Genome-wide copy number variation study associates metabotropic glutamate receptor gene networks with attention deficit hyperactivity disorder
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Hakon Hakonarson and colleagues report a genome-wide copy number variation study in 3,506 cases of attention-deficit hyperactivity disorder. The authors identify a statistically significant enrichment of CNVs impacting metabotropic glutamate receptor genes. Attention deficit hyperactivity disorder (ADHD) is a common, heritable neuropsychiatric disorder of unknown etiology. We performed a whole-genome copy number variation (CNV) study on 1,013 cases with ADHD and 4,105 healthy children of European ancestry using 550,000 SNPs. We evaluated statistically significant findings in multiple independent cohorts, with a total of 2,493 cases with ADHD and 9,222 controls of European ancestry, using matched platforms. CNVs affecting metabotropic glutamate receptor genes were enriched across all cohorts (P = 2.1 × 10−9). We saw GRM5 (encoding glutamate receptor, metabotropic 5) deletions in ten cases and one control (P = 1.36 × 10−6). We saw GRM7 deletions in six cases, and we saw GRM8 deletions in eight cases and no controls. GRM1 was duplicated in eight cases. We experimentally validated the observed variants using quantitative RT-PCR. A gene network analysis showed that genes interacting with the genes in the GRM family are enriched for CNVs in ∼10% of the cases (P = 4.38 × 10−10) after correction for occurrence in the controls. We identified rare recurrent CNVs affecting glutamatergic neurotransmission genes that were overrepresented in multiple ADHD cohorts.
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ADHD-associated CNVs span several glutamate receptor genes and the gene encoding neuropeptide Y.
“Finally, ADHD-associated CNVs also span several glutamate receptor genes, which are essential for neuronal glutamatergic transmission 44 , and the gene encoding neuropeptide Y, which is involved in signalling in the brain and autonomic nervous system 45 .”
From Attention-deficit/hyperactivity disorder (2015) · cites this paper as [44]
The paper reports ADHD-associated CNVs directly affecting several metabotropic glutamate receptor genes (Abstract, page not supplied). It also reports an association at NLN, which inactivates neuropeptide Y; it does not report that its CNVs span the gene encoding neuropeptide Y (main text indexed under Abstract, page not supplied). (LLM, conf=0.90)
Experimental — accuracy not yet measuredAlterations in glutamate receptors (GRM-1, GRM-5, GRM-7 and GRM-8) have been associated with ADHD.
“Alterations in glutamate receptors (GRM-1, GRM-5, GRM-7 and GRM-8) have been associated with ADHD [124].”
From Molecular Characterisation of the Mechanism of Action of Stimulant Drugs Lisdexamfetamine and Methylphenidate on ADHD Neurobiology: A Review (2022) · cites this paper as [124]
In a genome-wide study, copy-number variations in genes interacting with metabotropic glutamate receptors were enriched in 10% of ADHD cases.
“in a genome-wide study of children with ADHD and matched controls, variations in copy number within genes interacting with metabotropic glutamate receptors were enriched in 10% of ADHD cases (Elia et al 2011).”
From Prefrontal cortex executive processes affected by stress in health and disease (2018) · cites this paper as Elia et al 2011
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Cites
Cytoscape: A software Environment for integrated models of biomolecular interaction networks
Shannon, P., Markiel, A., Ozier, O., Baliga, N. S., Wang, J. T., Ramage, D., Amin, N., Schwikowski, B., & Ideker, T. (2003) · Genome Research · doi:10.1101/gr.1239303 · Cited by 51,888 · see citing works
The Human Genome Browser at UCSC
Kent, W. J., Sugnet, C. W., Furey, T. S., Roskin, K. M., Pringle, T. H., Zahler, A. M., & Haussler, A. D. (2002) · Genome Research · doi:10.1101/gr.229102 · Cited by 10,400 · see citing works
DAVID: Database for Annotation, Visualization, and Integrated Discovery
Dennis, G., Sherman, B. T., Hosack, D. A., Yang, J., Gao, W., Lane, H. C., & Lempicki, R. A. (2003) · Genome Biology · doi:10.1186/gb-2003-4-5-p3 · Cited by 9,327 · see citing works
PHARMACOLOGY AND FUNCTIONS OF METABOTROPIC GLUTAMATE RECEPTORS
Conn, P. J., & Pin, J. (1997) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.37.1.205 · Cited by 3,083 · see citing works
Functional impact of global rare copy number variation in autism spectrum disorders
Pinto, D., Pagnamenta, A. T., Klei, L., Anney, R., Merico, D., Regan, R., Conroy, J., Magalhaes, T. R., Correia, C., Abrahams, B. S., et al. (2010) · Nature · doi:10.1038/nature09146 · Cited by 2,013 · cited 1× · see citing works
“Most neurodevelopmental disorders have been difficult to study by GWAS, apart from some progress that has been made in autis”
BackgroundSelf-citationStructural Variation of Chromosomes in Autism Spectrum Disorder
Marshall, C. R., Noor, A., Vincent, J. B., Lionel, A. C., Feuk, L., Skaug, J., Shago, M., Moessner, R., Pinto, D., Ren, Y., et al. (2008) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2007.12.009 · Cited by 1,815 · see citing works
Wang, K., Li, M., Hadley, D., Liu, R., Glessner, J., Grant, S. F. A., Hakonarson, H., & Bucan, M. (2007) · Genome Research · doi:10.1101/gr.6861907 · Cited by 1,792 · see citing works
Self-citationAutism genome-wide copy number variation reveals ubiquitin and neuronal genes
Glessner, J. T., Wang, K., Cai, G., Korvatska, O., Kim, C. E., Wood, S., Zhang, H., Estes, A., Brune, C. W., Bradfield, J. P., et al. (2009) · Nature · doi:10.1038/nature07953 · Cited by 1,421 · see citing works
