The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
Short telomeres on human chromosome 17p
Abstract
Human chromosomes terminate in a series of T2AG3 repeats, which, together with associated proteins, are essential for chromosome stability. In somatic cells, these sequences are known to be gradually lost through successive cells divisions; however, information about changes on specific chromosomes is not available. Individual telomeres could mediate important biological effects as was shown in yeast, in which loss of a single telomere results in cell-cycle arrest and chromosome loss. We now demonstrate by quantitative fluorescence in situ hybridization (Q-FISH; ref. 7) that the number of T2AG3 repeats on specific chromosome arms is very similar in different tissues from the same donor and varies only to some extent between donors. In all sixteen individuals studied, telomeres on chromosome 17p were shorter than the median telomere length--a finding confirmed by analysis of terminal restriction fragments from sorted chromosomes. These observations provide evidence of chromosome-specific factors regulating the number of T2AG3 repeats in individual telomeres and raise the possibility that the relatively short telomeres on chromosome 17p contribute to the frequent loss of 17p alleles in human cancers.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“The loss of telomeric sequences was readily detected using the Q-FISH technique with a telomere-speci®c probe (Figure 5A and B) (Martens et al., 1998).”
From A highly selective telomerase inhibitor limiting human cancer cell proliferation (2001) · cites this paper as Martens et al., 1998
Citations
Cites
Telomeres shorten during ageing of human fibroblasts
Harley, C. B., Futcher, A. B., & Greider, C. W. (1990) · Nature · doi:10.1038/345458a0 · Cited by 5,750
Moyzis, R. K., Buckingham, J. M., Cram, L. S., Dani, M. A. C., Deaven, L. L., Jones, M. D., Meyne, J., Ratliff, R. L., & Wu, J. R. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.18.6622 · Cited by 2,326
Telomere Shortening and Tumor Formation by Mouse Cells Lacking Telomerase RNA
Blasco, M. A., Lee, H.-W., Hande, M. P., Samper, E., Lansdorp, P. M., DePinho, R. A., & Greider, C. W. (1997) · Cell · doi:10.1016/s0092-8674(01)80006-4 · Cited by 2,108
Self-citationChromosome 17 Deletions and p53 Gene Mutations in Colorectal Carcinomas
Baker, S. J., Fearon, E. R., Nigro, J. M., Hamilton, S. R., Preisinger, A. C., Jessup, J. M., vanTuinen, P., Ledbetter, D. H., Barker, D. F., Nakamura, Y., et al. (1989) · Science · doi:10.1126/science.2649981 · Cited by 2,097
Telomere reduction in human colorectal carcinoma and with ageing
Hastie, N. D., Dempster, M., Dunlop, M. G., Thompson, A. M., Green, D. K., & Allshire, R. C. (1990) · Nature · doi:10.1038/346866a0 · Cited by 1,650
Evidence for a mitotic clock in human hematopoietic stem cells: loss of telomeric DNA with age.
Vaziri, H., Dragowska, W., Allsopp, R. C., Thomas, T. E., Harley, C. B., & Lansdorp, P. M. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.21.9857 · Cited by 1,132
Self-citationGreider, C. W. (1996) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.65.070196.002005 · Cited by 1,032
Heterogeneity in telomere length of human chromosomes
Lansdorp, P. M. (1996) · Human Molecular Genetics · doi:10.1093/hmg/5.5.685 · Cited by 886
Self-citationLoss of a yeast telomere: Arrest, recovery, and chromosome loss
Sandell, L. J. (1993) · Cell · doi:10.1016/0092-8674(93)90493-a · Cited by 792
Genetic determination of telomere size in humans: a twin study of three age groups.
Slagboom, P. E., Droog, S., & Boomsma, D. I. (1994) · PubMed Central · Cited by 734
Flagged first, then by citations
Research works printed but not linked: 3
- Slagboom P.E., 1994, Am. J. Hum. Genet., 55, 876
- Cornelis R.S., 1994, Cancer Res., 54, 4200
- Monard, S.P. & Young, B.D. Chromosome analysis by flow cytometry. in Human Chromosomes: Principles and Techniques, Vol. 2 (eds Verma, R.S. & Babu, A.) 172–180 (McGraw-Hill, New York, 1995).
