The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
Adipocytes arise from multiple lineages that are heterogeneously and dynamically distributed
Open accessAbstract
Adipose tissue development is poorly understood. Here we use a lineage-tracing strategy optimal for adipocytes to provide evidence that Myf5 precursors are not the exclusive source of brown adipocytes and contribute more to the mature white and brite adipocyte populations than previously thought. Moreover, Myf5-lineage distribution in adipose tissue changes in response to modifiable and non-modifiable factors. We also find that the Pax3 lineage largely overlaps with the Myf5 lineage in brown fat and subcutaneous white fat, but exhibits gender-linked divergence in visceral white fat while the MyoD1 lineage does not give rise to any adipocytes. Finally, by deleting insulin receptor beta in the Myf5 lineage, we provide in vivo evidence that the insulin receptor is essential for adipogenesis and that adipocyte lineages have plasticity. These data establish a conceptual framework for adipose tissue development and could explain body fat patterning variations in healthy and lipodystrophic or obese humans. Myf5 lineage precursor cells give rise to brown adipocytes. Here, the authors show that the Myf5 lineage, as well as the Pax3 lineage, contribute to white and brite mature adipocytes and describe the effects of Myf5 lineage-specific deletion of the insulin receptor on adipose tissue formation in mice.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
A global double-fluorescent Cre reporter mouse
Muzumdar, M. D., Tasic, B., Miyamichi, K., Li, L., & Luo, L. (2007) · genesis · doi:10.1002/dvg.20335 · Cited by 3,491
What we talk about when we talk about fat
Rosen, E. D., & Spiegelman, B. M. (2014) · Cell · doi:10.1016/j.cell.2013.12.012 · Cited by 2,373
PRDM16 controls a brown fat/skeletal muscle switch
Seale, P., Bjork, B., Yang, W., Kajimura, S., Chin, S., Kuang, S., Scimè, A., Devarakonda, S., Conroe, H. M., Erdjument-Bromage, H., et al. (2008) · Nature · doi:10.1038/nature07182 · Cited by 2,347
Developmental Origin of Fat: Tracking Obesity to Its Source
Gesta, S., Tseng, Y.-H., & Kahn, C. R. (2007) · Cell · doi:10.1016/j.cell.2007.10.004 · Cited by 1,508
Identification of White Adipocyte Progenitor Cells In Vivo
Rodeheffer, M. S., Birsoy, K., & Friedman, J. M. (2008) · Cell · doi:10.1016/j.cell.2008.09.036 · Cited by 949
Blüher, M., Michael, M. D., Peroni, O. D., Ueki, K., Carter, N., Kahn, B. B., & Kahn, C. R. (2002) · Developmental Cell · doi:10.1016/s1534-5807(02)00199-5 · Cited by 806
Bi-directional interconversion of brite and white adipocytes
Rosenwald, M., Perdikari, A., Rülicke, T., & Wolfrum, C. (2013) · Nature Cell Biology · doi:10.1038/ncb2740 · Cited by 800
Transcriptional mechanisms regulating skeletal muscle differentiation, growth and homeostasis
Braun, T., & Gautel, M. (2011) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3118 · Cited by 713
Cinti, S. (2005) · Prostaglandins, Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2005.04.010 · Cited by 692
Lee, Y.-H., Petkova, A. P., Mottillo, E. P., & Granneman, J. G. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.03.009 · Cited by 681
Recruited vs. nonrecruited molecular signatures of brown, “brite,” and white adipose tissues
Waldén, T. B., Hansen, I. R., Timmons, J. A., Cannon, B., & Nedergaard, J. (2012) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00249.2011 · Cited by 569
Characterization of the adipocyte cellular lineage in vivo
Berry, R., & Rodeheffer, M. S. (2013) · Nature Cell Biology · doi:10.1038/ncb2696 · Cited by 550
Insulin-like growth factor-I is an essential regulator of the differentiation of 3T3-L1 adipocytes.
