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Cited by 626

The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.

Identification of common variants associated with human hippocampal and intracranial volumes

Open access
the Alzheimer's Disease Neuroimaging Initiative (ADNI), Stein, Jason L, EPIGEN Consortium, IMAGEN Consortium, Saguenay Youth Study Group (SYS), Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium, for the Enhancing Neuro Imaging Genetics through Meta-Analysis (ENIGMA) Consortium, Medland, Sarah E, Vasquez, Alejandro Arias, Hibar, Derrek P, Senstad, Rudy E, Winkler, Anderson M, Toro, Roberto, Appel, Katja, Bartecek, Richard, Bergmann, Ørjan, Bernard, Manon, Brown, Andrew A, Cannon, Dara M, Chakravarty, M Mallar, Christoforou, Andrea, Domin, Martin, Grimm, Oliver, Hollinshead, Marisa, Holmes, Avram J, Homuth, Georg, Hottenga, Jouke-Jan, Langan, Camilla, Lopez, Lorna M, Hansell, Narelle K, Hwang, Kristy S, Kim, Sungeun, Laje, Gonzalo, Lee, Phil H, Liu, Xinmin, Loth, Eva, Lourdusamy, Anbarasu, Mattingsdal, Morten, Mohnke, Sebastian, Maniega, Susana Muñoz, Nho, Kwangsik, Nugent, Allison C, O'Brien, Carol, Papmeyer, Martina, Pütz, Benno, Ramasamy, Adaikalavan, Rasmussen, Jerod, Rijpkema, Mark, Risacher, Shannon L, Roddey, J Cooper, Rose, Emma J, Ryten, Mina, Shen, Li, Sprooten, Emma, Strengman, Eric, Teumer, Alexander, Trabzuni, Daniah, Turner, Jessica, van Eijk, Kristel, van Erp, Theo G M, van Tol, Marie-Jose, Wittfeld, Katharina, Wolf, Christiane, Woudstra, Saskia, Aleman, Andre, Alhusaini, Saud, Almasy, Laura, Binder, Elisabeth B, Brohawn, David G, Cantor, Rita M, Carless, Melanie A, Corvin, Aiden, Czisch, Michael, Curran, Joanne E, Davies, Gail, de Almeida, Marcio A A, Delanty, Norman, Depondt, Chantal, Duggirala, Ravi, Dyer, Thomas D, Erk, Susanne, Fagerness, Jesen, Fox, Peter T, Freimer, Nelson B, Gill, Michael, Göring, Harald H H, Hagler, Donald J, Hoehn, David, Holsboer, Florian, Hoogman, Martine, Hosten, Norbert, Jahanshad, Neda, Johnson, Matthew P, Kasperaviciute, Dalia, Kent, Jack W, Kochunov, Peter, Lancaster, Jack L, Lawrie, Stephen M, Liewald, David C, Mandl, René, Matarin, Mar, Mattheisen, Manuel, Meisenzahl, Eva, Melle, Ingrid, Moses, Eric K, Mühleisen, Thomas W, Nauck, Matthias, Nöthen, Markus M, Olvera, Rene L, Pandolfo, Massimo, Pike, G Bruce, Puls, Ralf, Reinvang, Ivar, Rentería, Miguel E, Rietschel, Marcella, Roffman, Joshua L, Royle, Natalie A, Rujescu, Dan, Savitz, Jonathan, Schnack, Hugo G, Schnell, Knut, Seiferth, Nina, Smith, Colin, Steen, Vidar M, Valdés Hernández, Maria C, Van den Heuvel, Martijn, van der Wee, Nic J, Van Haren, Neeltje E M, Veltman, Joris A, Völzke, Henry, Walker, Robert, Westlye, Lars T, Whelan, Christopher D, Agartz, Ingrid, Boomsma, Dorret I, Cavalleri, Gianpiero L, Dale, Anders M, Djurovic, Srdjan, Drevets, Wayne C, Hagoort, Peter, Hall, Jeremy, Heinz, Andreas, Jack, Clifford R, Foroud, Tatiana M, Le Hellard, Stephanie, Macciardi, Fabio, Montgomery, Grant W, Poline, Jean Baptiste, Porteous, David J, Sisodiya, Sanjay M, Starr, John M, Sussmann, Jessika, Toga, Arthur W, Veltman, Dick J, Walter, Henrik, Weiner, Michael W, Bis, Joshua C, Ikram, M Arfan, Smith, Albert V, Gudnason, Vilmundur, Tzourio, Christophe, Vernooij, Meike W, Launer, Lenore J, DeCarli, Charles, Seshadri, Sudha, Andreassen, Ole A, Apostolova, Liana G, Bastin, Mark E, Blangero, John, Brunner, Han G, Buckner, Randy L, Cichon, Sven, Coppola, Giovanni, de Zubicaray, Greig I, Deary, Ian J, Donohoe, Gary, de Geus, Eco J C, Espeseth, Thomas, Fernández, Guillén, Glahn, David C, Grabe, Hans J, Hardy, John, Hulshoff Pol, Hilleke E, Jenkinson, Mark, Kahn, René S, McDonald, Colm, McIntosh, Andrew M, McMahon, Francis J, McMahon, Katie L, Meyer-Lindenberg, Andreas, Morris, Derek W, Müller-Myhsok, Bertram, Nichols, Thomas E, Ophoff, Roel A, Paus, Tomas, Pausova, Zdenka, Penninx, Brenda W, Potkin, Steven G, Sämann, Philipp G, Saykin, Andrew J, Schumann, Gunter, Smoller, Jordan W, Wardlaw, Joanna M, Weale, Michael E, Martin, Nicholas G, Franke, Barbara, Wright, Margaret J, Thompson, Paul M·2012·Nature Genetics
DOI 10.1038/ng.2250
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Abstract

