A comprehensive 1000 Genomes–based genome-wide association meta-analysis of coronary artery disease

the CARDIoGRAMplusC4D Consortium·2015·Nature Genetics

DOI 10.1038/ng.3396

Cited by (1,004)

Items 401–500 of 1,004

Causal Association Between Anemia and Cardiovascular Disease: A 2‐Sample Bidirectional Mendelian Randomization Study
Ting Gan, Jing Hu, Wenhu Liu, Li Cui, Qian Xu, Ya Wang, Shuai Lu, Anwer Khalid Okab Aledan, Yan Wang, Zhaohui Wang · 2023 · Journal of the American Heart Association
Systolic Blood Pressure and Risk of Type 2 Diabetes: A Mendelian Randomization Study
Rachael C. Aikens, Wei Zhao, Danish Saleheen, Muredach P. Reilly, Stephen E. Epstein, Emmi Tikkanen, Veikko V Salomaa, Benjamin F. Voight · 2016 · Diabetes
HOPS: a quantitative score reveals pervasive horizontal pleiotropy in human genetic variation is driven by extreme polygenicity of human traits and diseases
Jordan, Daniel M., Verbanck, Marie, Do, Ron · 2019 · Genome Biology
A role for collagen type IV in cardiovascular disease?
Lasse Bach Steffensen, Lars Melholt Rasmussen · 2018 · American Journal of Physiology-Heart and Circulatory Physiology
Clinical utility of polygenic risk scores: a critical 2023 appraisal
Sebastian Koch, Jörg Schmidtke, Michael Krawczak, Amke Caliebe · 2023 · Journal of Community Genetics
Red blood cell distribution width: Genetic evidence for aging pathways in 116,666 volunteers
Luke C. Pilling, Janice L. Atkins, Michael O. Duff, Robin N. Beaumont, Samuel E. Jones, Jessica Tyrrell, Chia‐Ling Kuo, Katherine S. Ruth, Marcus A. Tuke, Hanieh Yaghootkar et al. · 2017 · PLoS ONE
Promoter interactome of human embryonic stem cell-derived cardiomyocytes connects GWAS regions to cardiac gene networks
Mun‐Kit Choy, Biola M. Javierre, Simon G. Williams, Stephanie L. Baross, Yingjuan Liu, Steven Wingett, Artur Akbarov, Chris Wallace, Paula Freire-Pritchett, Peter J. Rugg‐Gunn et al. · 2018 · Nature Communications
IGF-1 and cardiometabolic diseases: a Mendelian randomisation study
Susanna C. Larsson, Karl Michaëlsson, Stephen Burgess · 2020 · Diabetologia
Polygenic risk scores for the prediction of cardiometabolic disease
Jack William O’Sullivan, Euan Angus Ashley, Perry M Elliot · 2022 · European Heart Journal
TCF21 and the environmental sensor aryl-hydrocarbon receptor cooperate to activate a pro-inflammatory gene expression program in coronary artery smooth muscle cells
Juyong Brian Kim, Milos Pjanic, Trieu Nguyen, Clint L. Miller, Dharini Iyer, Boxiang Liu, Ting Wang, Olga Sazonova, Ivan Carcamo‐Orive, Ljubica Perisic Matic et al. · 2017 · PLoS Genetics
Susceptibility to corticosteroid-induced adrenal suppression: a genome-wide association study
Daniel B. Hawcutt, Ben Francis, Daniel F. Carr, Andrea Jorgensen, Peng Yin, Naomi Wallin, Natalie O'Hara, Eunice J. Zhang, Katarzyna M. Bloch, Amitava Ganguli et al. · 2018 · The Lancet Respiratory Medicine
Relative effects of LDL-C on ischemic stroke and coronary disease
Elsa Valdés‐Márquez, Sarah Parish, Robert Clarke, Traiani Stari, Bradford B. Worrall, Jemma C. Hopewell · 2019 · Neurology
Genetic loci associated with coronary artery disease harbor evidence of selection and antagonistic pleiotropy
Sean Byars, Qin Qin Huang, Lesley-Ann Gray, Andrew Bakshi, Samuli Ripatti, Gad Abraham, Stephen C. Stearns, Michael Inouye · 2017 · PLoS Genetics
