Genetics of schizophrenia: new findings and challenges
Abstract
The work conducted using genome-wide approaches during the past several years has invigorated the field, and represents the dawn of molecular genetics of schizophrenia. The aggregate data increasingly support a combination of rare and common genetic variation in schizophrenia, a major role for polygenic inheritance, and a genetic overlap of schizophrenia and other psychiatric disorders, such as bipolar disorder and autism. The current and upcoming resequencing programs (full exomes to full genomes), in combination with the use of more informative genotyping arrays, will allow a more thorough dissection of the molecular genetics of the disorder. A main challenge for the field is the translation of established genetic associations into a better pathophysiological understanding of schizophrenia.
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Current models of schizophrenia suggest that the disorder is due to both common and rare gene mutations, copy-number variations, and possibly epigenetic factors, all of which can affect multiple brain neurotransmitter systems and multiple risk genes.
“Current models of schizophrenia suggest that the disorder is due to both common and rare gene mutations, copy-number variations, and possibly epigenetic factors [361], all of which can affect multiple brain neurotransmitter systems and multiple risk genes [362-364].”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [361]
Similar copy number variants are found across many genomic loci in both ASD and schizophrenia.
“This observation is consistent with recent reports that similar copy number variants (CNVs) are found across many genomic loci in both ASD and schizophrenia (Cook and Scherer, 2008; Gejman et al., 2011; Moreno-De-Luca et al., 2010; Sanders et al., 2011).”
From Modeling Autism by SHANK Gene Mutations in Mice (2013) · cites this paper as Gejman et al., 2011
Cites
Diagnostic and Statistical Manual of Mental Disorders
Williams, J. B. W., & First, M. B. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 109,841 · see citing works
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls
The Wellcome Trust Case Control Consortium, Management Committee, Burton, P. R., Clayton, D. G., Cardon, L. R., Craddock, N., Deloukas, P., Duncanson, A., Kwiatkowski, D. P., McCarthy, M. I., et al. (2007) · Nature · doi:10.1038/nature05911 · Cited by 9,442 · see citing works
Finding the missing heritability of complex diseases
Manolio, T. A., Collins, F. S., Cox, N. J., Goldstein, D. B., Hindorff, L. A., Hunter, D. J., McCarthy, M. I., Ramos, E. M., Cardon, L. R., Chakravarti, A., et al. (2009) · Nature · doi:10.1038/nature08494 · Cited by 8,336 · see citing works
Common polygenic variation contributes to risk of schizophrenia and bipolar disorder
The International Schizophrenia Consortium (2009) · Nature · doi:10.1038/nature08185 · Cited by 4,821 · see citing works
Common SNPs explain a large proportion of the heritability for human height
Yang, J., Benyamin, B., McEvoy, B. P., Gordon, S., Henders, A. K., Nyholt, D. R., Madden, P. A., Heath, A. C., Martin, N. G., Montgomery, G. W., et al. (2010) · Nature Genetics · doi:10.1038/ng.608 · Cited by 4,446 · see citing works
XV.—The Correlation between Relatives on the Supposition of Mendelian Inheritance.
Fisher, R. A. (1919) · Transactions of the Royal Society of Edinburgh · doi:10.1017/s0080456800012163 · Cited by 4,387 · see citing works
Hindorff, L. A., Sethupathy, P., Junkins, H. A., Ramos, E. M., Mehta, J. P., Collins, F. S., & Manolio, T. A. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0903103106 · Cited by 4,013 · see citing works
The Human Connectome: A Structural Description of the Human Brain
Sporns, O., Tononi, G., & Kötter, R. (2005) · PLoS Computational Biology · doi:10.1371/journal.pcbi.0010042 · Cited by 3,260 · see citing works
Genome-wide association studies for complex traits: consensus, uncertainty and challenges
McCarthy, M. I., Abecasis, G. R., Cardon, L. R., Goldstein, D. B., Little, J., Ioannidis, J. P. A., & Hirschhorn, J. N. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2344 · Cited by 2,891 · see citing works
Miller, D. T., Adam, M. P., Aradhya, S., Biesecker, L. G., Brothman, A. R., Carter, N. P., Church, D. M., Crolla, J. A., Eichler, E. E., Epstein, C. J., et al. (2010) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2010.04.006 · Cited by 2,882 · see citing works
Strong association of de novo copy number mutations with autism
Sebat, J., Lakshmi, B., Malhotra, D., Troge, J., Lese-Martin, C., Walsh, T., Yamrom, B., Yoon, S., Krasnitz, A., Kendall, J., et al. (2007) · Science · doi:10.1126/science.1138659 · Cited by 2,795 · see citing works
Mendelson, G. (1995) · Australian & New Zealand Journal of Psychiatry · doi:10.3109/00048679509064964 · Cited by 2,592 · see citing works
Schizophrenia as a Complex Trait: Evidence From a Meta-analysis of Twin Studies
Sullivan, P. F., Kendler, K. S., & Neale, M. C. (2003) · Archives of General Psychiatry · doi:10.1001/archpsyc.60.12.1187 · Cited by 2,356 · see citing works
Self-citationSchizophrenia: A Concise Overview of Incidence, Prevalence, and Mortality
McGrath, J., Saha, S., Chant, D., & Welham, J. (2008) · Epidemiologic Reviews · doi:10.1093/epirev/mxn001 · Cited by 2,280 · see citing works
Lichtenstein, P., Yip, B. H., Björk, C., Pawitan, Y., Cannon, T. D., Sullivan, P. F., & Hultman, C. M. (2009) · The Lancet · doi:10.1016/s0140-6736(09)60072-6 · Cited by 2,125 · see citing works
Animal models of neuropsychiatric disorders
Nestler, E. J., & Hyman, S. E. (2010) · Nature Neuroscience · doi:10.1038/nn.2647 · Cited by 2,023 · see citing works
Schizophrenia genes, gene expression, and neuropathology: on the matter of their convergence
Harrison, P. J., & Weinberger, D. R. (2005) · Molecular Psychiatry · doi:10.1038/sj.mp.4001558 · Cited by 2,020 · see citing works
van Os, J., & Kapur, S. (2009) · The Lancet · doi:10.1016/s0140-6736(09)60995-8 · Cited by 1,971 · see citing works
Wellcome Trust Case Control Consortium, Zeggini, E., Scott, L. J., Saxena, R., Voight, B. F., Marchini, J. L., Hu, T., de Bakker, P. I., Abecasis, G. R., Almgren, P., et al. (2008) · Nature Genetics · doi:10.1038/ng.120 · Cited by 1,864 · see citing works
Structural Variation of Chromosomes in Autism Spectrum Disorder
Marshall, C. R., Noor, A., Vincent, J. B., Lionel, A. C., Feuk, L., Skaug, J., Shago, M., Moessner, R., Pinto, D., Ren, Y., et al. (2008) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2007.12.009 · Cited by 1,815 · see citing works
Rare Structural Variants Disrupt Multiple Genes in Neurodevelopmental Pathways in Schizophrenia
Walsh, T., McClellan, J. M., McCarthy, S. E., Addington, A. M., Pierce, S. B., Cooper, G. M., Nord, A. S., Kusenda, M., Malhotra, D., Bhandari, A., et al. (2008) · Science · doi:10.1126/science.1155174 · Cited by 1,800 · see citing works
Large recurrent microdeletions associated with schizophrenia.
