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Aldara activates TLR7-independent immune defence

Walter, Anne, Schäfer, Matthias, Cecconi, Virginia, Matter, Claudia, Urosevic-Maiwald, Mirjana, Belloni, Benedetta, Schönewolf, Nicola, Dummer, Reinhard, Bloch, Wilhelm, Werner, Sabine, Beer, Hans-Dietmar, Knuth, Alexander, van den Broek, Maries·2013·Nature Communications

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Crossref · 10.1038/ncomms2566

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  • Aldara vehicle cream contains isostearic acid, which can trigger low-grade innate immune activation, including IL-1 release.

    “It has been reported that Aldara vehicle cream contains isostearic acid, which has been reported to trigger low-grade innate immune activation, including IL-1 release38,39.”

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Research works printed but not linked: 51

  1. Lacarrubba, F., Nasca, M. R. & Micali, G. Advances in the use of topical imiquimod to treat dermatologic disorders. Ther. Clin. Risk Manage. 4, 87–97 (2008) . · DOI
  2. Navi, D. & Huntley, A. Imiquimod 5 percent cream and the treatment of cutaneous malignancy. Dermatol. J. 10, 4 (2004) .
  3. Oldfield, V., Keating, G. M. & Perry, C. M. Imiquimod: in superficial basal cell carcinoma. Am. J. Clin. Dermatol. 6, 195–200 discussion 201-2 (2005) . · DOI
  4. Dummer, R. et al. Imiquimod in basal cell carcinoma: how does it work? Br. J. Dermatol. 149, (Suppl 66): 57–58 (2003) . · DOI
  5. Urosevic, M. et al. Mechanisms underlying imiquimod-induced regression of basal cell carcinoma in vivo. Arch. Dermatol. 139, 1325–1332 (2003) . · DOI
  6. Urosevic, M. et al. Disease-independent skin recruitment and activation of plasmacytoid predendritic cells following imiquimod treatment. J. Natl Cancer Inst. 97, 1143–1153 (2005) . · DOI
  7. Drobits, B. et al. Imiquimod clears tumors in mice independent of adaptive immunity by converting pDCs into tumor-killing effector cells. J. Clin. Invest. 122, 575–585 (2012) . · DOI
  8. Cai, Y. Pivotal role of dermal IL-17-producing gd T Cells in skin inflammation. Immunity 35, 596–610 (2011) . · DOI
  9. Huang, S. J. et al. Imiquimod enhances IFN-gamma production and effector function of T cells infiltrating human squamous cell carcinomas of the skin. J. Invest. Dermatol. 129, 2676–2685 (2009) . · DOI
  10. Stary, G. et al. Tumoricidal activity of TLR7/8-activated inflammatory dendritic cells. J. Exper Med 204, 1441–1451 (2007) . · DOI
  11. Suzuki, H. et al. Imiquimod, a topical immune response modifier, induces migration of Langerhans cells. J. Invest. Dermatol. 114, 135–141 (2000) . · DOI
  12. Walter, A. et al. Cancer-testis antigens and immunosurveillance in human cutaneous squamous cell and basal cell carcinomas. Clin. Cancer Res. 16, 3562–3570 (2010) . · DOI
  13. Berman, B., Sullivan, T., De Araujo, T. & Nadji, M. Expression of Fas-receptor on basal cell carcinomas after treatment with imiquimod 5% cream or vehicle. Br. J. Dermatol. 149, (Suppl 66): 59–61 (2003) . · DOI
  14. Vidal, D., Matias-Guiu, X. & Alomar, A. Efficacy of imiquimod for the expression of Bcl-2, Ki67, p53 and basal cell carcinoma apoptosis. Br. J. Dermatol. 151, 656–662 (2004) . · DOI
