CoChat
Sign Up
Cited by 238

The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.

Ascorbic acid prevents loss of Dlk1-Dio3 imprinting and facilitates generation of all–iPS cell mice from terminally differentiated B cells

Stadtfeld, Matthias, Apostolou, Effie, Ferrari, Francesco, Choi, Jiho, Walsh, Ryan M, Chen, Taiping, Ooi, Steen S K, Kim, Sang Yong, Bestor, Timothy H, Shioda, Toshi, Park, Peter J, Hochedlinger, Konrad·2012·Nature Genetics
DOI 10.1038/ng.1110PMC PMC3538378
Open this paper in CoChat — free account

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1038/ng.1110

Cites

5 of 5 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Vitamin C, IL-6, TGFβ and bone morphogenetic proteins regulate cellular reprogramming by affecting DNA methylation levels, thereby adjusting the expression of certain microRNAs or facilitating the mesenchymal-to-epithelial transition (MET).

    “In addition to cell intrinsic transcription factors for cellular reprogramming, modulators such as vitamin C [62][63][64][65] , IL-6 [66][67][68] , TGFβ 69 and bone morphogenetic proteins 70 have been shown to regulate cellular reprogramming by affecting DNA methylation levels, thereby adjusting the expression of certain microRNAs or facilitating the mesenchymal-to-epithelial transition (MET).”

    From Mechanisms, pathways and strategies for rejuvenation through epigenetic reprogramming (2023) · cites this paper as [64]

    The “Serum replacement and ascorbic acid prevent Gtl2 silencing” section reports that vitamin C prevented abnormal DNA hypermethylation during fibroblast reprogramming and increased reprogramming efficiency. The Discussion only raises the possibility that maintaining Dlk1-Dio3 imprinting could affect a microRNA involved in reprogramming; it does not establish that mechanism or report facilitation of MET. This verdict addresses the vitamin C portion to which this paper’s citation is attached, not the separately cited modulators. (LLM, conf=0.84)

    Experimental — accuracy not yet measured

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Flagged first, then by citations

