Geographical genomics of human leukocyte gene expression variation in southern Morocco
Open accessAbstract
Studies of the genetics of gene expression can identify expression SNPs (eSNPs) that explain variation in transcript abundance. Here we address the robustness of eSNP associations to environmental geography and population structure in a comparison of 194 Arab and Amazigh individuals from a city and two villages in southern Morocco. Gene expression differed between pairs of locations for up to a third of all transcripts, with notable enrichment of transcripts involved in ribosomal biosynthesis and oxidative phosphorylation. Robust associations were observed in the leukocyte samples: cis eSNPs (P < 10(-08)) were identified for 346 genes, and trans eSNPs (P < 10(-11)) for 10 genes. All of these associations were consistent both across the three sample locations and after controlling for ancestry and relatedness. No evidence of large-effect trans-acting mediators of the pervasive environmental influence was found; instead, genetic and environmental factors acted in a largely additive manner.
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Gibson and colleagues found that approximately 5% of genes expressed in leukocytes showed appreciable genetic regulation, whereas more than 50% showed significant differences in expression across pastoral, rural, and urban social environments.
“Gibson and colleagues found that ∼5% of genes expressed in leukocytes showed appreciable genetic regulation (e.g., via expression quantitative trait loci), whereas >50% showed significant differences in expression across pastoral, rural, and urban social environments [11].”
From Human Social Genomics (2014) · cites this paper as [11]
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- Authors
- Idaghdour, Y., Czika, W., Shianna, K. V., Lee, S. H., Visscher, P. M., Martin, H. C., Miclaus, K., Jadallah, S. J., Goldstein, D. B., Wolfinger, R. D., & Gibson, G.
- Affiliations
- North Carolina State University (US)
- SAS Institute (United States) (US)
- Duke University (US)
- QIMR Berghofer Medical Research Institute (AU)
- The University of Queensland (AU)
- Corresponding author
- Gibson, Greg
- ORCID
- Venue
- Nature Genetics
- Published
- 2009-12-06
- Volume
- 42
- Issue
- 1
- Pages
- 62-67
- ISSN
- 1061-4036 (ISSN-L)
- 1546-1718
- PMC
- PMC2798927
- OpenAlex
- W2015751862
- Cited by
- 151
- References
- 45
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 8 · 2023: 7 · 2022: 3 · 2021: 8 · 2020: 2 · 2019: 9 · 2018: 3 · 2017: 7 · 2016: 7 · 2015: 8 · 2014: 14 · 2013: 20 · 2012: 23
- FWCI
- 9.75
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Genetics (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
- Funders
- University of Queensland
- National Institute of General Medical Sciences (R01GM061600)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Mapping and Diversity in Plants and Animals
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic diversity and population structure
- Keywords
- gene expression variation, leukocytes, environmental geography, ethnicity, southern Morocco, population structure, oxidative phosphorylation, gene-environment interaction
- MeSH terms
- Genetics, Population, Geography, Humans, Leukocytes, Morocco, Genetic Variation, Arabs, Genetic Predisposition to Disease, Polymorphism, Single Nucleotide, Gene Expression Profiling, Genomics, Principal Component Analysis, Genome-Wide Association Study
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