Sex-Specific Gene Expression and Life Span Regulation

The mitochondrial basis of aging

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Extension of Life-Span by Loss of CHICO, a Drosophila Insulin Receptor Substrate Protein

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The sirtuin SIRT6 regulates lifespan in male mice

Kanfi, Y., Naiman, S., Amir, G., Peshti, V., Zinman, G., Nahum, L., Bar-Joseph, Z., & Cohen, H. Y. (2012) · Nature · doi:10.1038/nature10815 · Cited by 1,059 · see citing works

Mechanisms of Life Span Extension by Rapamycin in the Fruit Fly Drosophila Melanogaster

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Coordination of mitophagy and mitochondrial biogenesis during ageing in C. elegans

Palikaras, K., Lionaki, E., & Tavernarakis, N. (2015) · Nature · doi:10.1038/nature14300 · Cited by 770 · see citing works

Meta-analysis of age-related gene expression profiles identifies common signatures of aging

de Magalhães, J. P., Curado, J., & Church, G. M. (2009) · Bioinformatics · doi:10.1093/bioinformatics/btp073 · Cited by 737 · see citing works

Sex Differences in the Brain: The Not So Inconvenient Truth

McCarthy, M. M., Arnold, A. P., Ball, G. F., Blaustein, J. D., & De Vries, G. J. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.5372-11.2012 · Cited by 724 · see citing works

Gene expression changes in the course of normal brain aging are sexually dimorphic

Berchtold, N. C., Cribbs, D. H., Coleman, P. D., Rogers, J., Head, E., Kim, R., Beach, T., Miller, C., Troncoso, J., Trojanowski, J. Q., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0806883105 · Cited by 626 · see citing works

Rapamycin‐mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction

Miller, R. A., Harrison, D. E., Astle, C. M., Fernández, E., Flurkey, K., Han, M. L., Javors, M. A., Li, X., Nadon, N. L., Nelson, J. F., et al. (2013) · Aging Cell · doi:10.1111/acel.12194 · Cited by 624 · see citing works

General Theory of Mortality and Aging

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The TFEB orthologue HLH-30 regulates autophagy and modulates longevity in Caenorhabditis elegans

Lapierre, L. R., Filho, C. D. D. M., McQuary, P. R., Chu, C., Visvikis, O., Chang, J. T., Gelino, S., Ong, B., Davis, A. E. M., Irazoqui, J. E., et al. (2013) · Nature Communications · doi:10.1038/ncomms3267 · Cited by 533 · see citing works

Distinct Shifts in Microbiota Composition during Drosophila Aging Impair Intestinal Function and Drive Mortality

Clark, R. I., Salazar, A., Yamada, R., Fitz-Gibbon, S., Morselli, M., Alcaraz, J., Rana, A., Rera, M., Pellegrini, M., Ja, W. W., et al. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.08.004 · Cited by 510 · see citing works

Genetic variation in the murine lifespan response to dietary restriction: from life extension to life shortening

Liao, C., Rikke, B. A., Johnson, T. E., Diaz, V., & Nelson, J. F. (2010) · Aging Cell · doi:10.1111/j.1474-9726.2009.00533.x · Cited by 501 · see citing works

Sex, body mass index, and dietary fiber intake influence the human gut microbiome

Dominianni, C., Sinha, R., Goedert, J. J., Pei, Z., Yang, L., Hayes, R. B., & Ahn, J. (2015) · PLOS ONE · doi:10.1371/journal.pone.0124599 · Cited by 468 · see citing works

Acarbose, 17-α-estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in males

Harrison, D. E., Strong, R., Allison, D. B., Ames, B. N., Astle, C. M., Atamna, H., Fernandez, E., Flurkey, K., Javors, M. A., Nadon, N. L., et al. (2014) · Aging Cell · doi:10.1111/acel.12170 · Cited by 445 · see citing works

Longevity pathways converge on autophagy genes to regulate life span inCaenorhabditis elegans

Tóth, M. L., Sigmond, T., Borsos, É., Barna, J., Erdélyi, P., Takács‐Vellai, K., Orosz, L., Kovács, A., Csikós, G., Sass, M., et al. (2008) · Autophagy · doi:10.4161/auto.5618 · Cited by 429 · see citing works

