The Knockout Mouse Project

Initial sequencing and analysis of the human genome

International Human Genome Sequencing Consortium, Whitehead Institute for Biomedical Research, C. F. G. R., Lander, E. S., Linton, L. M., Birren, B., Nusbaum, C., Zody, M. C., Baldwin, J., Devon, K., Dewar, K., et al. (2001) · Nature · doi:10.1038/35057062 · Cited by 24,216

The sequence of the human genome

Venter, J. C., Adams, M. D., Myers, E. W., Li, P. W., Mural, R. J., Sutton, G. G., Smith, H. O., Yandell, M., Evans, C. A., Holt, R. A., et al. (2001) · Science · doi:10.1126/science.1058040 · Cited by 13,909

Positional cloning of the mouse obese gene and its human homologue

Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L., & Friedman, J. M. (1994) · Nature · doi:10.1038/372425a0 · Cited by 13,419

Initial sequencing and comparative analysis of the mouse genome

Mouse Genome Sequencing Consortium (2002) · Nature · doi:10.1038/nature01262 · Cited by 7,187

A protein related to extracellular matrix proteins deleted in the mouse mutant reeler

D'Arcangelo, G., G. Miao, G., Chen, S.-C., Scares, H. D., Morgan, J. I., & Curran, T. (1995) · Nature · doi:10.1038/374719a0 · Cited by 1,748

Deficiency of methyl-CpG binding protein-2 in CNS neurons results in a Rett-like phenotype in mice

Chen, R. Z., Akbarian, S., Tudor, M., & Jaenisch, R. (2001) · Nature Genetics · doi:10.1038/85906 · Cited by 1,275

Molecular characterization of the mouse agouti locus

Bultman, S. J., Michaud, E. J., & Woychik, R. P. (1992) · Cell · doi:10.1016/s0092-8674(05)80067-4 · Cited by 805

High-throughput engineering of the mouse genome coupled with high-resolution expression analysis

Valenzuela, D. M., Murphy, A. J., Frendewey, D. A., Gale, N. W., Economides, A. N., Auerbach, W., Poueymirou, W. T., Adams, N. C., Rojas, J., Yasenchak, J., et al. (2003) · Nature Biotechnology · doi:10.1038/nbt822 · Cited by 583

Disruption and sequence identification of 2,000 genes in mouse embryonic stem cells

Zambrowicz, B., Friedrich, G. A., Buxton, E. C., Lilleberg, S. L., Person, C., & Sands, A. (1998) · Nature · doi:10.1038/33423 · Cited by 436

Gene-trap mutagenesis: past, present and beyond

Stanford, W. L., Cohn, J. B., & Cordes, S. P. (2001) · Nature Reviews Genetics · doi:10.1038/35093548 · Cited by 391

Chapter 23 A Path to Innovation: Gene Knockouts Model New Drug Action

Zambrowicz, B., & Sands, A. (2009) · Annual reports in medicinal chemistry · doi:10.1016/s0065-7743(09)04423-6 · Cited by 1

Behavioural Genetics: Finding Genes that Cause Complex Trait Variation

Christians, J. K., & Keightley, P. D. (2005) · Current Biology · doi:10.1016/j.cub.2004.12.013 · Cited by 1

Thematic review series: Systems Biology Approaches to Metabolic and Cardiovascular Disorders Approaches to lipid metabolism gene identification and characterization in the postgenomic era

Reue, K., & Vergnes, L. (2006) · Journal of Lipid Research · doi:10.1194/jlr.r600020-jlr200 · Cited by 1

New genetic resources for mammalian developmental biologists

Beier, D. R. (2010) · F1000 Biology Reports · doi:10.3410/b2-72 · Cited by 1

SURVEY AND SUMMARY Emerging functional and mechanistic paradigms of mammalian long non-coding RNAs

Moran, V. A., Perera, R. J., & Khalil, A. M. (2012) · Cited by 1

The Sheffield RNAi Screening Facility (SRSF): Portfolio Growth and Technology Development

Brown, S. (2014) · Combinatorial Chemistry & High Throughput Screening · doi:10.2174/1386207317666140323132531 · Cited by 1