GROUP, Stefansson, H., Rujescu, D., Cichon, S., Pietiläinen, O. P. H., Ingason, A., Steinberg, S., Fossdal, R., Sigurdsson, E., Sigmundsson, T., et al. (2008) · Nature · doi:10.1038/nature07229 · Cited by 1,745 · see citing works
Common variants conferring risk of schizophrenia
†Genetic Risk and Outcome in Psychosis (GROUP), Stefansson, H., Ophoff, R. A., Steinberg, S., Andreassen, O. A., Cichon, S., Rujescu, D., Werge, T., Pietiläinen, O. P. H., Mors, O., et al. (2009) · Nature · doi:10.1038/nature08186 · Cited by 1,677 · see citing works
Association between Microdeletion and Microduplication at 16p11.2 and Autism
Weiss, L. A., Shen, Y., Korn, J. M., Arking, D. E., Miller, D. T., Fossdal, R., Saemundsen, E., Stefansson, H., Ferreira, M. A. R., Green, T., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa075974 · Cited by 1,666 · see citing works
Why Most Discovered True Associations Are Inflated
Ioannidis, J. P. A. (2008) · Epidemiology · doi:10.1097/ede.0b013e31818131e7 · Cited by 1,495 · see citing works
Rare chromosomal deletions and duplications increase risk of schizophrenia
The International Schizophrenia Consortium (2008) · Nature · doi:10.1038/nature07239 · Cited by 1,475 · see citing works
Mapping autism risk loci using genetic linkage and chromosomal rearrangements
The Autism Genome Project Consortium (2007) · Nature Genetics · doi:10.1038/ng1985 · Cited by 1,402 · see citing works
Common variants at 30 loci contribute to polygenic dyslipidemia
Kathiresan, S., Willer, C. J., Peloso, G. M., Demissie, S., Musunuru, K., Schadt, E. E., Kaplan, L., Bennett, D., Li, Y., Tanaka, T., et al. (2009) · Nature Genetics · doi:10.1038/ng.291 · Cited by 1,364 · see citing works
Linkage strategies for genetically complex traits. I. Multilocus models.
RISCH, N. J. (1990) · PubMed · Cited by 1,315 · see citing works
Are Rare Variants Responsible for Susceptibility to Complex Diseases?
Pritchard, J. K. (2001) · The American Journal of Human Genetics · doi:10.1086/321272 · Cited by 1,197 · see citing works
On the allelic spectrum of human disease
Reich, D. E., & Lander, E. S. (2001) · Trends in Genetics · doi:10.1016/s0168-9525(01)02410-6 · Cited by 1,185 · see citing works
Schizophrenia: The epigenetic puzzle
Haier, R. J. (1982) · Psychiatry Research · doi:10.1016/0165-1781(92)90099-o · Cited by 1,173 · see citing works
Common variants on chromosome 6p22.1 are associated with schizophrenia
Shi, J., Levinson, D. F., Duan, J., Sanders, A. R., Zheng, Y., Pe’er, I., Dudbridge, F., Holmans, P., Whittemore, A. S., Mowry, B. J., et al. (2009) · Nature · doi:10.1038/nature08192 · Cited by 1,154 · see citing works
Self-citationIdentification of loci associated with schizophrenia by genome-wide association and follow-up
Molecular Genetics of Schizophrenia Collaboration, O'Donovan, M. C., Craddock, N., Norton, N., Williams, H., Peirce, T., Moskvina, V., Nikolov, I., Hamshere, M., Carroll, L., et al. (2008) · Nature Genetics · doi:10.1038/ng.201 · Cited by 1,070 · see citing works
Self-citationAllen, N. C., Bagade, S., McQueen, M. B., Ioannidis, J. P. A., Kavvoura, F. K., Khoury, M. J., Tanzi, R. E., & Bertram, L. (2008) · Nature Genetics · doi:10.1038/ng.171 · Cited by 1,054 · see citing works
Fragile X Syndrome: Loss of Local mRNA Regulation Alters Synaptic Development and Function
Bassell, G. J., & Warren, S. T. (2008) · Neuron · doi:10.1016/j.neuron.2008.10.004 · Cited by 1,051 · see citing works
Multiple common variants for celiac disease influencing immune gene expression
Dubois, P. C. A., Trynka, G., Franke, L., Hunt, K. A., Romanos, J., Curtotti, A., Zhernakova, A., Heap, G., Ádány, R., Aromaa, A. J., et al. (2010) · Nature Genetics · doi:10.1038/ng.543 · Cited by 1,026 · see citing works
High rates of schizophrenia in adults with velo-cardio-facial syndrome
Murphy, K. C., Jones, L. A., & Owen, M. J. (1999) · Archives of General Psychiatry · doi:10.1001/archpsyc.56.10.940 · Cited by 1,024 · see citing works
A Family Study of Schizoaffective, Bipolar I, Bipolar II, Unipolar, and Normal Control Probands
Gershon, E. S. (1982) · Archives of General Psychiatry · doi:10.1001/archpsyc.1982.04290100031006 · Cited by 987 · see citing works
Multiple loci identified in a genome-wide association study of prostate cancer
Thomas, G. D., Jacobs, K. B., Yeager, M., Kraft, P., Wacholder, S., Orr, N., Yu, K. F., Chatterjee, N., Welch, R., Hutchinson, A. A., et al. (2008) · Nature Genetics · doi:10.1038/ng.91 · Cited by 899 · see citing works
Long-Range Control of Gene Expression: Emerging Mechanisms and Disruption in Disease
Kleinjan, D. A., & van Heyningen, V. (2004) · The American Journal of Human Genetics · doi:10.1086/426833 · Cited by 868 · see citing works
Mapping complex disease traits with global gene expression
Cookson, W., Liang, L., Abecasis, G., Moffatt, M., & Lathrop, M. (2009) · Nature Reviews Genetics · doi:10.1038/nrg2537 · Cited by 849 · see citing works
Genome-wide association analysis identifies 20 loci that influence adult height
Initiative, D. G., Weedon, M. N., The Wellcome Trust Case Control Consortium, Cambridge GEM Consortium, Lango, H., Lindgren, C. M., Wallace, C., Evans, D. M., Mangino, M., Freathy, R. M., et al. (2008) · Nature Genetics · doi:10.1038/ng.121 · Cited by 826 · see citing works
Rates of Adult Schizophrenia Following Prenatal Exposure to the Chinese Famine of 1959-1961
Clair, D. S. (2005) · JAMA · doi:10.1001/jama.294.5.557 · Cited by 817 · see citing works
Strong association of de novo copy number mutations with sporadic schizophrenia
Xu, B., Roos, J. L., Levy, S., van Rensburg, E. J., Gogos, J. A., & Karayiorgou, M. (2008) · Nature Genetics · doi:10.1038/ng.162 · Cited by 813 · see citing works
Principles for the buffering of genetic variation