  15. Schon, M. P. & Schon, M. Imiquimod: mode of action. Br. J. Dermatol. 157, (Suppl 2): 8–13 (2007) . · DOI
  16. Chuang, T. H. & Ulevitch, R. J. Cloning and characterization of a sub-family of human toll-like receptors: hTLR7, hTLR8 and hTLR9. Eur. Cytokine Netw. 11, 372–378 (2000) .
  17. Lebre, M. C. et al. Human keratinocytes express functional Toll-like receptor 3, 4, 5, and 9. J. Invest. Dermatol. 127, 331–341 (2007) . · DOI
  18. Kono, T. et al. Effects of a novel topical immunomodulator, imiquimod, on keratinocyte cytokine gene expression. Lymphokine Cytokine Res. 13, 71–76 (1994) .
  19. Schon, M. P., Schon, M. & Klotz, K. N. The small antitumoral immune response modifier imiquimod interacts with adenosine receptor signaling in a TLR7- and TLR8-independent fashion. J. Invest. Dermatol. 126, 1338–1347 (2006) . · DOI
  20. Fanti, P. A., Dika, E., Vaccari, S., Miscial, C. & Varotti, C. Generalized psoriasis induced by topical treatment of actinic keratosis with imiquimod. Int. J. Dermatol. 45, 1464–1465 (2006) . · DOI
  21. Gilliet, M. et al. Psoriasis triggered by toll-like receptor 7 agonist imiquimod in the presence of dermal plasmacytoid dendritic cell precursors. Arch. Dermatol. 140, 1490–1495 (2004) . · DOI
  22. van der Fits, L. et al. Imiquimod-induced psoriasis-like skin inflammation in mice is mediated via the IL-23/IL-17 axis. J. Immunol. 182, 5836–5845 (2009) . · DOI
  23. Van Belle, A. B. et al. IL-22 is required for imiquimod-induced psoriasiform skin inflammation in mice. J. Immunol. 188, 462–469 (2011) . · DOI
  24. Pantelyushin, S. et al. Rorgammat+ innate lymphocytes and gammadelta T cells initiate psoriasiform plaque formation in mice. J. Clin. Invest. 122, 2252–2256 (2012) . · DOI
  25. Stanley, M. A. Imiquimod and the imidazoquinolones: mechanism of action and therapeutic potential. Clin. Exp. Dermatol. 27, 571–577 (2002) . · DOI
  26. Rao, K. S., Babu, K. K. & Gupta, P. D. Keratins and skin disorders. Cell. Biol. Int. 20, 261–274 (1996) . · DOI
  27. Swiecki, M. et al. Type I interferon negatively controls plasmacytoid dendritic cell numbers in vivo. J. Exp. Med. 208, 2367–2374 (2011) . · DOI
  28. Werner, S. & Smola, H. Paracrine regulation of keratinocyte proliferation and differentiation. Trends Cell Biol. 11, 143–146 (2001) . · DOI
  29. Werner, S., Krieg, T. & Smola, H. Keratinocyte-fibroblast interactions in wound healing. J. Invest. Dermatol. 127, 998–1008 (2007) . · DOI
  30. Adachi, O. et al. Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function. Immunity 9, 143–150 (1998) . · DOI
  31. Pinkus, H. & Mehregan, A. H. The primary histologic lesion of seborrheic dermatitis and psoriasis. J. Invest. Dermatol. 46, 109–116 (1966) . · DOI
  32. Schon, M., Denzer, D., Kubitza, R. C., Ruzicka, T. & Schon, M. P. Critical role of neutrophils for the generation of psoriasiform skin lesions in flaky skin mice. J. Invest. Dermatol. 114, 976–983 (2000) . · DOI
  33. Gebhardt, C., Nemeth, J., Angel, P. & Hess, J. S100A8 and S100A9 in inflammation and cancer. Biochem. Pharmacol. 72, 1622–1631 (2006) . · DOI · Paper page
  34. Frevert, C. W., Huang, S., Danaee, H., Paulauskis, J. D. & Kobzik, L. Functional characterization of the rat chemokine KC and its importance in neutrophil recruitment in a rat model of pulmonary inflammation. J. Immunol. 154, 335–344 (1995) . · DOI