Programmed cell death in aging

Tower, J. (2015) · Ageing Research Reviews · doi:10.1016/j.arr.2015.04.002 · Cited by 426 · see citing works

The biology of life span: A quantitative approach

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Increased Internal and External Bacterial Load during Drosophila Aging without Life-Span Trade-Off

Ren, C., Webster, P. C., Finkel, S. E., & Tower, J. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.06.006 · Cited by 363 · see citing works

Dietary restriction and lifespan: lessons from invertebrate models

Kapahi, P., Kaeberlein, M., & Hansen, M. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2016.12.005 · Cited by 340 · see citing works

Unusual maintenance of X chromosome inactivation predisposes female lymphocytes for increased expression from the inactive X

Wang, J., Syrett, C. M., Kramer, M. C., Basu, A., Atchison, M. L., & Anguera, M. C. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1520113113 · Cited by 322 · see citing works

Evidence for compensatory upregulation of expressed X-linked genes in mammals, Caenorhabditis elegans and Drosophila melanogaster

Deng, X., Hiatt, J. B., Nguyen, D. K., Ercan, S., Sturgill, D. M., Hillier, L. W., Schlesinger, F. J., Davis, C., Reinke, V., Gingeras, T., et al. (2011) · Nature Genetics · doi:10.1038/ng.948 · Cited by 286 · see citing works

Somatotropic Signaling: Trade-Offs Between Growth, Reproductive Development, and Longevity

Bartke, A., Sun, L. Y., & Longo, V. D. (2013) · Physiological Reviews · doi:10.1152/physrev.00006.2012 · Cited by 286 · see citing works

Sex difference in pathology of the ageing gut mediates the greater response of female lifespan to dietary restriction

Regan, J. C., Khericha, M., Dobson, A. J., Bolukbasi, E., Rattanavirotkul, N., & Partridge, L. (2016) · eLife · doi:10.7554/elife.10956 · Cited by 269 · see citing works

Sex Differences in the Effect of Dietary Restriction on Life Span and Mortality Rates in Female and Male Drosophila Melanogaster

Magwere, T., Chapman, T., & Partridge, L. (2004) · The Journals of Gerontology Series A · doi:10.1093/gerona/59.1.b3 · Cited by 264 · see citing works

Endocrine remodelling of the adult intestine sustains reproduction in Drosophila

Reiff, T., Jacobson, J., Cognigni, P., Antonello, Z. A., Ballesta‐Illán, E., Tan, K. J., Yew, J. Y., Domínguez, M., & Miguel‐Aliaga, I. (2015) · eLife · doi:10.7554/elife.06930 · Cited by 233 · see citing works

Dietary restriction in rats and mice: A meta-analysis and review of the evidence for genotype-dependent effects on lifespan

Swindell, W. R. (2011) · Ageing Research Reviews · doi:10.1016/j.arr.2011.12.006 · Cited by 230 · see citing works

Evolution of sex differences in lifespan and aging: causes and constraints

Maklakov, A. A., & Lummaa, V. (2013) · BioEssays · doi:10.1002/bies.201300021 · Cited by 227 · see citing works

Comparative and meta‐analytic insights into life extension via dietary restriction

Nakagawa, S., Lagisz, M., Hector, K. L., & Spencer, H. G. (2012) · Aging Cell · doi:10.1111/j.1474-9726.2012.00798.x · Cited by 219 · see citing works

The Mitochondrial Lon Protease Is Required for Age-Specific and Sex-Specific Adaptation to Oxidative Stress

Pomatto, L. C. D., Carney, C., Shen, B., Wong, S., Halaszynski, K., Salomon, M. P., Davies, K. J. A., & Tower, J. (2016) · Current Biology · doi:10.1016/j.cub.2016.10.044 · Cited by 211 · see citing works

Mitochondria, Maternal Inheritance, and Male Aging

Camus, M. F., Clancy, D. J., & Dowling, D. K. (2012) · Current Biology · doi:10.1016/j.cub.2012.07.018 · Cited by 209 · see citing works