Hartman, J. L., Garvik, B., & Hartwell, L. (2001) · Science · doi:10.1126/science.1056072 · Cited by 808 · see citing works
Principles for the Buffering of Genetic Variation
Hartman IV, J. L. (2001) · Science · doi:10.1126/science.291.5506.1001 · Cited by 808 · see citing works
Molecular networks as sensors and drivers of common human diseases
Schadt, E. E. (2009) · Nature · doi:10.1038/nature08454 · Cited by 806 · see citing works
Recurrent rearrangements of chromosome 1q21.1 and variable pediatric phenotypes
Mefford, H. C., Sharp, A. J., Baker, C., Itsara, A., Jiang, Z., Buysse, K., Huang, S., Maloney, V. K., Crolla, J. A., Baralle, D., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0805384 · Cited by 804 · see citing works
Heritability Estimates for Psychotic Disorders
Cardno, A. G., Marshall, E. J., Coid, B., Macdonald, A. M., Ribchester, T., Davies, N., Venturi, P., Jones, L. A., Lewis, S. W., Sham, P. C., et al. (1999) · Archives of General Psychiatry · doi:10.1001/archpsyc.56.2.162 · Cited by 789 · see citing works
Pe'er, I., Yelensky, R., Altshuler, D., & Daly, M. J. (2008) · Genetic Epidemiology · doi:10.1002/gepi.20303 · Cited by 783 · see citing works
Psychiatric Disorders in Foster Home Reared Children of Schizophrenic Mothers
Heston, L. L. (1966) · The British Journal of Psychiatry · doi:10.1192/bjp.112.489.819 · Cited by 776 · see citing works
Recurrent 16p11.2 microdeletions in autism
Kumar, R. A., KaraMohamed, S., Sudi, J., Conrad, D. F., Brune, C., Badner, J. A., Gilliam, T. C., Nowak, N. J., Cook, E. H., Dobyns, W. B., et al. (2007) · Human Molecular Genetics · doi:10.1093/hmg/ddm376 · Cited by 731 · see citing works
Kendler, K. S. (1993) · Archives of General Psychiatry · doi:10.1001/archpsyc.1993.01820190029004 · Cited by 729 · see citing works
Self-citationRisk Factors for Autism: Perinatal Factors, Parental Psychiatric History, and Socioeconomic Status
Larsson, H. J., Eaton, W. W., Madsen, K. M., Vestergaard, M., Olesen, A. V., Agerbo, E., Schendel, D., Thorsen, P., & Mortensen, P. B. (2005) · American Journal of Epidemiology · doi:10.1093/aje/kwi123 · Cited by 727 · see citing works
Schizophrenia After Prenatal Exposure to the Dutch Hunger Winter of 1944-1945
Susser, E. (1992) · Archives of General Psychiatry · doi:10.1001/archpsyc.1992.01820120071010 · Cited by 727 · see citing works
Kety, S. S., Rosenthal, D., Wender, P. H., & D, F. S. M. (1968) · Journal of Psychiatric Research · doi:10.1016/0022-3956(68)90026-5 · Cited by 715 · see citing works
Prediction of individual genetic risk to disease from genome-wide association studiesPreprint
Wray, N. R., Goddard, M. E., & Visscher, P. M. (2007) · Genome Research · doi:10.1101/gr.6665407 · Cited by 714 · see citing works
Microduplications of 16p11.2 are associated with schizophrenia
Wellcome Trust Case Control Consortium, McCarthy, S. E., Makarov, V., Kirov, G., Addington, A. M., McClellan, J., Yoon, S., Perkins, D. O., Dickel, D. E., Kusenda, M., et al. (2009) · Nature Genetics · doi:10.1038/ng.474 · Cited by 711 · see citing works
Estimation of significance thresholds for genomewide association scans
Dudbridge, F., & Gusnanto, A. (2008) · Genetic Epidemiology · doi:10.1002/gepi.20297 · Cited by 703 · see citing works
Whole-genome association study of bipolar disorder
Sklar, P. B., Smoller, J. W., Fan, J., Ferreira, M. A. R., Perlis, R. H., Chambert, K., Nimgaonkar, V. L., McQueen, M. B., Faraone, S. V., Kirby, A. W., et al. (2008) · Molecular Psychiatry · doi:10.1038/sj.mp.4002151 · Cited by 691 · see citing works
A polygenic theory of schizophrenia.
Gottesman, I. I., & Shields, J. (1967) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.58.1.199 · Cited by 636 · see citing works
Brunetti-Pierri, N., Berg, J. S., Scaglia, F., Belmont, J., Bacino, C. A., Sahoo, T., Lalani, S. R., Graham, B., Lee, B., Shinawi, M., et al. (2008) · Nature Genetics · doi:10.1038/ng.279 · Cited by 625 · see citing works
Population analysis of large copy number variants and hotspots of human genetic disease
Itsara, A., Cooper, G. M., Baker, C., Girirajan, S., Li, J., Absher, D., Krauss, R. M., Myers, R. M., Ridker, P. M., Chasman, D. I., et al. (2009) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2008.12.014 · Cited by 591 · see citing works
The Kraepelinian dichotomy – going, going … but still not gone
Craddock, N., & Owen, M. J. (2010) · British Journal of Psychiatry · doi:10.1192/bjp.bp.109.073429 · Cited by 587 · see citing works
A recurrent 15q13.3 microdeletion syndrome associated with mental retardation and seizures.
Sharp, A. J., Mefford, H. C., Li, K., Baker, C., Skinner, C., Stevenson, R. E., Schroer, R. J., Novara, F., De Gregori, M., Ciccone, R., et al. (2008) · Nature Genetics · doi:10.1038/ng.93 · Cited by 582 · see citing works
Shinawi, M., Liu, P., Kang, S.-H. L., Shen, J., Belmont, J. W., Scott, D. A., Probst, F. J., Craigen, W. J., Graham, B. H., Pursley, A., et al. (2010) · Journal of Medical Genetics · doi:10.1136/jmg.2009.073015 · Cited by 580 · see citing works
Disruption of neurexin 1 associated with autism spectrum disorder
Kim, H.-G., Kishikawa, S., Higgins, A. W., Seong, I.-S., Donovan, D. J., Shen, Y., Lally, E., Weiss, L. A., Najm, J., Kutsche, K., et al. (2008) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2007.09.011 · Cited by 578 · see citing works
The Genetics of Schizophrenia: A Current, Genetic-epidemiologic Perspective
Kendler, K. S., & Diehl, S. R. (1993) · Schizophrenia Bulletin · doi:10.1093/schbul/19.2.261 · Cited by 568 · see citing works
Self-citationAdvancing Paternal Age and the Risk of Schizophrenia
Malaspina, D., Harlap, S., Fennig, S., Heiman, D., Nahon, D., Feldman, D., & Susser, E. S. (2001) · Archives of General Psychiatry · doi:10.1001/archpsyc.58.4.361 · Cited by 562 · see citing works
15q13.3 microdeletions increase risk of idiopathic generalized epilepsy.