  35. Sanos, S. L. et al. RORgammat and commensal microflora are required for the differentiation of mucosal interleukin 22-producing NKp46+ cells. Nat. Immunol. 10, 83–91 (2009) . · DOI
  36. Sims, J. E. & Smith, D. E. The IL-1 family: regulators of immunity. Nat. Rev. Immunol. 10, 89–102 (2010) . · DOI
  37. Kanneganti, T. D. et al. Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3. Nature 440, 233–236 (2006) . · DOI
  38. Feldmeyer, L., Werner, S., French, L. E. & Beer, H. D. Interleukin-1, inflammasomes and the skin. Eur. J. Cell Biol. 89, 638–644 (2010) . · DOI
  39. Salcedo, R. et al. MyD88-mediated signaling prevents development of adenocarcinomas of the colon: role of interleukin 18. J. Exp. Med. 207, 1625–1636 (2010) . · DOI · Paper page
  40. Miao, E. A., Rajan, J. V. & Aderem, A. Caspase-1-induced pyroptotic cell death. Immunol. Rev. 243, 206–214 (2011) . · DOI
  41. Vandanmagsar, B. et al. The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance. Nat. Med. 17, 179–188 (2011) . · DOI · Paper page
  42. Wen, H. et al. Fatty acid-induced NLRP3-ASC inflammasome activation interferes with insulin signaling. Nat. Immunol. 12, 408–415 (2011) . · DOI · Paper page
  43. Keller, M., Ruegg, A., Werner, S. & Beer, H. D. Active caspase-1 is a regulator of unconventional protein secretion. Cell 132, 818–831 (2008) . · DOI
  44. Brauchle, M., Angermeyer, K., Hubner, G. & Werner, S. Large induction of keratinocyte growth factor expression by serum growth factors and pro-inflammatory cytokines in cultured fibroblasts. Oncogene 9, 3199–3204 (1994) .
  45. Szabowski, A. et al. c-Jun and JunB antagonistically control cytokine-regulated mesenchymal-epidermal interaction in skin. Cell 103, 745–755 (2000) . · DOI
  46. Takematsu, H. & Tagami, H. Granulocyte-macrophage colony-stimulating factor in psoriasis. Dermatologica 181, 16–20 (1990) . · DOI
  47. Beutner, K. R. et al. Therapeutic response of basal cell carcinoma to the immune response modifier imiquimod 5% cream. J. Am. Acad. Dermatol. 41, 1002–1007 (1999) . · DOI
  48. van den Broek, M. F., Muller, U., Huang, S., Zinkernagel, R. M. & Aguet, M. Immune defence in mice lacking type I and/or type II interferon receptors. Immunol. Rev. 148, 5–18 (1995) . · DOI
  49. Hemmi, H. et al. Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway. Nat. Immunol. 3, 196–200 (2002) . · DOI
  50. Hoshino, K. et al. Cutting edge: generation of IL-18 receptor-deficient mice: evidence for IL-1 receptor-related protein as an essential IL-18 binding receptor. J. Immunol. 162, 5041–5044 (1999) . · DOI
  51. Eberl, G. et al. An essential function for the nuclear receptor RORgamma(t) in the generation of fetal lymphoid tissue inducer cells. Nat. Immunol. 5, 64–73 (2004) . · DOI

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Metadata

Authors
Walter, A., Schäfer, M., Cecconi, V., Matter, C., Urosevic-Maiwald, M., Belloni, B., Schönewolf, N., Dummer, R., Bloch, W., Werner, S., Beer, H.-D., Knuth, A., & van den Broek, M.
Venue
Nature Communications
Published
2013-03-05
Volume
4
Issue
1
ISSN
2041-1723
Cited by
245
References
2
Language
en

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