Advances in Genome Engineering Approaches

Chhabra, A. (2014) · Advancements in Genetic Engineering · doi:10.4172/2169-0111.1000e107 · Cited by 1

EMBRYONIC STEM CELLS - CURRENT KNOWLEDGE AND FUTURE PROSPECTS

Slamecka, J., & Chrenek, P. (2010) · Cited by 1

Microscopic Computed Tomography-Based Virtual Histology of Embryos

Prajapati, S. I., Rodríguez, D. R., & Keller, C. (2013) · Methods in molecular biology · doi:10.1007/978-1-60327-292-6_19 · Cited by 1

Applying In Silico Integrative Genomics to Genetic Studies of Human Disease

Saccone, S. F. (2012) · International review of neurobiology · doi:10.1016/b978-0-12-388408-4.00007-1 · Cited by 1

Generation of Knockout Alleles by RFLP Based BAC Targeting of Polymorphic Embryonic Stem Cells

Barakat, T. S., & Gribnau, J. H. (2014) · Methods in molecular biology · doi:10.1007/978-1-4939-1652-8_7 · Cited by 1

Trans-inner Cell Mass Injection of Embryonic Stem Cells Leads to Higher Chimerism Rates

Scott, G. J., Gruzdev, A., Hagler, T. B., & Ray, M. K. (2018) · Journal of Visualized Experiments · doi:10.3791/56955 · Cited by 1

Gene Editing Technologies and Use of Recombinant/Synthetic Nucleic Acids in Laboratory Animals

Landel, C. P., & Pritchett‐Corning, K. R. (2018) · Applied Biosafety · doi:10.1177/1535676018797353 · Cited by 1

Publication and Peer Review

Shamoo, A. E., & Resnik, D. B. (2022) · Oxford University Press eBooks · doi:10.1093/oso/9780197547090.003.0006 · Cited by 1

Misconduct in Research

Shamoo, A. E., & Resnik, D. B. (2022) · Oxford University Press eBooks · doi:10.1093/oso/9780197547090.003.0002 · Cited by 1

Cyfip2 allelic variation in C57BL/6J and C57BL/6NJ mice alters free‐choice ethanol drinking but not binge‐like drinking or wheel‐running activity

Hartmann, M. C., McCulley, W. D., Holbrook, S. E., Haney, M. M., Smith, C. G., Kumar, V., & Rosenwasser, A. M. (2023) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.15137 · Cited by 1

Autonomous and non-cell autonomous role of cilia in structural birth defects in mice

Francis, R. J. B., Agustin, J. T. S., Rogers, H. S., Cui, C., Jonassen, J. A., Eguether, T., Follit, J. A., Lo, C. W. Y., & Pazour, G. J. (2023) · PLoS Biology · doi:10.1371/journal.pbio.3002425 · Cited by 2

Stem Cell and Cell Products for Tissue Engineering and Regenerative Therapies in Dentistry

Ana, I. D., Rachmawati, M. W., & Anggraeni, R. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-15717-2.00080-9 · Cited by 1

Adaptive genetic mechanisms in mammalian Parp1 locus

Karpova, Y. D., & Tulin, A. V. (2024) · G3 Genes Genomes Genetics · doi:10.1093/g3journal/jkae165 · Cited by 1

Regulation and Expression of Nanog, Oct4, and Sox2 in the Bovine Blastocyst following Somatic Cell Nuclear Transfer

Hall, J. (2021) · Digital Commons - USU (Utah State University) · doi:10.26076/efd7-18ac · Cited by 1

Annotation, genetics and transcriptomics

Mott, R. (2008) · Springer eBooks · doi:10.1007/978-3-211-75123-7_7 · Cited by 1

Genetically modified mice- Methods, applications and outlook

Boroujeni, M. E., Miran, R. A., Afkhami, F., Tavakol, Z., & Shamsara, M. (2019) · Scientific Journal of Kurdistan University of Medical Sciences · doi:10.29252/sjku.24.1.24 · Cited by 1

Applications for stem cells

Bratt‐Leal, A. M., Zhang, A., Wang, Y., & Loring, J. F. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-818422-6.00025-3 · Cited by 1