Plasma Phospholipid Fatty Acids, FADS1 and Risk of 15 Cardiovascular Diseases: A Mendelian Randomisation Study
Shuai Yuan, Magnus Bäck, Maria Bruzelius, Amy M. Mason, Stephen Burgess, Susanna C. Larsson · 2019 · Nutrients
Mendelian Randomization Analysis Identifies CpG Sites as Putative Mediators for Genetic Influences on Cardiovascular Disease Risk
Tom G. Richardson, Jie Zheng, George Davey Smith, Nicholas John Timpson, Tom R. Gaunt, Caroline L. Relton, Gibran Hemani · 2017 · The American Journal of Human Genetics
Uncovering genetic mechanisms of hypertension through multi-omic analysis of the kidney
James Eales, Xiao Jiang, Xiaoguang Xu, Sushant Saluja, Artur Akbarov, Eddie Cano-Gamez, Michelle T. McNulty, Chris Finan, Hui Guo, Wojciech Wystrychowski et al. · 2021 · Nature Genetics
Mendelian randomization analysis of 37 clinical factors and coronary artery disease in East Asian and European populations
Kai Wang, Xian Shi, Ziwei Zhu, Xingjie Hao, Liangkai Chen, Shanshan Cheng, Roger Foo, Chaolong Wang · 2022 · Genome Medicine
Genome-Wide Association Studies of Hypertension and Several Other Cardiovascular Diseases
Yan Wang, Ji‐Guang Wang · 2018 · Pulse
Causal associations of sarcopenia‐related traits with cardiometabolic disease and Alzheimer's disease and the mediating role of insulin resistance: A Mendelian randomization study
Chaojie Ye, Lijie Kong, Yiying Wang, Jie Zheng, Min Xu, Yu Xu, Mian Li, Zhiyun Zhao, Jieli Lu, Yuhong Chen et al. · 2023 · Aging Cell
Exploiting the GTEx resources to decipher the mechanisms at GWAS loci
Alvaro Barbeira, Rodrigo Bonazzola, Eric R. Gamazon, Yanyu Liang, YoSon Park, Sarah Kim-Hellmuth, Gao T. Wang, Zhuoxun Jiang, Dan Zhou, Farhad Hormozdiari et al. · 2019 · bioRxiv (Cold Spring Harbor Laboratory)
Rationale and design of the Medical Research Council's Precision Medicine with Zibotentan in Microvascular Angina (PRIZE) trial
Andrew Morrow, Thomas Joseph Ford, Kenneth Mangion, Tushar Kotecha, Roby D. Rakhit, Gavin Galasko, Stephen Paul Hoole, Anthony P. Davenport, Rajesh K. Kharbanda, Vanessa M. Ferreira et al. · 2020 · American Heart Journal
Transcription Factor MAFF (MAF Basic Leucine Zipper Transcription Factor F) Regulates an Atherosclerosis Relevant Network Connecting Inflammation and Cholesterol Metabolism
Moritz von Scheidt, Yuqi Zhao, Thomas Q. de Aguiar Vallim, Nam Che, Michael Wierer, Marcus Michael Seldin, Oscar Franzén, Zeyneb Kurt, Shichao Pang, Dario Bongiovanni et al. · 2021 · Circulation
Habitual coffee consumption and risk of type 2 diabetes, ischemic heart disease, depression and Alzheimer’s disease: a Mendelian randomization study
Man Ki Kwok, Gabriel Matthew Leung, Catherine Mary Schooling · 2016 · Scientific Reports
Joint Genetic Inhibition of PCSK9 and CETP and the Association With Coronary Artery Disease: A Factorial Mendelian Randomization Study
Cupido, Arjen J., Reeskamp, Laurens F., Hingorani, Aroon D., Finan, Chris, Asselbergs, Folkert W., Hovingh, G. Kees, Schmidt, Amand F. · 2022 · JAMA Cardiology
Genetic predictors of testosterone and their associations with cardiovascular disease and risk factors: A Mendelian randomization investigation
Catherine Mary Schooling, Shan Luo, Shiu Lun Au Yeung, Deborah J. Thompson, Savita Karthikeyan, Thomas R Bolton, Amy M. Mason, Erik Ingelsson, Stephen Burgess · 2018 · International Journal of Cardiology
