The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Perilipin1 promotes unilocular lipid droplet formation through the activation of Fsp27 in adipocytes
Open accessAbstract
Mature white adipocytes contain a characteristic unilocular lipid droplet. However, the molecular mechanisms underlying unilocular lipid droplet formation are poorly understood. We previously showed that Fsp27, an adipocyte-specific lipid droplet-associated protein, promotes lipid droplet growth by initiating lipid exchange and transfer. Here, we identify Perilipin1 (Plin1), another adipocyte-specific lipid droplet-associated protein, as an Fsp27 activator. Plin1 interacts with the CIDE-N domain of Fsp27 and markedly increases Fsp27-mediated lipid exchange, lipid transfer and lipid droplet growth. Functional cooperation between Plin1 and Fsp27 is required for efficient lipid droplet growth in adipocytes, as depletion of either protein impairs lipid droplet growth. The CIDE-N domain of Fsp27 forms homodimers and disruption of CIDE-N homodimerization abolishes Fsp27-mediated lipid exchange and transfer. Interestingly, Plin1 can restore the activity of CIDE-N homodimerization-defective mutants of Fsp27. We thus uncover a novel mechanism underlying lipid droplet growth and unilocular lipid droplet formation that involves the cooperative action of Fsp27 and Plin1 in adipocytes.
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Cites
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Self-citationEvolutionarily conserved gene family important for fat storage
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Dynamics and functions of lipid droplets
Olzmann, J. A., & Carvalho, P. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0085-z · Cited by 2,740
The biophysics and cell biology of lipid droplets
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Self-citationTargeting senescent cells enhances adipogenesis and metabolic function in old age
Xu, M., Palmer, A. K., Ding, H., Weivoda, M. M., Pirtskhalava, T., White, T. A., Sepe, A., Johnson, K. O., Stout, M. B., Giorgadze, N., et al. (2015) · eLife · doi:10.7554/elife.12997 · Cited by 604
Convergent somatic mutations in metabolism genes in chronic liver disease
Ng, S. W. K., Rouhani, F. J., Brunner, S. F., Brzozowska, N., Aitken, S. J., Yang, M., Abascal, F., Moore, L., Nikitopoulou, E., Chappell, L., et al. (2021) · Nature · doi:10.1038/s41586-021-03974-6 · Cited by 190
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Metadata
- Authors
- Sun, Z., Gong, J., Wu, H., Xu, W., Wu, L., Xu, D., Gao, J., Wu, J.-W., Yang, H., Yang, M., & Li, P.
- Venue
- Nature Communications
- Published
- 2013-03-12
- Volume
- 4
- Issue
- 1
- Pages
- 1594-1594
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2026497980
- Cited by
- 258
- References
- 6
- FWCI
- 8.84
- Type
- journal article
- Language
- en
- Open access
- hybrid
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