Generation of global Spata19 knockout mouse using CRISPR/Cas9 nickase technology

Zargar, M., Jamshidizad, A., Tayefeh, A. R., Hashemi, E., Najafi, A., Shamsara, M., & Modarressi, M. H. (2020) · کومش · doi:10.29252/koomesh.22.3.380 · Cited by 1

Collaboration within Academia and with Industry

Shamoo, A. E., & Resnik, D. B. (2022) · Oxford University Press eBooks · doi:10.1093/oso/9780197547090.003.0004 · Cited by 3

Genetic Analysis of Development

Majumdar, T. D., & Dey, A. (2022) · Springer eBooks · doi:10.1007/978-981-16-7041-1_17 · Cited by 1

Genomic and Post- Genomic Tools for Studying Synapse Biology

Kittler, J. T., & Oliver, P. L. (2006) · Frontiers in neuroscience · doi:10.1201/9780203486283.ch15 · Cited by 1

The molecular basis of Marinesco-Sjögren syndrome

Anttonen, A. (2008) · Työväentutkimus Vuosikirja · Cited by 1

Evaluating synergy between deregulation of the Wnt, PI3-Kinase and MAP-Kinase pathways in prostate tumourigenesis

Jefferies, M. T. (2017) · ORCA Online Research @Cardiff (Cardiff University) · Cited by 1

Transcriptional and Epigenetic Regulation

Merchant, J. L., & Bai, L. (2006) · Elsevier eBooks · doi:10.1016/b978-012088394-3/50004-0 · Cited by 1

Meeting Report. Assessing Human Germ-Cell Mutagenesis in the Post-Genome Era: A Celebration of the Legacy of William Lawson (Bill) Russell

Wyrobek, A. J., Mulvihill, J. J., Wassom, J. S., Malling, H. V., Shelby, M. D., Lewis, S. E., Witt, K., Preston, R. J., Perreault, S. D., Allen, J. W., et al. (2006) · University of North Texas Digital Library (University of North Texas) · Cited by 1

A “CRISPY” tale on microalgal genome editing: featuring Nannochloropsis oceanica IMET1

Naduthodi, M. I. S. (2021) · doi:10.18174/555308 · Cited by 1

“Integration of multimodal data in the developing tooth reveals candidate dental disease genes”Preprint

Winchester, E. W., Hardy, A., & Cotney, J. L. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.03.15.483501 · Cited by 1

Autonomous and non-cell autonomous etiology of ciliopathy associated structural birth defectsPreprint

Francis, R. J. B., Agustin, J. T. S., Szabo‐Rogers, H. L., Cui, C., Jonassen, J. A., Eguether, T., Follit, J. A., Lo, C. W. Y., & Pazour, G. J. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.06.07.544132 · Cited by 1

LocusPackRat: a Semi-Automated Framework for Prioritizing Candidate Genes from Large GWAS IntervalsPreprint

Gural, B., Kimball, T. H., Luu, A. N., & Rau, C. D. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2025.12.03.692167 · Cited by 1

GSF - Publication List 2004

Pirker, C., Raidl, M., Steiner, E., Elbling, L., Holzmann, K., Spiegl-Kreinecker, S., Aubele, M. M., Marosi, C., Micksche, M., Berger, W., et al. (2005)

Genomics

Caldwell, J. S., Chanda, S. K., Irelan, J. T., & Koenig, R. (2007) · Elsevier eBooks · doi:10.1016/b0-08-045044-x/00073-0

Confirmation of Gene Function Using Translational Approaches

Zeiss, C. J. (2011) · doi:10.1002/9780470933947.ch17

Physiological Genomics of the Rat Renal Failure QTLs Rf-1 through Rf-5

van Dijk, S. J. (2005)

Mouse Genetic and Phenotypic Resources as Tools for Human Genetics

Hancock, J. M. (2013) · Wiley eBooks · doi:10.1002/9780470015902.a0025011

Computational analysis of genome-scale growth-interaction data in Saccharomyces cerevisiae

