Common genetic variants influence human subcortical brain structures
Open accessAbstract
The highly complex structure of the human brain is strongly shaped by genetic influences. Subcortical brain regions form circuits with cortical areas to coordinate movement, learning, memory and motivation, and altered circuits can lead to abnormal behaviour and disease. To investigate how common genetic variants affect the structure of these brain regions, here we conduct genome-wide association studies of the volumes of seven subcortical regions and the intracranial volume derived from magnetic resonance images of 30,717 individuals from 50 cohorts. We identify five novel genetic variants influencing the volumes of the putamen and caudate nucleus. We also find stronger evidence for three loci with previously established influences on hippocampal volume and intracranial volume. These variants show specific volumetric effects on brain structures rather than global effects across structures. The strongest effects were found for the putamen, where a novel intergenic locus with replicable influence on volume (rs945270; P = 1.08 × 10(-33); 0.52% variance explained) showed evidence of altering the expression of the KTN1 gene in both brain and blood tissue. Variants influencing putamen volume clustered near developmental genes that regulate apoptosis, axon guidance and vesicle transport. Identification of these genetic variants provides insight into the causes of variability in human brain development, and may help to determine mechanisms of neuropsychiatric dysfunction.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Effect sizes of individual SNPs were small but detectable due to inclusion of cohorts comprising thousands of individuals.
“As expected for a genetically complex neuroanatomical phenotype [22], effect sizes of individual SNPs were small (Figure 3C) but detectable here due to inclusion of cohorts comprising thousands of individuals.”
From Neandertal Introgression Sheds Light on Modern Human Endocranial Globularity (2019) · cites this paper as [22]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Fischl, B., Salat, D. H., Busa, E., Albert, M., Dieterich, M., Haselgrove, C., van der Kouwe, A., Killiany, R., Kennedy, D., Klaveness, S., et al. (2002) · Neuron · doi:10.1016/s0896-6273(02)00569-x · Cited by 8,610 · see citing works
Genetics of Food Intake Self-Regulation in Childhood: Literature Review and Research Opportunities
Faith, M. S., Carnell, S., & Kral, T. V. E. (2013) · Human Heredity · doi:10.1159/000353879 · Cited by 7,628 · see citing works
Biological insights from 108 schizophrenia-associated genetic loci
Schizophrenia Working Group of the Psychiatric Genomics Consortium (2014) · Nature · doi:10.1038/nature13595 · Cited by 7,577 · see citing works
METAL: fast and efficient meta-analysis of genomewide association scans
Willer, C. J., Li, Y., & Abecasis, G. R. (2010) · Bioinformatics · doi:10.1093/bioinformatics/btq340 · Cited by 5,205 · see citing works
Merlin—rapid analysis of dense genetic maps using sparse gene flow trees
Abecasis, G. R., Cherny, S. S., Cookson, W., & Cardon, L. R. (2001) · Nature Genetics · doi:10.1038/ng786 · Cited by 3,323 · see citing works
Genomic Control for Association Studies
Devlin, B., & Roeder, K. (1999) · Biometrics · doi:10.1111/j.0006-341x.1999.00997.x · Cited by 3,162 · see citing works
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index
MAGIC, Speliotes, E. K., on behalf of Procardis Consortium, Willer, C. J., Berndt, S. I., Monda, K. L., Thorleifsson, G., Jackson, A. U., Allen, H. L., Lindgren, C. M., et al. (2010) · Nature Genetics · doi:10.1038/ng.686 · Cited by 2,912 · see citing works
Self-citationMapping and analysis of chromatin state dynamics in nine human cell types
Ernst, J., Kheradpour, P., Mikkelsen, T. S., Shoresh, N., Ward, L. D., Epstein, C. B., Zhang, X., Wang, L., Issner, R., Coyne, M., et al. (2011) · Nature · doi:10.1038/nature09906 · Cited by 2,898 · see citing works
ChromHMM: automating chromatin-state discovery and characterization
Ernst, J., & Kellis, M. (2012) · Nature Methods · doi:10.1038/nmeth.1906 · Cited by 2,489 · see citing works
Detection of nonneutral substitution rates on mammalian phylogenies
Pollard, K. S., Hubisz, M. J., Rosenbloom, K. R., & Siepel, A. (2010) · Genome Research · doi:10.1101/gr.097857.109 · Cited by 2,353 · see citing works
A Bayesian model of shape and appearance for subcortical brain segmentation
Patenaude, B., Smith, S. M., Kennedy, D. N., & Jenkinson, M. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2011.02.046 · Cited by 2,287 · see citing works
Self-citationFunctional anatomy of the basal ganglia. I. The cortico-basal ganglia-thalamo-cortical loop
Parent, A., & Hazrati, L.-N. (1995) · Brain Research Reviews · doi:10.1016/0165-0173(94)00007-c · Cited by 2,161 · see citing works
Spatio-temporal transcriptome of the human brain
Kang, H. J., Kawasawa, Y. I., Cheng, F., Zhu, Y., Xu, X., Li, M., Sousa, A. M. M., Pletikos, M., Meyer, K. A., Sedmak, G., et al. (2011) · Nature · doi:10.1038/nature10523 · Cited by 2,084 · see citing works
Self-citationHundreds of variants clustered in genomic loci and biological pathways affect human height
Lango Allen, H., Estrada, K., Lettre, G., Berndt, S. I., Weedon, M. N., Rivadeneira, F., Willer, C. J., Jackson, A. U., Vedantam, S., Raychaudhuri, S., et al. (2010) · Nature · doi:10.1038/nature09410 · Cited by 1,945 · see citing works
Self-citationRegulation of parkinsonian motor behaviours by optogenetic control of basal ganglia circuitry
Kravitz, A. V., Freeze, B. S., Parker, P. R. L., Kay, K., Thwin, M. T., Deisseroth, K., & Kreitzer, A. C. (2010) · Nature · doi:10.1038/nature09159 · Cited by 1,885 · see citing works
MaCH: using sequence and genotype data to estimate haplotypes and unobserved genotypes
Li, Y., Willer, C. J., Ding, J., Scheet, P., & Abecasis, G. R. (2010) · Genetic Epidemiology · doi:10.1002/gepi.20533 · Cited by 1,843 · see citing works