Cited by
Sorted by citations
A DNA damage checkpoint response in telomere-initiated senescence
Fagagna, F. D. D., Reaper, P. M., Clay-Farrace, L., Fiegler, H., Carr, P., von Zglinicki, T., Saretzki, G., Carter, N. P., & Jackson, S. P. (2003) · Nature · doi:10.1038/nature02118 · Cited by 2,917
Hemann, M. T., Strong, M. A., Hao, L.-Y., & Greider, C. W. (2001) · Cell · doi:10.1016/s0092-8674(01)00504-9 · Cited by 1,219
Aubert, G., & Lansdorp, P. M. (2008) · Physiological Reviews · doi:10.1152/physrev.00026.2007 · Cited by 1,188
Self-citationLiving on a break: cellular senescence as a DNA-damage response
d'Adda di Fagagna, F. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2440 · Cited by 1,170
Leukocyte Telomere Length and Cardiovascular Disease in the Cardiovascular Health Study
Fitzpatrick, A. L., Kronmal, R. A., Gardner, J. P., Psaty, B. M., Jenny, N. S., Tracy, R. P., Walston, J., Kimura, M., & Aviv, A. (2006) · American Journal of Epidemiology · doi:10.1093/aje/kwj346 · Cited by 773
Rufer, N., Brümmendorf, T. H., Kolvraa, S., Bischoff, C., Christensen, K., Wadsworth, L., Schulzer, M., & Lansdorp, P. M. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.190.2.157 · Cited by 709
Self-citationDissociation among in vitro telomerase activity, telomere maintenance, and cellular immortalization
Counter, C. M., Hahn, W. C., Wei, W., Caddle, S. D., Beijersbergen, R. L., Lansdorp, P. M., Sedivy, J. M., & Weinberg, R. A. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.25.14723 · Cited by 649
Self-citationTelomere length dynamics in human lymphocyte subpopulations measured by flow cytometry
Rufer, N., Dragowska, W. H., Thornbury, G., Roosnek, E. E., & Lansdorp, P. M. (1998) · Nature Biotechnology · doi:10.1038/nbt0898-743 · Cited by 551
Self-citationAccumulation of single-strand breaks is the major cause of telomere shortening in human fibroblasts
von Zglinicki, T., Pilger, R., & Sitte, N. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(99)00207-5 · Cited by 546
Telomere Length in the Newborn
Okuda, K., Bardeguez, A., Gardner, J. P., Rodriguez, P., Ganesh, V., Kimura, M., Skurnick, J., Awad, G., & Aviv, A. (2002) · Pediatric Research · doi:10.1203/00006450-200209000-00012 · Cited by 507
Telomere Position Effect in Human Cells
Baur, J. A., Zou, Y. S., Shay, J. W., & Wright, W. E. (2001) · Science · doi:10.1126/science.1062329 · Cited by 502
Disease states associated with telomerase deficiency appear earlier in mice with short telomeres
Herrera, E., Samper, E., Martín‐Caballero, J., Flores, J. M., Lee, H., & Blasco, M. A. (1999) · The EMBO Journal · doi:10.1093/emboj/18.11.2950 · Cited by 471
Flow cytometry and FISH to measure the average length of telomeres (flow FISH)
Baerlocher, G. M., Vulto, I., de Jong, G., & Lansdorp, P. M. (2006) · Nature Protocols · doi:10.1038/nprot.2006.263 · Cited by 449
Self-citationRole of Oxidative Stress in Telomere Length Regulation and Replicative Senescence
von Zglinicki, T. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06639.x · Cited by 452
A highly selective telomerase inhibitor limiting human cancer cell proliferation
Damm, K., Hemmann, U., Garin‐Chesa, P., Hauel, N., Kauffmann, I., Priepke, H., Niestroj, C., Daiber, C., Enenkel, B., Guilliard, B., et al. (2001) · The EMBO Journal · doi:10.1093/emboj/20.24.6958 · Cited by 422
Self-citationGisselsson, D., Jonson, T., Petersén, Å., Strömbeck, B., Cin, P. D., Höglund, M., Mitelman, F., Mertens, F., & Mandahl, N. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.211357798 · Cited by 416
The telomerase reverse transcriptase regulates chromatin state and DNA damage responses
