 11 · 2019: 18 · 2018: 10 · 2017: 12 · 2016: 7 · 2015: 1
- FWCI
- 3.05
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- cc-by-nc
- Locations
- Current molecular imaging (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Swinburne figshare (Swinburne University of Technology) (submittedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (R01NS052407)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Photoreceptor and optogenetics research
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Optical Imaging and Spectroscopy Techniques
- Keywords
- optical neural stimulation, optogenetics, photoactive molecules, infrared neural stimulation, neural interfaces, light delivery, implant-induced inflammation
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