VanderSluis, B. (2014) · University of Minnesota Digital Conservancy (University of Minnesota)

Functional annotation of the mouse genome: the challenge of phenotyping

Brown, S. D. M. (2005) · Wiley eBooks · doi:10.1002/047001153x.g204317

Taking Advantage of New Tools and Techniques

Olsen, L., & McGinnis, J. M. (2010)

Tiermodelle in der biomedizinischen Forschung

Britsch, S., Strehle, M., & Birchmeier, C. (2003) · Springer eBooks · doi:10.1007/978-3-662-07588-3_10

Production of knockout mouse by gene trapping

Yamamura, K. (2007) · Folia Pharmacologica Japonica · doi:10.1254/fpj.129.337

Complex trait approaches to the analysis of behaviour in the mouse

Schalkwyk, L. C. (2005) · Psychiatry · doi:10.1383/psyt.2005.4.12.18

Mapeamento genético e caracterização fenotípica do mutante anêmico induzido por Ethyl-nitroso-urea.

da Cruz, C. C. (2009) · doi:10.11606/d.87.2009.tde-21122009-092858

Genetic Mouse Models of Psychiatric Disorders

Gogos, J. A., & Karayiorgou, M. (2006) · Contemporary clinical neuroscience · doi:10.1007/978-1-59745-058-4_9

Variation in sleep behaviour and its underlying causes: a study in a free-living blue tit population

Loës, C. (2012)

Applications of Gene Targeting in the Investigations of Human Airway

Zhang, Y. (2013)

Reduced Glutathione Enhances Fertility of Frozen/Thawed C57BL/6 Mouse Sperm after Exposure to Methyl-Beta-Cyclodextrin Short title: Glutathione facilitates fertilization in mice Summary sentence: Adding reduced glutathione to in vitro fertilization medium modifies the oocyte zona pellucida and enhances the fertilization rate using frozen/thawed C57BL/6 mouse sperm.

Takeo, T., & Nakagata, N. (2011)

Susceptibility to liver carcinogenesis is increased in a mouse model of conditional E-cadherin deficiency

Schneider, M. R. (2013)

Generation and Characterization of Spred-2 Knockout Mice

Würzburg, J.-M.-U. (2005)

Implication du gène Arntl2 lié au rythme circadien dans le diabète de type 1

Lebailly, B. (2015) · theses.fr (ABES) · doi:10.70675/b6eab70bz2ed4z4e49z8cdazaf060127c62d

A Brief Review on Mechanisms of Gene Regulation and Pathogenomics

Edwards, C. K. (2013) · Journal of Bioanalysis & Biomedicine · doi:10.4172/1948-593x.s3-e001

Establishment and future development of mouse resources toward unraveling the gene function

Yoshiki, A., Mei-Ling, J. A. N., & Mekada, K. (2007) · The Journal of Animal Genetics · doi:10.5924/abgri2000.35.83

Issues and solutions of conditional gene targeting

Lin, F., & Yang, X. Y. (2011) · Hereditas (Beijing) · doi:10.3724/sp.j.1005.2011.00469

Transcription and Epigenetic Regulation

Merchant, J. L. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-382026-6.00001-4

Exploring Appetite and Hypothalamic Circuitry through Manipulating Gene Expression

Jois, T., & Sleeman, M. W. (2016) · Wiley eBooks · doi:10.1002/9781118839317.ch7

行動テストバッテリーを用いた遺伝子改変マウスの表現型解析による遺伝子機能の探索：カルシニューリンノックアウトマウスの例を中心に

Miyakawa, T. (2005) · Proceedings of The Japanese Society of Animal Models for Human Diseases · doi:10.1538/expanim1992.21.70

Glycomic Analysis of Biomedically Important O-glycoconjugates

Ismail, M. N. (2011) · doi:10.25560/6217

High efficiencies of gene delivery and gene targeting in embryonic stem cells of the fish medaka as a lower vertebrate model

Yan, Y. (2011) · doi:10.32657/10356/46530

71 Obese Mouse Models

Good, D. J. (2008)

Anopheles/Plasmodium interactions at the ookinete-to-oocyst developmental transition

