The DOI matches its Crossref record; 93 of the 94 references it cites were found in a registry or an index.
Ghrelin, obesity and diabetes
Abstract
The high prevalence of obesity and diabetes will lead to higher rates of morbidity and mortality. The search for drugs to treat these metabolic disorders has, therefore, intensified. The stomach-derived peptide ghrelin regulates food intake and body weight. Recent work suggests that ghrelin also controls glucose metabolism. In addition, current evidence suggests that most of the actions of ghrelin could contribute to the metabolic syndrome. The ghrelin signaling system is, therefore, a promising target for the development of new drugs for the treatment of obesity and diabetes. Agents that block the ghrelin signaling system might be especially useful targets. This Review summarizes the potential and the limitations of ghrelin as a tool to better understand, prevent and treat obesity and diabetes.
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“Increased GLP-1 and PYY levels together with an absence of a compensatory rise in ghrelin in most RYGB patients would be expected to favor improved insulin sensitivity as these hormone affect glucose homeostasis in addition to appetitive behavior (8, 30–32).”
From Prospective study of gut hormone and metabolic changes after adjustable gastric banding and Roux-en-Y gastric bypass (2009) · cites this paper as [8]
Citations
Cites
Ghrelin is a growth-hormone-releasing acylated peptide from stomach
Kojima, M., Hosoda, H., Date, Y., Nakazato, M., Matsuo, H., & Kangawa, K. (1999) · Nature · doi:10.1038/45230 · Cited by 8,479
Abdominal obesity and metabolic syndrome
Després, J.-P., & Lemieux, I. (2006) · Nature · doi:10.1038/nature05488 · Cited by 4,354
Ghrelin induces adiposity in rodents
Tschöp, M., Smiley, D. L., & Heiman, M. L. (2000) · Nature · doi:10.1038/35038090 · Cited by 3,949
Self-citationA preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans
Cummings, D. E., Purnell, J. Q., Frayo, R. S., Schmidova, K., Wisse, B. E., & Weigle, D. S. (2001) · Diabetes · doi:10.2337/diabetes.50.8.1714 · Cited by 2,940
Circulating Ghrelin Levels Are Decreased in Human Obesity
Tschöp, M. H., Weyer, C., Tataranni, P. A., Devanarayan, V., Ravussin, É., & Heiman, M. L. (2001) · Diabetes · doi:10.2337/diabetes.50.4.707 · Cited by 2,031
Self-citationCowley, M. A., Smith, R. G., Diano, S., Tschöp, M., Pronchuk, N., Grove, K. L., Strasburger, C. J., Bidlingmaier, M., Esterman, M., Heiman, M. L., et al. (2003) · Neuron · doi:10.1016/s0896-6273(03)00063-1 · Cited by 1,679
Self-citationBiological, Physiological, Pathophysiological, and Pharmacological Aspects of Ghrelin
van der Lely, A. J., Tschöp, M., Heiman, M. L., & Ghigo, E. (2004) · Endocrine Reviews · doi:10.1210/er.2002-0029 · Cited by 1,187
Self-citationGuan, X.-M., Yu, H., Palyha, O., McKee, K., Feighner, S., Sirinathsinghji, D., Smith, R. G., van der Ploeg, L., & Howard, A. (1997) · Brain Research. Molecular Brain Research · doi:10.1016/s0169-328x(97)00071-5 · Cited by 1,185
Ghrelin is an appetite-stimulatory signal from stomach with structural resemblance to motilin
Asakawa, A., Inui, A., Kaga, O., Yuzuriha, H., Nagata, T., Ueno, N., Makino, S., Fujimiya, M., Niijima, A., Fujino, M., et al. (2001) · Gastroenterology · doi:10.1053/gast.2001.22158 · Cited by 1,182
Obestatin, a Peptide Encoded by the Ghrelin Gene, Opposes Ghrelin's Effects on Food Intake
Zhang, J. V., Ren, P., Avsian-Kretchmer, O., Luo, C., Rauch, R., Klein, C., & Hsueh, A. J. W. (2005) · Science · doi:10.1126/science.1117255 · Cited by 1,172
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1 of the 94 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- Tang-Christensen M et al. (2003) Ghrelin induces long lasting changes in food intake and locomotor behaviour. Abstract P3-94 presented at the 85th Annual Meeting of the Endocrine Society: 2003, June 19–22, Philadelphia, PA
