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A mouse model of ATR-Seckel shows embryonic replicative stress and accelerated aging
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“elimination of p53 aggravates the phenotypes of some progeroid mutant mice”
From The Hallmarks of Aging (2013) · cites this paper as Murga et al., 2009
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The DNA Damage Response: Ten Years After
Harper, J. W., & Elledge, S. J. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.11.015 · Cited by 1,705
Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age
Rossi, D. J., Bryder, D., Seita, J., Nussenzweig, A., Hoeijmakers, J., & Weissman, I. L. (2007) · Nature · doi:10.1038/nature05862 · Cited by 1,115
Self-citationATR disruption leads to chromosomal fragmentation and early embryonic lethality
Brown, E. J., & Baltimore, D. (2000) · Genes & Development · doi:10.1101/gad.14.4.397 · Cited by 951
DNA Repair, Genome Stability, and Aging
Lombard, D. B., Chua, K. F., Mostoslavsky, R., Franco, S., Gostissa, M., & Alt, F. W. (2005) · Cell · doi:10.1016/j.cell.2005.01.028 · Cited by 944
O'Driscoll, M., Ruiz-Perez, V. L., Woods, C. G., Jeggo, P. A., & Goodship, J. A. (2003) · Nature Genetics · doi:10.1038/ng1129 · Cited by 794
Essential and dispensable roles of ATR in cell cycle arrest and genome maintenance
Brown, E. J., & Baltimore, D. (2003) · Genes & Development · doi:10.1101/gad.1067403 · Cited by 511
Delayed ageing through damage protection by the Arf/p53 pathway
Matheu, A., Maraver, A., Klatt, P., Flores, I., Garcia-Cao, I., Borras, C., Flores, J. M., Viña, J., Blasco, M. A., & Serrano, M. (2007) · Nature · doi:10.1038/nature05949 · Cited by 466
Flagged first, then by citations
Research works printed but not linked: 43
- Sedelnikova, O.A. et al. Senescing human cells and ageing mice accumulate DNA lesions with unrepairable double-strand breaks. Nat. Cell Biol. 6, 168–170 (2004). · DOI · Paper page
- Schumacher, B., Garinis, G.A. & Hoeijmakers, J.H. Age to survive: DNA damage and aging. Trends Genet. 24, 77–85 (2008). · DOI
- Xu, Y. & Baltimore, D. Dual roles of ATM in the cellular response to radiation and in cell growth control. Genes Dev. 10, 2401–2410 (1996). · DOI
- Elson, A. et al. Pleiotropic defects in ataxia-telangiectasia protein-deficient mice. Proc. Natl. Acad. Sci. USA 93, 13084–13089 (1996). · DOI
- Barlow, C. et al. Atm-deficient mice: a paradigm of ataxia telangiectasia. Cell 86, 159–171 (1996). · DOI
- de Klein, A. et al. Targeted disruption of the cell-cycle checkpoint gene ATR leads to early embryonic lethality in mice. Curr. Biol. 10, 479–482 (2000). · DOI
- Seckel, H. Bird-Headed Dwarfs: Studies in Developmental Anthropology Including Human Proportions (Karger, Basel, Switzerland, 1960).