Masutomi, K., Possemato, R., Wong, J. M. Y., Currier, J. L., Tóthová, Z., Manola, J. B., Ganesan, S., Lansdorp, P. M., Collins, K., & Hahn, W. C. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0503095102 · Cited by 383
Self-citationT cells and aging january 2002 update
Pawelec, G. (2002) · Frontiers in bioscience · doi:10.2741/a831 · Cited by 372
Telomere Length Inversely Correlates With Pulse Pressure and Is Highly Familial
Jeanclos, E. M., Schork, N. J., Kyvik, K. O., Kimura, M., Skurnick, J., & Aviv, A. (2000) · Hypertension · doi:10.1161/01.hyp.36.2.195 · Cited by 355
Chromosomal instability in ulcerative colitis is related to telomere shortening
O'Sullivan, J. N., Bronner, M. P., Brentnall, T. A., Finley, J. C., Shen, W.-T., Emerson, S., Emond, M. J., Gollahon, K. A., Moskovitz, A. H., Crispin, D. A., et al. (2002) · Nature Genetics · doi:10.1038/ng989 · Cited by 346
Aubert, G., Hills, M., & Lansdorp, P. M. (2012) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2011.04.003 · Cited by 342
Self-citationTelomere lengths are characteristic in each human individual
Takubo, K., Izumiyama‐Shimomura, N., Honma, N., Sawabe, M., Arai, T., Kato, M., Oshimura, M., & Nakamura, K. (2002) · Experimental Gerontology · doi:10.1016/s0531-5565(01)00218-2 · Cited by 330
Telomere Length Dynamics and Chromosomal Instability in Cells Derived from Telomerase Null Mice
Hande, M. P., Samper, E., Lansdorp, P., & Blasco, M. A. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.144.4.589 · Cited by 313
Self-citationHunt, S. C., Chen, W., Gardner, J. P., Kimura, M., Srinivasan, S. R., Eckfeldt, J. H., Berenson, G. S., & Aviv, A. (2008) · Aging Cell · doi:10.1111/j.1474-9726.2008.00397.x · Cited by 309
Leukocyte Telomere Dynamics: Longitudinal Findings Among Young Adults in the Bogalusa Heart Study
Aviv, A., Chen, W., Gardner, J. P., Kimura, M., Brimacombe, M. B., Cao, X., Srinivasan, S. R., & Berenson, G. S. (2008) · American Journal of Epidemiology · doi:10.1093/aje/kwn338 · Cited by 293
Telomere biology in healthy aging and disease
Oeseburg, H., de Boer, R. A., van Gilst, W. H., & van der Harst, P. (2009) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-009-0728-1 · Cited by 279
Offspring's Leukocyte Telomere Length, Paternal Age, and Telomere Elongation in Sperm
Kimura, M., Cherkas, L. F., Kato, B. S., Demissie, S., Hjelmborg, J., Brimacombe, M. B., Cupples, L. A., Hunkin, J., Gardner, J. P., Lu, X., et al. (2005) · PLoS Genetics · doi:10.1371/journal.pgen.0040037 · Cited by 280
Accumulation of Short Telomeres in Human Fibroblasts Prior to Replicative Senescence
Martens, U. M., Chavez, E. A., Poon, S. S. S., Schmoor, C., & Lansdorp, P. M. (2000) · Experimental Cell Research · doi:10.1006/excr.2000.4823 · Cited by 263
Self-citationAubert, G., Baerlocher, G. M., Vulto, I. M., Poon, S. S. S., & Lansdorp, P. M. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1002696 · Cited by 262
Self-citationTelomere shortening and survival in free-living corvids
Salomons, H. M., Mulder, G. A., van de Zande, L., Haussmann, M. F., Linskens, M. H. K., & Verhulst, S. (2009) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2009.0517 · Cited by 268
No Association Between Telomere Length and Survival Among the Elderly and Oldest Old
Bischoff, C., Petersen, H. C., Graakjær, J., Andersen‐Ranberg, K., Vaupel, J. W., Bohr, V. A., Kølvraa, S., & Christensen, K. (2006) · Epidemiology · doi:10.1097/01.ede.0000199436.55248.10 · Cited by 243
Fang, B., Zborowski, M., & Moore, L. R. (1999) · Cytometry · doi:10.1002/(sici)1097-0320(19990801)36:4 · Cited by 33