Self-citationKoob, G. F., Sanna, P. P., & Bloom, F. E. (1998) · Neuron · doi:10.1016/s0896-6273(00)80557-7 · Cited by 1,026 · see citing works
Common genetic variants on 5p14.1 associate with autism spectrum disorders
Wang, K., Zhang, H., Ma, D., Bucan, M., Glessner, J. T., Abrahams, B. S., Salyakina, D., Imielinski, M., Bradfield, J. P., Sleiman, P. M. A., et al. (2009) · Nature · doi:10.1038/nature07999 · Cited by 989 · see citing works
Self-citationRole of Serotonin in the Paradoxical Calming Effect of Psychostimulants on Hyperactivity
Gainetdinov, R. R., Wetsel, W. C., Jones, S. R., Levin, E. D., Jaber, M., & Caron, M. G. (1999) · Science · doi:10.1126/science.283.5400.397 · Cited by 885 · see citing works
Kessler, R. C., Adler, L. A., Barkley, R., Biederman, J., Conners, C. K., Faraone, S. V., Greenhill, L. L., Jaeger, S., Secnik, K., Spencer, T., et al. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.04.001 · Cited by 663 · see citing works
Self-citationColella, S., Yau, C., Taylor, J. M., Mirza, G., Butler, H., Clouston, P., Bassett, A. S., Seller, A., Holmes, C. C., & Ragoussis, J. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm076 · Cited by 616 · see citing works
Williams, N. M., Zaharieva, I., Martin, A., Langley, K., Mantripragada, K., Fossdal, R., Stefansson, H., Stefansson, K., Magnusson, P., Gudmundsson, O. O., et al. (2010) · The Lancet · doi:10.1016/s0140-6736(10)61109-9 · Cited by 572 · see citing works
Self-citationElia, J., Gai, X., Xie, H. M., Perin, J. C., Geiger, E., Glessner, J. T., D'arcy, M., deBerardinis, R., Frackelton, E., Kim, C., et al. (2010) · Molecular Psychiatry · doi:10.1038/mp.2009.57 · Cited by 529 · see citing works
Self-citationAn RNA map predicting Nova-dependent splicing regulation
Ule, J., Stefani, G., Mele, A., Ruggiu, M., Wang, X., Taneri, B., Gaasterland, T., Blencowe, B. J., & Darnell, R. B. (2006) · Nature · doi:10.1038/nature05304 · Cited by 528 · see citing works
Nova regulates brain-specific splicing to shape the synapse
Ule, J., Ule, A., Spencer, J., Williams, A., Hu, J.-S., Cline, M., Wang, H., Clark, T., Fraser, C., Ruggiu, M., et al. (2005) · Nature Genetics · doi:10.1038/ng1610 · Cited by 509 · see citing works
Wang, L. Y., Zhu, C., Yong He, A., Zang, Y., Cao, Q., Zhang, H., Zhong, Q., & Wang, Y. (2008) · Human Brain Mapping · doi:10.1002/hbm.20530 · Cited by 480 · see citing works
Self-citationGenome-wide association studies in ADHD
Franke, B., Neale, B., & Faraone, S. (2009) · Human Genetics · doi:10.1007/s00439-009-0663-4 · Cited by 462 · see citing works
Self-citationLasky-Su, J. A., Neale, B. M., Franke, B., Anney, R., Zhou, K., Maller, J., Vásquez, A. A., Chen, W., Asherson, P. J., Buitelaar, J. K., et al. (2008) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30867 · Cited by 388 · see citing works
Self-citationLesch, K.-P., Timmesfeld, N., Renner, T. J., Halperin, R., Röser, C., Nguyen, T. T., Craig, D. W., Romanos, J., Heine, M., Meyer, J., et al. (2008) · Journal of Neural Transmission · doi:10.1007/s00702-008-0119-3 · Cited by 374 · see citing works
Self-citationAdjustment of genomic waves in signal intensities from whole-genome SNP genotyping platforms
Diskin, S. J., Li, M., Hou, C., Yang, S., Glessner, J., Hakonarson, H. H., Bućan, M., Maris, J. M., & Wang, K. (2008) · Nucleic Acids Research · doi:10.1093/nar/gkn556 · Cited by 350 · see citing works
Self-citationGenome-wide Association Scan of Attention Deficit Hyperactivity Disorder
Neale, B., Su, J., Anney, R., Franke, B., Zhou, K., Maller, J., Vásquez, A., Asherson, P., Chen, W., Banaschewski, T., et al. (2008) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30866 · Cited by 288 · see citing works
Self-citationCryan, J. F., Kelly, P. H., Neijt, H. C., Sansig, G., Flor, P. J., & van der Putten, H. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02667.x · Cited by 266 · see citing works
Genetics of Attention Deficit Hyperactivity Disorder
Mick, E. O., & Faraone, S. V. (2008) · Child and Adolescent Psychiatric Clinics of North America · doi:10.1016/j.chc.2007.11.011 · Cited by 230 · see citing works
Self-citationRenström, F., Payne, F., Nordström, A., Brito, E. C., Rolandsson, O., Hallmans, G., Barroso, I., Nordström, P., & Franks, P. W. (2009) · Human Molecular Genetics · doi:10.1093/hmg/ddp041 · Cited by 225 · see citing works
A Genome-Wide Association Study of Schizophrenia Using Brain Activation as a Quantitative Phenotype
Potkin, S. G., Turner, J. A., Guffanti, G., Lakatos, A., Fallon, J. H., Nguyen, D. D., Mathalon, D. H., Ford, J. M., Lauriello, J., & Macciardi, F. M. (2008) · Schizophrenia Bulletin · doi:10.1093/schbul/sbn155 · Cited by 219 · see citing works
Sagvolden, T., Johansen, E. B., Wøien, G., Walaas, S. I., Storm‐Mathisen, J., Bergersen, L. H., Hvalby, Ø., Jensen, V., Aase, H., Russell, V. A., et al. (2009) · Neuropharmacology · doi:10.1016/j.neuropharm.2009.08.004 · Cited by 206 · see citing works
Self-citationMeta-Analysis of Genome-Wide Linkage Scans of Attention Deficit Hyperactivity Disorder
Zhou, K., Dempfle, A., Arcos-Burgos, M., Bakker, S., Banaschewski, T., Biederman, J., Buitelaar, J., Castellanos, F., Doyle, A., Ebstein, R. P., et al. (2008) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30878 · Cited by 191 · see citing works
Self-citationFunctional connectivity of frontal cortex in healthy and ADHD children reflected in EEG coherence
Murias, M., Swanson, J. M., & Srinivasan, R. (2007) · Cerebral Cortex · doi:10.1093/cercor/bhl089 · Cited by 190 · see citing works
Glutamatergic modulation of hyperactivity in mice lacking the dopamine transporter