Intestinal Autophagy Improves Healthspan and Longevity in C. elegans during Dietary Restriction

Gelino, S., Chang, J. T., Kumsta, C., She, X., Davis, A. E. M., Nguyen, C. N., Panowski, S. H., & Hansen, M. (2016) · PLoS Genetics · doi:10.1371/journal.pgen.1006135 · Cited by 203 · see citing works

Synchronized age-related gene expression changes across multiple tissues in human and the link to complex diseases

Yang, J., Huang, T., Petralia, F., Long, Q., Zhang, B., Argmann, C., Zhao, Y. B., Mobbs, C. V., Schadt, E. E., Zhu, J., et al. (2015) · Scientific Reports · doi:10.1038/srep15145 · Cited by 198 · see citing works

Heat-Induced Longevity Extension in Drosophila. I. Heat Treatment, Mortality, and Thermotolerance

Khazaeli, A. A., Tatar, M., Pletcher, S. D., & Curtsinger, J. W. (1997) · The Journals of Gerontology Series A · doi:10.1093/gerona/52a.1.b48 · Cited by 181 · see citing works

Redox regulation of protein kinases

Truong, T. H., & Carroll, K. S. (2013) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.3109/10409238.2013.790873 · Cited by 172 · see citing works

Escape Artists of the X Chromosome

Balaton, B. P., & Brown, C. J. (2016) · Trends in Genetics · doi:10.1016/j.tig.2016.03.007 · Cited by 168 · see citing works

Heat shock proteins and Drosophila aging

Tower, J. (2010) · Experimental Gerontology · doi:10.1016/j.exger.2010.09.002 · Cited by 167 · see citing works

Control of intestinal bacterial proliferation in regulation of lifespan in Caenorhabditis elegans

Portal‐Celhay, C., Bradley, E., & Blaser, M. J. (2012) · BMC Microbiology · doi:10.1186/1471-2180-12-49 · Cited by 166 · see citing works

Males Shorten the Life Span of <i>C. elegans</i> Hermaphrodites via Secreted Compounds

Maures, T. J., Booth, L. N., Benayoun, B. A., Izrayelit, Y., Schroeder, F. C., & Brunet, A. (2014) · Science · doi:10.1126/science.1244160 · Cited by 165 · see citing works

Sexually dimorphic gene expression in the heart of mice and men

Isensee, J., Witt, H., Pregla, R., Hetzer, R., Regitz‐Zagrosek, V., & Ruíz, P. (2007) · Journal of Molecular Medicine · doi:10.1007/s00109-007-0240-z · Cited by 149 · see citing works

Sex Differences in Longevity and in Responses to Anti-Aging Interventions: A Mini-Review

Austad, S. N., & Bartke, A. (2015) · Gerontology · doi:10.1159/000381472 · Cited by 148 · see citing works

Drosophila Life Span and Physiology Are Modulated by Sexual Perception and Reward

Gendron, C. M., Kuo, T.-H., Harvanek, Z. M., Chung, B. Y., Yew, J. Y., Dierick, H. A., & Pletcher, S. D. (2013) · Science · doi:10.1126/science.1243339 · Cited by 144 · see citing works

Gene expression changes in response to aging compared to heat stress, oxidative stress and ionizing radiation in Drosophila melanogaster

Landis, G. N., Shen, J., & Tower, J. (2012) · Aging · doi:10.18632/aging.100499 · Cited by 142 · see citing works

Mating Induces Shrinking and Death in Caenorhabditis Mothers

Shi, C., & Murphy, C. T. (2013) · Science · doi:10.1126/science.1242958 · Cited by 135 · see citing works

Alterations in xenobiotic metabolism in the long‐lived Little mice

Amador‐Noguez, D., Dean, A., Huang, W., Setchell, K., Moore, D., & Darlington, G. (2007) · Aging Cell · doi:10.1111/j.1474-9726.2007.00300.x · Cited by 134 · see citing works

The Ubiquitin Ligase CHIP Integrates Proteostasis and Aging by Regulation of Insulin Receptor Turnover

Tawo, R., Pokrzywa, W., Kevei, É., Akyuz, M. E., Balaji, V., Adrian, S., Höhfeld, J., & Hoppe, T. (2017) · Cell · doi:10.1016/j.cell.2017.04.003 · Cited by 134 · see citing works