- Shanske, A., Caride, D.G., Menasse-Palmer, L., Bogdanow, A. & Marion, R.W. Central nervous system anomalies in Seckel syndrome: report of a new family and review of the literature. Am. J. Med. Genet. 70, 155–158 (1997). · DOI
- Ruzankina, Y. et al. Deletion of the developmentally essential gene ATR in adult mice leads to age-related phenotypes and stem cell loss. Cell Stem Cell 1, 113–126 (2007). · DOI
- Butler, M.G., Hall, B.D., Maclean, R.N. & Lozzio, C.B. Do some patients with Seckel syndrome have hematological problems and/or chromosome breakage? Am. J. Med. Genet. 27, 645–649 (1987). · DOI
- Rossi, D.J., Jamieson, C.H. & Weissman, I.L. Stems cells and the pathways to aging and cancer. Cell 132, 681–696 (2008). · DOI · Paper page
- Rosen, C.J. & Bouxsein, M.L. Mechanisms of disease: is osteoporosis the obesity of bone? Nat. Clin. Pract. Rheumatol. 2, 35–43 (2006). · DOI
- Morrison, S.J., Wandycz, A.M., Akashi, K., Globerson, A. & Weissman, I.L. The aging of hematopoietic stem cells. Nat. Med. 2, 1011–1016 (1996). · DOI
- Sudo, K., Ema, H., Morita, Y. & Nakauchi, H. Age-associated characteristics of murine hematopoietic stem cells. J. Exp. Med. 192, 1273–1280 (2000). · DOI · Paper page
- Bartke, A. Minireview: role of the growth hormone/insulin-like growth factor system in mammalian aging. Endocrinology 146, 3718–3723 (2005). · DOI
- Lombardi, G., Di Somma, C., Rota, F. & Colao, A. Associated hormonal decline in aging: is there a role for GH therapy in aging men? J. Endocrinol. Invest. 28, 99–108 (2005).
- van der Pluijm, I. et al. Impaired genome maintenance suppresses the growth hormone–insulin-like growth factor 1 axis in mice with Cockayne syndrome. PLoS Biol. 5, e2 (2007). · DOI
- Niedernhofer, L.J. et al. A new progeroid syndrome reveals that genotoxic stress suppresses the somatotroph axis. Nature 444, 1038–1043 (2006). · DOI · Paper page
- Cha, R.S. & Kleckner, N. ATR homolog Mec1 promotes fork progression, thus averting breaks in replication slow zones. Science 297, 602–606 (2002). · DOI
- Sogo, J.M., Lopes, M. & Foiani, M. Fork reversal and ssDNA accumulation at stalled replication forks owing to checkpoint defects. Science 297, 599–602 (2002). · DOI
- Stiff, T. et al. Nbs1 is required for ATR-dependent phosphorylation events. EMBO J. 24, 199–208 (2005). · DOI
- Casper, A.M., Nghiem, P., Arlt, M.F. & Glover, T.W. ATR regulates fragile site stability. Cell 111, 779–789 (2002). · DOI
- Casper, A.M., Durkin, S.G., Arlt, M.F. & Glover, T.W. Chromosomal instability at common fragile sites in Seckel syndrome. Am. J. Hum. Genet. 75, 654–660 (2004). · DOI
- Bobabilla-Morales, L. et al. Chromosome instability induced in vitro with mitomycin C in five Seckel syndrome patients. Am. J. Med. Genet. A. 123A, 148–152 (2003). · DOI
- Syrrou, M., Georgiou, I., Paschopoulos, M. & Lolis, D. Seckel syndrome in a family with three affected children and hematological manifestations associated with chromosome instability. Genet. Couns. 6, 37–41 (1995).
- Arnold, S.R., Spicer, D., Kouseff, B., Lacson, A. & Gilbert-Barness, E. Seckel-like syndrome in three siblings. Pediatr. Dev. Pathol. 2, 180–187 (1999). · DOI
- Boscherini, B. et al. Intrauterine growth retardation. A report of two cases with bird-headed appearance, skeletal changes and peripheral GH resistance. Eur. J. Pediatr. 137, 237–242 (1981). · DOI
- Fathizadeh, A., Soltani, K., Medenica, M. & Lorincz, A.L. Pigmentary changes in Seckel's syndrome. J. Am. Acad. Dermatol. 1, 52–54 (1979). · DOI
- Griffith, E. et al. Mutations in pericentrin cause Seckel syndrome with defective ATR-dependent DNA damage signaling. Nat. Genet. 40, 232–236 (2008). · DOI
- Goodship, J. et al. Autozygosity mapping of a Seckel syndrome locus to chromosome 3q22. 1-q24. Am. J. Hum. Genet. 67, 498–503 (2000). · DOI
- Fowden, A.L., Giussani, D.A. & Forhead, A.J. Intrauterine programming of physiological systems: causes and consequences. Physiology (Bethesda) 21, 29–37 (2006).