Helbig, I., Mefford, H. C., Sharp, A. J., Guipponi, M., Fichera, M., Franke, A., Muhle, H., de Kovel, C., Baker, C., von Spiczak, S., et al. (2009) · Nature Genetics · doi:10.1038/ng.292 · Cited by 551 · see citing works
Uncovering cryptic genetic variation
Gibson, G., & Dworkin, I. (2004) · Nature Reviews Genetics · doi:10.1038/nrg1426 · Cited by 546 · see citing works
Wellcome Trust Case Control Consortium, Green, E. K., Grozeva, D., Jones, I., Jones, L., Kirov, G., Caesar, S., Gordon-Smith, K., Fraser, C., Forty, L., et al. (2010) · Molecular Psychiatry · doi:10.1038/mp.2009.49 · Cited by 526 · see citing works
Discovery of expression QTLs using large-scale transcriptional profiling in human lymphocytes
Göring, H. H. H., Curran, J. E., Johnson, M. P., Dyer, T. D., Charlesworth, J., Cole, S. A., Jowett, J. B. M., Abraham, L. J., Rainwater, D. L., Comuzzie, A. G., et al. (2007) · Nature Genetics · doi:10.1038/ng2119 · Cited by 503 · see citing works
Systems genetics of complex traits in Drosophila melanogaster
Ayroles, J. F., Carbone, M. A., Stone, E. A., Jordan, K. W., Lyman, R. F., Magwire, M. M., Rollmann, S. M., Duncan, L. H., Lawrence, F., Anholt, R. R. H., et al. (2009) · Nature Genetics · doi:10.1038/ng.332 · Cited by 500 · see citing works
Disruption of the neurexin 1 gene is associated with schizophrenia
Rujescu, D., Ingason, A., Cichon, S., Pietiläinen, O. P. H., Barnes, M. R., Toulopoulou, T., Picchioni, M., Vassos, E., Ettinger, U., Bramon, E., et al. (2009) · Human Molecular Genetics · doi:10.1093/hmg/ddn351 · Cited by 471 · see citing works
The Genetic Epidemiology of Schizophrenia in a Finnish Twin Cohort
Cannon, T. D., Kaprio, J. A., Lönnqvist, J. K., HUTTUNEN, M. O., & Koskenvuo, M. J. (1998) · Archives of General Psychiatry · doi:10.1001/archpsyc.55.1.67 · Cited by 456 · see citing works
Confirming Unexpressed Genotypes for Schizophrenia
Gottesman, I. I. (1989) · Archives of General Psychiatry · doi:10.1001/archpsyc.1989.01810100009002 · Cited by 454 · see citing works
Genomewide Association Studies: History, Rationale, and Prospects for Psychiatric Disorders
Psychiatric GWAS Consortium Coordinating Committee (2009) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2008.08091354 · Cited by 450 · see citing works
Recurrent microdeletions at 15q11.2 and 16p13.11 predispose to idiopathic generalized epilepsies
de Kovel, C. G. F., Trucks, H., Helbig, I., Mefford, H. C., Baker, C., Leu, C., Kluck, C., Muhle, H., von Spiczak, S., Ostertag, P., et al. (2010) · Brain · doi:10.1093/brain/awp262 · Cited by 445 · see citing works
A Genome-Wide Investigation of SNPs and CNVs in Schizophrenia
Need, A. C., Ge, D., Weale, M. E., Maia, J. M., Feng, S., Heinzen, E. L., Shianna, K. V., Yoon, W., Kasperavičiūtė, D., Gennarelli, M., et al. (2009) · PLoS Genetics · doi:10.1371/journal.pgen.1000373 · Cited by 443 · see citing works
Levinson, D. F., Duan, J., Oh, S., Wang, K., Sanders, A. R., Shi, J., Zhang, N., Mowry, B. J., Olincy, A., Amin, F., et al. (2011) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2010.10060876 · Cited by 434 · see citing works
Self-citationGenetic research in psychiatry
Ronald, R. (1976) · Behavior Therapy · doi:10.1016/s0005-7894(76)80300-0 · Cited by 431 · see citing works
Miller, D. T., Shen, Y., Weiss, L. A., Korn, J., Anselm, I., Bridgemohan, C., Cox, G. F., Dickinson, H., Gentile, J., Harris, D. J., et al. (2009) · Journal of Medical Genetics · doi:10.1136/jmg.2008.059907 · Cited by 427 · see citing works
Psychotic Illness in Patients Diagnosed with Velo-Cardio-Facial Syndrome and Their Relatives
Pulver, A. E., Nestadt, G., Goldberg, R. B., Shprintzen, R. J., Lamacz, M., Wolyniec, P. S., Morrow, B. E., Karayiorgou, M., Antonarakis, S. E., Housman, D. E., et al. (1994) · The Journal of Nervous and Mental Disease · doi:10.1097/00005053-199408000-00010 · Cited by 421 · see citing works
Genetic Risk Prediction — Are We There Yet?
Kraft, P., & Hunter, D. J. (2009) · New England Journal of Medicine · doi:10.1056/nejmp0810107 · Cited by 406 · see citing works
Late‐Onset psychosis in the velo‐cardio‐facial syndrome
Shprintzen, R. J., Goldberg, R. B., Golding‐Kushner, K. J., & Marion, R. W. (1992) · American Journal of Medical Genetics · doi:10.1002/ajmg.1320420131 · Cited by 402 · see citing works
Rapoport, J. L., Chavez, A. M., GREENSTEIN, D. K., Addington, A. M., & Gogtay, N. (2008) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/chi.0b013e31818b1c63 · Cited by 401 · see citing works
Support for the involvement of large copy number variants in the pathogenesis of schizophrenia.
Kirov, G., Grozeva, D., Norton, N., Ivanov, D., Mantripragada, K. K., Holmans, P., International Schizophrenia Consortium, the Wellcome Trust Case Control Consortium, Craddock, N., Owen, M. J., et al. (2009) · Human Molecular Genetics · doi:10.1093/hmg/ddp043 · Cited by 390 · see citing works
Loss of the Parkinson's disease-linked gene DJ-1 perturbs mitochondrial dynamics
Irrcher, I., Aleyasin, H., Seifert, E. L., Hewitt, S. J., Chhabra, S., Phillips, M., Lutz, A. K., Rousseaux, M. W. C., Bevilacqua, L., Jahani‐Asl, A., et al. (2010) · Human Molecular Genetics · doi:10.1093/hmg/ddq288 · Cited by 386 · see citing works
Continuity and Discontinuity of Affective Disorders and Schizophrenia
Maier, W. (1993) · Archives of General Psychiatry · doi:10.1001/archpsyc.1993.01820230041004 · Cited by 384 · see citing works
DEVELOPMENTAL STABILITY, DISEASE AND MEDICINE
Thornhill, R., & Møller, A. P. (1997) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1017/s0006323197005082 · Cited by 381 · see citing works
Pulver, A. E., Karayiorgou, M., Wolyniec, P. S., Lasseter, V. K., Kasch, L. M., Nestadt, G., Antonarakis, S. E., Housman, D. E., Kazazian, H. H., Meyers, D. A., et al. (1994) · American Journal of Medical Genetics · doi:10.1002/ajmg.1320540108 · Cited by 381 · see citing works
Comparative genome hybridization suggests a role for NRXN1 and APBA2 in schizophrenia
Kirov, G., Gumus, D., Chen, W., Norton, N., Georgieva, L., Sari, M., O'Donovan, M. C., Erdogan, F., Owen, M. J., Ropers, H.-H., et al. (2007) · Human Molecular Genetics · doi:10.1093/hmg/ddm323 · Cited by 377 · see citing works
Endophenotype: a conceptual analysis
Kendler, K. S., & Neale, M. C. (2010) · Molecular Psychiatry · doi:10.1038/mp.2010.8 · Cited by 373 · see citing works
Self-citationDrachman, D. A. (2005) · Neurology · doi:10.1212/01.wnl.0000166914.38327.bb · Cited by 367 · see citing works