Sex-specific regulation of aging and apoptosis

Tower, J. (2006) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2006.05.001 · Cited by 125 · see citing works

Sex determination and maintenance: the role of DMRT1 and FOXL2

Ye, L., Chen, H., & Huang, S. (2016) · Asian Journal of Andrology · doi:10.4103/1008-682x.194420 · Cited by 122 · see citing works

Stroke sensitivity in the aged: sex chromosome complement vs. gonadal hormones

McCullough, L. D., Mirza, M. A., Xu, Y., Bentivegna, K., Steffens, E. B., Ritzel, R. M., & Liu, F. (2016) · Aging · doi:10.18632/aging.100997 · Cited by 114 · see citing works

Gender-specific proteomic alterations in glycolytic and mitochondrial pathways in aging monkey hearts

YAN, L., GE, H., LI, H., LIEBER, S., NATIVIDAD, F., RESUELLO, R., KIM, S., AKEJU, S., SUN, A., & LOO, K. (2004) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2004.06.012 · Cited by 111 · see citing works

Organ-specific mediation of lifespan extension: More than a gut feeling?

Rera, M., Azizi, M. J., & Walker, D. W. (2012) · Ageing Research Reviews · doi:10.1016/j.arr.2012.05.003 · Cited by 107 · see citing works

The Paradox of Mitochondrial Dysfunction and Extended Longevity

Munkácsy, E., & Rea, S. L. (2014) · Experimental Gerontology · doi:10.1016/j.exger.2014.03.016 · Cited by 101 · see citing works

Gene expression atlas of the mouse central nervous system: impact and interactions of age, energy intake and gender

Xu, X. Z. S., Zhan, M., Duan, W., Prabhu, V. V., Brenneman, R., Wood, W. H., Firman, J., Li, H., Zhang, P., Ibe, C. N., et al. (2007) · Genome biology · doi:10.1186/gb-2007-8-11-r234 · Cited by 100 · see citing works

Disruption of Protein Kinase A in Mice Enhances Healthy Aging

Enns, L. C., Morton, J., Treuting, P. R., Emond, M. J., Wolf, N. S., McKnight, G. S., Rabinovitch, P. S., & Ladiges, W. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005963 · Cited by 96 · see citing works

Longevity effect of IGF ‐1 R +/− mutation depends on genetic background‐specific receptor activation

Xu, J., Gontier, G., Chaker, Z., Lacube, P., Dupont, J., & Holzenberger, M. (2013) · Aging Cell · doi:10.1111/acel.12145 · Cited by 93 · see citing works

Age-Related Phasic Patterns of Mitochondrial Maintenance in Adult<i>Caenorhabditis elegans</i>Neurons

Morsci, N. S., Hall, D. H., Driscoll, M., & Sheng, Z.-H. (2016) · The Journal of Neuroscience · doi:10.1523/jneurosci.2799-15.2016 · Cited by 92 · see citing works

Hypermutation of the Inactive X Chromosome Is a Frequent Event in Cancer

Jäger, N., Schlesner, M., Jones, D. T. W., Raffel, S., Mallm, J.-P., Junge, K. M., Weichenhan, D., Bauer, T., Ishaque, N., Kool, M., et al. (2013) · Cell · doi:10.1016/j.cell.2013.09.042 · Cited by 90 · see citing works

The Biology of Life Span: A Quantitative Approach

Kannisto, V. X. E. I. X. F. (1992) · Population Studies · doi:10.1080/0032472031000146326 · Cited by 85 · see citing works

Stress and stem cells

Tower, J. (2012) · Wiley Interdisciplinary Reviews Developmental Biology · doi:10.1002/wdev.56 · Cited by 82 · see citing works

Age and sex dependent changes in liver gene expression during the life cycle of the rat

Kwekel, J. C., Desai, V. G., Moland, C. L., Branham, W. S., & Fuscoe, J. C. (2010) · BMC Genomics · doi:10.1186/1471-2164-11-675 · Cited by 81 · see citing works

