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Cited by 150

The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.

Cystatin C modulates cerebral β-amyloidosis

Kaeser, Stephan A, Herzig, Martin C, Coomaraswamy, Janaky, Kilger, Ellen, Selenica, Maj-Linda, Winkler, David T, Staufenbiel, Matthias, Levy, Efrat, Grubb, Anders, Jucker, Mathias·2007·Nature Genetics
DOI 10.1038/ng.2007.23
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Abstract

The CST3 Thr25 allele of CST3, which encodes cystatin C, leads to reduced cystatin C secretion and conveys susceptibility to Alzheimer's disease. Here we show that overexpression of human cystatin C in brains of APP-transgenic mice reduces cerebral amyloid-beta deposition and that cystatin C binds amyloid-beta and inhibits its fibril formation. Our results suggest that cystatin C concentrations modulate cerebral amyloidosis risk and provide an opportunity for genetic risk assessment and therapeutic interventions.

Overview

Integrity signals

Registry

Crossref · 10.1038/ng.2007.23

Cites

3 of 3 references verified0 citation errors · 0 not checkable

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Citations

Cites

Flagged first, then by citations

Research works printed but not linked: 12

  1. Levy, E. et al. Brain Pathol. 16, 60–70 (2006). · DOI
  2. Selenica, M.L. et al. Scand. J. Clin. Lab. Invest. 67, 179–190 (2007). · DOI
  3. Balbin, M. et al. Biol. Chem. Hoppe Seyler 373, 471–476 (1992). · DOI
  4. Finckh, U. et al. Arch. Neurol. 57, 1579–1583 (2000). · DOI
  5. Cathcart, H.M. et al. Neurology 64, 755–757 (2005). · DOI
  6. Benussi, L. et al. Neurobiol. Dis. 13, 15–21 (2003). · DOI
  7. Paraoan, L. et al. Traffic 5, 884–895 (2004). · DOI
  8. Eriksson, P. et al. Arterioscler. Thromb. Vasc. Biol. 24, 551–557 (2004). · DOI
  9. Chuo, L.J. et al. Dement. Geriatr. Cogn. Disord. 23, 251–257 (2007). · DOI · Paper page
  10. Ghidoni, R. et al. Neurobiol. Aging 28, 371–376 (2007). · DOI
  11. Bjarnadottir, M. et al. Amyloid 8, 1–10 (2001). · DOI
  12. Filler, G. et al. Clin. Biochem. 38, 1–8 (2005). · DOI

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Metadata

Authors
Kaeser, S. A., Herzig, M. C., Coomaraswamy, J., Kilger, E., Selenica, M.-L., Winkler, D. T., Staufenbiel, M., Levy, E., Grubb, A., & Jucker, M.
Venue
Nature Genetics
Publisher
Springer Science and Business Media LLC
Published
2007-11-18
Volume
39
Issue
12
Pages
1437-1439
ISSN
  • 1061-4036
  • 1546-1718
DOI
10.1038/ng.2007.23
Cited by
150
References
3
Language
en
Licence
www.springer.com/tdm (tdm)

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