Identifying genetic variants influencing human brain structures may reveal new biological mechanisms underlying cognition and neuropsychiatric illness. The volume of the hippocampus is a biomarker of incipient Alzheimer's disease and is reduced in schizophrenia, major depression and mesial temporal lobe epilepsy. Whereas many brain imaging phenotypes are highly heritable, identifying and replicating genetic influences has been difficult, as small effects and the high costs of magnetic resonance imaging (MRI) have led to underpowered studies. Here we report genome-wide association meta-analyses and replication for mean bilateral hippocampal, total brain and intracranial volumes from a large multinational consortium. The intergenic variant rs7294919 was associated with hippocampal volume (12q24.22; N = 21,151; P = 6.70 × 10−16) and the expression levels of the positional candidate gene TESC in brain tissue. Additionally, rs10784502, located within HMGA2, was associated with intracranial volume (12q14.3; N = 15,782; P = 1.12 × 10−12). We also identified a suggestive association with total brain volume at rs10494373 within DDR2 (1q23.3; N = 6,500; P = 5.81 × 10−7).

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Authors
(ADNI), T. A. D. N. I., Stein, J. L., EPIGEN Consortium, IMAGEN Consortium, Saguenay Youth Study Group (SYS), Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium, for the Enhancing Neuro Imaging Genetics through Meta-Analysis (ENIGMA) Consortium, Medland, S. E., Vasquez, A. A., Hibar, D. P., Senstad, R. E., Winkler, A. M., Toro, R., Appel, K., Bartecek, R., Bergmann, Ø., Bernard, M., Brown, A. A., Cannon, D. M., Chakravarty, M. M., Christoforou, A., Domin, M., Grimm, O., Hollinshead, M., Holmes, A. J., Homuth, G., Hottenga, J.-J., Langan, C., Lopez, L. M., Hansell, N. K., Hwang, K. S., Kim, S., Laje, G., Lee, P. H., Liu, X., Loth, E., Lourdusamy, A., Mattingsdal, M., Mohnke, S., Maniega, S. M., Nho, K., Nugent, A. C., O'Brien, C., Papmeyer, M., Pütz, B., Ramasamy, A., Rasmussen, J., Rijpkema, M., Risacher, S. L., Roddey, J. C., Rose, E. J., Ryten, M., Shen, L., Sprooten, E., Strengman, E., Teumer, A., Trabzuni, D., Turner, J., van Eijk, K., van Erp, T. G. M., van Tol, M.-J., Wittfeld, K., Wolf, C., Woudstra, S., Aleman, A., Alhusaini, S., Almasy, L., Binder, E. B., Brohawn, D. G., Cantor, R. M., Carless, M. A., Corvin, A., Czisch, M., Curran, J. E., Davies, G., de