Self-citationEstimating telomere length from whole genome sequence data
Ding, Z., Mangino, M., Aviv, A., Spector, T. D., & Durbin, R. M. (2014) · Nucleic Acids Research · doi:10.1093/nar/gku181 · Cited by 224
Verfaillie, C. M., Pera, M. F., & Lansdorp, P. M. (2002) · Hematology · doi:10.1182/asheducation-2002.1.369 · Cited by 223
Self-citationTelomere analysis by fluorescence in situ hybridization and flow cytometry
Hultdin, M., Gronlund, E., Norrback, K.-F., Eriksson-Lindstrom, E., Roos, G., & Just, T. (1998) · Nucleic Acids Research · doi:10.1093/nar/26.16.3651 · Cited by 223
Selectively Advantageous Mutations and Hitchhikers in Neoplasms
Maley, C. C., Galipeau, P. C., Li, X., Sanchez, C. A., Paulson, T. G., & Reid, B. J. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-3249 · Cited by 220
Telomere Length Assessment in Human Archival Tissues
Meeker, A. K., Gage, W. R., Hicks, J. L., Simon, I., Coffman, J. R., Platz, E. A., March, G. E., & De Marzo, A. M. (2002) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)62553-9 · Cited by 209
Loss of heterozygosity in human skin
Happle, R. (1999) · Journal of the American Academy of Dermatology · doi:10.1016/s0190-9622(99)70042-3 · Cited by 204
Brümmendorf, T. H., Holyoake, T. L., Rufer, N., Barnett, M. J., Schulzer, M., Eaves, C. J., Eaves, A. C., & Lansdorp, P. M. (2000) · Blood · doi:10.1182/blood.v95.6.1883 · Cited by 198
Self-citationFISH Glossary: An Overview of the Fluorescence in Situ Hybridization Technique
Volpi, E. V., & Bridger, J. M. (2008) · BioTechniques · doi:10.2144/000112811 · Cited by 203
Prognostic Value of Leukocyte Telomere Length in Patients With Stable Coronary Artery Disease
Farzaneh‐Far, R., Cawthon, R., Na, B., Browner, W. S., Schiller, N. B., & Whooley, M. A. (2008) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.108.167049 · Cited by 194
Telomere length in Hutchinson-Gilford Progeria Syndrome
Decker, M. L., Chavez, E. A., Vulto, I. M., & Lansdorp, P. M. (2009) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2009.03.001 · Cited by 191
Self-citationRufer, N., Migliaccio, M., Antonchuk, J., Humphries, R. K., Roosnek, E. E., & Lansdorp, P. M. (2001) · Blood · doi:10.1182/blood.v98.3.597 · Cited by 180
Self-citationLin, T. T., Letsolo, B. T., Jones, R. E., Rowson, J., Pratt, G., Hewamana, S., Fegan, C., Pepper, C., & Baird, D. M. (2010) · Blood · doi:10.1182/blood-2010-02-272104 · Cited by 178
Telomere maintenance mechanisms and cellular immortalization
Colgin, L. M., & Reddel, R. R. (1999) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(99)80014-8 · Cited by 177
Pancolonic chromosomal instability precedes dysplasia and cancer in ulcerative colitis.
Rabinovitch, P. S., Dziadon, S. M., Brentnall, T. A., Emond, M. J., Crispin, D. A., Haggitt, R. C., & Bronner, M. P. (1999) · PubMed · Cited by 174
Huang, A. H., Snyder, B. R., Cheng, P., & Chan, A. W. S. (2008) · Stem Cells · doi:10.1634/stemcells.2008-0285 · Cited by 165
Telomeres, telomerase and cancer: an up-date
Dhaene, K., Marck, E. V., & Parwaresch, R. M. (2000) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/s004280000189 · Cited by 166
Roumelioti, F., Sotiriou, S. K., Katsini, V., Chiourea, M., Halazonetis, T. D., & Gagos, S. (2016) · EMBO Reports · doi:10.15252/embr.201643169 · Cited by 170
Telomere instability in the male germline
Baird, D. M., Britt‐Compton, B., Rowson, J., Amso, N. N., Gregory, L., & Kipling, D. (2005) · Human Molecular Genetics · doi:10.1093/hmg/ddi424 · Cited by 157
Cyclosporine A induces senescence in renal tubular epithelial cells