Gainetdinov, R. R., Mohn, A. R., Bohn, L., & Caron, M. G. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.191353298 · Cited by 168 · see citing works
Lesch, K.-P., Selch, S., Renner, T. J., Jacob, C., Nguyen, T. T., Hahn, T., Romanos, M., Walitza, S., Shoichet, S., Dempfle, A., et al. (2011) · Molecular Psychiatry · doi:10.1038/mp.2010.29 · Cited by 167 · see citing works
Self-citationProton spectroscopy in medication-free pediatric attention-deficit/hyperactivity disorder
MacMaster, F. P., CARREY, N. J., Sparkes, S. J., & Kusumakar, V. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01401-4 · Cited by 122 · see citing works
Courvoisie, H. E., Hooper, S. R., Fine, C., Kwock, L., & Castillo, M. (2004) · Journal of Neuropsychiatry · doi:10.1176/jnp.16.1.63 · Cited by 119 · see citing works
Dorval, K. M., Wigg, K., Crosbie, J., Tannock, R., Kennedy, J. L., Ickowicz, A., Pathare, T., MALONE, M. A., Schachar, R. J., & Barr, C. L. (2006) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2006.00273.x · Cited by 117 · see citing works
Mick, E., Neale, B., Middleton, F. A., McGough, J. J., & Faraone, S. V. (2008) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30865 · Cited by 108 · see citing works
Self-citationRussell, V. A., Allie, S., & Wiggins, T. (2000) · Behavioural Brain Research · doi:10.1016/s0166-4328(00)00291-6 · Cited by 107 · see citing works
Russell, V. A. (2003) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2003.08.010 · Cited by 107 · see citing works
Turic, D., Langley, K., Mills, S., Stephens, M., Lawson, D. C., Govan, C., Williams, N. M., van den Bree, M. V. D., Craddock, N., Kent, L., et al. (2004) · Molecular Psychiatry · doi:10.1038/sj.mp.4001387 · Cited by 91 · see citing works
Self-citationMiyamoto, K.-I., Nakanishi, H., Moriguchi, S., Fukuyama, N., Eto, K., Wakamiya, J., Murao, K., Arimura, K., & Osame, M. (2001) · Brain Research · doi:10.1016/s0006-8993(01)02281-8 · Cited by 83 · see citing works
Jin, Z., Zang, Y., Zeng, Y. W., Zhang, L., & Wang, Y. (2001) · Neuroscience Letters · doi:10.1016/s0304-3940(01)02315-1 · Cited by 83 · see citing works
Metabolite Changes Resulting From Treatment in Children With ADHD: A 1H-MRS Study
CARREY, N. J., MacMaster, F. P., Fogel, J., Sparkes, S. J., Waschbusch, D. A., Sullivan, S. O., & Schmidt, M. V. (2003) · Clinical Neuropharmacology · doi:10.1097/00002826-200307000-00013 · Cited by 82 · see citing works
A Comparison of Molecular Alterations in Environmental and Genetic Rat Models of ADHD: a pilot study
Dasbanerjee, T., Middleton, F. A., Berger, D. F., Lombardo, J. P., Sagvolden, T., & Faraone, S. (2008) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30877 · Cited by 74 · see citing works
Self-citationHuman metabotropic glutamate receptor type 7: Molecular cloning and mRNA distribution in the CNS
MAKOFF, A. J., Pilling, C., Harrington, K. A., & Emson, P. C. (1996) · Molecular Brain Research · doi:10.1016/0169-328x(96)00110-6 · Cited by 73 · see citing works
Expression of metabotropic glutamate receptor subtype mRNA (mGluR1–8) in human cerebellum
Berthele, A., Platzer, S., Laurie, D., Weis, S., Sommer, B., Zieglgänsberger, W., Conrad, B., & Tölle, T. R. (1999) · Neuroreport · doi:10.1097/00001756-199912160-00026 · Cited by 72 · see citing works
Derks, E. M., Hudziak, J. J., Dolan, C. V., van Beijsterveldt, T. C. E. M., Verhulst, F. C., & Boomsma, D. I. (2007) · Behavior Genetics · doi:10.1007/s10519-007-9178-8 · Cited by 58 · see citing works
Screening for replication of genome-wide SNP associations in sporadic ALS
Cronin, S., Tomik, B., Bradley, D. G., Słowik, A., & Hardiman, O. M. (2008) · European Journal of Human Genetics · doi:10.1038/ejhg.2008.194 · Cited by 54 · see citing works
High heritability for a composite index of children's activity level measures
Wood, A. C., Rijsdijk, F., Saudino, K., Asherson, P., & Kuntsi, J. (2008) · Behavior Genetics · doi:10.1007/s10519-008-9196-1 · Cited by 52 · see citing works
Self-citationOades, R. D., Daniels, R., & Rascher, W. (1998) · Psychiatry Research · doi:10.1016/s0165-1781(98)00064-x · Cited by 41 · see citing works
Self-citationTranscriptomic responses in mouse brain exposed to chronic excess of the neurotransmitter glutamate
Wang, X., Bao, X., Pal, R., Aǵbaş, A., & Michaelis, E. K. (2010) · BMC Genomics · doi:10.1186/1471-2164-11-360 · Cited by 40 · see citing works
Haberstick, B. C., Timberlake, D. S., Hopfer, C. J., Lessem, J. M., Ehringer, M. A., & Hewitt, J. K. (2007) · Psychological Medicine · doi:10.1017/s0033291707001584 · Cited by 38 · see citing works
Elia, J., Capasso, M., Zaheer, Z., Lantieri, F., Ambrosini, P., Berrettini, W., Devoto, M., & Hakonarson, H. (2009) · Psychiatric Genetics · doi:10.1097/ypg.0b013e32832a5043 · Cited by 37 · see citing works
Self-citationA Metabotropic Glutamate Receptor Family Gene in Dictyostelium discoideum
Taniura, H., Sanada, N., Kuramoto, N., & Yoneda, Y. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m512723200 · Cited by 32 · see citing works
Turic, D., Langley, K., Williams, H. J., Norton, N., Williams, N. M., Moskvina, V., van den Bree, M. B. M., Owen, M. J., Thapar, A., & O’Donovan, M. C. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.03.025 · Cited by 31 · see citing works
Self-citationEffects of neonatal 6-hydroxydopamine lesion on the gene expression profile in young adult rats
Masuo, Y., Ishido, M., Morita, M., & Oka, S. (2002) · Neuroscience Letters · doi:10.1016/s0304-3940(02)01167-9 · Cited by 26 · see citing works
Bo, R. D., Ghezzi, S., Corti, S. P., Santoro, D., Prelle, A. C., Mancuso, M., Siciliano, G., Briani, C., Murri, L., Bresolin, N., et al. (2008) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2008.149146 · Cited by 22 · see citing works