Sexual Dimorphism in the Expression of Mitochondria-Related Genes in Rat Heart at Different Ages

Vijay, V., Han, T., Moland, C. L., Kwekel, J. C., Fuscoe, J. C., & Desai, V. G. (2015) · PLoS ONE · doi:10.1371/journal.pone.0117047 · Cited by 80 · see citing works

Dietary restriction of rodents decreases aging rate without affecting initial mortality rate – a meta‐analysis

Simons, M. J. P., Koch, W., & Verhulst, S. (2013) · Aging Cell · doi:10.1111/acel.12061 · Cited by 71 · see citing works

Mitophagy: In sickness and in health

Palikaras, K., Lionaki, E., & Tavernarakis, N. (2015) · Molecular & Cellular Oncology · doi:10.1080/23723556.2015.1056332 · Cited by 69 · see citing works

Genetic analysis of dTSPO , an outer mitochondrial membrane protein, reveals its functions in apoptosis, longevity, and Aβ42‐induced neurodegeneration

Lin, R., Angelin, A., Settimo, F. D., Martini, C., Taliani, S., Zhu, S., & Wallace, D. C. (2014) · Aging Cell · doi:10.1111/acel.12200 · Cited by 68 · see citing works

Mitochondrial maintenance failure in aging and role of sexual dimorphism

Tower, J. (2014) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2014.10.008 · Cited by 67 · see citing works

Influence of non-steroidal anti-inflammatory drugs on <i>Drosophila melanogaster</i> longevity

Danilov, A., Shaposhnikov, M., Shevchenko, O., Zemskaya, N., Zhavoronkov, A., & Moskalev, A. (2015) · Oncotarget · doi:10.18632/oncotarget.5118 · Cited by 64 · see citing works

Mechanisms of X Chromosome Dosage Compensation

Ercan, S. (2014) · Journal of Genomics · doi:10.7150/jgen.10404 · Cited by 64 · see citing works

Sexual Dimorphism and Aging Differentially Regulate Adaptive Homeostasis

Pomatto, L. C. D., Tower, J., & Davies, K. J. A. (2017) · The Journals of Gerontology Series A · doi:10.1093/gerona/glx083 · Cited by 56 · see citing works

A Mild Impairment of Mitochondrial Electron Transport Has Sex-Specific Effects on Lifespan and Aging in Mice

Hughes, B. G., & Hekimi, S. (2011) · PLoS ONE · doi:10.1371/journal.pone.0026116 · Cited by 48 · see citing works

High-glucose diets have sex-specific effects on aging in C. elegans: toxic to hermaphrodites but beneficial to males

Liggett, M. R., Hoy, M., Mastroianni, M., & Mondoux, M. A. (2015) · Aging · doi:10.18632/aging.100759 · Cited by 45 · see citing works

Meta-analysis of gene expression in the mouse liver reveals biomarkers associated with inflammation increased early during aging

Lee, J. S., Ward, W. O., Ren, H., Vallanat, B., Darlington, G., Han, E., Laguna, J. C., DeFord, J. H., Papaconstantinou, J., Selman, C., et al. (2012) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2012.05.006 · Cited by 43 · see citing works

Drosophila melanogaster Hsp22: a mitochondrial small heat shock protein influencing the aging process

Morrow, G., & Tanguay, R. M. (2015) · Frontiers in Genetics · doi:10.3389/fgene.2015.00103 · Cited by 42 · see citing works

Parallel Universes for Models of X Chromosome Dosage Compensation in Drosophila: A Review

Birchler, J. A. (2016) · Cytogenetic and Genome Research · doi:10.1159/000445924 · Cited by 39 · see citing works

Strehler-Mildvan correlation is a degenerate manifold of Gompertz fit

Tarkhov, A. E., Men’shikov, L. I., & Fedichev, P. O. (2017) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2017.01.017 · Cited by 39 · see citing works

Molecular antagonism between X-chromosome and autosome signals determines nematode sexPreprint

Farboud, B., Nix, P., Jow, M. M., Gladden, J. M., & Meyer, B. J. (2013) · Genes & Development · doi:10.1101/gad.217026.113 · Cited by 35 · see citing works