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Items 101–112 of 112
48 Effects of Bariatric Surgery on Diabetes
Soni, A., Shukla, A. P., & Rubino, F. (2014) · Springer eBooks · doi:10.1007/978-1-4939-1637-5_48
Both ghrelin deletion and unacylated ghrelin overexpression preserve muscles in aging mice
Agosti, E., Feudis, M. D., Angelino, E., Belli, R., Alves, T. M., Zaggia, I., Raiteri, T., Scircoli, A., Graziani, A., Prodam, F., et al. (2020) · Endocrine Abstracts · doi:10.1530/endoabs.70.oc4.2
Autocuidado, condicionantes y evolución de los pacientes con diabetes mellitus tipo 2
Vite-Solorzano, F. A., Barrera-Paz, L., Párraga, J. A. S., & Morillo, A. V. S. (2020) · Revista Arbitrada Interdisciplinaria de Ciencias de la Salud Salud y Vida · doi:10.35381/s.v.v4i8.1011
Hormones and Gastrointestinal Function of Newborns
Prodam, F., Bellone, S., Ricotti, R., Monzani, A., Genoni, G., Giglione, E., & Bona, G. (2018) · Springer eBooks · doi:10.1007/978-3-319-29489-6_184
Children Obesity, Glucose Tolerance, Ghrelin, and Prader Willi Syndrome
Bellone, S., Ricotti, R., Solito, A., Mones, E., Mele, C., Aimaretti, G., & Prodam, F. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-812840-4.00014-1
Gupta, M. M., Bhojane, C. V., Rode, S. B., & Salankar, H. V. (2023) · Egyptian Pharmaceutical Journal · doi:10.4103/epj.epj_72_23
Neuronal Regulation of Thermogenesis and Energy Expenditure in Metabolic Syndrome
Kumar, S., Gawli, C., & Patil, C. R. (2024) · Advances in biochemistry in health and disease · doi:10.1007/978-3-031-75686-3_16
Growth Hormone Deficiency and Therapy During Aging
Herodes, M., Leonardi, C., & Garcia, J. M. (2025) · Springer eBooks · doi:10.1007/978-3-031-89650-7_25
The emerging role of epsilon cells in glucose homeostasis and lipostasis
Pavithra, N., Singh, S. A., Begum, R. F., Undela, K., Nirenjen, S., Keerthana, B., Singh, A., Mageswari, R., & Sabarathinam, S. (2025) · Obesity Medicine · doi:10.1016/j.obmed.2025.100672
The Role of Nutrition in Promoting Physiological Functions and Maintaining General Health
LAFY, R. F., Muhammad, T. M. T., & Agwaan, H. W. K. (2025) · University of Thi-Qar Journal of agricultural research · doi:10.54174/qyf13153
Do Nutritional Status and Dietary Intake Influence the Ghrelin Response?
Radziszewska, M., Smarkusz-Zarzecka, J., Cwalina, U., Zyśk, B., Buczyńska, A., Moroz, M., Roszkowska, J., Stołyhwo-Gofron, M., Adamska-Patruno, E., Kretowski, A. J., et al. (2026) · Nutrients · doi:10.3390/nu18193271
Metadata
- Authors
- Wiedmer, P., Nogueiras, R., Broglio, F., D'Alessio, D., & Tschöp, M. H.
- Affiliations
- German Institute of Human Nutrition (DE)
- University of Cincinnati (US)
- University of Turin (IT)
- Corresponding author
- Tschöp, Matthias H
- Venue
- Nature Clinical Practice Endocrinology & Metabolism
- Published
- 2007-10
- Volume
- 3
- Issue
- 10
- Pages
- 705-712
- ISSN
- 1745-8366 (ISSN-L)
- 1745-8374
- OpenAlex
- W2021729437
- Cited by
- 111
- References
- 94
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 3 · 2023: 6 · 2022: 6 · 2021: 5 · 2020: 5 · 2019: 4 · 2018: 7 · 2017: 2 · 2016: 9 · 2014: 10 · 2013: 8 · 2012: 9
- FWCI
- 0.81
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Clinical Practice Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Keywords
- ghrelin, obesity, type 2 diabetes, glucose homeostasis, growth hormone secretagogue receptor, energy balance, dietary intake, metabolic syndrome, ghrelin signaling, anti-obesity drugs, antidiabetic drugs
- MeSH terms
- Animals, Blood Glucose, Diabetes Mellitus, Energy Metabolism, Humans, Obesity, Peptide Hormones, Ghrelin
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