Structural variations in attention-deficit hyperactivity disorder
Elia, J., Gai, X., Hakonarson, H. H., & White, P. S. (2011) · The Lancet · doi:10.1016/s0140-6736(11)60120-7 · Cited by 6 · see citing works
Self-citationGenomic Expression in the Epileptogenic Hippocampus and Psychiatric Co-Morbidities
de Lanerolle, N. C., Eid, T., & Lee, T.-S. W. (2010) · Current Psychiatry Reviews · doi:10.2174/157340010791196448 · Cited by 2 · see citing works
Flagged first, then by citations
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Sorted by citations
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Faraone, S. V., Asherson, P., Banaschewski, T., Biederman, J., Buitelaar, J. K., Ramos-Quiroga, J. A., Rohde, L. A., Sonuga-Barke, E. J. S., Tannock, R., & Franke, B. (2015) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2015.20 · Cited by 1,479 · see citing works
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Faraone, S. V., & Larsson, H. (2019) · Molecular Psychiatry · doi:10.1038/s41380-018-0070-0 · Cited by 1,338 · see citing works
Self-citationCNVs: Harbingers of a Rare Variant Revolution in Psychiatric Genetics
Malhotra, D., & Sebat, J. (2012) · Cell · doi:10.1016/j.cell.2012.02.039 · Cited by 854 · see citing works
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Posner, J., Polanczyk, G. V., & Sonuga-Barke, E. (2020) · The Lancet · doi:10.1016/s0140-6736(19)33004-1 · Cited by 835 · see citing works
Self-citationUpdated European Consensus Statement on diagnosis and treatment of adult ADHD
Kooij, J. J. S., Bijlenga, D., Salerno, L., Jaeschke, R., Bitter, I., Balázs, J., Thome, J., Dom, G., Kasper, S., Nunes Filipe, C., et al. (2019) · European Psychiatry · doi:10.1016/j.eurpsy.2018.11.001 · Cited by 686 · see citing works
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Weischenfeldt, J., Symmons, O., Spitz, F., & Korbel, J. O. (2013) · Nature Reviews Genetics · doi:10.1038/nrg3373 · Cited by 648 · see citing works
Faraone, S. V. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.02.001 · Cited by 631 · see citing works
Self-citationLesch, K.-P., & Waider, J. (2012) · Neuron · doi:10.1016/j.neuron.2012.09.013 · Cited by 435 · see citing works
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Taurines, R., Schwenck, C., Westerwald, E., Sachse, M., Siniatchkin, M., & Freitag, C. (2012) · ADHD Attention Deficit and Hyperactivity Disorders · doi:10.1007/s12402-012-0086-2 · Cited by 301 · see citing works
Self-citationNovel Insights into NeuN: from Neuronal Marker to Splicing Regulator
Duan, W., Zhang, Y., Hou, Z., Huang, C. L., Zhu, H., Zhang, C., & Yin, Q. (2015) · Molecular Neurobiology · doi:10.1007/s12035-015-9122-5 · Cited by 296 · see citing works
Bolea-Alamañac, B., Nutt, D. J., Adamou, M., Asherson, P., Bazire, S., Coghill, D., Heal, D., Müller, U., Nash, J., Santosh, P., et al. (2014) · Journal of Psychopharmacology · doi:10.1177/0269881113519509 · Cited by 287 · see citing works
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Grant, S. G. (2012) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2012.02.002 · Cited by 248 · see citing works
Self-citationJoubert, B. R., den Dekker, H. T., Felix, J. F., Bohlin, J., Ligthart, S., Beckett, E., Tiemeier, H. W., van Meurs, J. B. J., Uitterlinden, A. G., Albert Hofman, D., et al. (2016) · Nature Communications · doi:10.1038/ncomms10577 · Cited by 262 · see citing works
Basolateral amygdala and stress-induced hyperexcitability affect motivated behaviors and addiction
Sharp, B. M. (2017) · Translational Psychiatry · doi:10.1038/tp.2017.161 · Cited by 244 · see citing works
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Yang, L., Neale, B. M., Liu, L., Lee, S. H., Wray, N. R., Ji, N., Li, H., Qian, Q., Wang, D., Li, J., et al. (2013) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32169 · Cited by 171 · see citing works
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Self-citationNext-Generation Treatments for Mental Disorders
Insel, T. R. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3004873 · Cited by 161 · see citing works
ClusterViz: A Cytoscape APP for Cluster Analysis of Biological Network
Wang, J.-X., Zhong, J., Chen, G., Li, M., Wu, F.-X., & Pan, Y. (2015) · IEEE/ACM Transactions on Computational Biology & Bioinformatics · doi:10.1109/tcbb.2014.2361348 · Cited by 137 · see citing works
Clinically relevant copy number variations detected in cerebral palsy
Oskoui, M., Gazzellone, M. J., Thiruvahindrapuram, B., Zarrei, M., Andersen, J. C., Wei, J., Wang, Z., Wintle, R. F., Marshall, C. R., Cohn, R. D., et al. (2015) · Nature Communications · doi:10.1038/ncomms8949 · Cited by 152 · see citing works
The comorbidity of ADHD and autism spectrum disorder
Antshel, K. M., Zhang-James, Y., & Faraone, S. V. (2013) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.2013.840417 · Cited by 147 · see citing works
Self-citationNaaijen, J., Bralten, J., Poelmans, G., The IMAGE consortium, Faraone, S., Asherson, P., Banaschewski, T., Buitelaar, J., Franke, B., P Ebstein, R., et al. (2017) · Translational Psychiatry · doi:10.1038/tp.2016.273 · Cited by 142 · see citing works
Self-citationGlutamatergic synapses in neurodevelopmental disorders
Moretto, E., Murru, L., Martano, G., Sassone, J., & Passafaro, M. (2017) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.09.014 · Cited by 136 · see citing works
The Cambridge Handbook of Personality Psychology
(2020) · Cambridge University Press eBooks · doi:10.1017/9781108264822 · Cited by 140 · see citing works
Timms, A. E., Dorschner, M. O., Wechsler, J., Choi, K. Y., Kirkwood, R., Girirajan, S., Baker, C. A., Eichler, E. E., Korvatska, O., Roche, K. W., et al. (2013) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2013.1195 · Cited by 133 · see citing works
