Biological interpretation of genome-wide association studies using predicted gene functions

Pers, Tune H., Karjalainen, Juha M., Chan, Yingleong, Westra, Harm-Jan, Wood, Andrew R., Yang, Jian, Lui, Julian C., Vedantam, Sailaja +10 more·2015·Nature Communications
DOI 10.1038/ncomms6890

Cited by (824)

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  79. Systematic Mendelian randomization framework elucidates hundreds of CpG sites which may mediate the influence of genetic variants on disease
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  96. Genome-wide association study identifies nine novel loci for 2D:4D finger ratio, a putative retrospective biomarker of testosterone exposure in utero
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  99. Genomic SEM Provides Insights into the Multivariate Genetic Architecture of Complex Traits
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