Research works printed but not linked: 29

  1. Stadtfeld, M. & Hochedlinger, K. Induced pluripotency: history, mechanisms, and applications. Genes Dev. 24, 2239–2263 (2010). · DOI
  2. Wu, S.M. & Hochedlinger, K. Harnessing the potential of induced pluripotent stem cells for regenerative medicine. Nat. Cell Biol. 13, 497–505 (2011). · DOI
  3. da Rocha, S.T., Edwards, C.A., Ito, M., Ogata, T. & Ferguson-Smith, A.C. Genomic imprinting at the mammalian Dlk1-Dio3 domain. Trends Genet. 24, 306–316 (2008). · DOI
  4. Stadtfeld, M. et al. Aberrant silencing of imprinted genes on chromosome 12qF1 in mouse induced pluripotent stem cells. Nature 465, 175–181 (2010). · DOI
  5. Zhou, Y. et al. Activation of paternally expressed genes and perinatal death caused by deletion of the Gtl2 gene. Development 137, 2643–2652 (2010). · DOI
  6. Liu, L. et al. Activation of the imprinted Dlk1-Dio3 region correlates with pluripotency levels of mouse stem cells. J. Biol. Chem. 285, 19483–19490 (2010). · DOI
  7. Stadtfeld, M., Maherali, N., Borkent, M. & Hochedlinger, K. A reprogrammable mouse strain from gene-targeted embryonic stem cells. Nat. Methods 7, 53–55 (2010). · DOI
  8. Kaneda, M. et al. Essential role for de novo DNA methyltransferase Dnmt3a in paternal and maternal imprinting. Nature 429, 900–903 (2004). · DOI
  9. Kato, Y. et al. Role of the Dnmt3 family in de novo methylation of imprinted and repetitive sequences during male germ cell development in the mouse. Hum. Mol. Genet. 16, 2272–2280 (2007). · DOI
  10. Bourc'his, D. & Bestor, T.H. Meiotic catastrophe and retrotransposon reactivation in male germ cells lacking Dnmt3L. Nature 431, 96–99 (2004). · DOI
  11. Blelloch, R., Venere, M., Yen, J. & Ramalho-Santos, M. Generation of induced pluripotent stem cells in the absence of drug selection. Cell Stem Cell 1, 245–247 (2007). · DOI
  12. Chung, T.L. et al. Vitamin C promotes widespread yet specific DNA demethylation of the epigenome in human embryonic stem cells. Stem Cells 28, 1848–1855 (2010). · DOI
  13. Esteban, M.A. et al. Vitamin C enhances the generation of mouse and human induced pluripotent stem cells. Cell Stem Cell 6, 71–79 (2010). · DOI · Paper page
  14. Li, W. et al. iPS cells generated without c-Myc have active Dlk1-Dio3 region and are capable of producing full-term mice through tetraploid complementation. Cell Res. 21, 550–553 (2011). · DOI
  15. Kang, L. et al. Viable mice produced from three-factor induced pluripotent stem (iPS) cells through tetraploid complementation. Cell Res. 21, 546–549 (2011). · DOI
  16. Carey, B.W. et al. Reprogramming factor stoichiometry influences the epigenetic state and biological properties of induced pluripotent stem cells. Cell Stem Cell 9, 588–598 (2011). · DOI
  17. Zhang, Y. et al. Chromatin methylation activity of Dnmt3a and Dnmt3a/3L is guided by interaction of the ADD domain with the histone H3 tail. Nucleic Acids Res. 38, 4246–4253 (2010). · DOI
  18. Otani, J. et al. Structural basis for recognition of H3K4 methylation status by the DNA methyltransferase 3A ATRX-DNMT3-DNMT3L domain. EMBO Rep. 10, 1235–1241 (2009). · DOI
  19. Bock, C. et al. Reference maps of human ES and iPS cell variation enable high-throughput characterization of pluripotent cell lines. Cell 144, 439–452 (2011). · DOI · Paper page
  20. Eggan, K. et al. Hybrid vigor, fetal overgrowth, and viability of mice derived by nuclear cloning and tetraploid embryo complementation. Proc. Natl. Acad. Sci. USA 98, 6209–6214 (2001). · DOI
  21. Nagy, A. et al. Embryonic stem cells alone are able to support fetal development in the mouse. Development 110, 815–821 (1990). · DOI
  22. Kim, J.B. et al. Pluripotent stem cells induced from adult neural stem cells by reprogramming with two factors. Nature 454, 646–650 (2008). · DOI
  23. Hanna, J. et al. Direct reprogramming of terminally differentiated mature B lymphocytes to pluripotency. Cell 133, 250–264 (2008). · DOI
  24. Wang, T. et al. The histone demethylases Jhdm1a/1b enhance somatic cell reprogramming in a vitamin-C–dependent manner. Cell Stem Cell 9, 575–587 (2011). · DOI · Paper page
  25. Miyoshi, N. et al. Reprogramming of mouse and human cells to pluripotency using mature microRNAs. Cell Stem Cell 8, 633–638 (2011). · DOI
  26. Hock, H. et al. Tel/Etv6 is an essential and selective regulator of adult hematopoietic stem cell survival. Genes Dev. 18, 2336–2341 (2004). · DOI
  27. Coser, K.R. et al. Global analysis of ligand sensitivity of estrogen inducible and suppressible genes in MCF7/BUS breast cancer cells by DNA microarray. Proc. Natl. Acad. Sci. USA 100, 13994–13999 (2003). · DOI
  28. Atkinson, M.J., Michnick, D.A., Paige, C.J. & Wu, G.E. Ig gene rearrangements on individual alleles of Abelson murine leukemia cell lines from (C57BL/6 × BALB/c) F1 fetal livers. J. Immunol. 146, 2805–2812 (1991). · DOI
  29. Kharchenko, P.V., Tolstorukov, M.Y. & Park, P.J. Design and analysis of ChIP-seq experiments for DNA-binding proteins. Nat. Biotechnol. 26, 1351–1359 (2008). · DOI

Cited by

Sorted by citations

Metadata

Authors
Stadtfeld, M., Apostolou, E., Ferrari, F., Choi, J., Walsh, R. M., Chen, T., Ooi, S. S. K., Kim, S. Y., Bestor, T. H., Shioda, T., Park, P. J., & Hochedlinger, K.
Venue
Nature Genetics
Publisher
Springer Science and Business Media LLC
Published
2012-03-04
Volume
44
Issue
4
Pages
398-405
ISSN
  • 1061-4036
  • 1546-1718
DOI
10.1038/ng.1110
PMC
PMC3538378
Cited by
238
References
5
Language
en
Update notices
erratum (2012-06-27)
Licence

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review