G protein-coupled receptors as promising cancer targets
Liu, Y., An, S., Ward, R. J., Yang, Y., Guo, X., Li, W., & Xu, T. (2016) · Cancer Letters · doi:10.1016/j.canlet.2016.03.031 · Cited by 128 · see citing works
Genetic Associations between Voltage-Gated Calcium Channels and Psychiatric Disorders
Andrade, A., Brennecke, A., Mallat, S., Brown, J., Gomez-Rivadeneira, J., Czepiel, N., & Londrigan, L. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20143537 · Cited by 127 · see citing works
Hiroi, N., Takahashi, T., Hishimoto, A., Izumi, T., Boku, S., & Hiramoto, T. (2013) · Molecular Psychiatry · doi:10.1038/mp.2013.92 · Cited by 122 · see citing works
Molecular genetic studies of ADHD and its candidate genes: A review
Li, Z., Chang, S., Zhang, L., Gao, L., & Wang, J. (2014) · Psychiatry Research · doi:10.1016/j.psychres.2014.05.005 · Cited by 123 · see citing works
Schöneberg, T., & Liebscher, I. (2020) · Pharmacological Reviews · doi:10.1124/pharmrev.120.000011 · Cited by 127 · see citing works
Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders
Li, J., Zhang, W., Yang, H., Howrigan, D. P., Wilkinson, B., Souaiaia, T., Evgrafov, O. V., Genovese, G., Clementel, V. A., Tudor, J. C., et al. (2017) · Nature Neuroscience · doi:10.1038/nn.4594 · Cited by 119 · see citing works
Self-citationRBFOX1 and RBFOX3 Mutations in Rolandic Epilepsy
Lal, D., Reinthaler, E. M., Altmüller, J., Toliat, M. R., Thiele, H., Nürnberg, P., Lerche, H., Hahn, A., Møller, R. S., Muhle, H., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0073323 · Cited by 113 · see citing works
Phasing of Many Thousands of Genotyped Samples
Williams, A. L., Patterson, N. J., Glessner, J., Hakonarson, H. H., & Reich, D. (2012) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2012.06.013 · Cited by 109 · see citing works
Self-citationGlutamate/glutamine and neuronal integrity in adults with ADHD: a proton MRS study
Maltezos, S., Horder, J., Coghlan, S., Skirrow, C., O'Gorman, R., Lavender, T. J., Mendez, M. A., Mehta, M., Daly, E., Xenitidis, K., et al. (2014) · Translational Psychiatry · doi:10.1038/tp.2014.11 · Cited by 112 · see citing works
Self-citationSex Differences in Psychiatric Disease: A Focus on the Glutamate System
Wickens, M. M., Bangasser, D. A., & Briand, L. A. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00197 · Cited by 114 · see citing works
Discoveries on the Genetics of ADHD in the 21st Century: New Findings and Their Implications
Thapar, A. (2018) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2018.18040383 · Cited by 111 · see citing works
Jarick, I., Volckmar, A.-L., Pütter, C., Pechlivanis, S., Nguyen, T. T., Dauvermann, M., Beck, S., Albayrak, Ö., Scherag, S., Gilsbach, S., et al. (2012) · Molecular Psychiatry · doi:10.1038/mp.2012.161 · Cited by 92 · see citing works
Self-citationTNiK Is Required for Postsynaptic and Nuclear Signaling Pathways and Cognitive Function
Coba, M. P., Komiyama, N. H., Nithianantharajah, J., Kopanitsa, M. V., Indersmitten, T., Skene, N., Tuck, E. J., Fricker, D. G., Elsegood, K. A., Stanford, L. E., et al. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.2433-12.2012 · Cited by 106 · see citing works
Self-citationAlcohol use disorders and ADHD.
Luderer, M., Ramos Quiroga, J. A., Faraone, S. V., Zhang-James, Y., & Reif, A. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.07.010 · Cited by 102 · see citing works
Self-citationHanć, T., & Cortese, S. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.05.017 · Cited by 103 · see citing works
The role of ADHD associated genes in neurodevelopment
Dark, C., Homman-Ludiye, J., & Bryson-Richardson, R. J. (2018) · Developmental Biology · doi:10.1016/j.ydbio.2018.03.023 · Cited by 101 · see citing works
Klein, M., Onnink, M., van Donkelaar, M. V., Wolfers, T., Harich, B., Shi, Y., Dammers, J. T., Arias-Vásquez, A., Hoogman, M., & Franke, B. (2017) · Neuroscience and Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.01.013 · Cited by 104 · see citing works
Self-citationThe role of GPCRs in bone diseases and dysfunctions
Luo, J., Sun, P., Siwko, S. K., Liu, M., & Xiao, J. (2019) · Bone Research · doi:10.1038/s41413-019-0059-6 · Cited by 100 · see citing works
Meechan, D. W., Maynard, T. M., Tucker, E. S., Fernandez, A., Karpinski, B. A., Rothblat, L. A., & LaMantia, A. (2015) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2015.03.004 · Cited by 97 · see citing works
The clinical significance of small copy number variants in neurodevelopmental disorders
Asadollahi, R., Oneda, B., Joset, P., Azzarello-Burri, S. M., Bartholdi, D., Steindl, K., Vincent, M., Cobilanschi, J., Sticht, H., Baldinger, R., et al. (2014) · Journal of Medical Genetics · doi:10.1136/jmedgenet-2014-102588 · Cited by 99 · see citing works
Stergiakouli, E., Davey Smith, G., Martin, J., Skuse, D. H., Viechtbauer, W., Ring, S. M., Ronald, A., Evans, D. E., Fisher, S. E., Thapar, A., et al. (2017) · Molecular Autism · doi:10.1186/s13229-017-0131-2 · Cited by 97 · see citing works
Lal, D., Ruppert, A., Trucks, H., Schulz, H., de Kovel, C. G. F., Trenité, D. G. A. K.-N., Sonsma, A. C. M., Koeleman, B. P. C., Lindhout, D., Weber, Y. G., et al. (2015) · PLoS Genetics · doi:10.1371/journal.pgen.1005226 · Cited by 97 · see citing works
Genetics of ADHD: What Should the Clinician Know?
Grimm, O., Kranz, T. M., & Reif, A. (2020) · Current Psychiatry Reports · doi:10.1007/s11920-020-1141-x · Cited by 97 · see citing works
Self-citationImpact of the ADHD-susceptibility gene CDH13 on development and function of brain networks.
