The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
In Vivo Identification of Bipotential Adipocyte Progenitors Recruited by β3-Adrenoceptor Activation and High-Fat Feeding
Open accessAbstract
Summary Nutritional and pharmacological stimuli can dramatically alter the cellular phenotypes in white adipose tissue (WAT). Utilizing genetic lineage tracing techniques, we demonstrate that brown adipocytes (BA) that are induced by β3-adrenergic receptor activation in abdominal WAT arise from the proliferation and differentiation of cells expressing platelet-derived growth factor receptor alpha (PDGFRα), CD34 and Sca1 (PDGFRα+ cells). PDGFRα+ cells have a unique morphology in which extended processes contact multiple cells in the tissue microenvironment. Surprisingly, these cells also give rise to white adipocytes (WA) that can comprise up to 25% of total fat cells in abdominal fat pads following 8 weeks of high fat feeding. Isolated PDGFRα+ cells differentiated into both BA and white adipocytes (WA) in vitro, and generated WA after transplantation in vivo. The identification of PDGFRα+ cells as bipotential adipocyte progenitors will enable further investigation of mechanisms that promote therapeutic cellular remodeling in adult WAT.
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A robust and high-throughput Cre reporting and characterization system for the whole mouse brain
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Self-citation
Cited by
Beige Adipocytes Are a Distinct Type of Thermogenic Fat Cell in Mouse and Human
Wu, J., Boström, P., Sparks, L. M., Ye, L., Choi, J. H., Giang, A.-H., Khandekar, M., Virtanen, K. A., Nuutila, P., Schaart, G., et al. (2012) · Cell · doi:10.1016/j.cell.2012.05.016 · Cited by 3,319
What we talk about when we talk about fat
Rosen, E. D., & Spiegelman, B. M. (2014) · Cell · doi:10.1016/j.cell.2013.12.012 · Cited by 2,373
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Harms, M., & Seale, P. (2013) · Nature Medicine · doi:10.1038/nm.3361 · Cited by 2,328
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Ghaben, A. L., & Scherer, P. E. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0093-z · Cited by 1,395
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Metadata
- Authors
- Lee, Y.-H., Petkova, A. P., Mottillo, E. P., & Granneman, J. G.
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2012-04
- Volume
- 15
- Issue
- 4
- Pages
- 480-491
- ISSN
- 1550-4131 (ISSN-L)
- OpenAlex
- W1993500521
- Cited by
- 681
- References
- 10
- FWCI
- 35.10
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Lee, Y.-H., Petkova, A. P., Mottillo, E. P., & Granneman, J. G. (2012). In Vivo Identification of Bipotential Adipocyte Progenitors Recruited by β3-Adrenoceptor Activation and High-Fat Feeding. Cell Metabolism. https://doi.org/10.1016/j.cmet.2012.03.009
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