Moskvina, V, Craddock, N., Holmans, P., Nikolov, I., Pahwa, J. S., Green, E., Wellcome Trust Case Control Consortium, Owen, M. J., & O'Donovan, M. C. (2009) · Molecular Psychiatry · doi:10.1038/mp.2008.133 · Cited by 363 · see citing works
Genomewide association for schizophrenia in the CATIE study: results of stage 1
Sullivan, P. F., Lin, D. Y., Tzeng, J., van den Oord, E. J. C. G., Perkins, D. O., Stroup, T. S., Wagner, M. J., Lee, S., Wright, F. A., Zou, F., et al. (2008) · Molecular Psychiatry · doi:10.1038/mp.2008.25 · Cited by 354 · see citing works
Sanders, A. R., Duan, J., Levinson, D. F., Shi, J., He, D., Hou, C., Burrell, G. J., Rice, J. P., Nertney, D. A., Olincy, A., et al. (2008) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2007.07101573 · Cited by 349 · see citing works
Self-citationZweier, C., de Jong, E. K., Zweier, M., Orrico, A., Ousager, L. B., Collins, A. L., Bijlsma, E. K., Oortveld, M. A. W., Ekici, A. B., Reis, A., et al. (2009) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2009.10.004 · Cited by 345 · see citing works
Hannes, F., Sharp, A. J., Mefford, H. C., de Ravel, T. J. L., Ruivenkamp, C. A. L., Breuning, M. H., Fryns, J., Devriendt, K., Buggenhout, G. V., Vogels, A., et al. (2008) · Journal of Medical Genetics · doi:10.1136/jmg.2007.055202 · Cited by 344 · see citing works
Characterization and localization of the FMR-1 gene product associated with fragile X syndrome
Verheij, C., Bakker, C. E., de Graaff, E., Keulemans, J., Willemsen, R., Verkerk, A. J. M. H., Galjaard, H., Reuser, A. J. J., Hoogeveen, A. T., & Oostra, B. A. (1993) · Nature · doi:10.1038/363722a0 · Cited by 343 · see citing works
A Controlled Family Study of Chronic Psychoses
Gershon, E. S. (1988) · Archives of General Psychiatry · doi:10.1001/archpsyc.1988.01800280038006 · Cited by 343 · see citing works
Mental Illness in the Biological and Adoptive Relatives of Schizophrenic Adoptees
Kety, S. S. (1994) · Archives of General Psychiatry · doi:10.1001/archpsyc.1994.03950060006001 · Cited by 334 · see citing works
Oligonucleotide Microarray Analysis of Genomic Imbalance in Children with Mental Retardation
Friedman, J. M., Baross, Á., Delaney, A. D., Ally, A., Arbour, L. T., Asano, J. K., Bailey, D. K., Barber, S., Birch, P. H., Brown-John, M., et al. (2006) · The American Journal of Human Genetics · doi:10.1086/507471 · Cited by 328 · see citing works
Genetic overlap between autism, schizophrenia and bipolar disorder
Carroll, L. S., & Owen, M. J. (2009) · Genome Medicine · doi:10.1186/gm102 · Cited by 326 · see citing works
Deletion 17q12 is a recurrent copy number variant that confers high risk of autism and schizophrenia
Moreno-De-Luca, D., Mulle, J. G., Kaminsky, E. B., Sanders, S. J., Myers, S. M., Adam, M. P., Pakula, A. T., Eisenhauer, N. J., Uhas, K., Weik, L., et al. (2010) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2010.10.004 · Cited by 324 · see citing works
Epidemiology of Schizophrenia: Review of Findings and Myths
Messias, E., Chen, C., & Eaton, W. W. (2007) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2007.04.007 · Cited by 310 · see citing works
Novel submicroscopic chromosomal abnormalities detected in autism spectrum disorder.
Christian, S. L., Brune, C. W., Sudi, J., Kumar, R. A., Liu, S., Karamohamed, S., Badner, J. A., Matsui, S., Conroy, J., McQuaid, D., et al. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.01.009 · Cited by 299 · see citing works
Deletions of NRXN1 (neurexin‐1) predispose to a wide spectrum of developmental disorders
Ching, M. S. L., Shen, Y., Tan, W., Jeste, S., Morrow, E. M., Chen, X., Mukaddes, N. M., Yoo, S.-Y., Hanson, E. M., Hundley, R. J., et al. (2010) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.31063 · Cited by 298 · see citing works
CNTNAP2 gene dosage variation is associated with schizophrenia and epilepsy
Friedman, J. I., Vrijenhoek, T., Markx, S., Janssen, I. M., van der Vliet, W. A., Faas, B. H. W., Knoers, N. V. A. M., Cahn, W., Kahn, R. S., Edelmann, L. J., et al. (2007) · Molecular Psychiatry · doi:10.1038/sj.mp.4002049 · Cited by 297 · see citing works
Ballif, B. C., Theisen, A. P., Coppinger, J., Gowans, G. C., Hersh, J. H., Madan‐Khetarpal, S., Schmidt, K. R., Tervo, R. C., Escobar, L., Friedrich, C. A., et al. (2008) · Molecular Cytogenetics · doi:10.1186/1755-8166-1-8 · Cited by 297 · see citing works
The Role of Genetics in the Etiology of Schizophrenia
Gejman, P. V., Sanders, A. R., & Duan, J. (2010) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2009.12.003 · Cited by 292 · see citing works
Self-citation3q29 Microdeletion Syndrome: Clinical and Molecular Characterization of a New Syndrome
Willatt, L. R., Cox, J. J., Barber, J. C. K., Cabanas, E. D., Collins, A., Donnai, D., FitzPatrick, D. R., Maher, E., Martin, H., Parnau, J., et al. (2005) · The American Journal of Human Genetics · doi:10.1086/431653 · Cited by 290 · see citing works
Parental psychiatric disorders associated with autism spectrum disorders in the offspring
Daniels, J. L., Forssen, U., Hultman, C. M., Cnattingius, S., Savitz, D. A., Feychting, M., & Sparen, P. (2008) · Pediatrics · doi:10.1542/peds.2007-2296 · Cited by 288 · see citing works
Ullmann, R., TURNER, G. M., Kirchhoff, M., Chen, W., Tonge, B. J., Rosenberg, C., Field, M., Vianna‐Morgante, A. M., Christie, L., Krepischi, A. C. V., et al. (2007) · Human Mutation · doi:10.1002/humu.20546 · Cited by 287 · see citing works
Genetic linkage and complex diseases, with special reference to psychiatric disorders
RISCH, N. J., & Rao, D. C. (1990) · Genetic Epidemiology · doi:10.1002/gepi.1370070103 · Cited by 280 · see citing works
Meta-analysis of 32 genome-wide linkage studies of schizophrenia
Ng, M., Levinson, D. F., Faraone, S. V., Suarez, B. K., DeLisi, L. E., Arinami, T., Riley, B. P., Paunio, T., Pulver, A. E., Irmansyah, et al. (2008) · Molecular Psychiatry · doi:10.1038/mp.2008.135 · Cited by 279 · see citing works
Self-citationNetwork Hubs Buffer Environmental Variation in Saccharomyces cerevisiae
Levy, S. F., & Siegal, M. L. (2008) · PLoS Biology · doi:10.1371/journal.pbio.0060264 · Cited by 279 · see citing works
Converging evidence for a pseudoautosomal cytokine receptor gene locus in schizophrenia
Lencz, T., Morgan, T., Athanasiou, M., Dain, B., Reed, C. R., Kane, J. M., Kucherlapati, R., & Malhotra, A. K. (2002) · Molecular Psychiatry · doi:10.1038/sj.mp.4001983 · Cited by 278 · see citing works