Conserved role of intragenic DNA methylation in regulating alternative promoters
Maunakea, A. K., Nagarajan, R. P., Bilenky, M., Ballinger, T. J., D’Souza, C., Fouse, S. D., Johnson, B. E., Hong, C., Nielsen, C., Zhao, Y., et al. (2010) · Nature · doi:10.1038/nature09165 · Cited by 1,743 · see citing works
Fast and accurate genotype imputation in genome-wide association studies through pre-phasing
Howie, B., Fuchsberger, C., Stephens, M., Marchini, J., & Abecasis, G. R. (2012) · Nature Genetics · doi:10.1038/ng.2354 · Cited by 1,737 · see citing works
Nyholt, D. R. (2004) · The American Journal of Human Genetics · doi:10.1086/383251 · Cited by 1,699 · see citing works
Systematic identification of trans eQTLs as putative drivers of known disease associations
Westra, H.-J., Peters, M. J., Esko, T., Yaghootkar, H., Schurmann, C., Kettunen, J., Christiansen, M. W., Fairfax, B. P., Schramm, K., Powell, J. E., et al. (2013) · Nature Genetics · doi:10.1038/ng.2756 · Cited by 1,658 · see citing works
Self-citationDopamine-dependent prediction errors underpin reward-seeking behaviour in humans
Pessiglione, M., Seymour, B., Flandin, G., Dolan, R. J., & Frith, C. D. (2006) · Nature · doi:10.1038/nature05051 · Cited by 1,584 · see citing works
High-Resolution Mapping and Characterization of Open Chromatin across the Genome
Boyle, A. P., Davis, S., Shulha, H. P., Meltzer, P., Margulies, E. H., Weng, Z., Furey, T. S., & Crawford, G. E. (2008) · Cell · doi:10.1016/j.cell.2007.12.014 · Cited by 1,415 · see citing works
OpenMx: An Open Source Extended Structural Equation Modeling Framework
Boker, S., Neale, M., Maes, H., Wilde, M., Spiegel, M., Brick, T. R., Spies, J. R., Estabrook, R., Kenny, S., Bates, T. C., et al. (2011) · Psychometrika · doi:10.1007/s11336-010-9200-6 · Cited by 1,283 · see citing works
Brunet, A., Datta, S. R., & Greenberg, M. E. (2001) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(00)00211-7 · Cited by 1,193 · see citing works
Massive Cell Death of Immature Hematopoietic Cells and Neurons in Bcl-x-Deficient Mice
Motoyama, N., Wang, F., Roth, K. A., Sawa, H., Nakayama, K., Nakayama, K., Negishi, I., Senju, S., Zhang, Q., Fujii, S., et al. (1995) · Science · doi:10.1126/science.7878471 · Cited by 1,164 · see citing works
Interactive memory systems in the human brain
Poldrack, R. A., Clark, J., Paré-Blagoev, E. J., Shohamy, D., Creso Moyano, J., Myers, C., & Gluck, M. A. (2001) · Nature · doi:10.1038/35107080 · Cited by 1,132 · see citing works
Functional anatomy of the basal ganglia
Yelnik, J. (2002) · Movement Disorders · doi:10.1002/mds.10138 · Cited by 957 · see citing works
Kirov, G., Pocklington, A. J., Holmans, P., Ivanov, D., Ikeda, M., Ruderfer, D., Moran, J., Chambert, K., Toncheva, D., Georgieva, L., et al. (2012) · Molecular Psychiatry · doi:10.1038/mp.2011.154 · Cited by 844 · cited 2× · see citing works
“ADNI2GO, (4) BETULA, (5) BFS, (6) BIG, (7) BIG-Rep, (8) BrainSCALE, (9) BRCDECC, (10) CHARGE, (11) EPIGEN, (12) GIG, (13) GSP, (14) HUBIN, (15) IMAGEN, (16) IMpACT, (17) LBC1936, (18) Lieber, (19) MAS, (20) MCIC, (21) MooDS, (22) MPIP, (23) NCNG, (24) NESDA, (25) neuroIMAGE, (26) neuroIMAGE-Rep, (27) NIMH, (28) NTR-Ad…”
A common inversion under selection in Europeans
Stefánsson, H., Helgason, A., Þorleifsson, G., Steinthórsdóttir, V., Másson, G., Barnard, J., Baker, A., Jónasdóttir, Á., Ingason, A., Gudnadottir, V. G., et al. (2005) · Nature Genetics · doi:10.1038/ng1508 · Cited by 830 · see citing works
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index
Speliotes, E. K., Willer, C. J., Berndt, S. I., Monda, K. L., Þorleifsson, G., Jackson, A., Allen, H. L., Lindgren, C. M., Luan, J., Mägi, R., et al. (2010) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/d3bn-7g86 · Cited by 767 · see citing works
Self-citationGenetic variability in the regulation of gene expression in ten regions of the human brain
UK Brain Expression Consortium, Ramasamy, A., North American Brain Expression Consortium, Trabzuni, D., Guelfi, S., Varghese, V., Smith, C., Walker, R., De, T., Coin, L., et al. (2014) · Nature Neuroscience · doi:10.1038/nn.3801 · Cited by 644 · see citing works
Self-citationThe IMAGEN study: reinforcement-related behaviour in normal brain function and psychopathology
Schumann, G., Loth, E., Banaschewski, T., Barbot, A., Barker, G. J., Büchel, C., Conrod, P., Dalley, J. W., Flor, H., Gallinat, J., et al. (2010) · Molecular Psychiatry · doi:10.1038/mp.2010.4 · Cited by 618 · see citing works
Self-citationIdentification of common variants associated with human hippocampal and intracranial volumes
Stein, J., Medland, S., Vásquez, A., Hibar, D., Senstad, R. E., Winkler, A., Toro, R., Appel, K., Barteček, R., Bergmann, Ø., et al. (2012) · Nature Genetics · doi:10.1038/ng.2250 · Cited by 568 · see citing works
Self-citationPostsynaptic organisation and regulation of excitatory synapses
Scannevin, R. H., & Huganir, R. L. (2000) · Nature reviews. Neuroscience · doi:10.1038/35039075 · Cited by 460 · see citing works
GATES: A Rapid and Powerful Gene-Based Association Test Using Extended Simes Procedure
Li, M., Gui, H., Kwan, J. S. H., & Sham, P. C. (2011) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2011.01.019 · Cited by 386 · see citing works
So, H.-C., Gui, A. H. S., Cherny, S. S., & Sham, P. C. (2011) · Genetic Epidemiology · doi:10.1002/gepi.20579 · Cited by 289 · see citing works
Connectivity-based segregation of the human striatum predicts personality characteristics
Cohen, M. X., Schoene‐Bake, J., Elger, C. E., & Weber, B. (2008) · Nature Neuroscience · doi:10.1038/nn.2228 · Cited by 281 · see citing works
Synaptic scaffold evolution generated components of vertebrate cognitive complexity
Nithianantharajah, J., Komiyama, N. H., McKechanie, A., Johnstone, M., Blackwood, D. H., Clair, D. S., Emes, R. D., van de Lagemaat, L. N., Saksida, L. M., Bussey, T. J., et al. (2013) · Nature Neuroscience · doi:10.1038/nn.3276 · Cited by 251 · see citing works