Rivero, O., Sich, S., Popp, S., Schmitt, A., Franke, B., & Lesch, K. (2013) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2012.06.009 · Cited by 104 · see citing works
Self-citationBralten, J., Franke, B., Waldman, I., Rommelse, N., Hartman, C., Asherson, P., Banaschewski, T., Ebstein, R. P., Gill, M., Miranda, A., et al. (2013) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2013.08.020 · Cited by 93 · see citing works
Self-citationCommon obesity risk alleles in childhood attention‐deficit/hyperactivity disorder
Albayrak, Ö., Pütter, C., Volckmar, A.-L., Cichon, S., Hoffmann, P., Nöthen, M., Jöckel, K., Schreiber, S., Wichmann, H., Faraone, S., et al. (2013) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32144 · Cited by 82 · see citing works
Self-citationPark, S., Jung, S.-W., Kim, B., Cho, S.-C., Shin, M., Kim, J.-W., Yoo, H. J., Cho, D.-Y., Chung, U., Son, J.-W., et al. (2013) · Behavioral and Brain Functions · doi:10.1186/1744-9081-9-1 · Cited by 91 · see citing works
Elia, J., Ungal, G., Kao, C., Ambrosini, A. P., Jesus-Rosario, N. D., Larsen, L., Chiavacci, R. M., Wang, T., Kurian, C. J., Titchen, K., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-02244-2 · Cited by 90 · see citing works
Self-citationSchizophrenia genetics: emerging themes for a complex disorder
Kavanagh, D. H., Tansey, K. E., O’Donovan, M. C., & Owen, M. J. (2014) · Molecular Psychiatry · doi:10.1038/mp.2014.148 · Cited by 86 · see citing works
Mosca, S. J., Langevin, L. M., Dewey, D., Innes, A. M., Lionel, A. C., Marshall, C. R., Scherer, S. W., Parboosingh, J. S., & Bernier, F. P. (2016) · Journal of Medical Genetics · doi:10.1136/jmedgenet-2016-103818 · Cited by 87 · see citing works
Temperament and brain networks of attention
Posner, M. I., & Rothbart, M. K. (2018) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2017.0254 · Cited by 87 · see citing works
Genetics of attention-deficit/hyperactivity disorder: an update
Akutagava-Martins, G. C., Rohde, L., & Hutz, M. (2016) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.2016.1130626 · Cited by 86 · see citing works
Moey, C., Hinze, S. J., Brueton, L. A., Morton, J., McMullan, D. J., Kamien, B., Barnett, C., Brunetti‐Pierri, N., Nicholl, J. K., Gécz, J., et al. (2015) · European Journal of Human Genetics · doi:10.1038/ejhg.2015.123 · Cited by 82 · see citing works
Genetic causes of developmental disorders
Vorstman, J. A. S., & Ophoff, R. A. (2013) · Current Opinion in Neurology · doi:10.1097/wco.0b013e32835f1a30 · Cited by 81 · see citing works
A current view on contactin-4, -5, and -6: Implications in neurodevelopmental disorders
Oguro‐Ando, A., Zuko, A., Kleijer, K. T. E., & Burbach, J. P. H. (2017) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2016.12.004 · Cited by 81 · see citing works
Adolescent Attention-Deficit/Hyperactivity Disorder: Understanding Teenage Symptom Trajectories
Shaw, P., & Sudre, G. P. (2020) · Biological Psychiatry · doi:10.1016/j.biopsych.2020.06.004 · Cited by 80 · see citing works
Self-citationGervin, K., Nordeng, H., Ystrøm, E., Reichborn-Kjennerud, T., & Lyle, R. (2017) · Clinical Epigenetics · doi:10.1186/s13148-017-0376-9 · Cited by 67 · see citing works
Serpeloni, F., Radtke, K. M., Hecker, T., Sill, J., Vukojevic, V., Assis, S. G. D., Schauer, M., Elbert, T., & Nätt, D. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2019.00269 · Cited by 77 · see citing works
Attention-deficit/hyperactive disorder updates
Kessi, M., Duan, H., Xiong, J., Chen, B., He, F., Yang, L., Ma, Y., Bamgbade, O. A., Peng, J., & Yin, F. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.925049 · Cited by 82 · see citing works
Glutamate receptor mutations in psychiatric and neurodevelopmental disorders
Soto, D., Altafaj, X., Sindreu, C. B., & Bayés, À. (2014) · Communicative & Integrative Biology · doi:10.4161/cib.27887 · Cited by 74 · see citing works
Diagnosis of attention deficit hyperactivity disorder using imaging and signal processing techniques
Sridhar, C., Bhat, S., Acharya, U. R., Adeli, H., & Bairy, G. M. (2017) · Computers in Biology and Medicine · doi:10.1016/j.compbiomed.2017.07.009 · Cited by 75 · see citing works
Dances with black widow spiders: Dysregulation of glutamate signalling enters centre stage in ADHD
Lesch, K., Merker, S., Reif, A., & Novak, M. (2012) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2012.07.013 · Cited by 73 · see citing works
Self-citationQuintero, J., Gutiérrez-Casares, J. R., & Álamo, C. (2022) · Neurology and Therapy · doi:10.1007/s40120-022-00392-2 · Cited by 70 · see citing works
“Caspase-3 CASP3 :; [124] 1498 Neurol Ther (2022) 11:1489–1517”
BackgroundInfluentialUnmet needs in paediatric psychopharmacology: Present scenario and future perspectives
Persico, A. M., Arango, C., Buitelaar, J. K., Correll, C. U., Glennon, J. C., Hoekstra, P. J., Moreno, C., Vitiello, B., Vorstman, J. A. S., & Zuddas, A. (2015) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2015.06.009 · Cited by 70 · see citing works
Self-citationPre- and Perinatal Ischemia-Hypoxia, the Ischemia-Hypoxia Response Pathway, and ADHD Risk
Smith, T. F., Schmidt‐Kastner, R., McGeary, J. E., Kaczorowski, J. A., & Knopik, V. S. (2016) · Behavior Genetics · doi:10.1007/s10519-016-9784-4 · Cited by 69 · see citing works
Attention-Deficit/Hyperactivity Disorder
Leung, A. K. C., & Hon, K. E. (2016) · Advances in Pediatrics · doi:10.1016/j.yapd.2016.04.017 · Cited by 69 · see citing works
Rare exonic deletions of the RBFOX1 gene increase risk of idiopathic generalized epilepsy
Lal, D., Trucks, H., Møller, R. S., Hjalgrim, H., Koeleman, B. P. C., de Kovel, C. G. F., Visscher, F., Weber, Y. G., Lerche, H., Becker, F., et al. (2013) · Epilepsia · doi:10.1111/epi.12084 · Cited by 67 · see citing works
ParseCNV integrative copy number variation association software with quality tracking
Glessner, J., Li, J., & Hakonarson, H. H. (2013) · Nucleic Acids Research · doi:10.1093/nar/gks1346 · Cited by 67 · see citing works
Self-citationPsychiatric gene discoveries shape evidence on ADHD’s biology