Stahlberg, O., Soderstrom, H., Rastam, M., & Gillberg, C. (2004) · Journal of Neural Transmission · doi:10.1007/s00702-004-0115-1 · Cited by 273 · see citing works
Are schizophrenic and bipolar disorders related? A review of family and molecular studies
Berrettini, W. H. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(00)00883-0 · Cited by 272 · see citing works
Recurrent CNVs Disrupt Three Candidate Genes in Schizophrenia Patients
Vrijenhoek, T., Buizer‐Voskamp, J. E., van der Stelt, I., Strengman, E., Sabatti, C., van Kessel, A. G., Brunner, H. G., Ophoff, R. A., & Veltman, J. A. (2008) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2008.09.011 · Cited by 265 · see citing works
Dibbens, L. M., Mullen, S. A., Helbig, K. L., Mefford, H. C., Bayly, M. A., Bellows, S. T., Leu, C., Trucks, H., Obermeier, T., Wittig, M., et al. (2009) · Human Molecular Genetics · doi:10.1093/hmg/ddp311 · Cited by 263 · see citing works
Ben-Shachar, S., Lanpher, B., German, J. R., Qasaymeh, M., Potocki, L., Nagamani, S. C. S., Franco, L. M., Malphrus, A., Bottenfield, G. W., Spence, J. E., et al. (2009) · Journal of Medical Genetics · doi:10.1136/jmg.2008.064378 · Cited by 261 · see citing works
Sebat, J., Levy, D. L., & McCarthy, S. E. (2009) · Trends in Genetics · doi:10.1016/j.tig.2009.10.004 · Cited by 260 · see citing works
The Population Genetic Theory of Hidden Variation and Genetic Robustness
Hermisson, J., & Wagner, G. P. (2004) · Genetics · doi:10.1534/genetics.104.029173 · Cited by 258 · see citing works
Copy number variations of chromosome 16p13.1 region associated with schizophrenia
Ingason, A., Rujescu, D., Cichon, S., Sigurdsson, E., Sigmundsson, T., Pietiläinen, O. P. H., Buizer-Voskamp, J. E., Strengman, E., Francks, C., Muglia, P., et al. (2011) · Molecular Psychiatry · doi:10.1038/mp.2009.101 · Cited by 258 · see citing works
Autistic Disorder and Schizophrenia: Diagnostic Overlaps
Konstantareas, M. M., & Hewitt, T. (2001) · Journal of Autism and Developmental Disorders · doi:10.1023/a:1005605528309 · Cited by 255 · see citing works
Ss, K., Rosenthal, D., Ph, W., D, F. S. M., & Jacobsen, B. (1975) · PubMed · Cited by 254 · see citing works
An Independent Analysis of the Copenhagen Sample of the Danish Adoption Study of Schizophrenia
Kendler, K. S. (1981) · Archives of General Psychiatry · doi:10.1001/archpsyc.1981.01780340034003 · Cited by 250 · see citing works
Self-citationGenome analysis : a laboratory manual
Green, E. D. (1997) · Cited by 248 · see citing works
Genetic variability in the SNCA gene influences α‐synuclein levels in the blood and brain
Fuchs, J., Tichopád, A., Golub, Y., Munz, M., Schweitzer, K. J., Wolf, B., Berg, D., Mueller, J. C., & Gasser, T. (2007) · The FASEB Journal · doi:10.1096/fj.07-9348com · Cited by 247 · see citing works
Severe Mental Disorders in Offspring With 2 Psychiatrically Ill Parents
Gottesman, I. I., Laursen, T. M., Bertelsen, A., & Mortensen, P. B. (2010) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2010.1 · Cited by 246 · see citing works
Are Schizophrenic and Bipolar Disorders Related? A Review of Family and Molecular Studies
Berrettini, W. H. (2019) · Routledge eBooks · doi:10.4324/9781315054308-5 · Cited by 245 · see citing works
Human MHC architecture and evolution: implications for disease association studies
Traherne, J. A. (2008) · International Journal of Immunogenetics · doi:10.1111/j.1744-313x.2008.00765.x · Cited by 232 · see citing works
Strong synaptic transmission impact by copy number variations in schizophrenia
Glessner, J., Reilly, M. P., Kim, C., Takahashi, N., Albano, A., Hou, C., Bradfield, J. P., Zhang, H., Abou‐Sleiman, P. M., Flory, J. H., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1000274107 · Cited by 231 · see citing works
Microdeletions of 3q29 confer high risk for schizophrenia
Mulle, J. G., Dodd, A. F., McGrath, J. A., Wolyniec, P. S., Mitchell, A. A., Shetty, A. C., Sobreira, N. L., Valle, D., Rudd, M. K., Satten, G., et al. (2010) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2010.07.013 · Cited by 223 · see citing works
The Finnish adoptive family study of schizophrenia. Implications for family research.
Tienari, P., Wynne, L. C., Moring, J., Lahti, I., Naarala, M., Sorri, A., Wahlberg, K.-E., Saarento, O., Seitamaa, M., & Kaleva, M. (1994) · PubMed · Cited by 220 · see citing works
Kendler, K. S. (1994) · Archives of General Psychiatry · doi:10.1001/archpsyc.1994.03950060020002 · Cited by 215 · see citing works
Self-citationAthanasiu, L., Mattingsdal, M., Kähler, A. K., Brown, A. A., Gústafsson, Ó., Agartz, I., Giegling, I., Muglia, P., Cichon, S., Rietschel, M., et al. (2010) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2010.02.002 · Cited by 210 · see citing works
Genome‐wide significance for dense SNP and resequencing data
Hoggart, C. J., Clark, T. G., Iorio, M. D., Whittaker, J. C., & Balding, D. J. (2008) · Genetic Epidemiology · doi:10.1002/gepi.20292 · Cited by 209 · see citing works
Gene-Environment Interaction and Covariation in Schizophrenia: The Role of Obstetric Complications
Mittal, V. A., Ellman, L. M., & Cannon, T. D. (2008) · Schizophrenia Bulletin · doi:10.1093/schbul/sbn080 · Cited by 203 · see citing works
Byrne, M., Agerbo, E., Bennedsen, B. E., Eaton, W. W., & Mortensen, P. B. (2007) · Schizophrenia Research · doi:10.1016/j.schres.2007.07.018 · Cited by 201 · see citing works
Smalley, S. L. (1997) · The American Journal of Human Genetics · doi:10.1086/515485 · Cited by 199 · see citing works
Caveolae compartmentalization of heme oxygenase‐1 in endothelial cells
Kim, H. P., Wang, X., Galbiati, F., Ryter, S. W., & Choi, A. M. K. (2004) · The FASEB Journal · doi:10.1096/fj.03-1391com · Cited by 198 · see citing works
Flora, A., Garcia, J. J., Christina Thaller, B., & Zoghbi, H. Y. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0707456104 · Cited by 193 · see citing works
Wender, P. H. (1974) · Archives of General Psychiatry · doi:10.1001/archpsyc.1974.01760070097016 · Cited by 189 · see citing works
Williams, H. J., Craddock, N. J., Russo, G., Hamshere, M. L., Moskvina, V., Dwyer, S., Smith, R., Green, E., Grozeva, D., Holmans, P., et al. (2010) · Human Molecular Genetics · doi:10.1093/hmg/ddq471 · Cited by 189 · see citing works
Rethinking psychosis: the disadvantages of a dichotomous classification now outweigh the advantages.