Akinosoglou, K.-A. (2011) · doi:10.25560/14690

The role of previously uncharacterized RNA binding proteins in hematopoiesis

Itisam, S. (2013) · doi:10.32657/10356/55060

zur Erlangung des Doktorgrades der Mathematisch-Naturwissenschaftlichen Fakultäten der Georg-August-Universität zu Göttingen

Malinouskaya, L. (2005)

INVESTIGATING TRIPLEX-FORMING OLIGONUCLEOTIDES THAT TARGET THE MOUSE Cd9 GENE

Asamoah, B. W. (2013)

Identification and characterisation of genes which are critical for murine gastrulation

Alzahrani, A. (2017) · ANU Open Research (Australian National University) · doi:10.25911/5d70f090cffb2

Genome Editing and Differentiation of Embryonic Stem Cells

Shy, B. R. (2017) · Figshare

Functional Genomics

Pevsner, J. (2009) · doi:10.1002/9780470451496.ch12

An inducible and reversible genetics platform for novel drug target discovery

Leong, M. L. (2019) · doi:10.32657/10220/48048

Diphtheria toxin‐mediated transposon‐driven poly (A)‐trapping efficiently disrupts transcriptionally silent genes in embryonic stem cells

Bai, J., Kondo, R., Mayasari, N. I., Shigeoka, T., Isotani, A., Ikawa, M., Sashida, G., Kawaichi, M., & Ishida, Y. (2020) · genesis · doi:10.1002/dvg.23386

Experimental Modulation of Heat Shock Response

Evgen’ev, M. B., Garbuz, D. G., & Zatsepina, O. G. (2014) · Springer eBooks · doi:10.1007/978-94-017-9235-6_8

Genetic analysis of synaptogenesis

Lu, C. S., & Vactor, D. V. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-823672-7.00004-1

Tiermodelle in der biomedizinischen Forschung

Strehle, M., & Britisch, S. (2008) · Springer eBooks · doi:10.1007/978-3-540-69414-4_9

Funktionelle Analyse des murinen Sall4-Gens

Malinouskaya, L. (2007) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-185

Funktionelle Analyse des murinen 66.3-kDa-Proteins

Kettwig, M. (2010) · doi:10.53846/goediss-885

Reviews and comment from the nature publishing group

(2004) · Nature Reviews Genetics · doi:10.1038/nrg1468

References

Crawley, J. N. (2006) · Wiley eBooks · doi:10.1002/9780470119051.refs

Transgenics

Müller, M. M., & Avitahl-Curtis, N. (2006) · Birkhäuser Basel eBooks · doi:10.1007/978-3-7643-7520-1_7

Large-Scale Homologous Recombination Approaches in Mouse Embryonic Stem Cells

Wiles, M. V., & Proetzel, G. (2006) · Springer eBooks · doi:10.1007/3-540-29623-9_2100

The Use of Animals in Research

Shamoo, A. E., & Resnik, D. B. (2022) · Oxford University Press eBooks · doi:10.1093/oso/9780197547090.003.0010

Scientific Research and Ethics

Shamoo, A. E., & Resnik, D. B. (2022) · Oxford University Press eBooks · doi:10.1093/oso/9780197547090.003.0001

Authorship

Shamoo, A. E., & Resnik, D. B. (2022) · Oxford University Press eBooks · doi:10.1093/oso/9780197547090.003.0005

Data Acquisition and Management

Shamoo, A. E., & Resnik, D. B. (2022) · Oxford University Press eBooks · doi:10.1093/oso/9780197547090.003.0003

Conclusion

Shamoo, A. E., & Resnik, D. B. (2022) · Oxford University Press eBooks · doi:10.1093/oso/9780197547090.003.0013

Mentoring and the Research Environment

Shamoo, A. E., & Resnik, D. B. (2022) · Oxford University Press eBooks · doi:10.1093/oso/9780197547090.003.0009

The Protection of Human Subjects in Research

Shamoo, A. E., & Resnik, D. B. (2022) · Oxford University Press eBooks · doi:10.1093/oso/9780197547090.003.0011

Intellectual Property

Shamoo, A. E., & Resnik, D. B. (2022) · Oxford University Press eBooks · doi:10.1093/oso/9780197547090.003.0007

Science and Social Responsibility

Shamoo, A. E., & Resnik, D. B. (2022) · Oxford University Press eBooks · doi:10.1093/oso/9780197547090.003.0012

Generation of Mouse Model of Hemophilia A by Introducing Novel Mutations, Using CRISPR/Nickase Gene Targeting System.

