The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Mutations in Plasmodium falciparum Dihydrofolate Reductase and Dihydropteroate Synthase and Epidemiologic Patterns of Pyrimethamine‐Sulfadoxine Use and Resistance
Open accessAbstract
To assess the relationship between mutations in Plasmodium falciparum dihydrofolate reductase (DHFR) and dihydropteroate synthase (DHPS) and clinical pyrimethamine-sulfadoxine resistance, polymerase chain reaction surveys and analyses for new mutations were conducted in four countries with increasing levels of pyrimethamine-sulfadoxine resistance: Mali, Kenya, Malawi, and Bolivia. Prevalence of mutations at DHFR codon 108 and a new mutation at DHPS 540 correlated with increased pyrimethamine-sulfadoxine resistance (P < .05). Mutations at DHFR 51, DHFR 59, and DHPS 437 correlated with resistance without achieving statistical significance. Mutations at DHFR 164 and DHPS 581 were common in Bolivia, where pyrimethamine-sulfadoxine resistance is widespread, but absent in African sites. Two new DHFR mutations, a point mutation at codon 50 and an insert at codon 30, were found only in Bolivia. DHFR and DHPS mutations occur in a progressive, stepwise fashion. Identification of specific sets of mutations causing in vivo drug failure may lead to the development of molecular surveillance methods for pyrimethamine-sulfadoxine resistance.
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Plowe, C. V., Djimde, A., Bouare, M., Doumbo, O., & Wellems, T. E. (1995) · The American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.1995.52.565 · Cited by 674
Self-citationPeterson, D. S., Walliker, D., & Wellems, T. E. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.23.9114 · Cited by 653
Cowman, A. F., Morry, M. J., Biggs, B. A., Cross, G. A., & Foote, S. J. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.23.9109 · Cited by 526
Triglia, T., Menting, J. G. T., Wilson, C., & Cowman, A. F. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.25.13944 · Cited by 422
Peterson, D. S., Milhous, W. K., & Wellems, T. E. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.8.3018 · Cited by 419
Wu, Y., Kirkman, L. A., & Wellems, T. E. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.3.1130 · Cited by 378
Brooks, D. R., Wang, P., Read, M., Watkins, W. M., Sims, P. F. G., & Hyde, J. E. (1994) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1994.00397.x · Cited by 369
Self-citationAntifolate-resistant mutants of Plasmodium falciparum dihydrofolate reductase
Sirawaraporn, W., Sathitkul, T., Sirawaraporn, R., Yuthavong, Y., & Santi, D. V. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.4.1124 · Cited by 341
Wang, P., Read, M., Sims, P. F. G., & Hyde, J. E. (1997) · Molecular Microbiology · doi:10.1046/j.1365-2958.1997.2821646.x · Cited by 307
Primary structure and expression of the dihydropteroate synthetase gene of Plasmodium falciparum.
Triglia, T., & Cowman, A. F. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.15.7149 · Cited by 304
Cited by
Epidemiology of drug-resistant malaria
Wongsrichanalai, C., Pickard, A. L., Wernsdorfer, W. H., & Meshnick, S. R. (2002) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(02)00239-6 · Cited by 817
Kublin, J. G., Cortese, J. F., Njunju, E. M., G. Mukadam, R. A., Wirima, J. J., Kazembe, P. N., Djimdé, A. A., Kouriba, B., Taylor, T. E., & Plowe, C. V. (2003) · The Journal of Infectious Diseases · doi:10.1086/375419 · Cited by 508
Self-citationMechanisms of Resistance of Malaria Parasites to Antifolates
Gregson, A., & Plowe, C. V. (2005) · Pharmacological Reviews · doi:10.1124/pr.57.1.4 · Cited by 499
Self-citationMultiple populations of artemisinin-resistant Plasmodium falciparum in Cambodia
Miotto, O., Almagro-Garcia, J., Manske, M., MacInnis, B., Campino, S., Rockett, K. A., Amaratunga, C., Lim, P., Suon, S., Sreng, S., et al. (2013) · Nature Genetics · doi:10.1038/ng.2624 · Cited by 462
Self-citationEffectiveness of Antimalarial Drugs
Baird, J. K. (2005) · New England Journal of Medicine · doi:10.1056/nejmra043207 · Cited by 375
Metadata
- Authors
- Plowe, C. V., Cortese, J. F., Djimde, A., Nwanyanwu, O. C., Watkins, W. M., Winstanley, P. A., Estrada‐Franco, J. G., Mollinedo, R. E., Avila, J. C., Cespedes, J. L., Carter, D., & Doumbo, O. K.
- Venue
- The Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 1997-12
- Volume
- 176
- Issue
- 6
- Pages
- 1590-1596
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W2160884305
- Cited by
- 414
- References
- 25
- FWCI
- 14.93
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Plowe, C. V., Cortese, J. F., Djimde, A., Nwanyanwu, O. C., Watkins, W. M., Winstanley, P. A., Estrada‐Franco, J. G., Mollinedo, R. E., Avila, J. C., Cespedes, J. L., Carter, D., & Doumbo, O. K. (1997). Mutations in Plasmodium falciparum Dihydrofolate Reductase and Dihydropteroate Synthase and Epidemiologic Patterns of Pyrimethamine‐Sulfadoxine Use and Resistance. The Journal of Infectious Diseases. https://doi.org/10.1086/514159
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