The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
Attomolar DNA detection with chiral nanorod assemblies
Open accessAbstract
Nanoscale plasmonic assemblies display exceptionally strong chiral optical activity. So far, their structural design was primarily driven by challenges related to metamaterials whose practical applications are remote. Here we demonstrate that gold nanorods assembled by the polymerase chain reaction into DNA-bridged chiral systems have promising analytical applications. The chiroplasmonic activity of side-by-side assembled patterns is attributed to a 7–9 degree twist between the nanorod axes. This results in a strong polarization rotation that matches theoretical expectations. The amplitude of the bisignate ‘wave’ in the circular dichroism spectra of side-by-side assemblies demonstrates excellent linearity with the amount of target DNA. The limit of detection for DNA using side-by-side assemblies is as low as 3.7 aM. This chiroplasmonic method may be particularly useful for biological analytes larger than 2–5 nm which are difficult to detect by methods based on plasmon coupling and ‘hot spots’. Circular polarization increases for inter-nanorod gaps between 2 and 20 nm when plasmonic coupling rapidly decreases. Reaching the attomolar limit of detection for simple and reliable bioanalysis of oligonucleotides may have a crucial role in DNA biomarker detection for early diagnostics of different diseases, forensics and environmental monitoring.
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Cites
Preparation and Growth Mechanism of Gold Nanorods (NRs) Using Seed-Mediated Growth Method
Nikoobakht, B., & El-Sayed, M. A. (2003) · Chemistry of Materials · doi:10.1021/cm020732l · Cited by 5,069
Elghanian, R., Storhoff, J. J., Mucic, R. C., Letsinger, R. L., & Mirkin, C. A. (1997) · Science · doi:10.1126/science.277.5329.1078 · Cited by 4,399
DNA-based self-assembly of chiral plasmonic nanostructures with tailored optical response
Kuzyk, A., Schreiber, R., Fan, Z., Pardatscher, G., Roller, E.-M., Högele, A., Simmel, F. C., Govorov, A. O., & Liedl, T. (2012) · Nature · doi:10.1038/nature10889 · Cited by 2,216
A Group-IV Ferromagnetic Semiconductor: Mn x Ge 1− x
Park, Y. D., Hanbicki, A. T., Erwin, S. C., Hellberg, C. S., Sullivan, J. M., Mattson, J. E., Ambrose, T. F., Wilson, A., Spanos, G., & Jonker, B. T. (2002) · Science · doi:10.1126/science.1066348 · Cited by 1,631
Properties and emerging applications of self-assembled structures made from inorganic nanoparticles
Nie, Z., Petukhova, A., & Kumacheva, E. (2010) · Nature Nanotechnology · doi:10.1038/nnano.2009.453 · Cited by 1,598
Array-Based Electrical Detection of DNA with Nanoparticle Probes
Park, S.-J., Taton, T. A., & Mirkin, C. A. (2002) · Science · doi:10.1126/science.1067003 · Cited by 1,515
種結晶を媒介とした成長法を用いた金ナノロッド(NR)の調製と成長メカニズム
Nikoobakht, B., & El-Sayed, M. A. (2003) · Chemistry of Materials · Cited by 1,419
Berova, N., Bari, L. D., & Pescitelli, G. (2007) · Chemical Society Reviews · doi:10.1039/b515476f · Cited by 1,376
Ultrasensitive detection and characterization of biomolecules using superchiral fields
Hendry, E., Carpy, T., Johnston, J., Popland, M., Mikhaylovskiy, R. V., Lapthorn, A. J., Kelly, S. M., Barron, L. D., Gadegaard, N., & Kadodwala, M. (2010) · Nature Nanotechnology · doi:10.1038/nnano.2010.209 · Cited by 1,258
Nanogap-engineerable Raman-active nanodumbbells for single-molecule detection
Lim, D.-K., Jeon, K.-S., Kim, H. M., Nam, J.-M., & Suh, Y. D. (2010) · Nature Materials · doi:10.1038/nmat2596 · Cited by 1,189
Cited by
Diverse Applications of Nanomedicine
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Self-citationHentschel, M., Schäferling, M., Duan, X., Giessen, H., & Liu, N. (2017) · Science Advances · doi:10.1126/sciadv.1602735 · Cited by 850
Enantiomer-dependent immunological response to chiral nanoparticles
Xu, L., Wang, X., Wang, W., Sun, M., Choi, W. J., Kim, J.-Y., Hao, C., Li, S., Qu, A., Lu, M., et al. (2022) · Nature · doi:10.1038/s41586-021-04243-2 · Cited by 641
Self-citationChirality detection of enantiomers using twisted optical metamaterials
Zhao, Y., Askarpour, A. N., Sun, L., Shi, J., Li, X., & Alù, A. (2017) · Nature Communications · doi:10.1038/ncomms14180 · Cited by 622
Gong, Z.-L., Zhu, X., Zhou, Z., Zhang, S.-W., Yang, D., Zhao, B., Zhang, Y.-P., Deng, J., Cheng, Y., Zheng, Y.-X., et al. (2021) · Science China Chemistry · doi:10.1007/s11426-021-1146-6 · Cited by 608
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Metadata
- Authors
- Ma, W., Kuang, H., Xu, L., Ding, L., Xu, C., Wang, L., & Kotov, N. A.
- Venue
- Nature Communications
- Published
- 2013-10-28
- Volume
- 4
- Issue
- 1
- Pages
- 2689-2689
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2056483398
- Cited by
- 531
- References
- 28
- FWCI
- 13.30
- Type
- journal article
- Language
- en
- Open access
- hybrid
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