Shamsara, M., Jamshidizad, A., Tayefeh, A. R., Davari, M., Zangi, A. R., Masoumi, F., & Zomorodipour, A. (2023) · PubMed Central · doi:10.22074/cellj.2023.1999800.1278

ROLE OF BIOINFORMATICS IN MENTAL HEALTH

Garg, S. (2024) · International Journal of Biology Pharmacy and Allied Sciences · doi:10.31032/ijbpas/2024/13.2.7763

Preface to the Fourth Edition

Shamoo, A. E., & Resnik, D. B. (2022) · Oxford University Press eBooks · doi:10.1093/oso/9780197547090.002.0005

Copyright Page

Shamoo, A. E., & Resnik, D. B. (2022) · Oxford University Press eBooks · doi:10.1093/oso/9780197547090.002.0003

The genetic basis of male infertility with “multiple morphological abnormalities of the flagella” and its intervention strategies

ZHENG, J., Wang, Y., Zhang, F., & Wang, L. (2025) · Scientia Sinica Vitae · doi:10.1360/ssv-2024-0230

Potential Applications of the CRISPR-Cas9 System for Research and Treatment of Osteoarthritis

Liang, L., Yang, Y., Elise, F. J., Yu, J., Yin, X., Lu, G., Chen, B., & Xing, J. (2025) · Zeitschrift für Orthopädie und Unfallchirurgie · doi:10.1055/a-2616-0819

A single-cell atlas inclusive of age-related menopause reveals global tissue and ovarian remodelingPreprint

VanBenschoten, H. M., Nugmanova, Z., Olmsted, A. M., Huang, R., Annepureddy, L. D., Gingerich, I. K., Kratka, C. E., Duncan, F. E., Kholod, O., & Goods, B. A. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.06.20.660779

The importance of imperfect pre-clinical models in adolescent idiopathic scoliosis

Sepich, D. S., Gray, R. S., Ahituv, N., Gurnett, C. A., Rios, J. J., Solnica‐Krezel, L., & Wise, C. A. (2025) · Disease Models & Mechanisms · doi:10.1242/dmm.052438

Exploring brain gene expression in animal models of behaviour.

Lindberg, J. H. (2007) · Europe PMC (PubMed Central)

BAC Transgenesis: Cell-Type Specific Expression in the Nervous System

Lai, C. (2009) · Elsevier eBooks · doi:10.1016/b978-008045046-9.00869-x

GENERATION OF TRANSGENIC ANIMALS

Zambrowicz, B., Holt, K. H., WALKE, D. W., Kirkpatrick, L., & Eberhart, D. E. (2007) · Elsevier eBooks · doi:10.1016/b978-012369393-8/50002-x · Cited by 7

A Mouse for Every Gene

Grimm, D. (2006) · Science · doi:10.1126/science.312.5782.1862 · Cited by 31

A note of caution on the Knockout Mouse Project

Accili, D. (2004) · Nature Genetics · doi:10.1038/ng1104-1132 · Cited by 7

Large‐scale mouse knockouts and phenotypes

Ramírez‐Solis, R., Ryder, E. J., Houghton, R., White, J. K., & BOTTOMLEY, J. R. (2012) · WIREs Systems Biology and Medicine · doi:10.1002/wsbm.1183 · Cited by 7

Disease model discovery from 3,328 gene knockouts by The International Mouse Phenotyping Consortium

Meehan, T. F., Conte, N., West, D. B., Jacobsen, J. O., Mason, J., Warren, J., Chen, C. K., Tudose, I., Relac, M., Matthews, P., et al. (2018) · Yearbook of pediatric endocrinology · doi:10.1530/ey.15.14.14 · Cited by 1