Common variants at 12q14 and 12q24 are associated with hippocampal volume
Bis, J., Decarli, C., Smith, A., van der Lijn, F., Crivello, F., Fornage, M., Debette, S., Shulman, J. M., Schmidt, H., Srikanth, V., et al. (2012) · Nature Genetics · doi:10.1038/ng.2237 · Cited by 249 · see citing works
Self-citationCheung, I., Shulha, H. P., Jiang, Y., Matevossian, A., Wang, J., Weng, Z., & Akbarian, S. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1001702107 · Cited by 235 · see citing works
Trabzuni, D., Ryten, M., Walker, R., Smith, C., Imran, S., Ramasamy, A., Weale, M. E., & Hardy, J. (2011) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2011.07432.x · Cited by 229 · see citing works
Self-citationBlokland, G. A. M., de Zubicaray, G. I., McMahon, K. L., & Wright, M. J. (2012) · Twin Research and Human Genetics · doi:10.1017/thg.2012.11 · Cited by 221 · see citing works
Self-citationTATES: Efficient Multivariate Genotype-Phenotype Analysis for Genome-Wide Association Studies
van der Sluis, S., Posthuma, D., & Dolan, C. V. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003235 · Cited by 215 · see citing works
Scan–rescan reliability of subcortical brain volumes derived from automated segmentation
Morey, R. A., Selgrade, E. S., Wagner, H. R., Huettel, S. A., Wang, L., & McCarthy, G. (2010) · Human Brain Mapping · doi:10.1002/hbm.20973 · Cited by 210 · see citing works
Dscam and DSCAM: complex genes in simple animals, complex animals yet simple genesPreprint
Schmucker, D., & Chen, B. (2009) · Genes & Development · doi:10.1101/gad.1752909 · Cited by 178 · see citing works
CTCFBSDB 2.0: a database for CTCF-binding sites and genome organization
Ziebarth, J. D., Bhattacharya, A., & Cui, Y. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks1165 · Cited by 171 · see citing works
Kinectin, an Essential Anchor for Kinesin-Driven Vesicle Motility
Kumar, J., Yu, H., & Sheetz, M. P. (1995) · Science · doi:10.1126/science.7892610 · Cited by 159 · see citing works
Common variants at 6q22 and 17q21 are associated with intracranial volume
Ikram, M. A., Taal, H. R., Mook‐Kanamori, D. O., Struchalin, M., Albert Hofman, D., Vernooij, M. W., Jaddoe, V. W. V., van Duijn, C. M., Breteler, M. M. B., Bergen, N. E., et al. (2012) · Nature Genetics · doi:10.1038/ng.2245 · Cited by 130 · see citing works
Self-citationHernandez, D. G., Nalls, M. A., Moore, M., Chong, S., Dillman, A., Trabzuni, D., Gibbs, J. R., Ryten, M., Arepalli, S., Weale, M. E., et al. (2012) · Neurobiology of Disease · doi:10.1016/j.nbd.2012.03.020 · Cited by 128 · see citing works
Self-citationControl of Neuronal Morphology by the Atypical Cadherin Fat3
Deans, M. R., Krol, A., Abraira, V. E., Copley, C. O., Tucker, A. F., & Goodrich, L. V. (2011) · Neuron · doi:10.1016/j.neuron.2011.06.026 · Cited by 108 · see citing works
Genetic architecture supports mosaic brain evolution and independent brain-body size regulation
Hager, R., Lu, L., Rosen, G. D., & Williams, R. W. (2012) · Nature Communications · doi:10.1038/ncomms2086 · Cited by 108 · see citing works
Self-citationHamasaki, T., Goto, S., Nishikawa, S., & Ushio, Y. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-12-04272.2001 · Cited by 94 · see citing works
Li, M., Kwan, J. S. H., & Sham, P. C. (2012) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2012.08.004 · Cited by 92 · see citing works
Ramasamy, A., Trabzuni, D., Gibbs, J. R., Dillman, A., Hernandez, D. G., Arepalli, S., WALKER, R. E., Smith, C., Ilori, G. P., Shabalin, A. A., et al. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt069 · Cited by 77 · see citing works
Self-citationGutman, B., Hua, X., Rajagopalan, P., Chou, Y., Wang, Y.-L., Yanovsky, I., Toga, A., Jack, C., Weiner, M., & Thompson, P. (2013) · NeuroImage · doi:10.1016/j.neuroimage.2012.12.052 · Cited by 76 · see citing works
Self-citationSo, H., Li, M., & Sham, P. C. (2011) · Genetic Epidemiology · doi:10.1002/gepi.20593 · Cited by 70 · see citing works
Erratum: Common variants at 6q22 and 17q21 are associated with intracranial volume
Ikram, M. A., Fornage, M., Smith, A. V., Seshadri, S. S., Schmidt, R., Debette, S., Vrooman, H. A., Sigurdsson, S. O., Ropele, S., Taal, H. R., et al. (2012) · Nature Genetics · doi:10.1038/ng0612-732c · Cited by 64 · see citing works
Self-citationShape matching with medial curves and 1-D group-wise registration
Gutman, B. A., Wang, Y., Rajagopalan, P., Toga, A. W., & Thompson, P. M. (2012) · IEEE International Symposium on Biomedical Imaging (ISBI) · doi:10.1109/isbi.2012.6235648 · Cited by 51 · see citing works
Self-citationZhang, X., Tee, Y. H., Heng, J. K., Zhu, Y., Hu, X., Margadant, F., Ballestrem, C., Bershadsky, A. D., Griffiths, G., & Yu, H. (2010) · Journal of Cell Science · doi:10.1242/jcs.069153 · Cited by 49 · see citing works
Kinectin distribution in chicken nervous system
Toyoshima, I., & Sheetz, M. P. (1996) · Neuroscience Letters · doi:10.1016/0304-3940(96)12752-x · Cited by 33 · see citing works
Apoptosis in the basal ganglia of the developing human nervous system
Itoh, K., Suzuki, K., Bise, K., Itoh, H., Mehraein, P., & Weis, S. (2001) · Acta Neuropathologica · doi:10.1007/s004010000252 · Cited by 23 · see citing works
Mukherjee, K. (2015) · Wiley Encyclopedia of Management · doi:10.1002/9781118785317.weom080060 · Cited by 11 · see citing works
Li, Y., Schwab, C. J., Ryan, S. L., et al. (2014) · Cited by 2 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Verbanck, M., Chen, C.-Y., Neale, B., & Do, R. (2018) · Nature Genetics · doi:10.1038/s41588-018-0099-7 · Cited by 8,591 · see citing works
The GTEx Consortium atlas of genetic regulatory effects across human tissues
The GTEx Consortium, Aguet, F., Anand, S., Ardlie, K. G., Gabriel, S., Getz, G. A., Graubert, A., Hadley, K., Handsaker, R. E., Huang, K. H., et al. (2020) · Science · doi:10.1126/science.aaz1776 · Cited by 5,547 · see citing works