Effects of lifelong testosterone exposure on health and disease using Mendelian randomization
Pedrum Mohammadi‐Shemirani, Michael Chong, Marie Pigeyre, Robert W. Morton, Hertzel C. Gerstein, Guillaume Paré · 2020 · eLife
Validation of Genome-Wide Polygenic Risk Scores for Coronary Artery Disease in French Canadians
Florian Wünnemann, Ken Sin Lo, Alexandra Langford‐Avelar, David Busseuil, Marie‐Pierre Dubé, Jean‐Claude Tardif, Guillaume Lettre · 2019 · Circulation Genomic and Precision Medicine
Genetic Variation in Targets of Antidiabetic Drugs and Alzheimer Disease Risk
Bowen Tang, Yunzhang Wang, Xia Jiang, Madhav Thambisetty, Luigi Ferrucci, Kristina Johnell, Sara Hägg · 2022 · Neurology
Common variation in atrial fibrillation: navigating the path from genetic association to mechanism
Nathan R. Tucker, Sebastian Clauß, Patrick T. Ellinor · 2016 · Cardiovascular Research
Oxidized phospholipids regulate amino acid metabolism through MTHFD2 to facilitate nucleotide release in endothelial cells
Juliane Hitzel, Eunjee Lee, Yi Zhang, Sofia Iris Bibli, Xiaogang Li, Sven Zukunft, Beatrice Pflüger, Jiong Hu, Christoph Schürmann, Andrea E Vasconez et al. · 2018 · Nature Communications
Genetically predicted education attainment in relation to somatic and mental health
Shuai Yuan, Ying Xiong, Madeleine Michaëlsson, Karl Michaëlsson, Susanna C. Larsson · 2021 · Scientific Reports
Risk factors mediating the effect of body mass index and waist-to-hip ratio on cardiovascular outcomes: Mendelian randomization analysis
Dipender Gill, Verena Zuber, Jesse Dawson, Jonathan Pearson‐Stuttard, Alice R Carter, Eleanor C. M. Sanderson, Ville Karhunen, Michael G. Levin, Robyn E. Wootton, VA Million Veteran Program et al. · 2021 · International Journal of Obesity
Discovery and systematic characterization of risk variants and genes for coronary artery disease in over a million participants
Krishna G. Aragam, Tao Jiang, Anuj Goel, Stavroula Kanoni, Brooke N. Wolford, Elle M. Weeks, Minxian Wang, George Hindy, Wei Zhou, Christopher Grace et al. · 2021 · medRxiv
Cross-trait analyses with migraine reveal widespread pleiotropy and suggest a vascular component to migraine headache
Katherine M. Siewert, Derek M. Klarin, Scott M. Damrauer, Kyong‐Mi Chang, Philip S. Tsao, Themistocles L. Assimes, George Davey Smith, Benjamin F. Voight, Padhraig Gormley, Verneri Anttila et al. · 2020 · International Journal of Epidemiology
Causal relationship between PCSK9 inhibitor and autoimmune diseases: a drug target Mendelian randomization study
Weijia Xie, Jiaxin Li, Hao Du, Jian Xia · 2023 · Arthritis Research & Therapy
Integration of a polygenic score into guideline-recommended prediction of cardiovascular disease
Ling Li, Shichao Pang, Fabian Starnecker, Bertram Müller‐Myhsok, Heribert Schunkert · 2024 · European Heart Journal
Machine Learning–Based Gene Prioritization Identifies Novel Candidate Risk Genes for Inflammatory Bowel Disease
Ofer Isakov, Iris Dotan, Shay Ben‐Shachar · 2017 · Inflammatory Bowel Diseases
Association of <i>FADS1/2</i> Locus Variants and Polyunsaturated Fatty Acids With Aortic Stenosis
Chen, Hao Yu, Cairns, Benjamin J., Small, Aeron M., Burr, Hannah A., Ambikkumar, Athithan, Martinsson, Andreas, Thériault, Sébastien, Munter, Hans Markus, Steffen, Brian, Zhang, Richard et al. · 2020 · JAMA Cardiology