Craddock, N. J., & Owen, M. J. (2007) · Europe PMC (PubMed Central) · Cited by 184 · see citing works
The Finnish Adoptive Family Study of Schizophrenia
Tienari, P., Wynne, L. C., Moring, J., Lahti, I., Naarala, M., Sorri, A., Wahlberg, K.-E., Saarento, O., Seitamaa, M., Kaleva, M., et al. (1994) · The British Journal of Psychiatry · doi:10.1192/s0007125000292696 · Cited by 182 · see citing works
Gard, D. L. (1991) · Developmental Biology · doi:10.1016/0012-1606(91)90085-h · Cited by 174 · see citing works
A 15q13.3 microdeletion segregating with autism
Pagnamenta, A. T., Wing, K., Akha, E. S., Knight, S. J. L., Bölte, S., Schmötzer, G., Duketis, E., Poustka, F., Klauck, S. M., Poustka, A., et al. (2008) · European Journal of Human Genetics · doi:10.1038/ejhg.2008.228 · Cited by 174 · see citing works
Genome-Wide Association Study of Schizophrenia in a Japanese Population
Ikeda, M., Aleksić, B., Kinoshita, Y., Okochi, T., Kawashima, K., Kushima, I., Ito, Y., Nakamura, Y., Kishi, T., Okumura, T., et al. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.07.010 · Cited by 172 · see citing works
Brockschmidt, A., Todt, U., Ryu, S., Hoischen, A., Landwehr, C., Birnbaum, S., Frenck, W., Radlwimmer, B., Lichter, P., Engels, H., et al. (2007) · Human Molecular Genetics · doi:10.1093/hmg/ddm099 · Cited by 170 · see citing works
Epigenetic mechanisms in schizophrenia
Roth, T. L., Lubin, F. D., Sodhi, M., & Kleinman, J. E. (2009) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2009.06.009 · Cited by 168 · see citing works
Tienari, P. (1991) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1991.tb03178.x · Cited by 165 · see citing works
The genetics of neurodevelopmental disease
Mitchell, K. J. (2011) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2010.08.009 · Cited by 164 · see citing works
Meta-analytic Evidence for Familial Coaggregation of Schizophrenia and Bipolar Disorder
Snellenberg, J. X. V., & de Candia, T. R. (2009) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2009.64 · Cited by 159 · see citing works
Schizophrenics' offspring reared in adoptive homes
ROSENTHAL, D. M., Wender, P. H., Kety, S. S., et al. (1968) · Journal of Psychiatric Research · doi:10.1016/0022-3956(68)90028-9 · Cited by 152 · see citing works
Geographical genomics of human leukocyte gene expression variation in southern Morocco
Idaghdour, Y., Czika, W., Shianna, K. V., Lee, S. H., Visscher, P. M., Martin, H. C., Miclaus, K., Jadallah, S. J., Goldstein, D. B., Wolfinger, R. D., et al. (2010) · Nature Genetics · doi:10.1038/ng.495 · Cited by 151 · see citing works
Schizophrenia and epilepsy: Is there a shared susceptibility?
Cascella, N. G., Schretlen, D. J., & Sawa, A. (2009) · Neuroscience Research · doi:10.1016/j.neures.2009.01.002 · Cited by 146 · see citing works
Zur Vererbung und Neuentstehung der Dementia Praecox
Rüdin, E. (1916) · Springer eBooks · Cited by 145 · see citing works
Khoury, M. J., Bertram, L., Boffetta, P., Butterworth, A. S., Chanock, S. J., Dolan, S. M., Fortier, I., García‐Closas, M., GWINN, M. L., Higgins, J. P. T., et al. (2009) · American Journal of Epidemiology · doi:10.1093/aje/kwp119 · Cited by 145 · see citing works
Complex Disease and the New Clinical Sciences
Rees, J. (2002) · Science · doi:10.1126/science.296.5568.698 · Cited by 140 · see citing works
Confirmed rare copy number variants implicate novel genes in schizophrenia
Tam, G. W. C., van de Lagemaat, L. N., Redon, R., Strathdee, K. E., Croning, M. D. R., Malloy, M. P., Muir, W. J., Pickard, B. S., Deary, I. J., Blackwood, D. H. R., et al. (2010) · Biochemical Society Transactions · doi:10.1042/bst0380445 · Cited by 139 · see citing works
INTERSNP: genome-wide interaction analysis guided by a priori information
Herold, C., Steffens, M., Brockschmidt, F. F., Baur, M. P., & Becker, T. (2009) · Bioinformatics · doi:10.1093/bioinformatics/btp596 · Cited by 138 · see citing works
The Finnish Adoptive Family Study of Schizophrenia
Tienari, P., Lahti, I., Sorri, A., et al. (1989) · The British Journal of Psychiatry · doi:10.1192/s0007125000295949 · Cited by 134 · see citing works
Copy-number variants in neurodevelopmental disorders: promises and challenges
Merikangas, A. K., Corvin, A. P., & Gallagher, L. (2009) · Trends in Genetics · doi:10.1016/j.tig.2009.10.006 · Cited by 133 · see citing works
A patient with vertebral, cognitive and behavioural abnormalities and a de novo deletion of NRXN1α
Zahir, F., Baross, Á., Delaney, A. D., Eydoux, P., Fernandes, N., Pugh, T. J., Marra, M. A., & Friedman, J. M. (2007) · Journal of Medical Genetics · doi:10.1136/jmg.2007.054437 · Cited by 132 · see citing works
Suggestion of Roles for Both Common and Rare Risk Variants in Genome-wide Studies of Schizophrenia
Owen, M. J., Craddock, N. J., & O’Donovan, M. C. (2010) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2010.69 · Cited by 126 · see citing works
Different Genetic Background of Schizophrenia Spectrum Psychoses: A Twin Study
Franzek, E., & Beckmann, H. (1998) · American Journal of Psychiatry · doi:10.1176/ajp.155.1.76 · Cited by 120 · see citing works
β-catenin–mediated Wnt signaling regulates neurogenesis in the ventral telencephalon
Gulácsi, A., & Anderson, S. A. (2008) · Nature Neuroscience · doi:10.1038/nn.2226 · Cited by 119 · see citing works
Sporadic cases are the norm for complex disease
Yang, J., Visscher, P. M., & Wray, N. R. (2009) · European Journal of Human Genetics · doi:10.1038/ejhg.2009.177 · Cited by 112 · see citing works
Genome-wide association studies: a primer
Corvin, A. P., Craddock, N. J., & Sullivan, P. F. (2009) · Psychological Medicine · doi:10.1017/s0033291709991723 · Cited by 111 · see citing works
Hyde, T. M., & Weinberger, D. R. (1997) · Schizophrenia Bulletin · doi:10.1093/schbul/23.4.611 · Cited by 111 · see citing works
Copy Number Variation in Schizophrenia in the Japanese Population
Ikeda, M., Aleksić, B., Kirov, G., Kinoshita, Y., Yamanouchi, Y., Kitajima, T., Kawashima, K., Okochi, T., Kishi, T., Zaharieva, I. T., et al. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.08.034 · Cited by 110 · see citing works
What Is Familial About Familial Bipolar Disorder?
Schulze, T. G., Hedeker, D., Zandi, P. P., Rietschel, M., & McMahon, F. J. (2006) · Archives of General Psychiatry · doi:10.1001/archpsyc.63.12.1368 · Cited by 110 · see citing works
Narrowing the Boundaries of the Genetic Architecture of Schizophrenia
Wray, N. R., & Visscher, P. M. (2009) · Schizophrenia Bulletin · doi:10.1093/schbul/sbp137 · Cited by 105 · see citing works
Increased morbid risk for schizophrenia in families of in-patients with bipolar illness
Vallès, V., van Os, J., Guillamat, R., Gutiérrez, B., Campillo, M., Gento, P., & Fañanás, L. (2000) · Schizophrenia Research · doi:10.1016/s0920-9964(99)00117-6 · Cited by 101 · see citing works
Goes, F. S., Zandi, P. P., Miao, K., McMahon, F. J., Steele, J., Willour, V. L., MacKinnon, D. F., Mondimore, F. M., Schweizer, B. W., Nürnberger, J. I., et al. (2007) · American Journal of Psychiatry · doi:10.1176/ajp.2007.164.2.236 · Cited by 100 · see citing works
Whatever Became of the Schizophrenogenic Mother?