Jennings, P., Koppelstaetter, C., Aydin, S., Abberger, T., Wolf, A. M., Mayer, G. J., & Pfaller, W. (2007) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00005.2007 · Cited by 155
Selective cytotoxicity and telomere damage in leukemia cells using the telomerase inhibitor BIBR1532
Eldaly, H., Kull, M., Zimmermann, S., Pantić, M., Waller, C. F., & Martens, U. M. (2004) · Blood · doi:10.1182/blood-2003-12-4322 · Cited by 159
Self-citationEvolution of Genetic Techniques: Past, Present, and Beyond
Durmaz, A., Karaca, E., Demkow, U. A., Törüner, G., Schoumans, J., & Çoğulu, Ö. (2015) · BioMed Research International · doi:10.1155/2015/461524 · Cited by 177
Telomeres, interstitial telomeric repeat sequences, and chromosomal aberrations
Bolzán, A. D., & de Bianchi, M. S. A. (2006) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2005.12.003 · Cited by 151
Mayer, S., Brüderlein, S., Perner, S., Waibel, I., Holdenried, A., Ciloglu, N., Hasel, C., Mattfeldt, T., Nielsen, K. V., & Möller, P. (2006) · Cytogenetic and Genome Research · doi:10.1159/000089870 · Cited by 156
Telomere shortening in mTR−/− embryos is associated with failure to close the neural tube
Herrera, E., Samper, E., & Blasco, M. A. (1999) · The EMBO Journal · doi:10.1093/emboj/18.5.1172 · Cited by 147
Impaired germinal center reaction in mice with short telomeres
Herrera, E., Martínez‐A, C., & Blasco, M. A. (2000) · The EMBO Journal · doi:10.1093/emboj/19.3.472 · Cited by 144
Tchirkov, A. (2003) · Human Molecular Genetics · doi:10.1093/hmg/ddg023 · Cited by 143
T cells and aging (update February 1999)
Pawelec, G. (1999) · Frontiers in bioscience · doi:10.2741/pawelec · Cited by 140
Telomere dysfunction, genome instability and cancer
Annie, L. M. C. (2007) · Frontiers in bioscience · doi:10.2741/2825 · Cited by 137
Niida, H., Shinkai, Y., Hande, M. P., Matsumoto, T., Takehara, S., Tachibana, M., Oshimura, M., Lansdorp, P. M., & Furuichi, Y. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.11.4115-4127.2000 · Cited by 138
Self-citationIntratumor genetic heterogeneity in advanced human colorectal adenocarcinoma
Baisse, B., Bouzourène, H., Saraga, E. P., Bosman, F. T., & Benhattar, J. (2001) · International Journal of Cancer · doi:10.1002/ijc.1343 · Cited by 135
Telomere length regulation in mice is linked to a novel chromosome locus
Zhu, L., Hathcock, K. S., Hande, M. P., Lansdorp, P. M., Seldin, M. F., & Hodes, R. J. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.15.8648 · Cited by 138
Self-citationNucleic Acid–Based Nanodevices in Biological Imaging
Chakraborty, K., Veetil, A. T., Jaffrey, S. R., & Krishnan, Y. (2016) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-060815-014244 · Cited by 131
Telomere biology in mammalian germ cells and during development
Bekaert, S., Derradji, H., & Baatout, S. (2004) · Developmental Biology · doi:10.1016/j.ydbio.2004.06.023 · Cited by 131
Differences in telomere length between homologous chromosomes in humans
Londono-Vallejo, J. A. (2001) · Nucleic Acids Research · doi:10.1093/nar/29.15.3164 · Cited by 130
Molecular pathology and age estimation
Meißner, C., & Ritz‐Timme, S. (2010) · Forensic Science International · doi:10.1016/j.forsciint.2010.07.010 · Cited by 135
Graakjær, J., Bischoff, C., Korsholm, L., Holstebroe, S., Vach, W., Bohr, V. A., Christensen, K., & Kølvraa, S. (2003) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(03)00081-2 · Cited by 130
Jennings, B. J., Ozanne, S. E., & Hales, C. N. (2000) · Molecular Genetics and Metabolism · doi:10.1006/mgme.2000.3077 · Cited by 129
Figueiredo, L. M., Freitas-Junior, L. H., Bottius, E., Olivo‐Marín, J., & Scherf, A. (2002) · The EMBO Journal · doi:10.1093/emboj/21.4.815 · Cited by 128