Examination of the associations between m6A-associated single-nucleotide polymorphisms and blood pressure
Xingbo Mo, Shu‐Feng Lei, Yonghong Zhang, Huan Zhang · 2019 · Hypertension Research
A Multi-Omics Perspective of Quantitative Trait Loci in Precision Medicine
Youqiong Ye, Zhao Zhang, Yaoming Liu, Lixia Diao, Leng Han · 2020 · Trends in Genetics
Circulating ceramides as biomarkers of cardiovascular disease: Evidence from phenotypic and genomic studies
Kathryn A. McGurk, Bernard D. Keavney, Anna Nicolaou · 2021 · Atherosclerosis
Prioritizing the Role of Major Lipoproteins and Subfractions as Risk Factors for Peripheral Artery Disease
Michael G. Levin, Verena Zuber, Venexia M. Walker, Derek M. Klarin, Julie Ann Lynch, Rainer Malik, Aaron W. Aday, Leonardo Bottolo, Aruna D. Pradhan, Martin Dichgans et al. · 2021 · Circulation
Differing genetic variants associated with liver fat and their contrasting relationships with cardiovascular diseases and cancer
Altayeb Ahmed, Madeleine Cule, Jimmy David Bell, Naveed A. Sattar, Hanieh Yaghootkar · 2024 · Journal of Hepatology
Network-Based Identification and Prioritization of Key Regulators of Coronary Artery Disease Loci
Yuqi Zhao, Jing Chen, Johannes Freudenberg, Qingying Meng, Deepak K. Rajpal, Xia Yang · 2016 · Arteriosclerosis Thrombosis and Vascular Biology
SVEP1 is a human coronary artery disease locus that promotes atherosclerosis
In‐Hyuk Jung, Jared S. Elenbaas, Arturo E. Alisio, Katherine Santana, Erica P. Young, Chul Joo Kang, Puja Kachroo, Kory J. Lavine, Babak Razani, Robert P. Mecham et al. · 2021 · Science Translational Medicine
Benchmarking Mendelian randomization methods for causal inference using genome-wide association study summary statistics
Xianghong Hu, Mingxuan Cai, Jiashun Xiao, Xiaomeng Wan, Zhiwei Wang, Hongyu Zhao, Can Yang · 2024 · The American Journal of Human Genetics
HEDD: Human Enhancer Disease Database
Zhen Wang, Quanwei Zhang, Wen Zhang, Jhih-Rong Lin, Ying Cai, Joydeep Mitra, Zhengdong D. Zhang · 2017 · Nucleic Acids Research
Genetic effects on promoter usage are highly context-specific and contribute to complex traits
Kaur Alasoo, Julia Rodrigues, John Danesh, Daniel F. Freitag, Dirk S. Paul, Daniel J. Gaffney · 2019 · eLife
Genetic Predisposition to Type 2 Diabetes and Risk of Subclinical Atherosclerosis and Cardiovascular Diseases Among 160,000 Chinese Adults
Wei Gan, Fiona Bragg, Robin G. Walters, Iona Y. Millwood, Kuang Lin, Yiping Chen, Yu Guo, Julien Vaucher, Zheng Bian, Derrick Bennett et al. · 2019 · Diabetes
Clonal Hematopoiesis: Somatic Mutations in Blood Cells and Atherosclerosis
Natarajan, Pradeep, Jaiswal, Siddhartha, Kathiresan, Sekar · 2018 · Circulation Genomic and Precision Medicine
Leveraging Human Genetics to Estimate Clinical Risk Reductions Achievable by Inhibiting Factor XI
Benjamin Georgi, Johanna Mielke, Mark D. Chaffin, Amit V. Khera, Lian Gelis, Hardi Mundl, J.J.J. van Giezen, Patrick T. Ellinor, Sekar Kathiresan, Karl B. Ziegelbauer et al. · 2019 · Stroke
Screening of Multiple Biomarkers Associated With Ischemic Stroke in Atrial Fibrillation
Ziad Hijazi, Lars C. Wallentin, Johan Lindbäck, John Hunter Alexander, Stuart J. Connolly, John W. Eikelboom, Michael D. Ezekowitz, Christopher Bull Granger, Renato D. Lópes, Tymon Pol et al. · 2020 · Journal of the American Heart Association
