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A genome-wide association meta-analysis identifies new childhood obesity loci
Open accessAbstract
Multiple genetic variants have been associated with adult obesity and a few with severe obesity in childhood; however, less progress has been made in establishing genetic influences on common early-onset obesity. We performed a North American, Australian and European collaborative meta-analysis of 14 studies consisting of 5,530 cases (≥95th percentile of body mass index (BMI)) and 8,318 controls (<50th percentile of BMI) of European ancestry. Taking forward the eight newly discovered signals yielding association with P < 5 × 10−6 in nine independent data sets (2,818 cases and 4,083 controls), we observed two loci that yielded genome-wide significant combined P values near OLFM4 at 13q14 (rs9568856; P = 1.82 × 10−9; odds ratio (OR) = 1.22) and within HOXB5 at 17q21 (rs9299; P = 3.54 × 10−9; OR = 1.14). Both loci continued to show association when two extreme childhood obesity cohorts were included (2,214 cases and 2,674 controls). These two loci also yielded directionally consistent associations in a previous meta-analysis of adult BMI.
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Self-citation
Metadata
- Authors
- the Early Growth Genetics (EGG) Consortium
- Venue
- Nature Genetics
- Published
- 2012-04-08
- Volume
- 44
- Issue
- 5
- Pages
- 526-531
- ISSN
- 1061-4036 (ISSN-L)
- 1546-1718
- OpenAlex
- W1983270011
- Cited by
- 428
- References
- 18
- FWCI
- 24.98
- Type
- journal article
- Language
- en
- Open access
- green
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