Novel Association of ABO Histo-Blood Group Antigen with Soluble ICAM-1: Results of a Genome-Wide Association Study of 6,578 Women
Open accessAbstract
While circulating levels of soluble Intercellular Adhesion Molecule 1 (sICAM-1) have been associated with diverse conditions including myocardial infarction, stroke, malaria, and diabetes, comprehensive analysis of the common genetic determinants of sICAM-1 is not available. In a genome-wide association study conducted among 6,578 participants in the Women's Genome Health Study, we find that three SNPs at the ICAM1 (19p13.2) locus (rs1799969, rs5498 and rs281437) are non-redundantly associated with plasma sICAM-1 concentrations at a genome-wide significance level (P<5x10(-8)), thus extending prior results from linkage and candidate gene studies. We also find that a single SNP (rs507666, P = 5.1x10(-29)) at the ABO (9q34.2) locus is highly correlated with sICAM-1 concentrations. The novel association at the ABO locus provides evidence for a previously unknown regulatory role of histo-blood group antigens in inflammatory adhesion processes.
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CSF Siglec-9, plasma sICAM-1, and brain PPAC have been replicated in other studies using a different proteomic approach, indicating these findings may not be driven by platform.
“CSF Siglec-9, plasma sICAM-1, and brain PPAC have been replicated in other studies16,29,31,32 using a different proteomic approach, which indicates that these findings may not be driven by platform.”
From Genomic atlas of the proteome from brain, CSF and plasma prioritizes proteins implicated in neurological disorders (2021) · cites this paper as [32]
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- Authors
- Paré, G., Chasman, D. I., Kellogg, M., Zee, R. Y. L., Rifai, N., Badola, S., Miletich, J. P., & Ridker, P. M.
- Affiliations
- Brigham and Women's Hospital (US)
- Harvard University (US)
- Amgen (United States) (US)
- Corresponding author
- Paré, Guillaume
- Venue
- PLoS Genetics
- Publisher
- Public Library of Science (PLoS)
- Published
- 2008-07-04
- Volume
- 4
- Issue
- 7
- Pages
- e1000118
- ISSN
- 1553-7390 (ISSN-L)
- 1553-7404
- PMC
- PMC2432033
- OpenAlex
- W2130171029
- Cited by
- 341
- References
- 55
- Citations by year
- 2026: 10 · 2025: 6 · 2024: 13 · 2023: 26 · 2022: 20 · 2021: 35 · 2020: 34 · 2019: 22 · 2018: 17 · 2017: 22 · 2016: 11 · 2015: 27 · 2014: 18 · 2013: 15 · 2012: 25
- FWCI
- 7.60
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS Genetics (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Figshare (submittedVersion, cc-by)
- Funders
- Doris Duke Charitable Foundation
- Amgen
- Fonds de Recherche du Québec - Santé
- National Cancer Institute
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Health Sciences › Medicine › Hematology › Blood groups and transfusion
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Mapping and Diversity in Plants and Animals
- Keywords
- soluble ICAM-1, ABO blood group system, histo-blood group antigens, ABO gene, single nucleotide polymorphisms, plasma biomarkers, genetic association, inflammation, inflammatory adhesions, women
- MeSH terms
- ABO Blood-Group System, Female, Humans, Genetic Linkage, Myocardial Infarction, Solubility, Genetic Variation, Genome, Human, Women's Health, Intercellular Adhesion Molecule-1, Polymorphism, Single Nucleotide
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