Causal Associations Between Circulating Adipokines and Cardiovascular Disease: A Mendelian Randomization Study
Delong Chen, Yuxuan Zhang, Abuduwufuer Yidilisi, Yi Xu, Qichao Dong, Jun Jiang · 2022 · The Journal of Clinical Endocrinology & Metabolism
The Association Between Psoriasis and Risk of Cardiovascular Disease: A Mendelian Randomization Analysis
Ning Gao, Minjian Kong, Xuebiao Li, Xian Zhu, Dongdong Wei, Ming Ni, Yifan Wang, Ze Hong, Aiqiang Dong · 2022 · Frontiers in Immunology
Associations between sleep duration and cardiovascular diseases: A meta-review and meta-analysis of observational and Mendelian randomization studies
Shanshan Wang, Zhexi Li, Xiaoyu Wang, Sheng Guo, Yujing Sun, Guohua Li, Chenhao Zhao, Wenhui Yuan, Meng Li, Xiaolei Li et al. · 2022 · Frontiers in Cardiovascular Medicine
Polygenic link between blood lipids and amyotrophic lateral sclerosis
Chen, Xu, Yazdani, Solmaz, Piehl, Fredrik, Magnusson, Patrik K.E., Fang, Fang · 2018 · Neurobiology of Aging
Polygenic overlap and shared genetic loci between loneliness, severe mental disorders, and cardiovascular disease risk factors suggest shared molecular mechanisms
Linn Nilsen Rødevand, Shahram Bahrami, Oleksandr Frei, Aihua Lin, Osman Gani, Alexey A. Shadrin, Olav Bjerkehagen Smeland, Kevin S. O’ Connell, Torbjørn Elvsåshagen, Adriano Winterton et al. · 2021 · Translational Psychiatry
Twenty-Five Novel Loci for Carotid Intima-Media Thickness: A Genome-Wide Association Study in >45 000 Individuals and Meta-Analysis of >100 000 Individuals
Ming Wai Yeung, Siqi Wang, Yordi J. van de Vegte, Oleg Borisov, Jessica van Setten, Harold Snieder, Niek Verweij, M. Abdullah Said, Pim van der Harst · 2021 · Arteriosclerosis Thrombosis and Vascular Biology
Genetic variation in CADM2 as a link between psychological traits and obesity
Julia Morris, Mark E.S. Bailey, Damiano Baldassarre, Breda Cullen, Ulf dé Fairé, Amy Ferguson, Bruna Gigante, Philippe Giral, Anuj Goel, Nicholas Graham et al. · 2019 · Scientific Reports
A Prospective Analysis of Genetic Variants Associated with Human Lifespan
Kevin M. Wright, Kristin A. Rand, Amir R. Kermany, Keith Noto, Don Curtis, Daniel Garrigan, Dmitri Slinkov, Ilya Dorfman, Julie M. Granka, Jake Byrnes et al. · 2019 · G3 Genes Genomes Genetics
Genetic susceptibility, plant-based dietary patterns, and risk of cardiovascular disease
Yoriko Heianza, Tao Zhou, Dianjianyi Sun, Frank B. Hu, JoAnn Elisabeth Manson, Lu Qi · 2020 · American Journal of Clinical Nutrition
Genetic comorbidity between major depression and cardio‐metabolic traits, stratified by age at onset of major depression
Hagenaars, Saskia P., Coleman, Jonathan R. I., Choi, Shing Wan, Gaspar, Héléna, Adams, Mark J., Howard, David M., Hodgson, Karen, Traylor, Matthew, Air, Tracy M., Andlauer, Till F. M. et al. · 2020 · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
A review of gene-by-air pollution interactions for cardiovascular disease, risk factors, and biomarkers
Cavin K Ward-Caviness · 2019 · Human Genetics
Genetically Determined Uric Acid and the Risk of Cardiovascular and Neurovascular Diseases: A Mendelian Randomization Study of Outcomes Investigated in Randomized Trials