Different Mechanisms of Longevity in Long-Lived Mouse and Caenorhabditis elegans Mutants Revealed by Statistical Analysis of Mortality Rates

Hughes, B. G., & Hekimi, S. (2016) · Genetics · doi:10.1534/genetics.116.192369 · Cited by 34 · see citing works

Moderate lifelong overexpression of tuberous sclerosis complex 1 (TSC1) improves health and survival in mice

Zhang, H., Diaz, V., Walsh, M. E., & Zhang, Y. (2017) · Scientific Reports · doi:10.1038/s41598-017-00970-7 · Cited by 33 · see citing works

Multiple Metazoan Life-span Interventions Exhibit a Sex-specific Strehler–Mildvan Inverse Relationship Between Initial Mortality Rate and Age-dependent Mortality Rate Acceleration

Shen, J., Landis, G. N., & Tower, J. (2016) · The Journals of Gerontology Series A · doi:10.1093/gerona/glw005 · Cited by 31 · see citing works

Mitochondrial functions in stem cells

Margineantu, D. H., & Hockenbery, D. M. (2016) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2016.05.004 · Cited by 29 · see citing works

Validated analysis of mortality rates demonstrates distinct genetic mechanisms that influence lifespan

Yen, K., Steinsaltz, D., & Mobbs, C. V. (2008) · Experimental Gerontology · doi:10.1016/j.exger.2008.09.006 · Cited by 27 · see citing works

Sex-Related Differences in GI Disorders

Prusator, D. K., & Chang, L. (2017) · Handbook of experimental pharmacology · doi:10.1007/164_2016_121 · Cited by 26 · see citing works

Complex-I-ty in aging

Hur, J. H., Stork, D. A., & Walker, D. W. (2014) · Journal of Bioenergetics and Biomembranes · doi:10.1007/s10863-014-9553-0 · Cited by 25 · see citing works

Mifepristone/RU486 acts in Drosophila melanogaster females to counteract the life span-shortening and pro-inflammatory effects of male Sex Peptide

Tower, J., Landis, G. N., Shen, J., Choi, R., Fan, Y., Lee, D., & Song, J. (2017) · Biogerontology · doi:10.1007/s10522-017-9703-y · Cited by 25 · see citing works

Sex‐specific Effects of the DAF‐12 Steroid Receptor on Aging in Caenorhabditis elegans

McCULLOCH, D., & Gems, D. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1404.018 · Cited by 24 · see citing works

Global, regional, and national burden of Alzheimer's disease and other dementias, 1990–2019

Li, X., Feng, X., Sun, X., Hou, N., Han, F., & Liu, Y. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.937486 · Cited by 736 · see citing works

Sex and gender differences and biases in artificial intelligence for biomedicine and healthcare

Cirillo, D., Catuara-Solarz, S., Morey, C., Guney, E., Subirats, L., Mellino, S., Gigante, A., Valencia, A., Rementeria, M. J., Chadha, A. S., et al. (2020) · npj Digital Medicine · doi:10.1038/s41746-020-0288-5 · Cited by 553 · see citing works

Sex differences and the neurobiology of affective disorders

Rubinow, D. R., & Schmidt, P. J. (2018) · Neuropsychopharmacology · doi:10.1038/s41386-018-0148-z · Cited by 274 · see citing works

Gut microbiota remodeling reverses aging-associated inflammation and dysregulation of systemic bile acid homeostasis in mice sex-specifically

Ma, J., Hong, Y., Zheng, N., Xie, G., Lyu, Y., Gu, Y., Xi, C., Chen, L., Wu, G., Li, Y., et al. (2020) · Gut Microbes · doi:10.1080/19490976.2020.1763770 · Cited by 171 · see citing works

Sex differences in the response to oxidative and proteolytic stress

Tower, J., Pomatto, L. C. D., & Davies, K. J. A. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101488 · Cited by 140 · see citing works

Superior Intrinsic Mitochondrial Respiration in Women Than in Men

Cardinale, D. A., Larsen, F. J., Schiffer, T. A., Morales‐Álamo, D., Ekblom, B. T., Calbet, J. A. L., Holmberg, H., & Boushel, R. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.01133 · Cited by 136 · see citing works