Self-citationNalls, M. A., Blauwendraat, C., Vallerga, C. L., Heilbron, K., Bandres-Ciga, S., Chang, D., Tan, M., Kia, D. A., Noyce, A. J., Xue, A., et al. (2019) · The Lancet Neurology · doi:10.1016/s1474-4422(19)30320-5 · Cited by 2,454 · see citing works
Self-citationMaintenance, reserve and compensation: the cognitive neuroscience of healthy ageing
Cabeza, R., Albert, M., Belleville, S., Craik, F. I. M., Duarte, A., Grady, C. L., Lindenberger, U., Nyberg, L., Park, D. C., Reuter-Lorenz, P. A., et al. (2018) · Nature Reviews Neuroscience · doi:10.1038/s41583-018-0068-2 · Cited by 1,289 · see citing works
for the ENIGMA-Major Depressive Disorder Working Group, Schmaal, L., Veltman, D. J., van Erp, T. G. M., Sämann, P. G., Frodl, T., Jahanshad, N., Loehrer, E., Tiemeier, H., Hofman, A., et al. (2016) · Molecular Psychiatry · doi:10.1038/mp.2015.69 · Cited by 1,172 · see citing works
Self-citationThe genetic architecture of the human cerebral cortex
Grasby, K. L., Jahanshad, N., Painter, J. N., Colodro-Conde, L., Bralten, J., Hibar, D. P., Lind, P. A., Pizzagalli, F., Ching, C. R. K., McMahon, M. A. B., et al. (2020) · Science · doi:10.1126/science.aay6690 · Cited by 876 · see citing works
Self-citation23andMe Research Team, Walters, R. K., Polimanti, R., Johnson, E. C., McClintick, J. N., Adams, M. J., Adkins, A. E., Aliev, F., Bacanu, S.-A., Batzler, A., et al. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0275-1 · Cited by 632 · see citing works
Self-citationEvolution of the Human Nervous System Function, Structure, and Development
Sousa, A. M. M., Meyer, K. A., Santpere, G., Gulden, F. O., & Sestan, N. (2017) · Cell · doi:10.1016/j.cell.2017.06.036 · Cited by 517 · see citing works
Topiwala, A., Allan, C. L., Valkanova, V., Zsoldos, E., Filippini, N., Sexton, C., Mahmood, A., Fooks, P., Singh-Manoux, A., Mackay, C. E., et al. (2017) · BMJ · doi:10.1136/bmj.j2353 · Cited by 455 · see citing works
Genetics and genomics of psychiatric disease
Geschwind, D. H., & Flint, J. (2015) · Science · doi:10.1126/science.aaa8954 · Cited by 424 · see citing works
Davies, G., Marioni, R. E., Liewald, D. C., Hill, W. D., Hagenaars, S. P., Harris, S. E., Ritchie, S. J., Luciano, M., Fawns-Ritchie, C., Lyall, D., et al. (2016) · Molecular Psychiatry · doi:10.1038/mp.2016.45 · Cited by 373 · see citing works
Self-citationZhao, B., Luo, T., Li, T., Li, Y., Zhang, J., Shan, Y., Wang, X., Yang, L., Zhou, F., Zhu, Z., et al. (2019) · Nature Genetics · doi:10.1038/s41588-019-0516-6 · Cited by 295 · see citing works
Doshi, J., Erus, G., Ou, Y., Resnick, S. M., Gur, R. C., Gur, R. E., Satterthwaite, T. D., Furth, S., & Davatzikos, C. (2016) · NeuroImage · doi:10.1016/j.neuroimage.2015.11.073 · Cited by 309 · see citing works
Novel genetic loci associated with hippocampal volume
Hibar, D. P., Adams, H. H. H., Jahanshad, N., Chauhan, G., Stein, J. L., Hofer, E., Renteria, M. E., Bis, J. C., Arias-Vasquez, A., Ikram, M. K., et al. (2017) · Nature Communications · doi:10.1038/ncomms13624 · Cited by 299 · see citing works
Self-citationWolfers, T., Buitelaar, J. K., Beckmann, C. F., Franke, B., & Marquand, A. F. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.08.001 · Cited by 290 · see citing works
Self-citationTylee, D. S., Sun, J., Hess, J. L., Tahir, M. A., Sharma, E., Malik, R., Worrall, B. B., Levine, A. J., Martinson, J. J., Nejentsev, S., et al. (2018) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32652 · Cited by 219 · see citing works
Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof of concept
Schizophrenia Working Group of the Psychiatric Genomics Consortium, Franke, B., Enigma Consortium, Stein, J. L., Ripke, S., Anttila, V., Hibar, D. P., van Hulzen, K. J. E., Arias-Vasquez, A., Smoller, J. W., et al. (2016) · Nature Neuroscience · doi:10.1038/nn.4228 · Cited by 216 · see citing works
Self-citationMagnetic resonance imaging in Alzheimer’s disease neuroimaging initiative 2
Jack, C. R., Barnes, J., Bernstein, M. A., Borowski, B. J., Brewer, J., Clegg, S., Dale, A. M., Carmichael, O., Ching, C., DeCarli, C., et al. (2015) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2015.05.002 · Cited by 220 · see citing works
Self-citationBiospecimens and the ABCD study: Rationale, methods of collection, measurement and early data
Uban, K. A., Horton, M. K., Jacobus, J., Heyser, C., Thompson, W. K., Tapert, S. F., Madden, P. A. F., & Sowell, E. R. (2018) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2018.03.005 · Cited by 175 · see citing works
Causal associations between modifiable risk factors and the Alzheimer's phenome
Andrews, S. J., Fulton‐Howard, B., O'Reilly, P., Marcora, E., Goate, A. M., & collaborators of the Alzheimer's Disease Genetics Consortium (2021) · Annals of Neurology · doi:10.1002/ana.25918 · Cited by 156 · see citing works
Dissecting the genetic relationship between cardiovascular risk factors and Alzheimer’s disease
Broce, I. J., Tan, C. H., Fan, C. C., Jansen, I., Savage, J. E., Witoelar, A., Wen, N., Hess, C. P., Dillon, W. P., Glastonbury, C. M., et al. (2019) · Acta Neuropathologica · doi:10.1007/s00401-018-1928-6 · Cited by 140 · see citing works
Structural Brain Abnormalities in Youth With Psychosis Spectrum Symptoms
Satterthwaite, T. D., Wolf, D. H., Calkins, M. E., Vandekar, S. N., Erus, G., Ruparel, K., Roalf, D. R., Linn, K. A., Elliott, M. A., Moore, T. M., et al. (2016) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2015.3463 · Cited by 132 · see citing works
Neandertal Introgression Sheds Light on Modern Human Endocranial Globularity
Gunz, P., Tilot, A. K., Wittfeld, K., Teumer, A., Shapland, C. Y., van Erp, T. G. M., Dannemann, M., Vernot, B., Neubauer, S., Guadalupe, T., et al. (2019) · Current Biology · doi:10.1016/j.cub.2018.10.065 · Cited by 117 · see citing works
“Hibar, D.P., Stein, J.L., Renteria, M.E., Arias-Vasquez, A., Desrivières, S., Jahanshad, N., Toro, R., Wittfeld, K., Abramovic, L., Andersson, M., et al.; Alzheimer’s Disease Neuroimaging Initiative; CHARGE Consortium; EPIGEN; IMAGEN; SYS (2015).”
