The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
Adipocytes arise from multiple lineages that are heterogeneously and dynamically distributed
Open accessAbstract
Adipose tissue development is poorly understood. Here we use a lineage-tracing strategy optimal for adipocytes to provide evidence that Myf5 precursors are not the exclusive source of brown adipocytes and contribute more to the mature white and brite adipocyte populations than previously thought. Moreover, Myf5-lineage distribution in adipose tissue changes in response to modifiable and non-modifiable factors. We also find that the Pax3 lineage largely overlaps with the Myf5 lineage in brown fat and subcutaneous white fat, but exhibits gender-linked divergence in visceral white fat while the MyoD1 lineage does not give rise to any adipocytes. Finally, by deleting insulin receptor beta in the Myf5 lineage, we provide in vivo evidence that the insulin receptor is essential for adipogenesis and that adipocyte lineages have plasticity. These data establish a conceptual framework for adipose tissue development and could explain body fat patterning variations in healthy and lipodystrophic or obese humans. Myf5 lineage precursor cells give rise to brown adipocytes. Here, the authors show that the Myf5 lineage, as well as the Pax3 lineage, contribute to white and brite mature adipocytes and describe the effects of Myf5 lineage-specific deletion of the insulin receptor on adipose tissue formation in mice.
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Metadata
- Authors
- Sanchez-Gurmaches, J., & Guertin, D. A.
- Venue
- Nature Communications
- Published
- 2014-06-19
- Volume
- 5
- Issue
- 1
- Pages
- 4099-4099
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2016543757
- Cited by
- 360
- References
- 28
- FWCI
- 18.27
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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