Neill, J. R. (1990) · American Journal of Psychotherapy · doi:10.1176/appi.psychotherapy.1990.44.4.499 · Cited by 99 · see citing works
Offspring of Monozygotic Twins Discordant for Schizophrenia
Kringlen, E. (1989) · Archives of General Psychiatry · doi:10.1001/archpsyc.1989.01810100015003 · Cited by 95 · see citing works
Of Flies and Man:Drosophilaas a Model for Human Complex Traits
Mackay, T. F. C., & Anholt, R. R. H. (2006) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev.genom.7.080505.115758 · Cited by 94 · see citing works
Paternal age as a risk factor for schizophrenia: How important is it?
Torrey, E. F., Buka, S. L., Cannon, T. D., Goldstein, J. M., Seidman, L. J., Liu, T., Hadley, T. R., Rosso, I. M., Bearden, C. E., & Yolken, R. H. (2009) · Schizophrenia Research · doi:10.1016/j.schres.2009.06.017 · Cited by 91 · see citing works
Kim, S., Jeon, B. S., Heo, C., Im, P. S., Ahn, T., Seo, J., Kim, H., Park, C. H., Choi, S. H., Cho, S., et al. (2004) · The FASEB Journal · doi:10.1096/fj.04-1917fje · Cited by 91 · see citing works
New Copy Number Variations in Schizophrenia
Magri, C., Sacchetti, E., Traversa, M., Valsecchi, P., Gardella, R., Bonvicini, C., Minelli, A., Gennarelli, M., & Barlati, S. (2010) · PLoS ONE · doi:10.1371/journal.pone.0013422 · Cited by 86 · see citing works
Sun, J., Jia, P., Fanous, A. H., Webb, B. T., van den Oord, E. J. C. G., Chen, X., Bukszár, J., Kendler, K. S., & Zhao, Z. (2009) · Bioinformatics · doi:10.1093/bioinformatics/btp428 · Cited by 80 · see citing works
Self-citationCorbo, R. M., Gambina, G., Ruggeri, M., & Scacchi, R. (2006) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000093315 · Cited by 79 · see citing works
The dichotomy of schizophrenia and affective disorders in extended pedigrees
Maier, W., Lichtermann, D., Franke, P. E., Heun, R., Falkai, P., & Rietschel, M. (2002) · Schizophrenia Research · doi:10.1016/s0920-9964(01)00288-2 · Cited by 79 · see citing works
Modifier genes in cystic fibrosis lung disease
Merlo, C. A., & Boyle, M. (2003) · Journal of Laboratory and Clinical Medicine · doi:10.1067/mlc.2003.29 · Cited by 76 · see citing works
TCF4, Schizophrenia, and Pitt-Hopkins Syndrome
Blake, D. J., Forrest, M. P., Chapman, R. M., Tinsley, C. L., O’Donovan, M. C., & Owen, M. J. (2010) · Schizophrenia Bulletin · doi:10.1093/schbul/sbq035 · Cited by 76 · see citing works
Kalscheuer, V. M., Feenstra, I., van Ravenswaaij‐Arts, C. M. A., Smeets, D., Menzel, C., Ullmann, R., Musante, L., & Ropers, H. (2008) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.32419 · Cited by 76 · see citing works
Schizophrenia and related disorders in children and adolescents
Remschmidt, H., & Theisen, F. (2006) · Springer eBooks · doi:10.1007/3-211-31222-6_7 · Cited by 73 · see citing works
Roles for gliotransmission in the nervous system
Zhang, Q., & Haydon, P. G. (2004) · Journal of Neural Transmission · doi:10.1007/s00702-004-0119-x · Cited by 68 · see citing works
Tuan, Y. (1984) · Geographical Review · doi:10.2307/214937 · Cited by 67 · see citing works
Effects of child rearing by schizophrenic mothers: A follow-up
Higgins, J. (1976) · Journal of Psychiatric Research · doi:10.1016/0022-3956(76)90004-2 · Cited by 65 · see citing works
Leukemia-Associated Antigens in the Mixed Leukocyte Culture Test
Bach, M. L., Bach, F. H., & Joo, P. (1969) · Science · doi:10.1126/science.166.3912.1520 · Cited by 65 · see citing works
Evaluation of the chromosome 2q37.3 geneCENTG2as an autism susceptibility gene
Wassink, T. H., Piven, J., Vieland, V. J., Jenkins, L., Frantz, R. S., Bartlett, C. W., Goedken, R. J., Childress, D., Spence, M. A., Smith, M., et al. (2005) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30180 · Cited by 65 · see citing works
Mouridsen, S. E., Rich, B., Isager, T., & Nedergaard, N. J. (2008) · Journal of Psychiatric Practice · doi:10.1097/01.pra.0000308490.47262.e0 · Cited by 58 · see citing works
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Identification of Distinct Psychosis Biotypes Using Brain-Based Biomarkers
Clementz, B. A., Sweeney, J. A., Hamm, J. P., Ivleva, E. I., Ethridge, L. E., Pearlson, G. D., Keshavan, M. S., & Tamminga, C. A. (2016) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2015.14091200 · Cited by 768 · see citing works
Modeling Autism by SHANK Gene Mutations in Mice
Jiang, Y.-H., & Ehlers, M. D. (2013) · Neuron · doi:10.1016/j.neuron.2013.03.016 · Cited by 488 · see citing works
Dichter, G. S., Damiano, C. A., & Allen, J. A. (2012) · Journal of Neurodevelopmental Disorders · doi:10.1186/1866-1955-4-19 · Cited by 299 · see citing works
The major histocompatibility complex and autism spectrum disorder
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Mechanistic insights into the genetics of affective psychosis from Prader-Willi syndrome
Aman, L. C. S., Manning, K. E., Whittington, J. E., & Holland, A. J. (2018) · The Lancet Psychiatry · doi:10.1016/s2215-0366(18)30009-9 · Cited by 42 · see citing works
- Authors
- Gejman, P. V., Sanders, A. R., & Kendler, K. S.
- Affiliations
- Endeavor Health (US)
- Virginia Commonwealth University (US)
- Venue
- Annual Review of Genomics and Human Genetics
- Publisher
- Annual Reviews
- Published
- 2011-09-22
- Volume
- 12
- Issue
- 1
- Pages
- 121-144
- ISSN
- 1527-8204 (ISSN-L)
- 1545-293X
- OpenAlex
- W2103560303
- Cited by
- 183
- References
- 218
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 5 · 2023: 4 · 2022: 9 · 2021: 5 · 2020: 9 · 2019: 11 · 2018: 6 · 2017: 10 · 2016: 13 · 2015: 21 · 2014: 20 · 2013: 24 · 2012: 36
- FWCI
- 3.70
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annual Review of Genomics and Human Genetics (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute of Mental Health (RC2MH090030)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genomic variations and chromosomal abnormalities
- Keywords
- schizophrenia, genetic architecture, polygenic inheritance, rare variants, common genetic variants, genome-wide association study, resequencing
- MeSH terms
- Adoption, Mental Disorders, Humans, Schizophrenia, Twin Studies as Topic, Genome-Wide Association Study, Genetic Pleiotropy
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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