Anthoula Efstathiadou, Dipender Gill, Frances McGrane, Terence J. Quinn, Jesse Dawson · 2019 · Journal of the American Heart Association
Targeting the epigenome in in-stent restenosis: from mechanisms to therapy
Xi Yang, Yanyan Yang, Junjie Guo, Yuanyuan Meng, Min Li, Panyu Yang, Xin Liu, Lynn Htet Htet Aung, Tao Yu, Yonghong Li · 2021 · Molecular Therapy — Nucleic Acids
European Heart Rhythm Association ( EHRA )/Heart Rhythm Society ( HRS )/Asia Pacific Heart Rhythm Society ( APHRS )/Latin American Heart Rhythm Society ( LAHRS ) Expert Consensus Statement on the state of genetic testing for cardiac diseases
Arthur A.M. Wilde, Christopher Semsarian, Manlio Fabio Márquez, Alireza Sepehri Shamloo, Michael John Ackerman, Euan Angus Ashley, Eduardo Back Sternick, Héctor Barajas-Martínez, Elijah Raphael Behr, Connie R. Bezzina et al. · 2022 · Journal of Arrhythmia
Smad3 regulates smooth muscle cell fate and mediates adverse remodeling and calcification of the atherosclerotic plaque
Paul P. Cheng, Robert C. Wirka, Juyong Brian Kim, Hyun-Jung Kim, Trieu Nguyen, Ramendra Krishna Kundu, Quanyi Zhao, Disha Sharma, Albert J Pedroza, Manabu Nagao et al. · 2022 · Nature Cardiovascular Research
Genetic risk factors have a substantial impact on healthy life years
Sakari Jukarainen, Tuomo Kiiskinen, Sara Kuitunen, Aki Samuli Havulinna, Juha M Karjalainen, Mattia Cordioli, Joel T Rämö, Nina Mars, FinnGen, Kaitlin E. Samocha et al. · 2022 · Nature Medicine
Genome-wide association study identifies seven novel loci associating with circulating cytokines and cell adhesion molecules in Finns
Sliz, Eeva, Kalaoja, Marita, Ahola-Olli, Ari, Raitakari, Olli, Perola, Markus, Salomaa, Veikko, Lehtimäki, Terho, Karhu, Toni, Viinamäki, Heimo, Salmi, Marko et al. · 2019 · Journal of Medical Genetics
Precision Cardiovascular Medicine: State of Genetic Testing
John R. Giudicessi, Iftikhar J. Kullo, Michael John Ackerman · 2017 · Mayo Clinic Proceedings
Genetic and Epigenetic Fine Mapping of Complex Trait Associated Loci in the Human Liver
Minal Çalışkan, Elisabetta Manduchi, H. Shanker Rao, Julian A. Segert, Márcia Holsbach Beltrame, Marco Trizzino, YoSon Park, Samuel W. Baker, Alessandra Chesi, Matthew E. Johnson et al. · 2019 · The American Journal of Human Genetics
Proteogenomic Data Integration Reveals CXCL10 as a Potentially Downstream Causal Mediator for IL-6 Signaling on Atherosclerosis
Savvina Prapiadou, Luka Živković, Barbara Thorand, Marc Jonathan George, Sander W. van der Laan, Rainer Malik, Christian Herder, Wolfgang Köenig, Thor Ueland, Ola Kleveland et al. · 2023 · Circulation
Coronary artery disease genes SMAD3 and TCF21 promote opposing interactive genetic programs that regulate smooth muscle cell differentiation and disease risk
Dharini Iyer, Quanyi Zhao, Robert C. Wirka, Ameay V. Naravane, Trieu Nguyen, Boxiang Liu, Manabu Nagao, Paul P. Cheng, Clint L. Miller, Juyong Brian Kim et al. · 2018 · PLoS Genetics
The Genome of the Human Pathogen Candida albicans Is Shaped by Mutation and Cryptic Sexual Recombination
Joshua M. Wang, Richard J. Bennett, Matthew Z. Anderson · 2018 · mBio
Over 1000 genetic loci influencing blood pressure with multiple systems and tissues implicated
Claudia Cabrera, Fu Liang Ng, Hannah Nicholls, Ajay Kumar Gupta, Michael R. Barnes, Patricia B. Munroe, Mark J. Caulfield · 2019 · Human Molecular Genetics
