Cited by 172Neuroinflammation and Neurodegeneration MechanismsCerebrospinal fluid and hydrocephalusBarrier Structure and Function Studies

Aging-associated deficit in CCR7 is linked to worsened glymphatic function, cognition, neuroinflammation, and β-amyloid pathology

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Da Mesquita, Sandro, Herz, Jasmin, Wall, Morgan, Dykstra, Taitea, de Lima, Kalil Alves, Norris, Geoffrey T., Dabhi, Nisha, Kennedy, Tatiana +2 more·2021·Science Advances

Abstract

Dysfunctional meningeal immunity is associated with cognitive decline, impaired glymphatics, and enhanced Alzheimer’s pathology.

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Authors
Da Mesquita, S., Herz, J., Wall, M., Dykstra, T., de Lima, K. A., Norris, G. T., Dabhi, N., Kennedy, T., Baker, W., & Kipnis, J.
Affiliations
  • Department of Neuroscience, Center for Brain Immunology and Glia (BIG), University of Virginia, Charlottesville, VA, USA.
  • Washington University in St. Louis (US)
  • University of Virginia (US)
  • Center for Brain Immunology and Glia (BIG), Washington University in St. Louis, St. Louis, MO, USA.
  • University of Washington (US)
Corresponding author
Kipnis, Jonathan
Venue
Science Advances
Published
2021-05-21
Volume
7
Issue
21
ISSN
2375-2548 (ISSN-L)
OpenAlex
W3163888514
Cited by
172
References
65
Citations by year
2026: 28 · 2025: 36 · 2024: 40 · 2023: 28 · 2022: 33 · 2021: 7
FWCI
11.11
Type
journal article
Language
en
Open access
Locations
  • Science Advances (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
  • Digital Commons@Becker (Washington University School of Medicine) (submittedVersion, cc-by-nc)
Funders
  • National Institute on Aging (AG034113, AG057496)
  • Cure Alzheimer’s Fund
Topics
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Cerebrospinal fluid and hydrocephalus
  • Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
Keywords
CCR7, brain aging, glymphatic system, meningeal lymphatic vessels, regulatory T cells, effector T cells, Alzheimer's disease, amyloid-beta pathology, neuroinflammation, cognitive decline, anti-CD25 therapy, 5xFAD mice, microglial activation, neurovascular unit, meningeal immunity

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