Cited by 609Animal Genetics and ReproductionCRISPR and Genetic EngineeringZebrafish Biomedical Research Applications

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The Knockout Mouse Project

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The Comprehensive Knockout Mouse Project Consortium·2004·Nature Genetics

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Abstract

Mouse knockout technology provides a powerful means of elucidating gene function in vivo, and a publicly available genome-wide collection of mouse knockouts would be significantly enabling for biomedical discovery. To date, published knockouts exist for only about 10% of mouse genes. Furthermore, many of these are limited in utility because they have not been made or phenotyped in standardized ways, and many are not freely available to researchers. It is time to harness new technologies and efficiencies of production to mount a high-throughput international effort to produce and phenotype knockouts for all mouse genes, and place these resources into the public domain.

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Target Selection and Validation in Drug Discovery
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Recent Progress in Biotechnology-based Gene Manipulating Systems to Produce Knock-In/Out Mouse Models
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Authors: The Comprehensive Knockout Mouse Project Consortium
Venue: Nature Genetics
Publisher: Springer Science and Business Media LLC
Published: 2004-09
Volume: 36
Issue: 9
Pages: 921-924
ISSN: 1061-4036 (ISSN-L)
1546-1718
DOI: 10.1038/ng0904-921
PMC: PMC2716027
OpenAlex: W2023630351
Cited by: 608
References: 24
Citations by year: 2026: 7 · 2025: 9 · 2024: 13 · 2023: 9 · 2022: 36 · 2021: 17 · 2020: 14 · 2019: 21 · 2018: 11 · 2017: 15 · 2016: 18 · 2015: 26 · 2014: 22 · 2013: 40 · 2012: 37
FWCI: 30.43
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Nature Genetics (publishedVersion, public-domain)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Cold Spring Harbor Laboratory Institutional Repository (Cold Spring Harbor Laboratory) (acceptedVersion)
The Mouseion at the JAXlibrary (Jackson Laboratory) (submittedVersion, public-domain)
Funders: GlaxoSmithKline
University of Pennsylvania
Wellcome Trust (077188)
University of Toronto
National Institutes of Health (10021)
National Institute of Mental Health
National Institute on Deafness and Other Communication Disorders
National Center for Research Resources
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Animal Genetics and Reproduction
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › CRISPR and Genetic Engineering
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Zebrafish Biomedical Research Applications
Keywords: knockout mice, gene function, phenotyping, mouse genetics
MeSH terms: Alleles, Animals, Phenotype, Mice, Knockout, Research Embryo Creation, Genetic Research, Mice

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