- Fowden, A.L., Forhead, A.J., Coan, P.M. & Burton, G.J. The placenta and intrauterine programming. J. Neuroendocrinol. 20, 439–450 (2008). · DOI
- Barker, D. The fetal origins of adult disease. Proc. R. Soc. Lond. B 262, 37–43 (1995). · DOI
- Murphy, D.P. Ovarian radiation—its effect on the health of subsequent children. Review of the literature, experimental and clinical, with a report of 320 human pregnancies. Surg. Gynecol. Obstet. 47, 201–215 (1928).
- Schmidt, S.L. & Lent, R. Effects of prenatal irradiation on the development of cerebral cortex and corpus callosum of the mouse. J. Comp. Neurol. 264, 193–204 (1987). · DOI
- Rodier, F., Campisi, J. & Bhaumik, D. Two faces of p53: aging and tumor suppression. Nucleic Acids Res. 35, 7475–7484 (2007). · DOI
- el-Deiry, W.S. et al. WAF1, a potential mediator of p53 tumor suppression. Cell 75, 817–825 (1993). · DOI · Paper page
- Sidi, S. et al. Chk1 suppresses a caspase-2 apoptotic response to DNA damage that bypasses p53, Bcl-2, and caspase-3. Cell 133, 864–877 (2008). · DOI
- Wang, Q. et al. UCN-01: a potent abrogator of G2 checkpoint function in cancer cells with disrupted p53. J. Natl. Cancer Inst. 88, 956–965 (1996). · DOI · Paper page
- Viale, A. et al. Cell-cycle restriction limits DNA damage and maintains self-renewal of leukaemia stem cells. Nature 457, 51–56 (2009). · DOI
- Liu, Q. et al. Chk1 is an essential kinase that is regulated by Atr and required for the G2/M DNA damage checkpoint. Genes Dev. 14, 1448–1459 (2000). · DOI
- Jacks, T. et al. Tumor spectrum analysis in p53-mutant mice. Curr. Biol. 4, 1–7 (1994). · DOI · Paper page
- Murga, M. et al. Global chromatin compaction limits the strength of the DNA damage response. J. Cell Biol. 178, 1101–1108 (2007). · DOI
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López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013) · Cell · doi:10.1016/j.cell.2013.05.039 · Cited by 14,982
Causes and consequences of replication stress
Zeman, M. K., & Cimprich, K. A. (2014) · Nature Cell Biology · doi:10.1038/ncb2897 · Cited by 2,079
The ATM protein kinase: regulating the cellular response to genotoxic stress, and more
Shiloh, Y., & Ziv, Y. (2013) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3546 · Cited by 1,649
Programmed cell senescence during mammalian embryonic development
Muñoz-Espín, D., Cañamero, M., Maraver, A., Gómez-López, G., Contreras, J., Murillo-Cuesta, S., Rodríguez-Baeza, A., Varela-Nieto, I., Ruberte, J., Collado, M., et al. (2013) · Cell · doi:10.1016/j.cell.2013.10.019 · Cited by 1,428
Self-citationATR prohibits replication catastrophe by preventing global exhaustion of RPA
Toledo, L. I., Altmeyer, M., Rask, M.-B., Lukas, C., Larsen, D. H., Povlsen, L. K., Bekker-Jensen, S., Mailand, N., Bartek, J., & Lukas, J. (2013) · Cell · doi:10.1016/j.cell.2013.10.043 · Cited by 911
Metadata
- Authors
- Murga, M., Bunting, S., Montaña, M. F., Soria, R., Mulero, F., Cañamero, M., Lee, Y., McKinnon, P. J., Nussenzweig, A., & Fernandez-Capetillo, O.
- Venue
- Nature Genetics
- Published
- 2009-07-20
- Volume
- 41
- Issue
- 8
- Pages
- 891-898
- ISSN
- 1061-4036
- 1546-1718
- PMC
- PMC2902278
- Cited by
- 340
- References
- 7
- Language
- en
- Licence
- www.springer.com/tdm (tdm)
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