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Cited by 564

The DOI matches its Crossref record; 74 of the 74 references it cites were found in a registry or an index.

Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma

Open access
Alcohol Genome-wide Association (AlcGen) Consortium, Chambers, John C, Diabetes Genetics Replication and Meta-analyses (DIAGRAM+) Study, Genetic Investigation of Anthropometric Traits (GIANT) Consortium, Global Lipids Genetics Consortium, Genetics of Liver Disease (GOLD) Consortium, International Consortium for Blood Pressure (ICBP-GWAS), Meta-analyses of Glucose and Insulin-Related Traits Consortium (MAGIC), Zhang, Weihua, Sehmi, Joban, Li, Xinzhong, Wass, Mark N, Van der Harst, Pim, Holm, Hilma, Sanna, Serena, Kavousi, Maryam, Baumeister, Sebastian E, Coin, Lachlan J, Deng, Guohong, Gieger, Christian, Heard-Costa, Nancy L, Hottenga, Jouke-Jan, Kühnel, Brigitte, Kumar, Vinod, Lagou, Vasiliki, Liang, Liming, Luan, Jian'an, Vidal, Pedro Marques, Leach, Irene Mateo, O'Reilly, Paul F, Peden, John F, Rahmioglu, Nilufer, Soininen, Pasi, Speliotes, Elizabeth K, Yuan, Xin, Thorleifsson, Gudmar, Alizadeh, Behrooz Z, Atwood, Larry D, Borecki, Ingrid B, Brown, Morris J, Charoen, Pimphen, Cucca, Francesco, Das, Debashish, de Geus, Eco J C, Dixon, Anna L, Döring, Angela, Ehret, Georg, Eyjolfsson, Gudmundur I, Farrall, Martin, Forouhi, Nita G, Friedrich, Nele, Goessling, Wolfram, Gudbjartsson, Daniel F, Harris, Tamara B, Hartikainen, Anna-Liisa, Heath, Simon, Hirschfield, Gideon M, Hofman, Albert, Homuth, Georg, Hyppönen, Elina, Janssen, Harry L A, Johnson, Toby, Kangas, Antti J, Kema, Ido P, Kühn, Jens P, Lai, Sandra, Lathrop, Mark, Lerch, Markus M, Li, Yun, Liang, T Jake, Lin, Jing-Ping, Loos, Ruth J F, Martin, Nicholas G, Moffatt, Miriam F, Montgomery, Grant W, Munroe, Patricia B, Musunuru, Kiran, Nakamura, Yusuke, O'Donnell, Christopher J, Olafsson, Isleifur, Penninx, Brenda W, Pouta, Anneli, Prins, Bram P, Prokopenko, Inga, Puls, Ralf, Ruokonen, Aimo, Savolainen, Markku J, Schlessinger, David, Schouten, Jeoffrey N L, Seedorf, Udo, Sen-Chowdhry, Srijita, Siminovitch, Katherine A, Smit, Johannes H, Spector, Timothy D, Tan, Wenting, Teslovich, Tanya M, Tukiainen, Taru, Uitterlinden, Andre G, Van der Klauw, Melanie M, Vasan, Ramachandran S, Wallace, Chris, Wallaschofski, Henri, Wichmann, H-Erich, Willemsen, Gonneke, Würtz, Peter, Xu, Chun, Yerges-Armstrong, Laura M, Abecasis, Goncalo R, Ahmadi, Kourosh R, Boomsma, Dorret I, Caulfield, Mark, Cookson, William O, van Duijn, Cornelia M, Froguel, Philippe, Matsuda, Koichi, McCarthy, Mark I, Meisinger, Christa, Mooser, Vincent, Pietiläinen, Kirsi H, Schumann, Gunter, Snieder, Harold, Sternberg, Michael J E, Stolk, Ronald P, Thomas, Howard C, Thorsteinsdottir, Unnur, Uda, Manuela, Waeber, Gérard, Wareham, Nicholas J, Waterworth, Dawn M, Watkins, Hugh, Whitfield, John B, Witteman, Jacqueline C M, Wolffenbuttel, Bruce H R, Fox, Caroline S, Ala-Korpela, Mika, Stefansson, Kari, Vollenweider, Peter, Völzke, Henry, Schadt, Eric E, Scott, James, Järvelin, Marjo-Riitta, Elliott, Paul, Kooner, Jaspal S·2011·Nature Genetics
DOI 10.1038/ng.970
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Abstract