Sex‐specific aging in animals: Perspective and future directions

Bronikowski, A., Meisel, R., Biga, P. R., Walters, J., Mank, J., Larschan, E. N., Wilkinson, G., Valenzuela, N., Conard, A., de Magalhães, J. D., et al. (2022) · Aging Cell · doi:10.1111/acel.13542 · Cited by 78 · see citing works

Sex differences in the response to dietary restriction in rodents

Kane, A. E., Sinclair, D. A., Mitchell, J. R., & Mitchell, S. J. (2018) · Current Opinion in Physiology · doi:10.1016/j.cophys.2018.03.008 · Cited by 85 · see citing works

The Y chromosome may contribute to sex-specific ageing in Drosophila

Brown, E. J., Nguyen, A. H., & Bachtrog, D. (2020) · Nature Ecology & Evolution · doi:10.1038/s41559-020-1179-5 · Cited by 78 · see citing works

Sex differences in antioxidant defence and the regulation of redox homeostasis in physiology and pathology

Tiberi, J., Cesarini, V., Stefanelli, R., Canterini, S., Fiorenza, M. T., & Rosa, P. L. (2023) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2023.111802 · Cited by 73 · see citing works

MECHANISMS IN ENDOCRINOLOGY: Lessons from growth hormone receptor gene-disrupted mice: are there benefits of endocrine defects?

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Female-biased upregulation of insulin pathway activity mediates the sex difference in Drosophila body size plasticity

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The parasitic worm product ES-62 promotes health- and life-span in a high calorie diet-accelerated mouse model of ageing

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Deficiency in insulin‐like growth factors signalling in mouse Leydig cells increase conversion of testosterone to estradiol because of feminization

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The global, regional, and national burden and attributable risk factors of Alzheimer's disease and other dementias, 1990-2021: A systematic analysis for the Global Burden of Disease Study

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Aging-Related Variation of Cuticular Hydrocarbons in Wild Type and Variant Drosophila melanogaster

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Exploring the Diverse Functional and Regulatory Consequences of Alternative Splicing in Development and Disease

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The interplay between microglial states and major risk factors in Alzheimer’s disease through the eyes of single-cell RNA-sequencing: beyond black and white

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Sex differences in transcriptomic profiles in aged kidney cells of renin lineage

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Neuron-specific overexpression of core clock genes improves stress-resistance and extends lifespan of Drosophila melanogaster

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Determinants of gene expression in the human liver: Impact of aging and sex on xenobiotic metabolism

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Influence of Sex on Neuroretinal Degeneration: Six-Month Follow-Up in Rats With Chronic Glaucoma

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“Just the Facts Ma’am”: Moral and Ethical Considerations for Artificial Intelligence in Medicine and its Potential to Impact Patient Autonomy and Hope

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Disordered Expression of shaggy, the Drosophila Gene Encoding a Serine-Threonine Protein Kinase GSK3, Affects the Lifespan in a Transcript-, Stage-, and Tissue-Specific Manner

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Mitonuclear interactions alter sex-specific longevity in a species without sex chromosomes

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Sexual Dimorphism in Cardiometabolic Diseases: From Development to Senescence and Therapeutic Approaches

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The burden of common neurological disorders in Asia: insights from the Global Burden of Disease Study (1990–2021)

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The role of mitochondria in sex- and age-specific gene expression in a species without sex chromosomes

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Geroprotective potential of genetic and pharmacological interventions to endogenous hydrogen sulfide synthesis in Drosophila melanogaster

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Correlation Between Telomere Attrition of Zona Fasciculata and Adrenal Weight Reduction in Older Men

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Poly(A) RNA sequencing reveals age-related differences in the prefrontal cortex of dogs

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Drosophila Flies in the Face of Aging

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The conserved alternative splicing factor caper regulates neuromuscular phenotypes during development and aging

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The Antioxidant and Geroprotective Properties of an Extract of Mountain Ash (Sorbus aucuparia L.) Fruits

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Experimental Life History Evolution Results in Sex-specific Evolution of Gene Expression in Seed Beetles