Self-citationJudd, N., Sauce, B., Wiedenhoeft, J., Tromp, J., Chaarani, B., Schliep, A., van Noort, B., Penttilä, J., Grimmer, Y., Insensee, C., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2001228117 · Cited by 105 · see citing works
Self-citationImaging transcriptomics of brain disorders
Arnatkeviciute, A., Fulcher, B. D., Bellgrove, M. A., & Fornito, A. (2022) · Biological Psychiatry Global Open Science · doi:10.1016/j.bpsgos.2021.10.002 · Cited by 113 · see citing works
Sanchez‐Roige, S., Fontanillas, P., Elson, S. L., The 23andMe Research Team, Gray, J. C., de Wit, H., Davis, L. K., MacKillop, J., & Palmer, A. A. (2019) · Addiction Biology · doi:10.1111/adb.12574 · Cited by 101 · see citing works
Genetic Risk Variants Associated With Comorbid Alcohol Dependence and Major Depression
Zhou, H., Polimanti, R., Yang, B.-Z., Wang, Q., Han, S., Sherva, R., Nuñez, Y. Z., Zhao, H., Farrer, L. A., Kranzler, H. R., et al. (2017) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2017.3275 · Cited by 94 · see citing works
15q11.2 CNV affects cognitive, structural and functional correlates of dyslexia and dyscalculia
Ulfarsson, M. O., Walters, G. B., Gustafsson, O., Steinberg, S., Silva, A., Doyle, O. M., Brammer, M., Gudbjartsson, D. F., Arnarsdottir, S., Jonsdottir, G. A., et al. (2017) · Translational Psychiatry · doi:10.1038/tp.2017.77 · Cited by 78 · see citing works
Reijnders, M. R. F., Kousi, M., van Woerden, G. M., Klein, M., Bralten, J., Mancini, G. M. S., van Essen, T., Proietti-Onori, M., Smeets, E. E. J., van Gastel, M., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-00933-6 · Cited by 76 · see citing works
Jordan, D. M., Verbanck, M., & Do, R. (2019) · Genome Biology · doi:10.1186/s13059-019-1844-7 · Cited by 73 · see citing works
Sønderby, I. E., Ching, C. R. K., Thomopoulos, S. I., van der Meer, D., Sun, D., Villalon‐Reina, J. E., Agartz, I., Amunts, K., Arango, C., Armstrong, N. J., et al. (2022) · Human Brain Mapping · doi:10.1002/hbm.25354 · Cited by 67 · see citing works
Self-citationOhi, K., Otowa, T., Shimada, M., Sasaki, T., & Tanii, H. (2020) · Psychological Medicine · doi:10.1017/s003329171900059x · Cited by 61 · see citing works
Heritability of Regional Brain Volumes in Large-Scale Neuroimaging and Genetic Studies
Zhao, B., Ibrahim, J. G., Li, Y., Li, T., Wang, Y., Shan, Y., Zhu, Z., Zhou, F., Zhang, J., Huang, C., et al. (2019) · Cerebral Cortex · doi:10.1093/cercor/bhy157 · Cited by 58 · see citing works
Self-citationAdhikari, B. M., Jahanshad, N., Shukla, D., Turner, J., Grotegerd, D., Dannlowski, U., Kugel, H., Engelen, J., Dietsche, B., Krug, A., et al. (2019) · Brain Imaging and Behavior · doi:10.1007/s11682-018-9941-x · Cited by 53 · see citing works
Self-citationThe Molecular Basis of Human Brain Evolution
Enard, W. (2016) · Current Biology · doi:10.1016/j.cub.2016.09.030 · Cited by 55 · see citing works
Lancaster, T. M., Linden, D. E., Tansey, K. E., Banaschewski, T., Bokde, A. L. W., Bromberg, U., Büchel, C., Cattrell, A., Conrod, P. J., Flor, H., et al. (2016) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2016.1135 · Cited by 49 · see citing works
Mooney, M. A., Bhatt, P., Hermosillo, R. J. M., Ryabinin, P., Nikolas, M., Faraone, S. V., Fair, D. A., Wilmot, B., & Nigg, J. T. (2021) · Psychological Medicine · doi:10.1017/s0033291719004148 · Cited by 33 · see citing works
Lee, P. H., Doyle, A. E., Li, X., Silberstein, M., Jung, J.-Y., Gollub, R. L., Nierenberg, A. A., Liu, R. T., Kessler, R. C., Perlis, R. H., et al. (2022) · Biological Psychiatry · doi:10.1016/j.biopsych.2021.11.026 · Cited by 30 · see citing works
Self-citationMathias, S. R., Knowles, E. E. M., Kent, J. W., McKay, D. R., Curran, J. E., de Almeida, M. A. A., Dyer, T. D., Göring, H. H. H., Olvera, R. L., Duggirala, R., et al. (2016) · Human Brain Mapping · doi:10.1002/hbm.23025 · Cited by 28 · see citing works
Self-citationGenome-wide association analysis identifies common variants influencing infant brain volumes
Xia, K., Zhang, J., Ahn, M., Jha, S., Crowley, J. J., Szatkiewicz, J., Li, T., Zou, F., Zhu, H., Hibar, D., et al. (2017) · Translational Psychiatry · doi:10.1038/tp.2017.159 · Cited by 30 · see citing works
Self-citationPleiotropic Contribution of MECOM and AVPR1A to Aggression and Subcortical Brain Volumes
van Donkelaar, M. M. J., Hoogman, M., Pappa, I., Tiemeier, H., Buitelaar, J. K., Franke, B., & Bralten, J. (2018) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2018.00061 · Cited by 16 · see citing works
Self-citationHöglund, A., Strempfl, K., Fogelholm, J., Wright, D., & Henriksen, R. (2020) · BMC Genomics · doi:10.1186/s12864-020-06908-0 · Cited by 14 · see citing works
