The DOI matches its Crossref record; 67 of the 67 references it cites were found in a registry or an index.
Metabolic cross-feeding via intercellular nanotubes among bacteria
Open accessAbstract
Bacteria frequently exchange metabolites by diffusion through the extracellular environment, yet it remains generally unclear whether bacteria can also use cell–cell connections to directly exchange nutrients. Here we address this question by engineering cross-feeding interactions within and between Acinetobacter baylyi and Escherichia coli, in which two distant bacterial species reciprocally exchange essential amino acids. We establish that in a well-mixed environment E. coli, but likely not A. baylyi, can connect to other bacterial cells via membrane-derived nanotubes and use these to exchange cytoplasmic constituents. Intercellular connections are induced by auxotrophy-causing mutations and cease to establish when amino acids are externally supplied. Electron and fluorescence microscopy reveal a network of nanotubular structures that connects bacterial cells and enables an intercellular transfer of cytoplasmic materials. Together, our results demonstrate that bacteria can use nanotubes to exchange nutrients among connected cells and thus help to distribute metabolic functions within microbial communities. Some bacteria can form nanotubes to transfer proteins and plasmids between neighbouring cells. Here, the authors show that nanotubes can also mediate the exchange of cytoplasmic amino acids between cells of the same or different bacterial species.
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Cited by
Milani, C., Duranti, S., Bottacini, F., Casey, E., Turroni, F., Mahony, J., Belzer, C., Delgado Palacio, S., Arboleya Montes, S., Mancabelli, L., et al. (2017) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00036-17 · Cited by 1,950
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Happy together: microbial communities that hook up to swap electrons
Lovley, D. R. (2017) · The ISME Journal · doi:10.1038/ismej.2016.136 · Cited by 384
Glycan Utilization and Cross-Feeding Activities by Bifidobacteria
Turroni, F., Milani, C., Duranti, S., Mahony, J., van Sinderen, D., & Ventura, M. (2018) · Trends in Microbiology · doi:10.1016/j.tim.2017.10.001 · Cited by 263
Weiss, T. L., Young, E. J., & Ducat, D. C. (2017) · Metabolic Engineering · doi:10.1016/j.ymben.2017.10.009 · Cited by 152
Metadata
- Authors
- Pande, S., Shitut, S., Freund, L., Westermann, M., Bertels, F., Colesie, C., Bischofs, I. B., & Kost, C.
- Venue
- Nature Communications
- Published
- 2015-02-23
- Volume
- 6
- Issue
- 1
- Pages
- 6238-6238
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2018672567
- Cited by
- 273
- References
- 67
- FWCI
- 18.09
- Type
- journal article
- Language
- en
- Open access
- gold
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