Thapar, A., Martin, J., Mick, E. O., Vásquez, A., Langley, K., Scherer, S., Schachar, R., Crosbie, J., Williams, N., Franke, B., et al. (2015) · Molecular Psychiatry · doi:10.1038/mp.2015.163 · Cited by 72 · see citing works
Self-citationNew Genes for Focal Epilepsies with Speech and Language Disorders
Turner, S. J., Morgan, A. T., Perez, E. R., & Scheffer, I. E. (2015) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-015-0554-0 · Cited by 66 · see citing works
Chen, Y.-C., Sudre, G. P., Sharp, W. S., Donovan, F. X., Chandrasekharappa, S. C., Hansen, N. F., Elnitski, L. L., & Shaw, P. (2017) · Molecular Psychiatry · doi:10.1038/mp.2017.45 · Cited by 61 · see citing works
Self-citationThe fine‐scale genetic structure and selection signals of Chinese indigenous pigs
Huang, M., Yang, B., Chen, H., Zhang, H., Wu, Z., Ai, H., Ren, J., & Huang, L. (2019) · Evolutionary Applications · doi:10.1111/eva.12887 · Cited by 64 · see citing works
Self-citationHadley, D., Wu, Z.-L., Kao, C., Kini, A., Mohamed-Hadley, A. A., Thomas, K., Vazquez, L., Qiu, H., Mentch, F. D., Pellegrino, R., et al. (2014) · Nature Communications · doi:10.1038/ncomms5074 · Cited by 63 · see citing works
Self-citationHuang, X., Wang, M., Zhang, Q., Chen, X., & Wu, J. (2019) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32726 · Cited by 62 · see citing works
Genetics of attention-deficit/hyperactivity disorder: current findings and future directions
Akutagava-Martins, G. C., Salatino-Oliveira, A., Kieling, C., Rohde, L., & Hutz, M. (2013) · Expert Review of Neurotherapeutics · doi:10.1586/ern.13.30 · Cited by 55 · see citing works
Maternal immune activation impairs cognitive flexibility and alters transcription in frontal cortex
Amodeo, D. A., Lai, C.-Y., Hassan, O., Mukamel, E. A., Behrens, M. M., & Powell, S. B. (2019) · Neurobiology of Disease · doi:10.1016/j.nbd.2019.01.025 · Cited by 59 · see citing works
the Janssen-CHOP Neuropsychiatric Genomics Working Group, Glessner, J., Li, J., Wang, D., March, M., Lima, L., Desai, A. G., Hadley, D., Kao, C., Gur, R. E., et al. (2017) · Genome Medicine · doi:10.1186/s13073-017-0494-1 · Cited by 58 · see citing works
Self-citationTreatment biomarkers for ADHD: Taking stock and moving forward
Michelini, G., Norman, L. J., Shaw, P., & Loo, S. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-02207-2 · Cited by 49 · see citing works
Self-citationNisar, S., & Haris, M. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-02060-9 · Cited by 63 · see citing works
F ifty Y ears of R esearch in ARDS. Genomic Contributions and Opportunities
Reilly, J. P., Christie, J. D., & Meyer, N. J. (2017) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201702-0405cp · Cited by 58 · see citing works
Genome-wide copy number variation analysis in adult attention-deficit and hyperactivity disorder.
Ramos-Quiroga, J., Sánchez-Mora, C., Casas, M., Garcia-Martínez, I., Bosch, R., Nogueira, M., Corrales, M., Palomar, G., Vidal, R., Coll-Tané, M., et al. (2014) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2013.10.022 · Cited by 55 · see citing works
Amyloidosis and cardiac involvement.
Cacoub, P., Axler, O., de Zuttere, D., Hausfater, P., Amoura, Z., Walter, S., Wechsler, B., Godeau, P., & Pietté, J. C. (2000) · PubMed · Cited by 54 · see citing works
Absent CNKSR 2 causes seizures and intellectual, attention, and language deficits
Vaags, A. K., Bowdin, S. C., Smith, M., Gilbert‐Dussardier, B., Holmefjord, K. S. B., Sinopoli, K. J., Gilles, C., Haaland, T. B., Vincent‐Delorme, C., Lagrue, E., et al. (2014) · Annals of Neurology · doi:10.1002/ana.24274 · Cited by 54 · see citing works
GRM7 Regulates Embryonic Neurogenesis via CREB and YAP
Xia, W., Liu, Y., & Jiao, J. (2015) · Stem Cell Reports · doi:10.1016/j.stemcr.2015.03.004 · Cited by 53 · see citing works
Dick, D. M., Cho, S. B., Latendresse, S. J., Alıev, F., Nürnberger, J. I., Edenberg, H. J., Schuckit, M. A., HESSELBROCK, V. M., Bernice Porjesz, A., Bucholz, K. K., et al. (2013) · Addiction Biology · doi:10.1111/adb.12066 · Cited by 52 · see citing works
Metabotropic Glutamate Receptor 7: A New Therapeutic Target in Neurodevelopmental Disorders
Fisher, N. M., Seto, M., Lindsley, C. W., & Niswender, C. M. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00387 · Cited by 52 · see citing works
Precision annotation of digital samples in NCBI’s gene expression omnibus
Hadley, D., Pan, J., El-Sayed, O. M., Aljabban, J., Aljabban, I., Azad, T. D., Hadied, M. O., Raza, S., Rayikanti, B. A., Chen, B., et al. (2017) · Scientific Data · doi:10.1038/sdata.2017.125 · Cited by 50 · see citing works
Self-citationNoroozi, R., Taheri, M. N., Movafagh, A., Mirfakhraie, R., Solgi, G., Sayad, A., Mazdeh, M., & Darvish, H. (2016) · Autism Research · doi:10.1002/aur.1640 · Cited by 52 · see citing works
Autism‐related behaviors in the cyclooxygenase‐2‐deficient mouse model
Wong, C. T., Bestard‐Lorigados, I., & Crawford, D. A. (2018) · Genes Brain & Behavior · doi:10.1111/gbb.12506 · Cited by 51 · see citing works
Su, L., Wang, N., Han, J., & Shen, Y. (2021) · The Neuroscientist · doi:10.1177/10738584211021018 · Cited by 50 · see citing works
- Authors
- Elia, J., Glessner, J. T., Wang, K., Takahashi, N., Shtir, C. J., Hadley, D., Sleiman, P. M. A., Zhang, H., Kim, C. E., Robison, R., Lyon, G. J., Flory, J. H., Bradfield, J. P., Imielinski, M., Hou, C., Frackelton, E. C., Chiavacci, R. M., Sakurai, T., Rabin, C., Middleton, F. A., Thomas, K. A., Garris, M., Mentch, F., Freitag, C. M., Steinhausen, H.-C., Todorov, A. A., Reif, A., Rothenberger, A., Franke, B., Mick, E. O., Roeyers, H., Buitelaar, J., Lesch, K.-P., Banaschewski, T., Ebstein, R. P., Mulas, F., Oades, R. D., Sergeant, J., Sonuga-Barke, E., Renner, T. J., Romanos, M., Romanos, J., Warnke, A., Walitza, S., Meyer, J., Pálmason, H., Seitz, C., Loo, S. K., Smalley, S. L., Biederman, J., Kent, L., Asherson, P., Anney, R. J. L., Gaynor, J. W., Shaw, P., Devoto, M., White, P. S., Grant, S. F. A., Buxbaum, J. D., Rapoport, J. L., Williams, N. M., Nelson, S. F., Faraone, S. V., & Hakonarson, H.
