Aging-associated deficit in CCR7 is linked to worsened glymphatic function, cognition, neuroinflammation, and β-amyloid pathology
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Dysfunctional meningeal immunity is associated with cognitive decline, impaired glymphatics, and enhanced Alzheimer’s pathology.
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During aging, the meninges undergo a shift towards pro-inflammatory immune responses, characterized by an increased number of T cells and B cells.
“During aging, the meninges undergo a shift towards pro-inflammatory immune responses, characterized by an increased number of T cells and B cells.”
From Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases (2024) · cites this paper as [683]
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- Authors
- Da Mesquita, S., Herz, J., Wall, M., Dykstra, T., de Lima, K. A., Norris, G. T., Dabhi, N., Kennedy, T., Baker, W., & Kipnis, J.
- Affiliations
- Department of Neuroscience, Center for Brain Immunology and Glia (BIG), University of Virginia, Charlottesville, VA, USA.
- Washington University in St. Louis (US)
- University of Virginia (US)
- Center for Brain Immunology and Glia (BIG), Washington University in St. Louis, St. Louis, MO, USA.
- University of Washington (US)
- Corresponding author
- Kipnis, Jonathan
- ORCID
- Venue
- Science Advances
- Published
- 2021-05-21
- Volume
- 7
- Issue
- 21
- ISSN
- 2375-2548 (ISSN-L)
- PMC
- PMC8139596
- OpenAlex
- W3163888514
- Cited by
- 172
- References
- 65
- Citations by year
- 2026: 28 · 2025: 36 · 2024: 40 · 2023: 28 · 2022: 33 · 2021: 7
- FWCI
- 11.11
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Science Advances (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Digital Commons@Becker (Washington University School of Medicine) (submittedVersion, cc-by-nc)
- Funders
- National Institute on Aging (AG034113, AG057496)
- Cure Alzheimer’s Fund
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Cerebrospinal fluid and hydrocephalus
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Keywords
- CCR7, brain aging, glymphatic system, meningeal lymphatic vessels, regulatory T cells, effector T cells, Alzheimer's disease, amyloid-beta pathology, neuroinflammation, cognitive decline, anti-CD25 therapy, 5xFAD mice, microglial activation, neurovascular unit, meningeal immunity
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