Phenome-wide investigation of the causal associations between childhood BMI and adult trait outcomes: a two-sample Mendelian randomization study
Shan‐Shan Dong, Kun Zhang, Yan Guo, Jing‐Miao Ding, Jun-Cheng Feng, Shi Yao, Shi Yao, Yu Rong, Feng Jiang, Jiabin Chen et al. · 2021 · Genome Medicine
Where the Action Is—Leukocyte Recruitment in Atherosclerosis
Carina Mauersberger, Julia Hinterdobler, Heribert Schunkert, Thorsten Kessler, Hendrik B. Sager · 2022 · Frontiers in Cardiovascular Medicine
Polygenic Contribution in Individuals With Early-Onset Coronary Artery Disease
Sébastien Thériault, Ricky Lali, Michael Chong, James L. Velianou, Madhu K. Natarajan, Guillaume Paré · 2018 · Circulation Genomic and Precision Medicine
Nutritional Genomics and Direct-to-Consumer Genetic Testing: An Overview
Marta Guasch‐Ferré, Hassan S. Dashti, Jordi Merino · 2018 · Advances in Nutrition
Current perspectives in assessing humoral immunity after measles vaccination
Iana H. Haralambieva, Richard B. Kennedy, Inna G. Ovsyannikova, Daniel J. Schaid, Gregory A. Poland · 2018 · Expert Review of Vaccines
Genomic profiling of human vascular cells identifies TWIST1 as a causal gene for common vascular diseases
Sylvia Nürnberg, Marie A. Guerraty, Robert C. Wirka, H. Shanker Rao, Milos Pjanic, Scott Norton, Felipe Serrano, Ljubica Perisic Matic, Susannah Elwyn, John B. Pluta et al. · 2020 · PLoS Genetics
RIPK1 gene variants associate with obesity in humans and can be therapeutically silenced to reduce obesity in mice
Denuja Karunakaran, Adam W. Turner, Anne‐Claire Duchez, Sébastien Soubeyrand, Adil Rasheed, David R. Smyth, David P. Cook, Majid Nikpay, Joshua W. Kandiah, Calvin Pan et al. · 2020 · Nature Metabolism
FMD and SCAD: Sex-Biased Arterial Diseases With Clinical and Genetic Pleiotropy
Esther S.H. Kim, Jacqueline Saw, Daniella L. Kadian‐Dodov, Malissa J. Wood, Santhi K. Ganesh · 2021 · Circulation Research
The Potential of Polygenic Risk Scores to Predict Antidepressant Treatment Response in Major Depression: A Systematic Review
Julia J. Meerman, Sophie E. ter Hark, Joost Janzing, Marieke J. H. Coenen · 2022 · Journal of Affective Disorders
Associations of genetically predicted fatty acid levels across the phenome: A mendelian randomisation study
Loukas Zagkos, Marie‐Joe Dib, Rui Climaco Pinto, Dipender Gill, Fotios Koskeridis, Fotios Drenos, Georgios Markozannes, Paul Elliott, Verena Zuber, Kostas Tsilidis et al. · 2022 · PLoS Medicine
JCAD , a Gene at the 10p11 Coronary Artery Disease Locus, Regulates Hippo Signaling in Endothelial Cells
Peter D. Jones, Michael Kaiser, Maryam Ghaderi Najafabadi, Simon Koplev, Yuqi Zhao, Gillian Douglas, Theodosios Kyriakou, Sarah Andrews, Rathinasabapathy Rajmohan, Hugh C Watkins et al. · 2018 · Arteriosclerosis Thrombosis and Vascular Biology
Contribution of Gene Regulatory Networks to Heritability of Coronary Artery Disease
Lingyao Zeng, Husain Ahammad Talukdar, Simon Koplev, Chiara Giannarelli, Torbjörn Ivert, Li‐Ming Gan, Arno Ruusalepp, Eric E. Schadt, Jason Ciril Kovacic, Aldons Jake Lusis et al. · 2019 · Journal of the American College of Cardiology
Genetic Correlation and Causal Relationships between Cardio-Metabolic Traits and Lung Function Impairment
Matthias Wielscher, André F.S. Amaral, Diana A. van der Plaat, Louise V. Wain, Sylvain P Sebert, David Mosén-Ansorena, JUHA P. AUVINEN, Karl‐Heinz Herzig, Abbas Dehghan, Deborah Jarvis et al. · 2020 · Genome Medicine
