Cited by 822Genomic variations and chromosomal abnormalitiesCancer Genomics and DiagnosticsChromatin Remodeling and Cancer

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Chromosome aberrations in solid tumors

Albertson, Donna G, Collins, Colin, McCormick, Frank, Gray, Joe W·2003·Nature Genetics

DOI 10.1038/ng1215

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Abstract

Chromosome aberrations in human solid tumors are hallmarks of gene deregulation and genome instability. This review summarizes current knowledge regarding aberrations, discusses their functional importance, suggests mechanisms by which aberrations may form during cancer progression and provides examples of clinical advances that have come from studies of chromosome aberrations.

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Authors: Albertson, D. G., Collins, C., McCormick, F., & Gray, J. W.
Affiliations: University of California, San Francisco (US)
Lawrence Berkeley National Laboratory (US)
Corresponding author: Albertson, Donna G
Gray, Joe W
ORCID: Albertson, Donna G
Collins, Colin
McCormick, Frank
Gray, Joe W
Venue: Nature Genetics
Publisher: Springer Science and Business Media LLC
Published: 2003-07-30
Volume: 34
Issue: 4
Pages: 369-376
ISSN: 1061-4036 (ISSN-L)
1546-1718
DOI: 10.1038/ng1215
OpenAlex: W2060084956
Cited by: 812
References: 167
Citations by year: 2026: 8 · 2025: 11 · 2024: 15 · 2023: 22 · 2022: 26 · 2021: 26 · 2020: 29 · 2019: 27 · 2018: 19 · 2017: 18 · 2016: 19 · 2015: 32 · 2014: 41 · 2013: 68 · 2012: 54
FWCI: 4.93
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Genetics (publishedVersion)
PubMed (publishedVersion)
Funders: Avon Foundation for Women
U.S. Public Health Service
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genomic variations and chromosomal abnormalities
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer Genomics and Diagnostics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
Keywords: chromosomal abnormalities, solid tumors, genomic instability, gene expression dysregulation, tumor progression, chromosomal instability
MeSH terms: Chromosome Aberrations, Biological Evolution, Humans, Models, Genetic, Neoplasms, Oncogenes, Prognosis, Signal Transduction, Gene Dosage, Receptor Protein-Tyrosine Kinases

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