Concentrations of liver enzymes in plasma are widely used as indicators of liver disease. We carried out a genome-wide association study in 61,089 individuals, identifying 42 loci associated with concentrations of liver enzymes in plasma, of which 32 are new associations (P = 10−8 to P = 10−190). We used functional genomic approaches including metabonomic profiling and gene expression analyses to identify probable candidate genes at these regions. We identified 69 candidate genes, including genes involved in biliary transport (ATP8B1 and ABCB11), glucose, carbohydrate and lipid metabolism (FADS1, FADS2, GCKR, JMJD1C, HNF1A, MLXIPL, PNPLA3, PPP1R3B, SLC2A2 and TRIB1), glycoprotein biosynthesis and cell surface glycobiology (ABO, ASGR1, FUT2, GPLD1 and ST3GAL4), inflammation and immunity (CD276, CDH6, GCKR, HNF1A, HPR, ITGA1, RORA and STAT4) and glutathione metabolism (GSTT1, GSTT2 and GGT), as well as several genes of uncertain or unknown function (including ABHD12, EFHD1, EFNA1, EPHA2, MICAL3 and ZNF827). Our results provide new insight into genetic mechanisms and pathways influencing markers of liver function.

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Authors
Alcohol Genome-wide Association (AlcGen) Consortium, Chambers, J. C., Study, D. G. R. A. M.-A. (., Genetic Investigation of Anthropometric Traits (GIANT) Consortium, Global Lipids Genetics Consortium, Genetics of Liver Disease (GOLD) Consortium, International Consortium for Blood Pressure (ICBP-GWAS), Meta-analyses of Glucose and Insulin-Related Traits Consortium (MAGIC), Zhang, W., Sehmi, J., Li, X., Wass, M. N., Van der Harst, P., Holm, H., Sanna, S., Kavousi, M., Baumeister, S. E., Coin, L. J., Deng, G., Gieger, C., Heard-Costa, N. L., Hottenga, J.-J., Kühnel, B., Kumar, V., Lagou, V., Liang, L., Luan, J., Vidal, P. M., Leach, I. M., O'Reilly, P. F., Peden, J. F., Rahmioglu, N., Soininen, P., Speliotes, E. K., Yuan, X., Thorleifsson, G., Alizadeh, B. Z., Atwood, L. D., Borecki, I. B., Brown, M. J., Charoen, P., Cucca, F., Das, D., de Geus, E. J. C., Dixon, A. L., Döring, A., Ehret, G., Eyjolfsson, G. I., Farrall, M., Forouhi, N. G., Friedrich, N., Goessling, W., Gudbjartsson, D. F., Harris, T. B., Hartikainen, A.-L., Heath, S., Hirschfield, G. M., Hofman, A., Homuth, G., Hyppönen, E., Janssen, H. L. A., Johnson, T., Kangas, A. J., Kema, I. P., Kühn, J. P., Lai, S., Lathrop, M., Lerch, M. M., Li, Y., Liang, T. J., Lin, J.-P., Loos, R. J. F., Martin, N. G., Moffatt, M. F., Montgomery, G. W., Munroe, P. B., Musunuru, K., Nakamura, Y., O'Donnell, C. J., Olafsson, I., Penninx, B. W., Pouta, A., Prins, B. P., Prokopenko, I., Puls, R., Ruokonen, A., Savolainen, M. J., Schlessinger, D., Schouten, J. N. L., Seedorf, U., Sen-Chowdhry, S., Siminovitch, K. A., Smit, J. H., Spector, T. D., Tan, W., Teslovich, T. M., Tukiainen, T., Uitterlinden, A. G., Van der Klauw, M. M., Vasan, R. S., Wallace, C., Wallaschofski, H., Wichmann, H.-E., Willemsen, G., Würtz, P., Xu, C., Yerges-Armstrong, L. M., Abecasis, G. R., Ahmadi, K. R., Boomsma, D. I., Caulfield, M., Cookson, W. O., van Duijn, C. M., Froguel, P., Matsuda, K., McCarthy, M. I., Meisinger, C., Mooser, V., Pietiläinen, K. H., Schumann, G., Snieder, H., Sternberg, M. J. E., Stolk, R. P., Thomas, H. C., Thorsteinsdottir, U., Uda, M., Waeber, G., Wareham, N. J., Waterworth, D. M., Watkins, H., Whitfield, J. B., Witteman, J. C. M., Wolffenbuttel, B. H. R., Fox, C. S., Ala-Korpela, M., Stefansson, K., Vollenweider, P., Völzke, H., Schadt, E. E., Scott, J., Järvelin, M.-R., Elliott, P., & Kooner, J. S.
Venue
Nature Genetics
Publisher
Springer Science and Business Media LLC
Published
2011-10-16
Volume
43
Issue
11
Pages
1131-1138
ISSN
  • 1061-4036 (ISSN-L)
  • 1546-1718
DOI
10.1038/ng.970
OpenAlex
W2143286837
Cited by
564
References
74
FWCI
22.66
Type
journal article
Language
en
Open access
bronze

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