Britt‐Compton, B., Rowson, J., Locke, M., Mackenzie, I. M., Kipling, D., & Baird, D. M. (2006) · Human Molecular Genetics · doi:10.1093/hmg/ddi486 · Cited by 131
Fluorescence In Situ Hybridization ( FISH )
Bayani, J., & Squire, J. A. (2004) · Current Protocols in Cell Biology · doi:10.1002/0471143030.cb2204s23 · Cited by 125
Extra-chromosomal telomeric DNA in cells from Atm-/- mice and patients with ataxia-telangiectasia
Hande, M. P. (2001) · Human Molecular Genetics · doi:10.1093/hmg/10.5.519 · Cited by 125
Bendix, L., Horn, P. B., Jensen, U. B., Rubelj, I., & Kølvraa, S. (2010) · Aging Cell · doi:10.1111/j.1474-9726.2010.00568.x · Cited by 128
Graakjær, J., Pascoe, L., Der‐Sarkissian, H., Thomas, G. D., Kølvraa, S., Christensen, K., & Londoño‐Vallejo, A. (2004) · Aging Cell · doi:10.1111/j.1474-9728.2004.00093.x · Cited by 125
Tong, W., Hande, M. P., Lansdorp, P. M., & Wang, Z. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.12.4046-4054.2001 · Cited by 123
Self-citationMosaic loss of human Y chromosome: what, how and why
Guo, X., Dai, X., Zhou, T., Wang, H., Ni, J., Xue, J., & Wang, X. (2020) · Human Genetics · doi:10.1007/s00439-020-02114-w · Cited by 124
Sizing the ends: Normal length of human telomeres
Samassékou, O., Gadji, M., Drouin, R., & Yan, J. (2010) · Annals of Anatomy - Anatomischer Anzeiger · doi:10.1016/j.aanat.2010.07.005 · Cited by 124
Öztürk, S., Sözen, B., & Demir, N. (2013) · Molecular Human Reproduction · doi:10.1093/molehr/gat055 · Cited by 114
Genome-Wide Association Study of Relative Telomere Length
Prescott, J., Kraft, P. L., Chasman, D. I., Savage, S. A., Mirabello, L. J., Berndt, S. I., Weissfeld, J. L., Han, J., Hayes, R. B., Chanock, S. J., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0019635 · Cited by 112
Calado, R. T., Cooper, J. N., Padilla‐Nash, H. M., Sloand, E. M., Wu, C. O., Scheinberg, P., Ried, T., & Young, N. S. (2011) · Leukemia · doi:10.1038/leu.2011.272 · Cited by 115
Mons, U., Müezzinler, A., Schöttker, B., Dieffenbach, A. K., Butterbach, K., Schick, M., Peasey, A., Vivo, I. D., Trichopoulou, A., Boffetta, P., et al. (2016) · American Journal of Epidemiology · doi:10.1093/aje/kww210 · Cited by 113
Perner, S., Brüderlein, S., Hasel, C., Waibel, I., Holdenried, A., Ciloglu, N., Chopurian, H., Nielsen, K. V., Plesch, A., Högel, J., et al. (2003) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63534-1 · Cited by 108
Cafueri, G., Parodi, F., Pistorio, A., Bertolotto, M. B., Ventura, F., Gambini, C., Bianco, P., Dallegri, F., Pistoia, V., Pezzolo, A., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0035312 · Cited by 113
Lansdorp, P. M. (2009) · The EMBO Journal · doi:10.1038/emboj.2009.172 · Cited by 109
Self-citationCharacterization of Multipotent Mesenchymal Stem Cells from the Bone Marrow of Rhesus Macaques
Izadpanah, R., Joswig, T., Tsien, F., Dufour, J., Kirijan, J. C., & Bunnell, B. A. (2005) · Stem Cells and Development · doi:10.1089/scd.2005.14.440 · Cited by 104
Changes of telomere length with aging
Takubo, K., Aida, J., Izumiyama‐Shimomura, N., Ishikawa, N., Sawabe, M., Kurabayashi, R., Shiraishi, H., Arai, T., & Nakamura, K. (2010) · Geriatrics and gerontology international/Geriatrics & gerontology international · doi:10.1111/j.1447-0594.2010.00605.x · Cited by 107
Major cutbacks at chromosome ends
Lansdorp, P. M. (2005) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2005.05.004 · Cited by 101
Self-citationEstimating age of humans based on telomere shortening