Antón-Galindo, E., Cabana-Domínguez, J., Torrico, B., Corominas, R., Cormand, B., & Fernàndez-Castillo, N. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2023.1293663 · Cited by 13 · see citing works
- Authors
- Initiative, T. A. D. N., Hibar, D. P., The CHARGE Consortium, EPIGEN, IMAGEN, SYS, Stein, J. L., Renteria, M. E., Arias-Vasquez, A., Desrivières, S., Jahanshad, N., Toro, R., Wittfeld, K., Abramovic, L., Andersson, M., Aribisala, B. S., Armstrong, N. J., Bernard, M., Bohlken, M. M., Boks, M. P., Bralten, J., Brown, A. A., Mallar Chakravarty, M., Chen, Q., Ching, C. R. K., Cuellar-Partida, G., den Braber, A., Giddaluru, S., Goldman, A. L., Grimm, O., Guadalupe, T., Hass, J., Woldehawariat, G., Holmes, A. J., Hoogman, M., Janowitz, D., Jia, T., Kim, S., Klein, M., Kraemer, B., Lee, P. H., Olde Loohuis, L. M., Luciano, M., Macare, C., Mather, K. A., Mattheisen, M., Milaneschi, Y., Nho, K., Papmeyer, M., Ramasamy, A., Risacher, S. L., Roiz-Santiañez, R., Rose, E. J., Salami, A., Sämann, P. G., Schmaal, L., Schork, A. J., Shin, J., Strike, L. T., Teumer, A., van Donkelaar, M. M. J., van Eijk, K. R., Walters, R. K., Westlye, L. T., Whelan, C. D., Winkler, A. M., Zwiers, M. P., Alhusaini, S., Athanasiu, L., Ehrlich, S., Hakobjan, M. M. H., Hartberg, C. B., Haukvik, U. K., Heister, A. J. G. A. M., Hoehn, D., Kasperaviciute, D., Liewald, D. C. M., Lopez, L. M., Makkinje, R. R. R., Matarin, M., Naber, M. A. M., Reese McKay, D., Needham, M., Nugent, A. C., Pütz, B., Royle, N. A., Shen, L., Sprooten, E., Trabzuni, D., van der Marel, S. S. L., van Hulzen, K. J. E., Walton, E., Wolf, C., Almasy, L., Ames, D., Arepalli, S., Assareh, A. A., Bastin, M. E., Brodaty, H., Bulayeva, K. B., Carless, M. A., Cichon, S., Corvin, A., Curran, J. E., Czisch, M., de Zubicaray, G. I., Dillman, A., Duggirala, R., Dyer, T. D., Erk, S., Fedko, I. O., Ferrucci, L., Foroud, T. M., Fox, P. T., Fukunaga, M., Raphael Gibbs, J., Göring, H. H. H., Green, R. C., Guelfi, S., Hansell, N. K., Hartman, C. A., Hegenscheid, K., Heinz, A., Hernandez, D. G., Heslenfeld, D. J., Hoekstra, P. J., Holsboer, F., Homuth, G., Hottenga, J.-J., Ikeda, M., Jack, C. R., Jenkinson, M., Johnson, R., Kanai, R., Keil, M., Kent, J. W., Kochunov, P., Kwok, J. B., Lawrie, S. M., Liu, X., Longo, D. L., McMahon, K. L., Meisenzahl, E., Melle, I., Mohnke, S., Montgomery, G. W., Mostert, J. C., Mühleisen, T. W., Nalls, M. A., Nichols, T. E., Nilsson, L. G., Nöthen, M. M., Ohi, K., Olvera, R. L., Perez-Iglesias, R., Bruce Pike, G., Potkin, S. G., Reinvang, I., Reppermund, S., Rietschel, M., Romanczuk-Seiferth, N., Rosen, G. D., Rujescu, D., Schnell, K., Schofield, P. R., Smith, C., Steen, V. M., Sussmann, J. E., Thalamuthu, A., Toga, A. W., Traynor, B. J., Troncoso, J., Turner, J. A., Valdés Hernández, M. C., van 't Ent, D., van der Brug, M., van der Wee, N. J. A., van Tol, M.-J., Veltman, D. J., Wassink, T. H., Westman, E., Zielke, R. H., Zonderman, A. B., Ashbrook, D. G., Hager, R., Lu, L., McMahon, F. J., Morris, D. W., Williams, R. W., Brunner, H. G., Buckner, R. L., Buitelaar, J. K., Cahn, W., Calhoun, V. D., Cavalleri, G. L., Crespo-Facorro, B., Dale, A. M., Davies, G. E., Delanty, N., Depondt, C., Djurovic, S., Drevets, W. C., Espeseth, T., Gollub, R. L., Ho, B.-C., Hoffmann, W., Hosten, N., Kahn, R. S., Le Hellard, S., Meyer-Lindenberg, A., Müller-Myhsok, B., Nauck, M., Nyberg, L., Pandolfo, M., Penninx, B. W. J. H., Roffman, J. L., Sisodiya, S. M., Smoller, J. W., van Bokhoven, H., van Haren, N. E. M., Völzke, H., Walter, H., Weiner, M. W., Wen, W., White, T., Agartz, I., Andreassen, O. A., Blangero, J., Boomsma, D. I., Brouwer, R. M., Cannon, D. M., Cookson, M. R., de Geus, E. J. C., Deary, I. J., Donohoe, G., Fernández, G., Fisher, S. E., Francks, C., Glahn, D. C., Grabe, H. J., Gruber, O., Hardy, J., Hashimoto, R., Hulshoff Pol, H. E., Jönsson, E. G., Kloszewska, I., Lovestone, S., Mattay, V. S., Mecocci, P., McDonald, C., McIntosh, A. M., Ophoff, R. A., Paus, T., Pausova, Z., Ryten, M., Sachdev, P. S., Saykin, A. J., Simmons, A., Singleton, A., Soininen, H., Wardlaw, J. M., Weale, M. E., Weinberger, D. R., Adams, H. H. H., Launer, L. J., Seiler, S., Schmidt, R., Chauhan, G., Satizabal, C. L., Becker, J. T., Yanek, L., van der Lee, S. J., Ebling, M., Fischl, B., Longstreth, W. T., Greve, D., Schmidt, H., Nyquist, P., Vinke, L. N., van Duijn, C. M., Xue, L., Mazoyer, B., Bis, J. C., Gudnason, V., Seshadri, S., Ikram, M. A., Martin, N. G., Wright, M. J., Schumann, G., Franke, B., Thompson, P. M., & Medland, S. E.