Smith, P. J., Wise, L. S., Berkowitz, R., Wan, C., & Rubin, C. S. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)76555-7 · Cited by 517
Pax3 functions at a nodal point in melanocyte stem cell differentiation
Lang, D., Lu, M. M., Huang, L., Engleka, K. A., Zhang, M., Chu, E. Y., Lipner, S., Skoultchi, A., Millar, S. E., & Epstein, J. A. (2005) · Nature · doi:10.1038/nature03292 · Cited by 397
The Health Risk of Obesity—Better Metrics Imperative
Ahima, R. S., & Lazar, M. A. (2013) · Science · doi:10.1126/science.1241244 · Cited by 381
Brown-fat paucity due to impaired BMP signalling induces compensatory browning of white fat
Schulz, T. J., Huang, P., Huang, T. L., Xue, R., McDougall, L. E., Townsend, K. L., Cypess, A. M., Mishina, Y., Gussoni, E., & Tseng, Y.-H. (2013) · Nature · doi:10.1038/nature11943 · Cited by 380
Cinti, S. (2012) · Disease Models & Mechanisms · doi:10.1242/dmm.009662 · Cited by 352
The developmental origins of adipose tissue
Berry, D. C., Stenesen, D., Zeve, D., & Graff, J. M. (2013) · Development · doi:10.1242/dev.080549 · Cited by 343
Sanchez-Gurmaches, J., Hung, C.-M., Sparks, C. A., Tang, Y., Li, H., & Guertin, D. A. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.08.003 · Cited by 342
Self-citationEHMT1 controls brown adipose cell fate and thermogenesis through the PRDM16 complex
Ohno, H., Shinoda, K., Ohyama, K., Sharp, L. Z., & Kajimura, S. (2013) · Nature · doi:10.1038/nature12652 · Cited by 329
The generation of adipocytes by the neural crest
Billon, N., Iannarelli, P., Monteiro, M. C., Glavieux-Pardanaud, C., Richardson, W. D., Kessaris, N., Dani, C., & Dupin, E. (2007) · Development · doi:10.1242/dev.002642 · Cited by 296
Early myotome specification regulates PDGFA expression and axial skeleton development
Tallquist, M. D., Weismann, K. E., Hellström, M., & Soriano, P. (2000) · Development · doi:10.1242/dev.127.23.5059 · Cited by 260
Rare adipose disorders (RADs) masquerading as obesity
Herbst, K. L. (2012) · Acta Pharmacologica Sinica · doi:10.1038/aps.2011.153 · Cited by 259
Two Cell Lineages, myf5 and myf5-Independent, Participate in Mouse Skeletal Myogenesis
Haldar, M., Karan, G., Tvrdík, P., & Capecchi, M. R. (2008) · Developmental Cell · doi:10.1016/j.devcel.2008.01.002 · Cited by 147
Boucher, J., Mori, M. A., Lee, K. Y., Smyth, G., Liew, C. W., Macotela, Y., Rourk, M., Bluher, M., Russell, S. J., & Kahn, C. R. (2012) · Nature Communications · doi:10.1038/ncomms1905 · Cited by 142
A multifunctional reporter mouse line for Cre‐ and FLP‐dependent lineage analysis
Yamamoto, M., Shook, N. A., Kanisicak, O., Yamamoto, S., Wosczyna, M. N., Camp, J. R., & Goldhamer, D. J. (2009) · genesis · doi:10.1002/dvg.20474 · Cited by 136
Gensch, N., Borchardt, T., Schneider, A., Riethmacher, D., & Braun, T. W. (2008) · Development · doi:10.1242/dev.019331 · Cited by 119
Cannon, B., & Nedergaard, J. (2012) · Nature · doi:10.1038/488286a · Cited by 47
Cited by
Adipose tissue dysfunction as determinant of obesity-associated metabolic complications
Longo, M., Zatterale, F., Naderi, J., Parrillo, L., Formisano, P., Raciti, G. A., Beguinot, F., & Miele, C. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20092358 · Cited by 1,575
The Common and Distinct Features of Brown and Beige Adipocytes
Ikeda, K., Maretich, P., & Kajimura, S. (2018) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2018.01.001 · Cited by 543
Adipose tissue plasticity: how fat depots respond differently to pathophysiological cues
Pellegrinelli, V., Carobbio, S., & Vidal-Puig, A. (2016) · Diabetologia · doi:10.1007/s00125-016-3933-4 · Cited by 432
Targeting thermogenesis in brown fat and muscle to treat obesity and metabolic disease
Betz, M. J., & Enerbäck, S. (2018) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2017.132 · Cited by 355
The “Big Bang” in obese fat: events initiating obesity-induced adipose tissue inflammation
Wensveen, F. M., Valentić, S., Šestan, M., Turk Wensveen, T., & Polić, B. (2015) · European Journal of Immunology · doi:10.1002/eji.201545502 · Cited by 348
Metadata
- Authors
- Sanchez-Gurmaches, J., & Guertin, D. A.
- Venue
- Nature Communications
- Published
- 2014-06-19
- Volume
- 5
- Issue
- 1
- Pages
- 4099-4099
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2016543757
- Cited by
- 360
- References
- 28
- FWCI
- 18.27
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