Almeida, M. A. A., Delanty, N., Depondt, C., Duggirala, R., Dyer, T. D., Erk, S., Fagerness, J., Fox, P. T., Freimer, N. B., Gill, M., Göring, H. H. H., Hagler, D. J., Hoehn, D., Holsboer, F., Hoogman, M., Hosten, N., Jahanshad, N., Johnson, M. P., Kasperaviciute, D., Kent, J. W., Kochunov, P., Lancaster, J. L., Lawrie, S. M., Liewald, D. C., Mandl, R., Matarin, M., Mattheisen, M., Meisenzahl, E., Melle, I., Moses, E. K., Mühleisen, T. W., Nauck, M., Nöthen, M. M., Olvera, R. L., Pandolfo, M., Pike, G. B., Puls, R., Reinvang, I., Rentería, M. E., Rietschel, M., Roffman, J. L., Royle, N. A., Rujescu, D., Savitz, J., Schnack, H. G., Schnell, K., Seiferth, N., Smith, C., Steen, V. M., Valdés Hernández, M. C., Van den Heuvel, M., van der Wee, N. J., Van Haren, N. E. M., Veltman, J. A., Völzke, H., Walker, R., Westlye, L. T., Whelan, C. D., Agartz, I., Boomsma, D. I., Cavalleri, G. L., Dale, A. M., Djurovic, S., Drevets, W. C., Hagoort, P., Hall, J., Heinz, A., Jack, C. R., Foroud, T. M., Le Hellard, S., Macciardi, F., Montgomery, G. W., Poline, J. B., Porteous, D. J., Sisodiya, S. M., Starr, J. M., Sussmann, J., Toga, A. W., Veltman, D. J., Walter, H., Weiner, M. W., Bis, J. C., Ikram, M. A., Smith, A. V., Gudnason, V., Tzourio, C., Vernooij, M. W., Launer, L. J., DeCarli, C., Seshadri, S., Andreassen, O. A., Apostolova, L. G., Bastin, M. E., Blangero, J., Brunner, H. G., Buckner, R. L., Cichon, S., Coppola, G., de Zubicaray, G. I., Deary, I. J., Donohoe, G., de Geus, E. J. C., Espeseth, T., Fernández, G., Glahn, D. C., Grabe, H. J., Hardy, J., Hulshoff Pol, H. E., Jenkinson, M., Kahn, R. S., McDonald, C., McIntosh, A. M., McMahon, F. J., McMahon, K. L., Meyer-Lindenberg, A., Morris, D. W., Müller-Myhsok, B., Nichols, T. E., Ophoff, R. A., Paus, T., Pausova, Z., Penninx, B. W., Potkin, S. G., Sämann, P. G., Saykin, A. J., Schumann, G., Smoller, J. W., Wardlaw, J. M., Weale, M. E., Martin, N. G., Franke, B., Wright, M. J., & Thompson, P. M.
Venue
Nature Genetics
Publisher
Springer Science and Business Media LLC
Published
2012-04-15
Volume
44
Issue
5
Pages
552-561
ISSN
  • 1061-4036 (ISSN-L)
  • 1546-1718
DOI
10.1038/ng.2250
OpenAlex
W2116668074
Cited by
626
References
17
FWCI
44.64
Type
journal article
Language
en
Open access
bronze

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(ADNI), T. A. D. N. I., Stein, J. L., EPIGEN Consortium, IMAGEN Consortium, Saguenay Youth Study Group (SYS), Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium, for the Enhancing Neuro Imaging Genetics through Meta-Analysis (ENIGMA) Consortium, Medland, S. E., Vasquez, A. A., Hibar, D. P., Senstad, R. E., Winkler, A. M., Toro, R., Appel, K., Bartecek, R., Bergmann, Ø., Bernard, M., Brown, A. A., Cannon, D. M., . . . Thompson, P. M. (2012). Identification of common variants associated with human hippocampal and intracranial volumes. Nature Genetics. https://doi.org/10.1038/ng.2250

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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