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Modulated Expression of the Protein Kinase GSK3 in Motor and Dopaminergic Neurons Increases Female Lifespan in Drosophila melanogaster

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Pleiotropic Locus 15q24.1 Reveals a Gender-Specific Association with Neovascular but Not Atrophic Age-Related Macular Degeneration (AMD)

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Negative genetic correlation between longevity and its hormetic extension by dietary restriction in Drosophila melanogaster

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The global burden and attributable risk factor analysis of age-related macular degeneration in 204 countries and territories, 1990–2021

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Sexual dimorphism in periodontal inflammation: A cross‐sectional study

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Of Mice, Whales, Jellyfish and Men: In Pursuit of Increased Longevity

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Ageing desexualizes the Drosophila brain transcriptome

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Dementia incidence among a cohort of lebanese older adults: first incidence estimates from the Middle East and North Africa region

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Simultaneous activation of the hydrogen sulfide biosynthesis genes (CBS and CSE) induces sex-specific geroprotective effects in Drosophila melanogaster

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Amyloid-β peptides slightly affect lifespan or antimicrobial peptide gene expression in Drosophila melanogaster

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Genetic polymorphisms of metabolic enzyme genes associated with leukocyte mitochondrial DNA copy number in PAHs exposure workers

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Alterations in brain glycogen levels influence life-history traits and reduce the lifespan in female Drosophila melanogaster

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Epigenetic clock and DNA methylation studies of roe deer in the wildPreprint

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Age and homeostasis

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Sex differences in postprandial blood glucose and body surface temperature are contingent on flight in the fruit bat, Cynopterus sphinx

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voyAGEr: free web interface for the analysis of age-related gene expression alterations in human tissuesPreprint

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MEG3 polymorphisms associated with peripheral blood leukocyte mitochondrial DNA copy number in PAHs-exposure workers

Li, X., Duan, X., & Wang, W. (2023) · Chemosphere · doi:10.1016/j.chemosphere.2023.140335 · Cited by 2 · see citing works

voyAGEr, a free web interface for the analysis of age-related gene expression alterations in human tissues

Schneider, A. L., Martins-Silva, R., Kaizeler, A., Saraiva-Agostinho, N., & Barbosa‐Morais, N. L. (2024) · eLife · doi:10.7554/elife.88623.3 · Cited by 2 · see citing works

Mitonuclear effects on sex ratio persist across generations in interpopulation hybrids

Edmands, S., Denova, J. R., Flanagan, B. A., Jah, M., & Applebaum, S. L. (2024) · Journal of Evolutionary Biology · doi:10.1093/jeb/voae123 · Cited by 2 · see citing works

Parasitic worm-derived ES-62 promotes health- and life-span in high calorie diet-fed micePreprint

Crowe, J., Lumb, F. E., Doonan, J., Broussard, M., Tarafdar, A., Pineda, M. A., Landabaso, C., Mulvey, L., Hoskisson, P. A., Babayan, S. A., et al. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/622753 · Cited by 2 · see citing works

Sex-specific differences in mitochondrial function and its role in health disparities

Mishra, S., & Singh, K. K. (2023) · Principles of Gender-Specific Medicine · doi:10.1016/b978-0-323-88534-8.00014-6 · Cited by 1 · see citing works

Sex-specific regulation of aging and apoptosis

Tower, J. (2006) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2006.05.001 · Cited by 125 · see citing works

Sex Differences in the Effect of Dietary Restriction on Life Span and Mortality Rates in Female and Male

Melanogaster, D., Magwere, T., Chapman, T., & Partridge, L. (2016)

Mitochondrial maintenance failure in aging and role of sexual dimorphism

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Sex difference in pathology of the ageing gut mediates the greater response of female lifespan to dietary restriction

Regan, J. C., Khericha, M., Dobson, A. J., Bolukbasi, E., Rattanavirotkul, N., & Partridge, L. (2016) · eLife · doi:10.7554/elife.10956 · Cited by 269 · see citing works

Why do sexes differ in lifespan extension? Sex-specific pathways of aging and underlying mechanisms for dimorphic responses

Garratt, M. (2019) · Nutrition and Healthy Aging · doi:10.3233/nha-190067 · Cited by 28 · see citing works