- Affiliations
- Children's Hospital of Philadelphia (US)
- Icahn School of Medicine at Mount Sinai (US)
- University of California, Los Angeles (US)
- University of Utah (US)
- National Institute of Mental Health (US)
- SUNY Upstate Medical University (US)
- Goethe University Frankfurt (DE)
- University of Basel (CH)
- Washington University in St. Louis (US)
- University of Würzburg (DE)
- University of Göttingen (DE)
- Radboud University Nijmegen (NL)
- Harvard University (US)
- Ghent University (BE)
- Radboud University Medical Center (NL)
- Heidelberg University (DE)
- National University of Singapore (SG)
- Hospital Universitari i Politècnic La Fe (ES)
- University of Duisburg-Essen (DE)
- Vrije Universiteit Amsterdam (NL)
- University of Zurich (CH)
- Universität Trier (DE)
- Saarland University (DE)
- University of St Andrews (GB)
- St. James's Hospital (IE)
- Cardiff University (GB)
- Corresponding author
- Hakonarson, Hakon
- ORCID
- Elia, Josephine
- Glessner, Joseph T
- Takahashi, Nagahide
- Hadley, Dexter
- Zhang, Haitao
- Robison, Reid
- Lyon, Gholson J
- Imielinski, Marcin
- Sakurai, Takeshi
- Middleton, Frank A
- Thomas, Kelly A
- Mentch, Frank
- Freitag, Christine M
- Steinhausen, Hans-Christoph
- Reif, Andreas
- Rothenberger, Aribert
- Franke, Barbara
- Mick, Eric O
- Roeyers, Herbert
- Buitelaar, Jan
- Lesch, Klaus-Peter
- Banaschewski, Tobias
- Ebstein, Richard P
- Sergeant, Joseph
- Sonuga-Barke, Edmund
- Romanos, Marcel
- Walitza, Susanne
- Loo, Sandra K
- Smalley, Susan L
- Biederman, Joseph
- Kent, Lindsey
- Asherson, Philip
- Anney, Richard J L
- Gaynor, J William
- Shaw, Philip
- Devoto, Marcella
- White, Peter S
- Grant, Struan F A
- Buxbaum, Joseph D
- Williams, Nigel M
- Faraone, Stephen V
- Hakonarson, Hakon
- Venue
- Nature Genetics
- Published
- 2011-12-04
- Volume
- 44
- Issue
- 1
- Pages
- 78-84
- ISSN
- 1061-4036 (ISSN-L)
- 1546-1718
- PMC
- PMC4310555
- OpenAlex
- W2171396537
- Cited by
- 406
- References
- 58
- Citations by year
- 2026: 11 · 2025: 14 · 2024: 14 · 2023: 16 · 2022: 32 · 2021: 14 · 2020: 74 · 2019: 23 · 2018: 27 · 2017: 33 · 2016: 26 · 2015: 32 · 2014: 32 · 2013: 30 · 2012: 26
- FWCI
- 19.47
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- public-domain
- www.springer.com/tdm (tdm)
- Locations
- Nature Genetics (publishedVersion, public-domain)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Cold Spring Harbor Laboratory Institutional Repository (Cold Spring Harbor Laboratory) (acceptedVersion)
- Ghent University Academic Bibliography (Ghent University) (submittedVersion, public-domain)
- National University of Singapore (submittedVersion)
- DuEPublico (University of Duisburg-Essen) (submittedVersion)
- ePrints Soton (University of Southampton) (submittedVersion)
- ORCA Online Research @Cardiff (Cardiff University) (submittedVersion)
- IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
- Research Portal (King's College London) (submittedVersion)
- GRO (submittedVersion)
- Radboud Repository (Radboud University) (submittedVersion)
- Hirsla (Landspítali University Hospital) (submittedVersion)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
- Funders
- Pfizer
- Children's Hospital of Philadelphia (UL1-RR-024134)
- University of Pennsylvania (UL1 RR024134)
- Cotswold Foundation
- Deutsche Forschungsgemeinschaft (SFB 581, TRR‐58, KFO125, ME 1923/5-1, 1923/5-1, SFB TRR 58)
- National Institutes of Health (5k23mh066275-05)
- National Institute of Mental Health (R01 MH 62873, R01MH083823, P50MH066392, RC2MH089924, R01MH062873, K23MH066275)
- National Center for Research Resources (UL1RR024134)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genomic variations and chromosomal abnormalities
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- attention deficit hyperactivity disorder, copy number variation, metabotropic glutamate receptors, GRM5, GRM7, GRM8, glutamatergic neurotransmission, gene network analysis, European ancestry
- MeSH terms
- Attention Deficit Disorder with Hyperactivity, Child, Child, Preschool, Humans, Gene Deletion, Receptors, Metabotropic Glutamate, Genetic Predisposition to Disease, Polymorphism, Single Nucleotide, Gene Regulatory Networks, DNA Copy Number Variations, Receptor, Metabotropic Glutamate 5
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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