- Affiliations
- University of Southern California (US)
- QIMR Berghofer Medical Research Institute (AU)
- Radboud University Medical Center (NL)
- King's College London (GB)
- Centre National de la Recherche Scientifique (FR)
- Universitätsmedizin Greifswald (DE)
- University of Toronto (CA)
- University Medical Center Utrecht (NL)
- Lagos State University (NG)
- The University of Sydney (AU)
- University of Oslo (NO)
- Douglas Mental Health University Institute (CA)
- Oslo University Hospital (NO)
- Lieber Institute for Brain Development (US)
- Haukeland University Hospital (NO)
- Heidelberg University (DE)
- Radboud University Nijmegen (NL)
- Yale University (US)
- University of California, Los Angeles (US)
- Broad Institute (US)
- Royal Edinburgh Hospital (GB)
- Amsterdam Neuroscience (NL)
- Universidad de Cantabria (ES)
- Trinity College Dublin (IE)
- Max Planck Institute of Psychiatry (DE)
- University of Maryland, Baltimore (US)
- Stockholm University (SE)
- The University of Queensland (AU)
- Montreal Neurological Institute and Hospital (CA)
- Hartford Hospital (US)
- King Faisal Specialist Hospital & Research Centre (SA)
- National Institutes of Health (US)
- UNSW Sydney (AU)
- Texas Biomedical Research Institute (US)
- The Royal Melbourne Hospital (AU)
- University of Basel (CH)
- University of Bonn (DE)
- The University of Texas at San Antonio Health Science Center (US)
- National Institute on Aging (US)
- Brigham and Women's Hospital (US)
- UCL Queen Square Institute of Neurology (GB)
- University Medical Center Groningen (NL)
- The University of Melbourne (AU)
- Mayo Clinic (US)
- Fujita Health University (JP)
- University of Warwick (GB)
- Centro de Investigación Biomédica en Red de Salud Mental (ES)
- University of California, Irvine (US)
- Beth Israel Deaconess Medical Center (US)
- Johns Hopkins University (US)
- Georgia State University (US)
- University of Iowa (US)
- Karolinska Institutet (SE)
- University of Tennessee Health Science Center (US)
- Massachusetts General Hospital (US)
- Mind Research Network (US)
- Harvard University (US)
- National Institute of Mental Health (US)
- Royal College of Surgeons in Ireland (IE)
- Université Libre de Bruxelles (BE)
- Diakonhjemmet Hospital (NO)
- Erasmus MC (NL)
- Ollscoil na Gaillimhe – University of Galway (IE)
- Max Planck Institute for Psycholinguistics (NL)
- Medical University of Lodz (PL)
- University of Oxford (GB)
- University of Eastern Finland (FI)
- Indiana University Indianapolis (US)
- Université de Bordeaux (FR)
- Boston University (US)
- University of Pittsburgh (US)
- University of Washington (US)
- Corresponding author
- Thompson, Paul M.
- Medland, Sarah E.
- ORCID
- Stein, Jason L.
- Desrivières, Sylvane
- Jahanshad, Neda
- Toro, Roberto
- Wittfeld, Katharina
- Abramovic, Lucija
- Andersson, Micael
- Aribisala, Benjamin S.
- Armstrong, Nicola J.
- Bernard, Manon
- Boks, Marco P.
- Bralten, Janita
- Brown, Andrew A.
- Chen, Qiang
- Ching, Christopher R. K.
- Goldman, Aaron L.
- Holmes, Avram J.
- Hoogman, Martine
- Janowitz, Deborah
- Jia, Tianye
- Kim, Sungeun
- Klein, Marieke
- Lee, Phil H.
- Mather, Karen A.
- Mattheisen, Manuel
- Milaneschi, Yuri
- Nho, Kwangsik
- Ramasamy, Adaikalavan
- Risacher, Shannon L.
- Rose, Emma J.
- Salami, Alireza
- Sämann, Philipp G.
- Schmaal, Lianne
- Schork, Andrew J.
- Shin, Jean
- Strike, Lachlan T.
- Teumer, Alexander
- Walters, Raymond K.
- Westlye, Lars T.
- Whelan, Christopher D.
- Winkler, Anderson M.
- Zwiers, Marcel P.
- Alhusaini, Saud
- Athanasiu, Lavinia
- Ehrlich, Stefan
- Hartberg, Cecilie B.
- Haukvik, Unn K.
- Hoehn, David
- Liewald, David C. M.
- Lopez, Lorna M.
- Nugent, Allison C.
- Pütz, Benno
- Shen, Li
- Sprooten, Emma
- Trabzuni, Daniah
- Walton, Esther
- Wolf, Christiane
- Almasy, Laura
- Bastin, Mark E.
- Brodaty, Henry
- Bulayeva, Kazima B.
- Carless, Melanie A.
- Cichon, Sven
- Corvin, Aiden
- Curran, Joanne E.
- Czisch, Michael
- Dillman, Allissa
- Dyer, Thomas D.
- Erk, Susanne
- Fedko, Iryna O.
- Ferrucci, Luigi
- Foroud, Tatiana M.
- Fox, Peter T.
- Fukunaga, Masaki
- Göring, Harald H. H.
- Green, Robert C.
- Guelfi, Sebastian
- Hansell, Narelle K.
- Hartman, Catharina A.
- Hegenscheid, Katrin
- Heinz, Andreas
- Hernandez, Dena G.
- Hoekstra, Pieter J.
- Homuth, Georg
- Hottenga, Jouke-Jan
- Ikeda, Masashi
- Jack, Clifford R.
- Jenkinson, Mark
- Keil, Maria
- Kent, Jack W.
- Kochunov, Peter
- Kwok, John B.
- Lawrie, Stephen M.
- Liu, Xinmin
- McMahon, Katie L.
- Meisenzahl, Eva
- Melle, Ingrid
- Mohnke, Sebastian
- Montgomery, Grant W.
- Mostert, Jeanette C.
- Mühleisen, Thomas W.
- Nichols, Thomas E.
- Nöthen, Markus M.
- Ohi, Kazutaka
- Olvera, Rene L.
- Potkin, Steven G.
- Reppermund, Simone
- Rietschel, Marcella
- Rosen, Glenn D.
- Rujescu, Dan
- Schnell, Knut
- Schofield, Peter R.
- Smith, Colin
- Steen, Vidar M.
- Thalamuthu, Anbupalam
- Toga, Arthur W.
- Traynor, Bryan J.
- Troncoso, Juan
- Turner, Jessica A.
- Veltman, Dick J.
- Wassink, Thomas H.
- Westman, Eric
- Zonderman, Alan B.
- Ashbrook, David G.
- Hager, Reinmar
- Lu, Lu
- McMahon, Francis J.
- Morris, Derek W.
- Williams, Robert W.
- Brunner, Han G.
- Buckner, Randy L.
- Buitelaar, Jan K.
- Cahn, Wiepke
- Calhoun, Vince D.