Neural network-based integration of polygenic and clinical information: development and validation of a prediction model for 10-year risk of major adverse cardiac events in the UK Biobank cohort
Jakob Steinfeldt, Thore Buergel, Lukas Loock, Paul Kittner, Greg Ruyoga, Julius Upmeier zu Belzen, Simon Sasse, Henrik Strangalies, Lara Christmann, Noah Hollmann et al. · 2022 · The Lancet Digital Health
Effect of Cheese Intake on Cardiovascular Diseases and Cardiovascular Biomarkers
Mengjin Hu, Jiang‐Shan Tan, Xiaojin Gao, Jingang Yang, Yuejin Yang · 2022 · Nutrients
Causal associations between gut microbiome and cardiovascular disease: A Mendelian randomization study
Yuxuan Zhang, Xinyi Zhang, Delong Chen, Jia Lu, Qinyan Gong, Jiacheng Fang, Jun Jiang · 2022 · Frontiers in Cardiovascular Medicine
Functional Analysis of a Novel Genome-Wide Association Study Signal in SMAD3 That Confers Protection From Coronary Artery Disease
Adam W. Turner, Amy Martinuk, Anada Silva, Paulina Lau, Majid Nikpay, Per Olof Eriksson, Lasse Folkersen, Ljubica Perisic Matic, Ulf Hedin, Sébastien Soubeyrand et al. · 2016 · Arteriosclerosis Thrombosis and Vascular Biology
Large-Scale Exome-wide Association Analysis Identifies Loci for White Blood Cell Traits and Pleiotropy with Immune-Mediated Diseases
Salman M. Tajuddin, Ursula M. Schick, John D. Eicher, Nathalie Chami, Ayush Giri, Jennifer A. Brody, William David Hill, Tim Kacprowski, Jin Li, Leo‐Pekka Lyytikäinen et al. · 2016 · The American Journal of Human Genetics
Applications of the 1000 Genomes Project resources
Xiangqun Zheng-Bradley, Paul Flicek · 2016 · Briefings in Functional Genomics
Cohort Profile: The Oxford Biobank
Fredrik Karpe, Senthil Kandaswamy Vasan, Sandy M. Humphreys, John M. Miller, Jane Cheeseman, Andrea Dennis, Matt J. Neville · 2017 · International Journal of Epidemiology
The polygenic nature of telomere length and the anti-ageing properties of lithium
Fiona Coutts, Alish Palmos, Rodrigo R. R. Duarte, Simone de Jong, Cathryn M. Lewis, Danai Dima, Timothy R. Powell · 2018 · Neuropsychopharmacology
Colocalization of GWAS and eQTL signals at loci with multiple signals identifies additional candidate genes for body fat distribution
Ying Wu, K. Alaine Broadaway, Chelsea K. Raulerson, Laura J. Scott, Calvin Pan, Arthur Ko, Aiqing He, Charles A. Tilford, Christian Fuchsberger, Adam E. Locke et al. · 2019 · Human Molecular Genetics
Circulating interleukins in relation to coronary artery disease, atrial fibrillation and ischemic stroke and its subtypes: A two-sample Mendelian randomization study
Shuai Yuan, Ang Lin, Qi‐qiang He, Stephen Burgess, Susanna C. Larsson · 2020 · International Journal of Cardiology
Highly elevated polygenic risk scores are better predictors of myocardial infarction risk early in life than later
Monica Isgut, Jimeng Sun, Arshed Ali Quyyumi, Greg C. Gibson · 2021 · Genome Medicine
Self-reported daytime napping, daytime sleepiness, and other sleep phenotypes in the development of cardiometabolic diseases: a Mendelian randomization study
Yiming Jia, Daoxia Guo, Lulu Sun, Mengyao Shi, Kaixin Zhang, Pinni Yang, Yuhan Zang, Yu Wang, Fanghua Liu, Yonghong Zhang et al. · 2022 · European Journal of Preventive Cardiology