Tsuji, A., Ishiko, A., Takasaki, T., & Ikeda, N. (2002) · Forensic Science International · doi:10.1016/s0379-0738(02)00086-5 · Cited by 99
Telomeres and Longevity: Testing an Evolutionary Hypothesis
Haussmann, M. F., & Mauck, R. A. (2007) · Molecular Biology and Evolution · doi:10.1093/molbev/msm244 · Cited by 100
Breaks at telomeres and TRF2-independent end fusions in Fanconi anemia
Callén, E. (2002) · Human Molecular Genetics · doi:10.1093/hmg/11.4.439 · Cited by 98
Telomeres and telomerasePreprint
Blasco, M. A., Gasser, S. M., & Lingner, J. (1999) · Genes & Development · doi:10.1101/gad.13.18.2353 · Cited by 99
Human telomere length is chromosome end–specific and conserved across individuals
Karimian, K., Groot, A. C. G.-D., Huso, V. L., Kahidi, R., Tan, K., Sholes, S. L., Keener, R., McDyer, J. F., Alder, J. K., Li, H., et al. (2024) · Science · doi:10.1126/science.ado0431 · Cited by 97
Ongoing chromothripsis underpins osteosarcoma genome complexity and clonal evolution
Valle-Inclán, J. E., Noon, S. D., Trevers, K. E., Elrick, H., van Belzen, I. A. E. M., Zumalave, S., Sauer, C. M., Tanguy, M., Butters, T., Muyas, F., et al. (2025) · Cell · doi:10.1016/j.cell.2024.12.005 · Cited by 105
Telomere length as a biological marker in malignancy
Svenson, U., & Roos, G. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2009.01.017 · Cited by 99
Telomere Dynamics in Macaques and Humans
Gardner, J. P., Kimura, M., Chai, W., Durrani, J. F., Tchakmakjian, L., Cao, X., Lu, X., Li, G., Peppas, A. P., Skurnick, J., et al. (2007) · The Journals of Gerontology Series A · doi:10.1093/gerona/62.4.367 · Cited by 100
Fouladi, B., Sabatier, L., Miller, D., Pottier, G., & Murnane, J. P. (2000) · Neoplasia · doi:10.1038/sj.neo.7900107 · Cited by 96
New developments in telomere length analysis
Baird, D. M. (2005) · Experimental Gerontology · doi:10.1016/j.exger.2005.02.008 · Cited by 99
Telomeres, aging, and cancer: the big picture
Lansdorp, P. M. (2022) · Blood · doi:10.1182/blood.2021014299 · Cited by 96
Self-citationThe shortest telomeres drive karyotype evolution in transformed cells
Der‐Sarkissian, H., Bacchetti, S., Cazes, L., & Londoño‐Vallejo, A. (2004) · Oncogene · doi:10.1038/sj.onc.1207152 · Cited by 97
Metadata
- Authors
- Martens, U. M., Zijlmans, J. M. J. M., Poon, S. S. S., Dragowska, W., Yui, J., Chavez, E. A., Ward, R. K., & Lansdorp, P. M.
- Affiliations
- University of British Columbia (CA)
- Venue
- Nature Genetics
- Published
- 1998-01
- Volume
- 18
- Issue
- 1
- Pages
- 76-80
- ISSN
- 1061-4036 (ISSN-L)
- OpenAlex
- W2011734959
- Cited by
- 393
- References
- 28
- Citations by year
- 2026: 7 · 2025: 10 · 2024: 8 · 2023: 3 · 2022: 4 · 2021: 5 · 2020: 5 · 2019: 5 · 2018: 5 · 2017: 9 · 2016: 8 · 2015: 4 · 2014: 9 · 2013: 8 · 2012: 12
- FWCI
- 18.35
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nature Genetics (publishedVersion)
- PubMed (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
- Funders
- National Institutes of Health (1r01gm056162-01)
- National Institute of General Medical Sciences (GM56162)
- National Institute of Allergy and Infectious Diseases (AI 29524)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Chromosomal and Genetic Variations
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Keywords
- telomere length, chromosome 17p, chromosome stability
- MeSH terms
- Adult, Bone Marrow Cells, Carbocyanines, Cells, Cultured, Chromosomes, Human, Pair 17, Fibroblasts, Fluorescent Dyes, Humans, Image Processing, Computer-Assisted, Indoles, Metaphase, Repetitive Sequences, Nucleic Acid, Telomere, In Situ Hybridization, Fluorescence
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