- Cavalleri, Gianpiero L.
- Dale, Anders M.
- Delanty, Norman
- Depondt, Chantal
- Djurovic, Srdjan
- Drevets, Wayne C.
- Espeseth, Thomas
- Gollub, Randy L.
- Ho, Beng-Choon
- Hoffmann, Wolfgang
- Hosten, Norbert
- Kahn, René S.
- Nauck, Matthias
- Nyberg, Lars
- Pandolfo, Massimo
- Penninx, Brenda W. J. H.
- Roffman, Joshua L.
- Sisodiya, Sanjay M.
- Smoller, Jordan W.
- Völzke, Henry
- Walter, Henrik
- Weiner, Michael W.
- Wen, Wei
- White, Tonya
- Agartz, Ingrid
- Andreassen, Ole A.
- Blangero, John
- Boomsma, Dorret I.
- Brouwer, Rachel M.
- Cannon, Dara M.
- Cookson, Mark R.
- Deary, Ian J.
- Donohoe, Gary
- Fernández, Guillén
- Fisher, Simon E.
- Francks, Clyde
- Glahn, David C.
- Grabe, Hans J.
- Gruber, Oliver
- Hardy, John
- Hashimoto, Ryota
- Jönsson, Erik G.
- Lovestone, Simon
- Mattay, Venkata S.
- Mecocci, Patrizia
- McDonald, Colm
- McIntosh, Andrew M.
- Ophoff, Roel A.
- Ryten, Mina
- Sachdev, Perminder S.
- Saykin, Andrew J.
- Singleton, Andrew
- Soininen, Hilkka
- Wardlaw, Joanna M.
- Weale, Michael E.
- Weinberger, Daniel R.
- Adams, Hieab H. H.
- Launer, Lenore J.
- Seiler, Stephan
- Schmidt, Reinhold
- Chauhan, Ganesh
- Becker, James T.
- Yanek, Lisa
- Fischl, Bruce
- Greve, Douglas
- Schmidt, Helena
- Nyquist, Paul
- Vinke, Louis N.
- Xue, Luting
- Mazoyer, Bernard
- Bis, Joshua C.
- Gudnason, Vilmundur
- Seshadri, Sudha
- Ikram, M. Arfan
- Martin, Nicholas G.
- Wright, Margaret J.
- Franke, Barbara
- Thompson, Paul M.
- Medland, Sarah E.
- Venue
- Nature
- Published
- 2015-01-21
- Volume
- 520
- Issue
- 7546
- Pages
- 224-229
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC4393366
- OpenAlex
- W2140054173
- Cited by
- 858
- References
- 63
- Citations by year
- 2026: 35 · 2025: 42 · 2024: 61 · 2023: 53 · 2022: 42 · 2021: 63 · 2020: 102 · 2019: 105 · 2018: 91 · 2017: 107 · 2016: 95 · 2015: 59 · 2014: 1 · 2012: 1
- FWCI
- 80.18
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Research Publications (Maastricht University) (publishedVersion, other-oa)
- Pure Amsterdam UMC (publishedVersion, other-oa)
- Research Explorer (The University of Manchester) (publishedVersion)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (publishedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (publishedVersion)
- Explore Bristol Research (publishedVersion)
- VU Research Portal (publishedVersion)
- ARAN (University of Galway Research Repository) (Ollscoil na Gaillimhe – University of Galway) (acceptedVersion, cc-by-nc-nd)
- Maynooth University ePrints and eTheses Archive (Maynooth University) (acceptedVersion)
- Edinburgh Research Explorer (University of Edinburgh) (acceptedVersion, other-oa)
- PubMed Central (acceptedVersion)
- UNSWorks (UNSW Sydney) (submittedVersion, cc-by-nc-nd)
- eScholarship (California Digital Library) (submittedVersion)
- Sussex Research Online (University of Sussex) (submittedVersion)
- Murdoch University Research Portal (submittedVersion)
- ScholarWorks @ UTRGV (The University of Texas Rio Grande Valley) (submittedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
- RePub (Erasmus University Rotterdam) (submittedVersion, other-oa)
- Arrow@dit (Dublin Institute of Technology) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- HAL (submittedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Leiden Repository (Leiden University) (submittedVersion)
- ARAN (University of Galway Research Repository) (Ollscoil na Gaillimhe – University of Galway) (submittedVersion, cc-by-nc-nd)
- Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
- Dépôt institutionnel de l'Université libre de Bruxelles (Université Libre de Bruxelles) (submittedVersion)
- Discovery Research Portal (University of Dundee) (submittedVersion)
- Utrecht University Repository (Utrecht University) (submittedVersion, other-oa)
- UCL Discovery (University College London) (submittedVersion)
- Max Planck Digital Library (submittedVersion)
- Figshare (submittedVersion)
- Research Portal (King's College London) (submittedVersion)
- Open Repository and Bibliography (University of Liège) (submittedVersion, other-oa)
- Papyrus : Institutional Repository (Université de Montréal) (submittedVersion)
- DZNE Pub (submittedVersion)
- GRO (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Radboud Repository (Radboud University) (submittedVersion)
- RePub (Erasmus University Rotterdam) (submittedVersion)
- University of Galway Research Repository (submittedVersion, cc-by-nc)
- IUScholarWorks (Indiana University) (submittedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
- Research Publications (Maastricht University) (submittedVersion)
- Utrecht University Repository (Utrecht University) (submittedVersion)
- Research Repository UCD (University College Dublin) (cc-by-nc)
- Funders
- Wellcome Trust (104036, 100309/A/12/Z, 100309)
- National Institute for Health and Care Research (NF-SI-0512-10053, ACF-2012-17-017)
- Lundbeckfonden (R155-2014-1724)
- Medical Research Council (MR/K026992/1, MR/L016400/1, MR/N000390/1)
- Biotechnology and Biological Sciences Research Council (1088088, BB/F019394/1)
- Japan Society for the Promotion of Science (26293266, 221S0003, 26670541, 25293250)
- National Institute of Mental Health (K99MH101367)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Mapping and Diversity in Plants and Animals
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- subcortical structures, brain volume, genetic variants, putamen, caudate nucleus, hippocampal volume, intracranial volume, head size, brain development, neuropsychiatric dysfunction, novel genetic loci, intergenic variants
- MeSH terms
- Adolescent, Adult, Aged, Aged, 80 and over, Aging, Brain, Caudate Nucleus, Child, Female, Hippocampus, Humans, Magnetic Resonance Imaging, Male, Membrane Proteins, Middle Aged, Organ Size, Putamen, Sex Characteristics, Skull, Genetic Variation, Apoptosis, Gene Expression Regulation, Developmental, Genome-Wide Association Study, Young Adult, Genetic Loci
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
